{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "LEU-SESN2",
  "claim": "Leucine inhibits Sestrin2",
  "source": {
   "name": "Leucine",
   "entity": "leucine"
  },
  "target": {
   "name": "Sestrin2",
   "entity": "sestrin2"
  },
  "effect": "inhibits",
  "type": "binding",
  "directness": "direct",
  "timescale": "seconds",
  "compartment": "cytosol",
  "map_band": "cytosol",
  "species": [
   "human cells",
   "rat"
  ],
  "mechanism": "Leucine binds a pocket inside Sestrin2 with roughly 20 uM affinity - close to the concentration at which cells actually feel leucine coming and going. The bound sensor can no longer hold GATOR2, so leucine effectively switches the brake off.",
  "mechanism_beginner": "Leucine sticks to a pocket inside Sestrin2 and makes it let go of the next protein in line – that's how the cell notices leucine is around.",
  "context": null,
  "boundary": "Affinity was measured in vitro; whether the same 20 uM setpoint holds in tissues with different leucine transport is untested. SHIM2026 is a 2026 rat study (dexamethasone-induced muscle atrophy, not an ageing model) with human myotubes; it tests a leucine-mimetic prodrug and supports Sestrin2-dependent mTORC1 activation, not the 20 uM leucine setpoint.",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Structural",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "WOL2015",
    "SAX2015",
    "SHIM2026"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/LEU-SESN2/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/LEU-SESN2.json"
 }
}