{ "meta": { "api_version": "1.0.0", "dataset_version": "2.0.1+unreleased", "live_matches_release": false, "archived_release": { "version": "2.0.1", "version_doi": "10.5281/zenodo.23090261", "date": "2026-10-01", "studies": 428 }, "data_fingerprint": "902cee5f48b5ec3c7b68ab77cd461448d3b00c4f4b77f38a9e1b5affcf85f063", "corpus_snapshot": "2026-11-09T16:23:12+0100", "source_commit": "ddd2837263b4e46b1074542b3dff085b860093b3", "license": "CC-BY-4.0", "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963", "docs": "https://mtor-atlas.org/api/" }, "count": 929, "data": [ { "id": "david-m-sabatini", "name": "David M. Sabatini", "corpus_name": "Sabatini DM", "orcid": "0000-0002-1446-7256", "lab": "Sabatini Group, IOCB Prague (Prague, Czech Republic)", "lab_url": "https://sabatini.group.uochb.cz/en", "role": "Identified mTOR (as RAFT1) in 1994. His lab then mapped much of the machinery around it: raptor and rictor at the core of mTORC1 and mTORC2, the Rag–Ragulator system that docks mTORC1 on the lysosome, and the sensors that detect leucine, arginine and SAM", "studies": [ "WYA2018", "KIM2003", "WOL2015", "EFE2012", "SAB1994", "SAR2006", "SAN2008", "BAR2012", "BUR1998", "SAX2017", "SAB2017", "LIU2020", "SAR2004", "FRI2006", "GUE2007", "LAP2012", "GUE2006", "SAX2016", "TSU2013", "SHE2019", "SAX2015", "CHA2014", "GUE2009", "VAL2022", "SCH2003", "WOL2017", "THO2009", "LAM2012", "BAR2013", "SET2012", "ANA2019", "WAG2014", "SAN2007", "HSU2011", "WYA2017", "WAN2015", "SHE2018B", "CHA2016", "ROB2012", "YIP2010", "GRA2014", "SAN2010", "ZON2011", "ROG2019", "WOLF2017", "YIL2012", "THO2012", "KAN2013", "SHE2018", "KIM2002", "ZON2010", "PET2011", "SEN2010", "CON2021", "SAR2005", "GU2017", "PET2009" ], "url": "https://mtor-atlas.org/author/david-m-sabatini/" }, { "id": "michael-n-hall", "name": "Michael N. Hall", "corpus_name": "Hall MN", "orcid": "0000-0002-2998-0757", "lab": "Hall Lab, Biozentrum Basel (Basel, Switzerland)", "lab_url": "https://www.biozentrum.unibas.ch/research/research-groups/research-groups-a-z/overview/unit/research-group-michael-n-hall", "role": "Discovered TOR in yeast in 1991 and established it as a central controller of cell growth that responds to nutrients. His lab later showed that TOR works in two distinct complexes, TORC1 and TORC2, only one of which is blocked by rapamycin", "studies": [ "HEI1991", "GUR2017", "HAG2012", "BEN2008", "GUR2016", "BAT2022", "MOS2018", "BETZ2013", "POL2008", "JAC2004", "LOE2002", "BET2013", "SHI2014", "SCA2020", "ROB2013", "AYL2015", "ZIN2011", "WUL2006", "DUR2012", "STU2018" ], "url": "https://mtor-atlas.org/author/michael-n-hall/" }, { "id": "kun-liang-guan", "name": "Kun-Liang Guan", "corpus_name": "Guan KL", "orcid": "0000-0003-1892-0174", "lab": "Guan Lab, Westlake University (Hangzhou, Zhejiang, China)", "lab_url": "https://lifesciences.westlake.edu.cn/labs/kunliang-guan/molecular-cell-biology-laboratory/lab-home/", "role": "Showed how growth-factor and energy signals reach mTORC1 through TSC2 and Rheb, and, in parallel with the Sabatini lab, that the Rag GTPases carry the amino-acid signal. His lab also found that AMPK and mTORC1 control autophagy by phosphorylating the kinase ULK1 at different sites", "studies": [ "INOK2003", "INO2002", "JEW2015", "PAR2014", "KIM2019", "YAN2006", "KIM2008", "INO2006", "RUS2013", "INO2003", "CHE2008", "ALE2010", "COR2004", "KIM2011" ], "url": "https://mtor-atlas.org/author/kun-liang-guan/" }, { "id": "brendan-d-manning", "name": "Brendan D. Manning", "corpus_name": "Manning BD", "orcid": "0000-0003-3895-5956", "lab": "Manning Lab, Harvard Chan School (Boston, Massachusetts, USA)", "lab_url": "https://hsph.harvard.edu/research/manning-lab/", "role": "Was among the groups that in 2002 identified TSC2 as a direct target of Akt (MAN2002), linking insulin and PI3K signalling to mTORC1, and later found TBC1D7 as the third subunit of the TSC complex. His lab has shown how mTORC1 turns growth signals into the synthesis of lipids and nucleotides", "studies": [ "KAL2026", "VAL2019", "BEN2013", "VAL2017", "DIB2012", "HOX2019", "DIB2013", "BEN2016", "HOW2017", "MEN2014", "TEE2002", "BRU2004", "DUV2010", "LAP2026", "MAN2002", "TEE2003", "SHAW2004" ], "url": "https://mtor-atlas.org/author/brendan-d-manning/" }, { "id": "john-blenis", "name": "John Blenis", "corpus_name": "Blenis J", "orcid": "0000-0003-3622-2337", "lab": "Blenis Lab, Weill Cornell Medicine (New York, New York, USA)", "lab_url": "http://www.blenislab.org/", "role": "Showed early on that rapamycin blocks S6 kinase, then worked out how mTORC1 drives cell growth through its two main translation targets, S6K1 and 4E-BP1. His lab also found, in parallel with the Sabatini lab, that mTORC1 phosphorylates Grb10, a feedback brake on insulin signalling", "studies": [ "MAX2009", "CHU1992", "HOL2005", "LIU2015", "BRU1999", "POD2001", "KUO1992", "SCH2003", "FIN2002", "TEE2002", "YUX2011", "MAN2002", "TEE2003", "HE2025" ], "url": "https://mtor-atlas.org/author/john-blenis/" }, { "id": "roberto-zoncu", "name": "Roberto Zoncu", "corpus_name": "Zoncu R", "orcid": "0000-0003-1611-1891", "lab": "Zoncu Lab, UC Berkeley (Berkeley, California, USA)", "lab_url": "http://www.robertozonculab.org/", "role": "Showed as a postdoc that mTORC1 senses amino acids from inside the lysosome, through the v-ATPase and Ragulator. His Berkeley lab has