{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "21bd609b55973b7b5b84e545fdde629d79115243854f1595680c534e6e1ef96f",
  "corpus_snapshot": "2026-11-02T19:05:06+0100",
  "source_commit": "1e9de0d56d4ea503818c4095460addc4a0c7f4a3",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "FOXO-LONGEVITY",
  "claim": "FOXO1/3 activates Longevity",
  "source": {
   "name": "FOXO1/3",
   "entity": "foxo"
  },
  "target": {
   "name": "Longevity",
   "entity": "longevity"
  },
  "effect": "activates",
  "type": "functional-consequence",
  "directness": "indirect",
  "timescale": "chronic",
  "compartment": null,
  "map_band": "outcome",
  "species": [
   "C. elegans"
  ],
  "mechanism": "Genetic TORC1 inhibition in C. elegans extends lifespan through BOTH SKN-1/Nrf and DAF-16/FoxO, which activate protective genes and raise stress resistance. Rapamycin does NOT work the same way: it triggers a similar protective response but extends worm lifespan dependent on SKN-1 and NOT on DAF-16, apparently by interfering with TORC2 alongside TORC1 (ROB2012). This FoxO arrow therefore holds for the genetic arm, not for the drug.",
  "mechanism_beginner": "Part of how this pathway affects lifespan runs through stress-resistance genes switched on by FOXO – so far shown mainly in simple animals like worms, not yet in mammals.",
  "context": null,
  "boundary": "An invertebrate result, and the two arms must not be merged. ROB2012's title reads 'TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO', but its own abstract splits them: the DAF-16/FoxO requirement belongs to genetic TORC1 inhibition, while the rapamycin effect is SKN-1-dependent and DAF-16-INDEPENDENT. Not shown in mammals in this corpus.",
  "boundary_tags": [
   "single-study"
  ],
  "conflict": null,
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "untested",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "ROB2012"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/FOXO-LONGEVITY/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/FOXO-LONGEVITY.json"
 }
}