{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "21bd609b55973b7b5b84e545fdde629d79115243854f1595680c534e6e1ef96f",
  "corpus_snapshot": "2026-11-02T19:05:06+0100",
  "source_commit": "1e9de0d56d4ea503818c4095460addc4a0c7f4a3",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "MTORC1-LONGEVITY",
  "claim": "mTORC1 inhibits Longevity",
  "source": {
   "name": "mTORC1",
   "entity": "mtorc1"
  },
  "target": {
   "name": "Longevity",
   "entity": "longevity"
  },
  "effect": "inhibits",
  "type": "functional-consequence",
  "directness": "indirect",
  "timescale": "chronic",
  "compartment": null,
  "map_band": "outcome",
  "species": [
   "multiple species"
  ],
  "mechanism": "Lowering mTORC1 activity extends lifespan across yeast, worms, flies and mice - one of the most conserved interventions in ageing biology, alongside dietary restriction.",
  "mechanism_beginner": "Turning mTORC1 down extends lifespan in yeast, worms, flies and mice – one of the best-replicated anti-ageing effects in laboratory animals. In mice, how big the effect is depends on sex, strain, diet and when treatment starts, and it has not been shown in people.",
  "context": "Strongly modified by sex, strain, diet and the age at which inhibition starts. Effect direction is reproducible; effect size is not transferable between models.",
  "boundary": "No human hard-endpoint evidence. This is the Atlas's flagged 'human endpoint desert'.",
  "boundary_tags": [],
  "conflict": null,
  "note": "Links to ATLAS_FINDINGS human-endpoint desert.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "untested",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "HAR2009",
    "LAM2012",
    "ROB2012",
    "VEL2003",
    "HAN2008",
    "POW2006",
    "WAN2026"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/MTORC1-LONGEVITY/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/MTORC1-LONGEVITY.json"
 }
}