since mapped how the Rag GTPases and the folliculin complex switch mTORC1 on, and how lysosomal cholesterol feeds into the same system", "studies": [ "ESP2026", "GOU2023", "EFE2012", "LAW2019", "BAR2012", "TSU2013", "MAN2016", "SET2012", "SUX2017", "WAN2015", "LAW2018", "SAN2010", "ZON2011", "ZON2010" ], "url": "https://mtor-atlas.org/author/roberto-zoncu/" }, { "id": "robert-a-saxton", "name": "Robert A. Saxton", "corpus_name": "Saxton RA", "orcid": "0000-0001-9777-8270", "lab": "Saxton Lab, UC Berkeley (Berkeley, California, USA)", "lab_url": "https://www.saxtonlabucb.org/", "role": "Solved, as a Sabatini-lab graduate student, the structures of the leucine sensor Sestrin2 and the arginine sensor CASTOR1, showing how each one grips its amino acid. He also co-wrote a widely cited 2017 review of mTOR signalling with David Sabatini", "studies": [ "WOL2015", "SAX2017", "SAX2016", "SAX2015", "CHA2014", "VAL2022", "CHA2016", "GU2017" ], "url": "https://mtor-atlas.org/author/robert-a-saxton/" }, { "id": "do-hyung-kim", "name": "Do-Hyung Kim", "corpus_name": "Kim DH", "orcid": "0000-0002-2924-4370", "lab": "Kim Lab, University of Minnesota (Minneapolis, Minnesota, USA)", "lab_url": "https://cbs.umn.edu/kim-lab", "role": "Co-discovered raptor, the defining partner of mTOR in mTORC1, and then mLST8 (GbetaL) as a Sabatini-lab postdoc. His Minnesota lab identified PRAS40 as an insulin-regulated link to mTORC1 and studies how mTORC1 controls autophagy", "studies": [ "KIM2003", "SAR2004", "KIM2002", "VAN2007", "KIM2012" ], "url": "https://mtor-atlas.org/author/do-hyung-kim/" }, { "id": "dos-d-sarbassov", "name": "Dos D. Sarbassov", "corpus_name": "Sarbassov DD", "orcid": "0000-0002-6848-1133", "lab": "Faculty profile, Nazarbayev University (Astana, Kazakhstan)", "lab_url": "https://research.nu.edu.kz/en/persons/dos-sarbassov/", "role": "Discovered rictor as a Sabatini-lab postdoc, in parallel with Michael Hall's lab, defining mTOR Complex 2, and showed that this complex is the long-sought kinase that phosphorylates Akt on serine 473. He also found that prolonged rapamycin treatment can block mTORC2 assembly", "studies": [ "KIM2003", "SAR2006", "SAR2004", "KIM2002", "SAR2005" ], "url": "https://mtor-atlas.org/author/dos-d-sarbassov/" }, { "id": "yasemin-sancak", "name": "Yasemin Sancak", "corpus_name": "Sancak Y", "orcid": null, "lab": "Sancak Lab, University of Washington (Seattle, Washington, USA)", "lab_url": "https://www.sancaklab.org/", "role": "Showed as a Sabatini-lab graduate student, in parallel with Kun-Liang Guan's lab, that the Rag GTPases relay amino-acid signals to mTORC1, and that Ragulator anchors them to the lysosome where mTORC1 is switched on. She also identified PRAS40 as an insulin-regulated inhibitor of mTORC1", "studies": [ "SAN2008", "SAN2007", "SAN2010", "ZON2011", "PET2009" ], "url": "https://mtor-atlas.org/author/yasemin-sancak/" }, { "id": "randy-strong", "name": "Randy Strong", "corpus_name": "Strong R", "orcid": "0000-0001-6643-3288", "lab": "Faculty profile, Barshop Institute (San Antonio, Texas, USA)", "lab_url": "https://barshopinstitute.uthscsa.edu/team-member/strong-randy/", "role": "Leads the San Antonio site of the NIA Interventions Testing Program, which tests each compound in parallel at three sites under one shared protocol. He first-authored the program's reports on resveratrol and other supplements (2012) and on rapamycin combined with acarbose (2022)", "studies": [ "MAJ2012", "STR2012", "HAR2014", "CAC2010", "HAL2012", "STR2022", "WIL2012", "SPI2010", "FLY2013", "MIL2011", "MIL2014", "HAR2009" ], "url": "https://mtor-atlas.org/author/randy-strong/" }, { "id": "richard-a-miller", "name": "Richard A. Miller", "corpus_name": "Miller RA", "orcid": "0000-0001-9266-9649", "lab": "Miller Lab, University of Michigan (Ann Arbor, Michigan, USA)", "lab_url": "https://www.richmillerlab.com/", "role": "Leads the University of Michigan site of the NIA Interventions Testing Program. His papers showed that rapamycin extends mouse lifespan when started in middle age, and that the size of the benefit depends on dose and differs between males and females", "studies": [ "STR2012", "HAR2014", "STR2022", "WIL2012", "MIL2011", "MIL2014", "HAR2009" ], "url": "https://mtor-atlas.org/author/richard-a-miller/" }, { "id": "david-e-harrison", "name": "David E. Harrison", "corpus_name": "Harrison DE", "orcid": null, "lab": "Faculty profile, The Jackson Laboratory (Bar Harbor, Maine, USA)", "lab_url": "https://www.jax.org/research-and-faculty/faculty/david-harrison", "role": "Led the Jackson Laboratory site of the NIA Interventions Testing Program. His 2009 Nature paper showed that rapamycin extends the lifespan of genetically diverse mice even when feeding starts at 20 months of age, which the authors described as the first pharmacological extension of lifespan in both sexes of a mammal", "studies": [ "STR2012", "HAR2014", "STR2022", "WIL2012", "MIL2011", "MIL2014", "HAR2009" ], "url": "https://mtor-atlas.org/author/david-e-harrison/" }, { "id": "carson-c-thoreen", "name": "Carson C. Thoreen", "corpus_name": "Thoreen CC", "orcid": null, "lab": "Thoreen Lab, Yale (New Haven, Connecticut, USA)", "lab_url": "https://campuspress.yale.edu/thoreenlab/", "role": "Used Torin1, one of the first ATP-competitive mTOR inhibitors, to reveal functions of mTORC1 that