{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "4EBP1-MITO",
  "claim": "4E-BP1 context-dependent Mitochondrial biogenesis",
  "source": {
   "name": "4E-BP1",
   "entity": "4e-bp1"
  },
  "target": {
   "name": "Mitochondrial biogenesis",
   "entity": "mitochondrial-biogenesis"
  },
  "effect": "context-dependent",
  "type": "functional-consequence",
  "directness": "indirect",
  "timescale": "hours",
  "compartment": "mito",
  "map_band": "mito",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "In mammalian cells (MOR2013) 4E-BPs repress translation of nucleus-encoded mitochondrial mRNAs, so mTORC1 raises mitochondrial output by inhibiting them; this arm is less rapamycin-sensitive than the S6K arm. In flies on dietary restriction (ZID2009) upregulated 4E-BP instead enhances translation of mitochondrial respiratory mRNAs. The sign depends on organism and nutrient state, so it is drawn as conditional.",
  "mechanism_beginner": "The 4E-BP branch helps set how many mitochondrial proteins get built. In mammalian cells it holds them back; in fruit flies on a restricted diet it boosts them, so the direction depends on the organism and the diet.",
  "context": null,
  "boundary": "Scope: mammalian cells, MOR2013. The sign holds where 4E-BP represses translation of nuclear-encoded mitochondrial mRNAs (TFAM, mitochondrial ribosomal proteins), which is why this branch survives rapamycin better than the S6K arm. It does NOT hold universally across species and nutrient states: in Drosophila under dietary restriction, ZID2009 reports that 4E-BP ENHANCES mitochondrial activity, and that this is how it extends lifespan. Treat the mammalian-cell direction as scoped, not general.",
  "note": "ZID2009 is recorded as conflicting evidence on this edge (moved out of the supporting list on 2026-08-30): its own title says 4E-BP ENHANCES mitochondrial activity under dietary restriction in flies, which is the opposite sign to this mammalian-cell edge.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "untested",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "MOR2013"
   ],
   "conflicting": [
    "ZID2009"
   ]
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/4EBP1-MITO/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/4EBP1-MITO.json"
 }
}