{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "MTORC1-S6K1",
  "claim": "mTORC1 activates S6K1",
  "source": {
   "name": "mTORC1",
   "entity": "mtorc1"
  },
  "target": {
   "name": "S6K1",
   "entity": "s6k1"
  },
  "effect": "activates",
  "type": "phosphorylation",
  "directness": "direct",
  "timescale": "minutes",
  "compartment": "cytosol",
  "map_band": "cytosol",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "mTORC1 phosphorylates S6K1, switching on the translation machinery. This is the classic rapamycin-sensitive output and the readout most papers actually measure.",
  "mechanism_beginner": "mTORC1 switches on S6K1, which turns on the cell's protein-building machinery – the classic effect most studies of this drug class measure.",
  "context": "Standard mTORC1 readout, but a readout is not the whole output. S6K1 phosphorylation is fully rapamycin-sensitive while 4E-BP1 is not, so 'mTORC1 activity' measured by S6K1 alone systematically overstates how much rapamycin inhibits mTORC1.",
  "boundary": "Caution: p-S6K is a proxy, not the phenotype. Many 'mTORC1 activity' claims rest on this single band.",
  "note": "Worth flagging on the page: readout != outcome.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Direct biochemical",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "BUR1998",
    "CHU1992",
    "HOL2005",
    "KAN2013",
    "HAR1998",
    "NOJ2003"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/MTORC1-S6K1/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/MTORC1-S6K1.json"
 }
}