rapamycin cannot block. He then showed that mTORC1 controls translation of mRNAs for the protein-making machinery mainly through the 4E-BP proteins", "studies": [ "SAN2008", "FRI2006", "GUE2006", "THO2009", "SAN2007", "THO2012", "PET2009" ], "url": "https://mtor-atlas.org/author/carson-c-thoreen/" }, { "id": "lynne-chantranupong", "name": "Lynne Chantranupong", "corpus_name": "Chantranupong L", "orcid": null, "lab": "Chantranupong Lab, Boston University (Boston, Massachusetts, USA)", "lab_url": "https://www.chantranlab.org", "role": "Showed as a Sabatini-lab graduate student that the Sestrins act through GATOR2 to regulate amino-acid signalling to mTORC1. She then discovered the CASTOR proteins, the cell's arginine sensors for the pathway", "studies": [ "WOL2015", "SAX2016", "TSU2013", "SAX2015", "CHA2014", "VAL2022", "WOL2017", "BAR2013", "WAN2015", "CHA2016", "THO2012", "SHE2018" ], "url": "https://mtor-atlas.org/author/lynne-chantranupong/" }, { "id": "ken-inoki", "name": "Ken Inoki", "corpus_name": "Inoki K", "orcid": null, "lab": "Inoki Lab, U. Michigan LSI (Ann Arbor, Michigan, USA)", "lab_url": "https://www.lsi.umich.edu/science/our-labs/inoki-lab", "role": "Showed as a postdoc in Kun-Liang Guan's lab that Akt switches off TSC2, that TSC2 is the off-switch (GAP) for the small GTPase Rheb, and that AMPK and GSK3 feed energy and Wnt signals into the same brake. His Michigan lab studies mTOR signalling in metabolism and kidney disease", "studies": [ "INOK2003", "INO2002", "YAN2006", "INO2006", "INO2003", "ALE2010", "COR2004" ], "url": "https://mtor-atlas.org/author/ken-inoki/" }, { "id": "siraj-m-ali", "name": "Siraj M. Ali", "corpus_name": "Ali SM", "orcid": null, "lab": "Translational Medicine, Lunit (Seoul, South Korea)", "lab_url": "https://www.lunit.io/en/our-team/", "role": "Worked in the Sabatini lab on the papers that discovered raptor, mLST8 and rictor, and on the finding that the rictor-mTOR complex phosphorylates Akt. He later moved into cancer genomics and clinical diagnostics", "studies": [ "KIM2003", "SAR2006", "SAR2004", "KIM2002", "SAR2005" ], "url": "https://mtor-atlas.org/author/siraj-m-ali/" }, { "id": "hediye-erdjument-bromage", "name": "Hediye Erdjument-Bromage", "corpus_name": "Erdjument-Bromage H", "orcid": "0000-0003-0224-3594", "lab": "Mass Spectrometry Core, NYU Langone (New York, New York, USA)", "lab_url": "https://med.nyu.edu/research/neubert-lab/mass-spectrometry-core-neuroscience", "role": "Ran the mass-spectrometry analyses in Paul Tempst's lab at Memorial Sloan Kettering that identified the unknown proteins in the raptor, mLST8 and rictor purifications, and contributed the same approach to work on how ERK inactivates TSC2", "studies": [ "KIM2003", "SAB1994", "SAR2004", "KIM2002", "MA2005" ], "url": "https://mtor-atlas.org/author/hediye-erdjument-bromage/" }, { "id": "paul-tempst", "name": "Paul Tempst", "corpus_name": "Tempst P", "orcid": "0000-0002-6680-3987", "lab": "Tempst Lab, Sloan Kettering Institute (New York, New York, USA)", "lab_url": "https://www.mskcc.org/research/ski/labs/paul-tempst", "role": "Developed mass-spectrometry methods for identifying proteins from tiny samples, and led the Memorial Sloan Kettering proteomics laboratory that identified the unknown partners of mTOR in the raptor, mLST8 and rictor purifications", "studies": [ "KIM2003", "SAB1994", "SAR2004", "KIM2002", "MA2005" ], "url": "https://mtor-atlas.org/author/paul-tempst/" }, { "id": "reuben-j-shaw", "name": "Reuben J. Shaw", "corpus_name": "Shaw RJ", "orcid": null, "lab": "Shaw Lab, Salk Institute (La Jolla, California, USA)", "lab_url": "https://shaw.salk.edu/", "role": "Showed, in parallel with two other groups, that the tumour suppressor LKB1 directly activates AMPK, and that AMPK brakes mTORC1 by phosphorylating raptor. His Salk lab also linked AMPK to autophagy through ULK1 and helped explain how metformin acts in the liver", "studies": [ "GWI2008", "EGA2010", "SHW2004", "HOW2017", "SHAW2004" ], "url": "https://mtor-atlas.org/author/reuben-j-shaw/" }, { "id": "rachel-l-wolfson", "name": "Rachel L. Wolfson", "corpus_name": "Wolfson RL", "orcid": "0000-0003-3873-829X", "lab": "Wolfson Lab, Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://wolfsonlab.hms.harvard.edu/", "role": "Identified Sestrin2 as the direct leucine sensor of the mTORC1 pathway as a Sabatini-lab MD-PhD student. She also co-discovered KICSTOR, the complex that recruits GATOR1 to the lysosome", "studies": [ "WOL2015", "EFE2012", "SAX2015", "CHA2014", "WOL2017", "WYA2017", "WAN2015", "WOLF2017" ], "url": "https://mtor-atlas.org/author/rachel-l-wolfson/" }, { "id": "dudley-w-lamming", "name": "Dudley W. Lamming", "corpus_name": "Lamming DW", "orcid": "0000-0002-0079-4467", "lab": "Lamming Lab, UW-Madison (Madison, Wisconsin, USA)", "lab_url": "https://lamminglab.medicine.wisc.edu/", "role": "Showed as a postdoc that rapamycin's harm to glucose metabolism comes largely from its effect on mTORC2, while the lifespan benefit tracks mTORC1. His Wisconsin lab studies intermittent rapamycin dosing and how restricting dietary protein or single amino acids affects metabolism and ageing", "studies": [ "ARR2015", "KNO2026", "KEN2016", "ARR2016", "LAM2012", "ROB2012", "BAB2025", "YIL2012", "LAN2026" ], "url": "https://mtor-atlas.org/author/dudley-w-lamming/" }, { "id": "liron-bar-peled", "name": "Liron