{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "MTORC1-4EBP1",
  "claim": "mTORC1 inhibits 4E-BP1",
  "source": {
   "name": "mTORC1",
   "entity": "mtorc1"
  },
  "target": {
   "name": "4E-BP1",
   "entity": "4e-bp1"
  },
  "effect": "inhibits",
  "type": "phosphorylation",
  "directness": "direct",
  "timescale": "minutes",
  "compartment": "cytosol",
  "map_band": "cytosol",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "mTORC1 phosphorylates 4E-BP1, which lets go of eIF4E and frees cap-dependent translation. Rapamycin blocks this arm only partially - the origin of the whole 'rapamycin-resistant output' problem.",
  "mechanism_beginner": "mTORC1 tags 4E-BP1 so it lets go of another protein, freeing up protein-building – but the standard drug (rapamycin) only partly blocks this step.",
  "context": null,
  "boundary": "Cell and in vitro evidence (human and mouse cells, with C. elegans RNAi in one study). Rapamycin blocks this phosphorylation only partly, and individual sites differ in how sensitive they are (KAN2013). Not shown in people by these studies.",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Direct biochemical",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "BUR1998",
    "HARA2002",
    "FEL2009",
    "GIN1999",
    "KAN2013",
    "HAR1998",
    "BRU1997",
    "NOJ2003"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/MTORC1-4EBP1/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/MTORC1-4EBP1.json"
 }
}