{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "4823f516b720e66843f0b75952daf5ccc5279a7c20c0cb7c0d1ac126ff6ca768",
  "corpus_snapshot": "2026-10-24T21:34:23+0200",
  "source_commit": "8f0f14a10e115daab72bb59e5bf8c63eda1daeb8",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "4EBP1-EIF4E",
  "claim": "4E-BP1 inhibits eIF4E",
  "source": {
   "name": "4E-BP1",
   "entity": "4e-bp1"
  },
  "target": {
   "name": "eIF4E",
   "entity": "eif4e"
  },
  "effect": "inhibits",
  "type": "competitive-inhibition",
  "directness": "direct",
  "timescale": "seconds",
  "compartment": "cytosol",
  "map_band": "cytosol",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "Unphosphorylated 4E-BP1 clamps onto eIF4E and stops it assembling the cap-binding complex. mTORC1 phosphorylates 4E-BP1 to release that grip - so the brake on translation is released, not the accelerator pressed.",
  "mechanism_beginner": "Untagged 4E-BP1 clamps onto eIF4E and blocks it; mTORC1 tags 4E-BP1 to make it let go – releasing a brake, not pressing an accelerator.",
  "context": null,
  "boundary": "Biochemical and cell-culture evidence (in vitro assays, mammalian and mouse cells, plus one review). It establishes the binding switch itself. It does not measure how much translation changes in a given tissue, in whole animals or in people.",
  "boundary_tags": [],
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "plausible",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Direct biochemical",
   "strongest": {
    "code": "M",
    "label": "Molecular — cells, biochemistry, structure"
   },
   "supporting": [
    "MAX2009",
    "THO2012",
    "SCH2003",
    "FIN2002"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/4EBP1-EIF4E/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/4EBP1-EIF4E.json"
 }
}