Bar-Peled", "corpus_name": "Bar-Peled L", "orcid": null, "lab": "Bar-Peled Lab, MGH & Harvard (Boston, Massachusetts, USA)", "lab_url": "https://www.barpeledlab.org/", "role": "Showed as a Sabatini-lab graduate student that Ragulator switches the Rag GTPases on, acting as their GEF. He also discovered GATOR1 and GATOR2; GATOR1 switches the Rags off and its genes are mutated in some cancers", "studies": [ "SAN2008", "BAR2012", "TSU2013", "CHA2014", "BAR2013", "WAN2015", "SAN2010", "ZON2011" ], "url": "https://mtor-atlas.org/author/liron-bar-peled/" }, { "id": "lewis-c-cantley", "name": "Lewis C. Cantley", "corpus_name": "Cantley LC", "orcid": "0000-0002-1298-7653", "lab": "Cantley Lab, Dana-Farber (Boston, Massachusetts, USA)", "lab_url": "https://cantleylab.dana-farber.org/", "role": "Co-discovered PI3K, the pathway that feeds into mTOR from growth factors", "studies": [ "SAC2011", "LIU2015", "SHW2004", "CAN2002", "CAR2008", "DIB2015", "MEN2014", "TEE2002", "YUX2011", "MAN2002", "TEE2003", "SHAW2004" ], "url": "https://mtor-atlas.org/author/lewis-c-cantley/" }, { "id": "david-a-guertin", "name": "David A. Guertin", "corpus_name": "Guertin DA", "orcid": null, "lab": "Guertin Lab, UMass Chan (Worcester, Massachusetts, USA)", "lab_url": "https://www.umassmed.edu/guertinlab/", "role": "Built the mouse genetics that defined mTORC2's biological roles", "studies": [ "SAR2004", "GUE2007", "GUE2006", "GUE2009", "LAM2012", "PET2011", "SAR2005" ], "url": "https://mtor-atlas.org/author/david-a-guertin/" }, { "id": "matt-kaeberlein", "name": "Matt Kaeberlein", "corpus_name": "Kaeberlein M", "orcid": "0000-0002-1311-3421", "lab": "Dog Aging Institute (Seattle, Washington, USA)", "lab_url": "https://dogaginginstitute.org/team/", "role": "Extended TOR/aging research from yeast to mice to pet dogs", "studies": [ "KAE2005", "BIT2016", "JOH2013", "POW2006", "STR2022", "URF2017", "BAR2023", "COL2025" ], "url": "https://mtor-atlas.org/author/matt-kaeberlein/" }, { "id": "andrea-ballabio", "name": "Andrea Ballabio", "corpus_name": "Ballabio A", "orcid": "0000-0003-1381-4604", "lab": "Ballabio Lab, TIGEM (Naples, Italy)", "lab_url": "https://www.tigem.it/research/research-faculty/ballabio", "role": "Discovered that the transcription factor TFEB is a master switch for building lysosomes (SAR2009) and for autophagy. His lab was one of the groups that showed in 2012 that mTORC1 keeps TFEB out of the nucleus from the lysosome surface, and later (2020) that constitutive TFEB activation drives the kidney disease of Birt-Hogg-Dubé syndrome", "studies": [ "ESP2026", "ZHANG2026", "NAP2020", "CUI2025", "ZAU2026", "FER2026", "SET2012", "CUI2023", "SET2011", "SAR2009", "SET2013" ], "url": "https://mtor-atlas.org/author/andrea-ballabio/" }, { "id": "estela-jacinto", "name": "Estela Jacinto", "corpus_name": "Jacinto E", "orcid": "0000-0001-7118-1759", "lab": "Jacinto Lab, Rutgers RWJMS (Piscataway, New Jersey, USA)", "lab_url": "https://sites.rutgers.edu/jacinto-lab/", "role": "Co-discovered mammalian mTORC2 as a postdoc in Michael Hall's lab, showing that it controls the actin cytoskeleton and is insensitive to rapamycin. Her Rutgers lab, with Bing Su's group, was among those that found SIN1 holds mTORC2 together and studies how both mTOR complexes control metabolism", "studies": [ "JAC2006", "SZW2021", "JAC2004", "LOE2002", "FAC2008" ], "url": "https://mtor-atlas.org/author/estela-jacinto/" }, { "id": "robert-r-latek", "name": "Robert R. Latek", "corpus_name": "Latek RR", "orcid": null, "lab": "Sabatini Lab, Whitehead Institute for Biomedical Research (Cambridge, Massachusetts, USA)", "lab_url": null, "role": "Bioinformatics scientist at the Whitehead Institute who worked on the Sabatini-lab papers that described raptor, mLST8 (GbetaL) and rictor (raptor and rictor were reported in parallel by other labs), the core partners of mTOR in its two complexes", "studies": [ "KIM2003", "SAR2004", "KIM2002" ], "url": "https://mtor-atlas.org/author/robert-r-latek/" }, { "id": "joan-b-mannick", "name": "Joan B. Mannick", "corpus_name": "Mannick JB", "orcid": "0000-0002-9681-4126", "lab": "Profile, Altos Labs (Redwood City, California, USA)", "lab_url": "https://www.altoslabs.com/team/joan-mannick", "role": "Ran early clinical trials of low-dose mTOR inhibitors in older adults, which improved their response to flu vaccination and, in a phase 2a trial, their rate of self-reported infections; a larger phase 3 trial of RTB101 (2021) did not confirm a reduction in respiratory illness. She led this work first at Novartis and then at resTORbio", "studies": [ "MAN2014", "MAN2021", "MAN2018" ], "url": "https://mtor-atlas.org/author/joan-b-mannick/" }, { "id": "arlan-richardson", "name": "Arlan Richardson", "corpus_name": "Richardson A", "orcid": null, "lab": "Faculty profile, OU Health (Oklahoma City, Oklahoma, USA)", "lab_url": "https://www.ouhealth.com/research-experts/arlan-richardson-phd2/", "role": "Studies how rapamycin slows ageing in mice, including the broad changes it causes in the liver, and co-authored early studies showing that rapamycin protects memory in Alzheimer's-model mice", "studies": [ "MAJ2012", "CAC2010", "HAL2012", "LAM2012", "FIS2015", "FOK2014", "SPI2010" ], "url": "https://mtor-atlas.org/author/arlan-richardson/" }, { "id": "davide-ruggero", "name": "Davide