{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "CGASSTING-SENESCENCE",
  "claim": "cGAS-STING pathway activates Cellular senescence",
  "source": {
   "name": "cGAS-STING pathway",
   "entity": "cgas-sting-pathway"
  },
  "target": {
   "name": "Cellular senescence",
   "entity": "cellular-senescence"
  },
  "effect": "activates",
  "type": "functional-consequence",
  "directness": "indirect",
  "timescale": "days",
  "compartment": null,
  "map_band": "outcome",
  "species": [
   "mouse"
  ],
  "mechanism": "cGAS-STING activation in aged macrophages drives a paracrine inflammatory senescence programme that spreads the phenotype to neighbouring cells, contributing to systemic ageing.",
  "mechanism_beginner": "In aged immune cells called macrophages, cGAS-STING switches on an inflammatory programme that spreads to neighbouring cells, so the ageing effect does not stay in the cell where it started. This comes from a single mouse study, and whether the same spread happens in human tissue has not been tested.",
  "context": null,
  "boundary": "Single mouse study; the human magnitude of this effect, and whether the same paracrine spread occurs in human tissue, are untested.",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "untested",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Genetic loss-of-function / rescue",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "LV2026"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/CGASSTING-SENESCENCE/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/CGASSTING-SENESCENCE.json"
 }
}