{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "MTORC1-MAPK",
  "claim": "mTORC1 inhibits ERK / RSK (MAPK)",
  "source": {
   "name": "mTORC1",
   "entity": "mtorc1"
  },
  "target": {
   "name": "ERK / RSK (MAPK)",
   "entity": "erk-rsk-mapk"
  },
  "effect": "inhibits",
  "type": "signal-relay",
  "directness": "indirect",
  "timescale": "hours",
  "compartment": "cytosol",
  "map_band": "cytosol",
  "species": [
   "patient tumour biopsies (RAD001)",
   "mouse",
   "human cells"
  ],
  "mechanism": "A second feedback arm: inhibiting mTORC1 releases a PI3K-dependent brake and MAPK signalling goes up. Together with S6K1-IRS1 this is why single-agent mTOR inhibition tends to be met by compensatory growth signalling.",
  "mechanism_beginner": "Blocking mTORC1 can backfire by releasing a brake on a different growth pathway (MAPK) – one reason mTOR-blocking drugs alone often aren't enough.",
  "context": null,
  "boundary": "Single-study edge in this corpus. CAR2008 includes tumour biopsies from patients with advanced solid tumours treated with RAD001 (everolimus), in which MAPK activation depended on the dosing schedule, plus a mouse prostate cancer model, xenografts and cell lines.",
  "note": "CAR2008 was already in the corpus but carried no edge until 2026-07-29.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "established",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "CAR2008"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/MTORC1-MAPK/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/MTORC1-MAPK.json"
 }
}