Ruggero", "corpus_name": "Ruggero D", "orcid": null, "lab": "Ruggero Lab, UCSF (San Francisco, California, USA)", "lab_url": "https://ruggerolab.ucsf.edu/", "role": "Showed that oncogenic mTOR signalling reprograms which mRNAs are translated, and that tumours become addicted to this through the 4E-BP–eIF4E axis. His UCSF lab found that mTOR-driven translation of a specific set of mRNAs promotes prostate cancer invasion and metastasis", "studies": [ "HSI2012", "GKO2013", "FEL2009", "HSI2010" ], "url": "https://mtor-atlas.org/author/davide-ruggero/" }, { "id": "george-thomas", "name": "George Thomas", "corpus_name": "Thomas G", "orcid": "0000-0003-3518-8149", "lab": "Metabolism and Cancer group, IDIBELL (L'Hospitalet de Llobregat, Spain)", "lab_url": "https://idibell.cat/en/research/cancer-area/molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell/cancer-metabolism/", "role": "Purified and cloned S6K1, the kinase that became the classic readout of mTORC1 activity. His lab later showed that mice lacking S6K1 resist diet-induced obesity, and that amino acids signal to mTORC1 through the lipid kinase hVps34 (GUL2008)", "studies": [ "MON1999", "DEN2001", "PEN2000", "UMX2004", "OLD2000", "GAR2003", "KAL2010", "COT2006", "CAR2008", "SHI1998", "SEL2009", "JEF1997", "GUL2008", "STO2003" ], "url": "https://mtor-atlas.org/author/george-thomas/" }, { "id": "alexander-j-valvezan", "name": "Alexander J. Valvezan", "corpus_name": "Valvezan AJ", "orcid": "0000-0002-4369-6074", "lab": "Valvezan Lab, Rutgers CABM (Piscataway, New Jersey, USA)", "lab_url": "https://sites.rutgers.edu/valvezan-lab/", "role": "Showed as a Manning-lab postdoc that mTORC1 matches nucleotide production to demand, creating a weak point that can be targeted in tumours with TSC loss. His Rutgers lab found that mTORC1 activity rises and falls through the cell cycle and helps drive entry into mitosis", "studies": [ "JOS2024", "VAL2019", "VAL2017", "MEN2014" ], "url": "https://mtor-atlas.org/author/alexander-j-valvezan/" }, { "id": "joseph-avruch", "name": "Joseph Avruch", "corpus_name": "Avruch J", "orcid": null, "lab": "Profile, MGH Research Institute (Boston, Massachusetts, USA)", "lab_url": "https://researchers.mgh.harvard.edu/profile/3588924/Joseph-Avruch", "role": "Showed in 1998 that amino acids, not only insulin, are needed for mTOR to activate S6K1 and 4E-BP1. His Massachusetts General Hospital group, with Kazuyoshi Yonezawa's lab in Kobe, then co-discovered raptor in 2002 and found that Rheb binds mTOR directly", "studies": [ "HARA2002", "OSH2007", "LON2005", "PRI1992", "HAR1998", "NOJ2003" ], "url": "https://mtor-atlas.org/author/joseph-avruch/" }, { "id": "christian-c-dibble", "name": "Christian C. Dibble", "corpus_name": "Dibble CC", "orcid": "0000-0002-1122-9017", "lab": "Dibble Lab, BIDMC & Harvard (Boston, Massachusetts, USA)", "lab_url": "https://www.dibblelab.com/", "role": "Identified TBC1D7 as the third subunit of the TSC complex that controls mTORC1, as a Manning-lab graduate student. His lab at Beth Israel Deaconess studies how PI3K signalling and nutrient supply are integrated to control mTORC1 and cell metabolism", "studies": [ "DIB2012", "DIB2015", "DIB2013", "MEN2014" ], "url": "https://mtor-atlas.org/author/christian-c-dibble/" }, { "id": "nathanael-s-gray", "name": "Nathanael S. Gray", "corpus_name": "Gray NS", "orcid": null, "lab": "Gray Lab, Stanford (Stanford, California, USA)", "lab_url": "https://graylab.stanford.edu/", "role": "Medicinal chemist whose lab designed Torin1, an ATP-competitive mTOR inhibitor that blocks functions of mTORC1 that rapamycin misses. His lab is also known for covalent kinase inhibitors and targeted protein degraders", "studies": [ "THO2009", "HSU2011", "THO2012", "PET2009" ], "url": "https://mtor-atlas.org/author/nathanael-s-gray/" }, { "id": "seong-a-kang", "name": "Seong A. Kang", "corpus_name": "Kang SA", "orcid": null, "lab": "Sabatini Lab, Whitehead Institute for Biomedical Research (Cambridge, Massachusetts, USA)", "lab_url": null, "role": "Contributed to the Sabatini-lab studies that identified PRAS40 and DEPTOR, two of the cell's own mTOR inhibitors, and to the first characterisation of the mTOR inhibitor Torin1", "studies": [ "THO2009", "SAN2007", "HSU2011", "YIP2010", "KAN2013", "PET2011", "PET2009" ], "url": "https://mtor-atlas.org/author/seong-a-kang/" }, { "id": "timothy-r-peterson", "name": "Timothy R. Peterson", "corpus_name": "Peterson TR", "orcid": null, "lab": "Profile, WashU Musculoskeletal Center (St. Louis, Missouri, USA)", "lab_url": "https://musculoskeletal.wustl.edu/people/tim-peterson/", "role": "Discovered DEPTOR, an inhibitor that binds mTOR in both complexes and is overexpressed in some multiple myelomas. He also showed that mTORC1 controls fat synthesis by regulating where the enzyme lipin 1 sits in the cell, and through it the SREBP pathway", "studies": [ "SAN2008", "SAN2007", "HSU2011", "PET2011", "SEN2010", "PET2009" ], "url": "https://mtor-atlas.org/author/timothy-r-peterson/" }, { "id": "jonathan-d-powell", "name": "Jonathan D. Powell", "corpus_name": "Powell JD", "orcid": null, "lab": "Profile, Calico Life Sciences (South San Francisco, California, USA)", "lab_url": "https://www.calicolabs.com/people/jonathan-powell-m-d-ph-d/", "role": "Showed that T cells lacking mTOR become regulatory T cells