{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "4823f516b720e66843f0b75952daf5ccc5279a7c20c0cb7c0d1ac126ff6ca768",
  "corpus_snapshot": "2026-10-24T21:34:23+0200",
  "source_commit": "8f0f14a10e115daab72bb59e5bf8c63eda1daeb8",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "MTORC2-ACTIN",
  "claim": "mTORC2 activates Actin cytoskeleton",
  "source": {
   "name": "mTORC2",
   "entity": "mtorc2"
  },
  "target": {
   "name": "Actin cytoskeleton",
   "entity": "actin-cytoskeleton"
  },
  "effect": "activates",
  "type": "functional-consequence",
  "directness": "indirect",
  "timescale": "minutes",
  "compartment": "cytosol",
  "map_band": "cytosol",
  "species": [
   "mammalian cells",
   "yeast"
  ],
  "mechanism": "One of the first functions assigned to mTORC2 was shaping the cell's skeleton. In yeast it was the original TOR2 phenotype; in mammalian cells it showed that the second complex is acutely rapamycin-insensitive.",
  "mechanism_beginner": "mTORC2's first known job was shaping the cell's internal skeleton. It was found in yeast first, as the original TOR2 phenotype, and then in mammalian cells - where it stood out precisely because rapamycin didn't block it.",
  "context": null,
  "boundary": "Mammalian cells, yeast, Drosophila and conditional Rictor-knockout mice (JAC2004, SAR2004, LOE2002, HUA2013). The cytoskeleton phenotype was defined in cell lines and yeast; its role in intact tissue is less tested.",
  "boundary_tags": [],
  "note": "The two-complex model itself came from biochemistry (LOE2002, JAC2004, SAR2004).",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "JAC2004",
    "SAR2004",
    "LOE2002",
    "HUA2013"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/MTORC2-ACTIN/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/MTORC2-ACTIN.json"
 }
}