{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "BISTERIC-MTORC1",
  "claim": "Bi-steric mTORC1-selective inhibitors inhibits mTORC1",
  "source": {
   "name": "Bi-steric mTORC1-selective inhibitors",
   "entity": "bi-steric-mtorc1-selective-inhibitors"
  },
  "target": {
   "name": "mTORC1",
   "entity": "mtorc1"
  },
  "effect": "inhibits",
  "type": "competitive-inhibition",
  "directness": "indirect",
  "timescale": "hours",
  "compartment": "lyso",
  "map_band": "lyso",
  "species": [
   "human"
  ],
  "mechanism": "A bivalent molecule engages an FKBP12-dependent site and the active site simultaneously, producing deeper mTORC1 inhibition than a rapalog while sparing mTORC2.",
  "mechanism_beginner": "A two-part drug grips mTORC1 at two places at once, which blocks it more completely than rapamycin-type drugs. So far only a first safety trial in people with advanced tumours has reported on it.",
  "context": null,
  "boundary": "Phase 1 in advanced solid tumours – a safety and pharmacodynamic result, not an efficacy verdict. Directness is graded indirect because, like rapalogs, the mechanism requires FKBP12. Consensus is emerging: one trial.",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "plausible",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Pharmacological",
   "strongest": {
    "code": "H",
    "label": "Human study"
   },
   "supporting": [
    "SCH2025"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/BISTERIC-MTORC1/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/BISTERIC-MTORC1.json"
 }
}