instead of effector cells, and that mTORC1 and mTORC2 each steer a different type of helper T cell", "studies": [ "POL2015", "DEL2011", "POW2011", "DEL2009" ], "url": "https://mtor-atlas.org/author/jonathan-d-powell/" }, { "id": "kuang-shen", "name": "Kuang Shen", "corpus_name": "Shen K", "orcid": null, "lab": "Shen Lab, UMass Chan (Worcester, Massachusetts, USA)", "lab_url": "https://www.umassmed.edu/shenlab/", "role": "Solved, as a Sabatini-lab postdoc, cryo-EM structures of GATOR1 and of the FLCN–FNIP2–Rag–Ragulator complex, two switches that set mTORC1 activity. His UMass Chan lab studies the structural basis of nutrient sensing", "studies": [ "WOL2015", "SHE2019", "WOL2017", "WAN2015", "SHE2018B", "CHA2016", "GRA2014", "SHE2018" ], "url": "https://mtor-atlas.org/author/kuang-shen/" }, { "id": "kazuyoshi-yonezawa", "name": "Kazuyoshi Yonezawa", "corpus_name": "Yonezawa K", "orcid": null, "lab": "Researcher record (KAKEN), Kobe University (Kobe, Japan)", "lab_url": "https://nrid.nii.ac.jp/ja/nrid/1000070283900/", "role": "Led the Kobe University group that co-discovered raptor in 2002, in parallel with the Sabatini lab. His team then showed that raptor binds mTOR's substrates through their TOS motif and that PRAS40 is itself an mTORC1 substrate", "studies": [ "HARA2002", "OSH2007", "LON2005", "HAR1998", "NOJ2003" ], "url": "https://mtor-atlas.org/author/kazuyoshi-yonezawa/" }, { "id": "andrew-r-tee", "name": "Andrew R. Tee", "corpus_name": "Tee AR", "orcid": null, "lab": "Faculty profile, Cardiff University (Cardiff, Wales, United Kingdom)", "lab_url": "https://profiles.cardiff.ac.uk/staff/teea", "role": "First author of one of several 2003 papers showing that the TSC1–TSC2 complex acts as a GTPase-activating protein for Rheb", "studies": [ "TEE2002", "MAN2002", "TEE2003" ], "url": "https://mtor-atlas.org/author/andrew-r-tee/" }, { "id": "sue-menon", "name": "Sue Menon", "corpus_name": "Menon S", "orcid": null, "lab": "Profile, Manning Lab (Harvard Chan) (Boston, Massachusetts, USA)", "lab_url": "https://www.hsph.harvard.edu/manning-lab/people/sue-menon/", "role": "Showed insulin controls mTORC1 by moving the TSC complex on and off the lysosome", "studies": [ "MEN2014", "DUV2010" ], "url": "https://mtor-atlas.org/author/sue-menon/" }, { "id": "jay-n-joshi", "name": "Jay N. Joshi", "corpus_name": "Joshi JN", "orcid": null, "lab": "Valvezan Lab, Rutgers (Piscataway, New Jersey, USA)", "lab_url": "https://sites.rutgers.edu/valvezan-lab/lab-members/", "role": "Showed mTORC1 activity itself rises and falls across the cell cycle, not just in response to nutrients", "studies": [ "JOS2024" ], "url": "https://mtor-atlas.org/author/jay-n-joshi/" }, { "id": "shuyu-wang", "name": "Shuyu Wang", "corpus_name": "Wang S", "orcid": null, "lab": "Manoli Lab, UCSF (San Francisco, California, USA)", "lab_url": "https://manolilab.ucsf.edu/lab-members", "role": "Co-discovered SLC38A9 as a Sabatini-lab MD-PhD student, a lysosomal amino-acid transporter that signals arginine sufficiency to mTORC1", "studies": [ "WAN2015", "ZON2011" ], "url": "https://mtor-atlas.org/author/shuyu-wang/" }, { "id": "anne-brunet", "name": "Anne Brunet", "corpus_name": "Brunet A", "orcid": null, "lab": "Brunet Lab, Stanford (Stanford, California, USA)", "lab_url": "https://web.stanford.edu/group/brunet/", "role": "Showed that Akt directly phosphorylates and controls FOXO, the transcription-factor switch linking insulin/IGF-1 signaling to lifespan", "studies": [ "BRU1999" ], "url": "https://mtor-atlas.org/author/anne-brunet/" }, { "id": "miriam-ginzberg", "name": "Miriam Ginzberg", "corpus_name": "Ginzberg M", "orcid": null, "lab": "Kafri Lab, SickKids (Toronto, Ontario, Canada)", "lab_url": "https://www.kafrilab.org/the-team", "role": "Helped build a way to read a signal's history from still images of fixed cells, then used it to catch mTORC1's fingerprint on Akt", "studies": [ "GIN2026" ], "url": "https://mtor-atlas.org/author/miriam-ginzberg/" }, { "id": "ran-kafri", "name": "Ran Kafri", "corpus_name": "Kafri R", "orcid": "0000-0002-9656-0189", "lab": "Kafri Lab, SickKids (Toronto, Ontario, Canada)", "lab_url": "https://lab.research.sickkids.ca/kafri/", "role": "Studies how mTORC1 sets and enforces a target size for cells", "studies": [ "GIN2026" ], "url": "https://mtor-atlas.org/author/ran-kafri/" }, { "id": "lingjun-lu", "name": "Lingjun Lu", "corpus_name": "Lu L", "orcid": null, "lab": "Androulakis Group, Rutgers (Piscataway, New Jersey, USA)", "lab_url": "https://www.ipandro.com/about-me", "role": "Built a computational model treating mTORC1 as a rhythm set by meal timing, not a fixed level", "studies": [ "LU2026" ], "url": "https://mtor-atlas.org/author/lingjun-lu/" }, { "id": "ioannis-p-androulakis", "name": "Ioannis P. Androulakis", "corpus_name": "Androulakis IP", "orcid": "0000-0002-3795-3628", "lab": "Androulakis Group, Rutgers (Piscataway, New Jersey, USA)", "lab_url": "https://www.ipandro.com/", "role": "Models how circadian rhythm and nutrient-sensing pathways like mTORC1 stay synchronized", "studies": [ "LU2026" ], "url": "https://mtor-atlas.org/author/ioannis-p-androulakis/" }, { "id": "ruizhao-wang", "name": "Ruizhao Wang", "corpus_name": "Wang R", "orcid": "0000-0003-1608-2322", "lab": "Piatkevich Lab, Westlake University (Hangzhou, Zhejiang, China)", "lab_url": "https://www.piatkevich-lab.com/alimni", "role": "Built