{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "LARS-RAG",
  "claim": "LARS (leucyl-tRNA synthetase) activates Rag GTPases",
  "source": {
   "name": "LARS (leucyl-tRNA synthetase)",
   "entity": "lars-leucyl-trna-synthetase"
  },
  "target": {
   "name": "Rag GTPases",
   "entity": "rag-gtpases"
  },
  "effect": "activates",
  "type": "gap-activity",
  "directness": "unresolved",
  "timescale": "seconds",
  "compartment": "lyso",
  "map_band": "lyso",
  "species": [
   "human cells"
  ],
  "mechanism": "In this model LARS acts as a GAP for RagD, doing for the RagC/D half what FLCN does - an alternative route from leucine to the Rags.",
  "mechanism_beginner": "In that model, this enzyme flips the other Rag protein into its working shape – an alternative route from leucine to the Rags.",
  "context": null,
  "boundary": "Human cell biochemistry only, and cell-type dependence was never mapped. The reaction it claims - GAP activity on the RagC/D half - is the same reaction this Atlas assigns to FLCN, and the two assignments have never been reconciled head-to-head. Read together with LEU-LARS: if the upstream leucine-sensing claim does not hold, this edge loses its input.",
  "note": "See LEU-LARS.",
  "consensus_contested": true,
  "curation_contested": true,
  "contested": true,
  "confidence": {
   "mechanistic": "low",
   "human_relevance": "untested",
   "consensus": "contested"
  },
  "evidence": {
   "kind": "Direct biochemical",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "HAN2012"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Contested",
  "url": "https://mtor-atlas.org/relation/LARS-RAG/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/LARS-RAG.json"
 }
}