{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "ef11bce8836642f77eb39d518489732eccd33e90f310d6d036f854144306220b",
  "corpus_snapshot": "2026-11-02T15:22:39+0100",
  "source_commit": "c46ff8a4fae379631c451b4504a94a5b75f27712",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "MTORC2-INSULINRES",
  "claim": "mTORC2 inhibits Insulin resistance",
  "source": {
   "name": "mTORC2",
   "entity": "mtorc2"
  },
  "target": {
   "name": "Insulin resistance",
   "entity": "insulin-resistance"
  },
  "effect": "inhibits",
  "type": "functional-consequence",
  "directness": "indirect",
  "timescale": "chronic",
  "compartment": null,
  "map_band": "outcome",
  "species": [
   "mouse"
  ],
  "mechanism": "Losing mTORC2 uncouples Akt from insulin signalling and produces glucose intolerance - and this is separable from the lifespan benefit.",
  "mechanism_beginner": "Losing mTORC2 disconnects Akt from insulin signalling and can cause blood-sugar problems – a separate effect from any lifespan benefit.",
  "context": null,
  "boundary": "In mice, intermittent dosing largely spared glucose tolerance while keeping mTORC1 inhibition (ARR2015); not tested against this endpoint in humans.",
  "boundary_tags": [
   "single-species",
   "time-dependent"
  ],
  "conflict": null,
  "note": "Feeds hypothesis H2 in Knowledge_Gaps.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "plausible",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "LAM2012",
    "ARR2015"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/MTORC2-INSULINRES/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/MTORC2-INSULINRES.json"
 }
}