FPTT, fluorescent 'ticker tapes' that record several signalling pathways in living cells over days, and used its mTOR version to follow mTOR activity oscillating through the cell cycle", "studies": [ "WANG2026C" ], "url": "https://mtor-atlas.org/author/ruizhao-wang/" }, { "id": "jian-jiang", "name": "Jian Jiang", "corpus_name": "Jiang J", "orcid": "0000-0002-1922-7489", "lab": "Xie Lab (Biosystems Engineering Laboratory), Westlake University (Hangzhou, Zhejiang, China)", "lab_url": "https://en.westlake.edu.cn/faculty/mingqi-xie.html", "role": "Co-developed FPTT, fluorescent 'ticker tapes' that record several signalling pathways in living cells over days, including an mTOR recorder that tracked mTOR activity oscillating through the cell cycle", "studies": [ "WANG2026C" ], "url": "https://mtor-atlas.org/author/jian-jiang/" }, { "id": "stuart-l-schreiber", "name": "Stuart L. Schreiber", "corpus_name": "Schreiber SL", "orcid": null, "lab": "Faculty profile, Harvard University (Cambridge, Massachusetts, USA)", "lab_url": "https://www.chemistry.harvard.edu/people/stuart-l-schreiber", "role": "Co-discovered mTOR in 1994 (his group called it FRAP) as the mammalian target of the FKBP12–rapamycin complex, and helped found chemical biology as a field", "studies": [ "BRO1994", "CHO1996" ], "url": "https://mtor-atlas.org/author/stuart-l-schreiber/" }, { "id": "nahum-sonenberg", "name": "Nahum Sonenberg", "corpus_name": "Sonenberg N", "orcid": null, "lab": "Faculty profile, McGill University (Montreal, Quebec, Canada)", "lab_url": "https://www.mcgill.ca/biochemistry/faculty-members/sonenberg", "role": "Co-discovered the mRNA cap-binding protein eIF4E and the 4E-BP proteins that restrain it, and showed how mTOR releases this brake to control protein synthesis", "studies": [ "GKO2013", "MOR2013", "TAN2002", "COS2009", "GIN1999", "LAR2012" ], "url": "https://mtor-atlas.org/author/nahum-sonenberg/" }, { "id": "dario-r-alessi", "name": "Dario R. Alessi", "corpus_name": "Alessi DR", "orcid": "0000-0002-2140-9185", "lab": "Principal investigator page, MRC Protein Phosphorylation Unit, University of Dundee (Dundee, Scotland, United Kingdom)", "lab_url": "https://www.ppu.mrc.ac.uk/research/principal-investigator/dario-alessi", "role": "Co-discovered PDK1, the master kinase that switches on Akt and related AGC kinases, and showed that mTORC2 activates the kinase SGK1", "studies": [ "LOF2011", "GAR2009", "GAR2008" ], "url": "https://mtor-atlas.org/author/dario-r-alessi/" }, { "id": "nikola-p-pavletich", "name": "Nikola P. Pavletich", "corpus_name": "Pavletich NP", "orcid": null, "lab": "Pavletich Lab, Memorial Sloan Kettering Cancer Center (New York, New York, USA)", "lab_url": "https://www.mskcc.org/research/ski/labs/nikola-pavletich", "role": "Solved the crystal structure of the mTOR kinase, revealing the FRB domain as a gatekeeper of its active site, and later showed how RHEB switches mTORC1 on and PRAS40 blocks it", "studies": [ "YAN2013", "YAN2017" ], "url": "https://mtor-atlas.org/author/nikola-p-pavletich/" }, { "id": "j-wade-harper", "name": "J. Wade Harper", "corpus_name": "Harper JW", "orcid": "0000-0002-6944-7236", "lab": "Harper Lab, Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://harper.hms.harvard.edu/", "role": "Co-discovered the F-box motif that links substrates to SCF ubiquitin ligases, and co-leads with Steven Gygi the BioPlex protein-interaction map, which contributed to the discoveries of the CASTOR and SAMTOR nutrient sensors", "studies": [ "CHA2016", "GU2017" ], "url": "https://mtor-atlas.org/author/j-wade-harper/" }, { "id": "steven-p-gygi", "name": "Steven P. Gygi", "corpus_name": "Gygi SP", "orcid": "0000-0001-7626-0034", "lab": "Gygi Lab, Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://gygi.hms.harvard.edu/", "role": "Mass-spectrometry scientist whose Harvard lab builds large-scale proteomics methods, including the BioPlex human protein-interaction map, and contributed proteomics to the discoveries of the CASTOR and SAMTOR nutrient sensors", "studies": [ "HOL2005", "CHA2014", "CHA2016", "GIN1999", "GU2017", "YUX2011" ], "url": "https://mtor-atlas.org/author/steven-p-gygi/" }, { "id": "kevan-m-shokat", "name": "Kevan M. Shokat", "corpus_name": "Shokat KM", "orcid": null, "lab": "Faculty profile, UCSF (San Francisco, California, USA)", "lab_url": "https://profiles.ucsf.edu/kevan.shokat", "role": "Co-developed the ATP-competitive 'TORKinib' mTOR inhibitors that block both mTORC1 and mTORC2, and later, with Neal Rosen's lab at Memorial Sloan Kettering, RapaLink-1, a third-generation inhibitor that overcomes mTOR resistance mutations", "studies": [ "HSI2012", "FEL2009", "HSI2010", "ROD2016" ], "url": "https://mtor-atlas.org/author/kevan-m-shokat/" }, { "id": "pier-paolo-pandolfi", "name": "Pier Paolo Pandolfi", "corpus_name": "Pandolfi PP", "orcid": null, "lab": "Personal website (Reno, Nevada, USA)", "lab_url": "https://pierpaolopandolfi.org/", "role": "Showed that ERK directly phosphorylates and inactivates TSC2, wiring Ras/MAPK signalling into mTORC1 control, and that blocking mTORC1 in patients' tumours triggers a feedback rise in MAPK signalling", "studies": [ "CAR2008", "MA2005" ], "url": "https://mtor-atlas.org/author/pier-paolo-pandolfi/" }, { "id": "brian-k-kennedy", "name": "Brian