{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "GATOR2-GATOR1",
  "claim": "GATOR2 inhibits GATOR1",
  "source": {
   "name": "GATOR2",
   "entity": "gator2"
  },
  "target": {
   "name": "GATOR1",
   "entity": "gator1"
  },
  "effect": "inhibits",
  "type": "binding",
  "directness": "direct",
  "timescale": "seconds",
  "compartment": "lyso",
  "map_band": "lyso",
  "species": [
   "human cells"
  ],
  "mechanism": "Released GATOR2 suppresses GATOR1 - a double negative. Two brakes in series is why the sensors can flip mTORC1 on so sharply.",
  "mechanism_beginner": "Everyone agrees GATOR2 holds GATOR1 back when amino acids are around. Exactly how it does it is not settled by the work this Atlas holds, and the gap is left visible on purpose.",
  "context": null,
  "boundary": "The epistasis is solid. VAL2022 resolved GATOR2's architecture by cryo-EM - a 1.1 MDa cage - and mapped where the sensors dock, but exactly how GATOR2 suppresses GATOR1's GAP activity is still not settled.",
  "note": "Good candidate for a 'mechanism gap' flag - textbook arrow, thin mechanistic evidence.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "plausible",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "BAR2013",
    "PAR2014",
    "VAL2022"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/GATOR2-GATOR1/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/GATOR2-GATOR1.json"
 }
}