{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "IGF1-PI3K",
  "claim": "Growth hormone / IGF-1 axis activates PI3K",
  "source": {
   "name": "Growth hormone / IGF-1 axis",
   "entity": "growth-hormone-igf-1-axis"
  },
  "target": {
   "name": "PI3K",
   "entity": "pi3k"
  },
  "effect": "activates",
  "type": "signal-relay",
  "directness": "indirect",
  "timescale": "seconds",
  "compartment": "pm",
  "map_band": "pm",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "IGF-1 docks on the IGF-1 receptor, which recruits IRS proteins and switches on PI3K to make the lipid messenger PIP3. Growth hormone does not use this receptor: it signals through its own receptor and JAK2/STAT5b, and reaches this arm mostly by inducing hepatic IGF-1. The node is drawn as one axis because the Atlas's lifespan evidence comes from interventions that lower the whole axis at once.",
  "mechanism_beginner": "IGF-1 latches onto its own receptor and switches on PI3K, which builds a signalling lipid. Growth hormone works one step further back: it does not land on this receptor itself, it makes the liver release IGF-1, which then does. Insulin takes a receptor of its own into the same arm.",
  "context": null,
  "boundary": "Compressed on purpose: growth hormone and IGF-1 are one node here, but they are not one molecule and they do not share a receptor. GH signals GHR-JAK2-STAT5b and acts on this arm largely by inducing hepatic IGF-1; patients with a homozygous STAT5b mutation have GH insensitivity with low IGF-1 and low IGFBP-3 (Kofoed 2003, PMID 13679528, outside this corpus). The dwarf-mouse lifespan evidence on this axis lowers GH and IGF-1 together, so it does not tell the two apart. Insulin enters the same arm through its own receptor and is drawn separately (INS-PI3K).",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Direct biochemical",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "CAN2002",
    "ROM2001"
   ],
   "conflicting": []
  },
  "external_refs": [
   {
    "pmid": "13679528",
    "cited_in": [
     "boundary"
    ],
    "in_corpus": false,
    "url": "https://pubmed.ncbi.nlm.nih.gov/13679528/"
   }
  ],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/IGF1-PI3K/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/IGF1-PI3K.json"
 }
}