{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "4823f516b720e66843f0b75952daf5ccc5279a7c20c0cb7c0d1ac126ff6ca768",
  "corpus_snapshot": "2026-10-24T21:34:23+0200",
  "source_commit": "8f0f14a10e115daab72bb59e5bf8c63eda1daeb8",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "IRS1-PI3K",
  "claim": "IRS-1 / IRS-2 activates PI3K",
  "source": {
   "name": "IRS-1 / IRS-2",
   "entity": "irs-1-irs-2"
  },
  "target": {
   "name": "PI3K",
   "entity": "pi3k"
  },
  "effect": "activates",
  "type": "recruitment",
  "directness": "direct",
  "timescale": "seconds",
  "compartment": "pm",
  "map_band": "pm",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "IRS proteins are the adaptors that carry the signal from the insulin/IGF-1 receptor to PI3K. Deplete them and the receptor is still there but the wire is cut.",
  "mechanism_beginner": "IRS proteins carry the signal from the insulin receptor to PI3K; without them, the receptor is still there but the wire connecting it is cut.",
  "context": null,
  "boundary": "Cell studies (TSC1/TSC2-null mouse cells and human cells) plus a review. An adaptor relationship shown in cultured cells; differences between IRS-1 and IRS-2 by tissue are not resolved by these sources.",
  "boundary_tags": [],
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Direct biochemical",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "HAR2004",
    "CAN2002"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/IRS1-PI3K/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/IRS1-PI3K.json"
 }
}