{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "21bd609b55973b7b5b84e545fdde629d79115243854f1595680c534e6e1ef96f",
  "corpus_snapshot": "2026-11-02T19:05:06+0100",
  "source_commit": "1e9de0d56d4ea503818c4095460addc4a0c7f4a3",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "MTOR-MTORC2",
  "claim": "mTOR required-for mTORC2",
  "source": {
   "name": "mTOR",
   "entity": "mtor"
  },
  "target": {
   "name": "mTORC2",
   "entity": "mtorc2"
  },
  "effect": "required-for",
  "type": "complex-assembly",
  "directness": "direct",
  "timescale": "constitutive",
  "compartment": "cytosol",
  "map_band": "cytosol",
  "species": [
   "human cells",
   "yeast"
  ],
  "mechanism": "mTORC2 is built around the same mTOR kinase as mTORC1 - the partner subunits, not the catalytic core, are what make the two complexes different.",
  "mechanism_beginner": "mTORC2 is built from the very same mTOR enzyme as mTORC1 – it's the partner proteins around it that make the two complexes different.",
  "context": null,
  "boundary": "Cryo-EM structures of the complex from human cells and yeast (CHE2018, SCA2020, STU2018, KAR2017). Structural evidence shows how the complex is built, not how often or where it forms in living tissue.",
  "boundary_tags": [],
  "conflict": null,
  "note": "Three independent structures - unusually well supported for this corpus.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Structural",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "CHE2018",
    "SCA2020",
    "STU2018",
    "KAR2017"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/MTOR-MTORC2/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/MTOR-MTORC2.json"
 }
}