{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "21bd609b55973b7b5b84e545fdde629d79115243854f1595680c534e6e1ef96f",
  "corpus_snapshot": "2026-11-02T19:05:06+0100",
  "source_commit": "1e9de0d56d4ea503818c4095460addc4a0c7f4a3",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "AMPK-MTORC1",
  "claim": "AMPK inhibits mTORC1",
  "source": {
   "name": "AMPK",
   "entity": "ampk"
  },
  "target": {
   "name": "mTORC1",
   "entity": "mtorc1"
  },
  "effect": "inhibits",
  "type": "phosphorylation",
  "directness": "direct",
  "timescale": "minutes",
  "compartment": "lyso",
  "map_band": "lyso",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "AMPK also hits mTORC1 directly by phosphorylating Raptor, imposing a metabolic checkpoint independent of TSC.",
  "mechanism_beginner": "AMPK also hits mTORC1 directly, adding a second, energy-based checkpoint on top of TSC.",
  "context": "The Raptor arm is the TSC2-independent route, which is why it is measurable in TSC-null cells. Its relative contribution versus the TSC2 arm varies by cell type and by how deep the energy stress is.",
  "boundary": "Cell biochemistry in human and mouse cells (GWI2008) plus one study in aged mice (YAN2026B). Direct Raptor phosphorylation is shown in cells; how much it adds beside the TSC route in living tissue, and in people, is not shown.",
  "boundary_tags": [],
  "conflict": null,
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Direct biochemical",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "GWI2008",
    "YAN2026B"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/AMPK-MTORC1/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/AMPK-MTORC1.json"
 }
}