{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "21bd609b55973b7b5b84e545fdde629d79115243854f1595680c534e6e1ef96f",
  "corpus_snapshot": "2026-11-02T19:05:06+0100",
  "source_commit": "1e9de0d56d4ea503818c4095460addc4a0c7f4a3",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "RAG-MTORC1",
  "claim": "Rag GTPases recruits mTORC1",
  "source": {
   "name": "Rag GTPases",
   "entity": "rag-gtpases"
  },
  "target": {
   "name": "mTORC1",
   "entity": "mtorc1"
  },
  "effect": "recruits",
  "type": "recruitment",
  "directness": "direct",
  "timescale": "minutes",
  "compartment": "lyso",
  "map_band": "lyso",
  "species": [
   "human cells"
  ],
  "mechanism": "The active Rag dimer grabs Raptor and physically drags mTORC1 to the lysosomal surface. This is a relocation, not an activation - the kinase is moved to where its activator waits.",
  "mechanism_beginner": "The switched-on Rag proteins grab mTORC1 and drag it to the lysosome. This moves it into place; it doesn't turn it on by itself.",
  "context": null,
  "boundary": "Rag paralogues are not interchangeable: RagC/D sets substrate specificity downstream (RagD favors TFEB/TFE3 phosphorylation via tighter LAMTOR binding, while both Rags are involved for non-lysosomal substrates like S6K), and RagA/B sets the response to amino acid withdrawal (RagB-expressing cells keep mTORC1 lysosomal and active even when starved) — GOL2022.",
  "boundary_tags": [],
  "conflict": null,
  "note": "The conceptual crux of the whole route: teach recruitment vs activation as two separate ideas.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Direct biochemical",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "SAN2008",
    "SAN2010",
    "LAW2018",
    "GOL2022",
    "EFE2012",
    "CUI2025",
    "NAR2011",
    "KIM2008",
    "ANA2019",
    "KIM2012"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/RAG-MTORC1/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/RAG-MTORC1.json"
 }
}