{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "21bd609b55973b7b5b84e545fdde629d79115243854f1595680c534e6e1ef96f",
  "corpus_snapshot": "2026-11-02T19:05:06+0100",
  "source_commit": "1e9de0d56d4ea503818c4095460addc4a0c7f4a3",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "CR-LONGEVITY",
  "claim": "Fasting / caloric restriction activates Longevity",
  "source": {
   "name": "Fasting / caloric restriction",
   "entity": "caloric-restriction"
  },
  "target": {
   "name": "Longevity",
   "entity": "longevity"
  },
  "effect": "activates",
  "type": "functional-consequence",
  "directness": "indirect",
  "timescale": "chronic",
  "compartment": null,
  "map_band": "outcome",
  "species": [
   "rhesus",
   "mouse"
  ],
  "mechanism": "Caloric restriction improved health and survival in rhesus monkeys (MAT2017). In mice fed one of 25 diets ad libitum, lowering calories by diluting the food did not extend lifespan, while a lower protein-to-carbohydrate ratio did (SOL2014). That study is carried as conflicting evidence on which variable matters: calories, or protein.",
  "mechanism_beginner": "Eating less improved health and survival in monkeys. But in mice that could eat as much as they wanted, cutting calories by watering down the food did not make them live longer; eating less protein compared with carbohydrate did. So whether it is the calories or the protein that counts is still open.",
  "context": null,
  "boundary": "No human lifespan data exists. Effect direction is reproducible across several species; effect size and even the responsible variable (calories versus composition) are not settled.",
  "boundary_tags": [
   "single-study"
  ],
  "conflict": {
   "type": "Opposing result",
   "basis": "In mice fed 25 diets ad libitum, calorie restriction achieved by dietary dilution or by high-protein diets had no beneficial effect on lifespan; lifespan followed the protein-to-carbohydrate ratio (SOL2014)."
  },
  "note": "2026-10-10: SOL2014 moved from supporting to conflicting. Full text: 'energy restriction achieved by dietary dilution in ad libitum-fed animals does not extend life-span'; lifespan tracked the protein:carbohydrate ratio, not calorie intake. It cannot support a calories-extend-life arrow.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "untested",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "MAT2017"
   ],
   "conflicting": [
    "SOL2014"
   ]
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/CR-LONGEVITY/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/CR-LONGEVITY.json"
 }
}