{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "GHIGF1-LONGEVITY",
  "claim": "Growth hormone / IGF-1 axis inhibits Longevity",
  "source": {
   "name": "Growth hormone / IGF-1 axis",
   "entity": "growth-hormone-igf-1-axis"
  },
  "target": {
   "name": "Longevity",
   "entity": "longevity"
  },
  "effect": "inhibits",
  "type": "functional-consequence",
  "directness": "indirect",
  "timescale": "chronic",
  "compartment": null,
  "map_band": "outcome",
  "species": [
   "mouse"
  ],
  "mechanism": "Growth hormone / IGF-1 signalling acts as a brake on lifespan: mice whose GH signalling is blocked, either lifelong or from middle age, live longer and are less frail in old age.",
  "mechanism_beginner": "Less growth-hormone signalling, longer life in mice.",
  "context": null,
  "boundary": "Mouse only. A lifelong GH-receptor-antagonist transgenic (LIST2026; an earlier study of the same line did not detect extension) and a tamoxifen-inducible whole-body Ghr knockout started at 12 months (DUR2026). mTOR signalling was not measured in either, so the route through PI3K-Akt-mTOR is inferred, not shown here.",
  "note": "2026-10-10: Interaction type signal-relay -> functional-consequence. The target is a lifespan outcome, not a signalling node, and mTOR signalling was not measured in either study.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "LIST2026",
    "DUR2026"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/GHIGF1-LONGEVITY/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/GHIGF1-LONGEVITY.json"
 }
}