K. Kennedy", "corpus_name": "Kennedy BK", "orcid": "0000-0002-5754-1874", "lab": "Faculty profile, National University of Singapore (Singapore)", "lab_url": "https://medicine.nus.edu.sg/bch/faculty/brian-kennedy/", "role": "Showed with Matt Kaeberlein that reducing TOR or Sch9 signalling extends yeast lifespan in the same way as dietary restriction, and has since championed mTOR as a target for slowing human ageing", "studies": [ "KEN2016", "KAE2005", "POW2006", "FLY2013" ], "url": "https://mtor-atlas.org/author/brian-k-kennedy/" }, { "id": "linda-partridge", "name": "Linda Partridge", "corpus_name": "Partridge L", "orcid": "0000-0001-9615-0094", "lab": "Emerita profile, Max Planck Institute for Biology of Ageing (Cologne, North Rhine-Westphalia, Germany)", "lab_url": "https://www.age.mpg.de/402884/partridge", "role": "Showed that rapamycin extends fruit-fly lifespan through TORC1, via autophagy and reduced protein synthesis, and that it adds benefit even on top of dietary restriction", "studies": [ "FON2010", "BJE2010", "SEL2009" ], "url": "https://mtor-atlas.org/author/linda-partridge/" }, { "id": "john-j-kopchick", "name": "John J. Kopchick", "corpus_name": "Kopchick JJ", "orcid": null, "lab": "Institute for Molecular Medicine and Aging, Ohio University (formerly Edison Biotechnology Institute) (Athens, Ohio, USA)", "lab_url": "https://www.ohio.edu/directory/john-kopchick", "role": "Discovered the growth hormone receptor antagonist that became the acromegaly drug pegvisomant (Somavert), and studies how blocking growth hormone signalling extends lifespan in mice", "studies": [ "LIST2026", "DUR2026" ], "url": "https://mtor-atlas.org/author/john-j-kopchick/" }, { "id": "darlene-e-berryman", "name": "Darlene E. Berryman", "corpus_name": "Berryman DE", "orcid": "0000-0003-4240-9229", "lab": "Institute for Molecular Medicine and Aging, Ohio University Heritage College of Osteopathic Medicine (Athens, Ohio, USA)", "lab_url": "https://www.ohio.edu/medicine/staff/berrymad", "role": "Showed that growth hormone reshapes fat tissue in a depot-specific way that links body composition to metabolic aging", "studies": [ "LIST2026", "DUR2026" ], "url": "https://mtor-atlas.org/author/darlene-e-berryman/" }, { "id": "edward-o-list", "name": "Edward O. List", "corpus_name": "List EO", "orcid": "0000-0002-8230-6331", "lab": "Institute for Molecular Medicine and Aging, Ohio University Heritage College of Osteopathic Medicine (Athens, Ohio, USA)", "lab_url": "https://www.ohio.edu/medicine/about/directory/list", "role": "Carries out mouse studies, in John Kopchick's group, on how disrupting growth hormone receptor signaling extends mammalian lifespan", "studies": [ "LIST2026", "DUR2026" ], "url": "https://mtor-atlas.org/author/edward-o-list/" }, { "id": "alejo-efeyan", "name": "Alejo Efeyan", "corpus_name": "Efeyan A", "orcid": "0000-0002-3806-6799", "lab": "Metabolism and Cell Signalling Group, Spanish National Cancer Research Centre (CNIO) (Madrid, Spain)", "lab_url": "https://www.cnio.es/en/research-innovation/scientific-programmes/tumour-biology-programme/metabolism-and-cell-signalling-group/", "role": "Showed that the Rag GTPases, which relay amino-acid signals to mTORC1, are a life-or-death switch for newborn mice surviving the fast before their first feeding", "studies": [ "EFE2012", "ZON2011", "ZON2010" ], "url": "https://mtor-atlas.org/author/alejo-efeyan/" }, { "id": "sue-c-bodine", "name": "Sue C. Bodine", "corpus_name": "Bodine SC", "orcid": "0000-0002-5742-9145", "lab": "Aging & Metabolism Research Program, Oklahoma Medical Research Foundation (OMRF) (Oklahoma City, Oklahoma, USA)", "lab_url": "https://omrf.org/researcher/sue-bodine-ph-d/", "role": "Showed that turning on the Akt-mTOR pathway is enough, by itself, to make skeletal muscle grow and to stop it from wasting away", "studies": [ "BOD2001", "ROM2001" ], "url": "https://mtor-atlas.org/author/sue-c-bodine/" }, { "id": "xiaomeng-long", "name": "Xiaomeng Long", "corpus_name": "Long X", "orcid": null, "lab": "Avruch Lab, Massachusetts General Hospital / Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://molbio.mgh.harvard.edu/members/avruch", "role": "Discovered that Rheb binds directly to the mTOR kinase domain and switches it on", "studies": [ "HARA2002", "LON2005" ], "url": "https://mtor-atlas.org/author/xiaomeng-long/" }, { "id": "kenta-hara", "name": "Kenta Hara", "corpus_name": "Hara K", "orcid": null, "lab": "Department of Diabetes & Endocrinology, Kita Harima Medical Center (Ono, Hyogo, Japan)", "lab_url": "https://www.kitahari-mc.jp/1059/1066/9381.html", "role": "Showed in 1998 that amino acids are needed for mTOR to activate S6K1 and 4E-BP1, and as first author co-discovered raptor in 2002", "studies": [ "HARA2002", "OSH2007", "HAR1998", "NOJ2003" ], "url": "https://mtor-atlas.org/author/kenta-hara/" }, { "id": "noriko-oshiro-rapley", "name": "Noriko Oshiro-Rapley", "corpus_name": "Oshiro N", "orcid": null, "lab": "Xavier Lab, MGH Center for Computational & Integrative Biology / Broad Institute (Boston, Massachusetts, USA)", "lab_url": "https://ccib.mgh.harvard.edu/xavier", "role": "In one of several 2007 studies, identified PRAS40 as a raptor-bound mTORC1 substrate that gates access to mTORC1's other substrates", "studies": [ "HARA2002", "OSH2007", "HOS2009", "NOJ2003" ], "url": "https://mtor-atlas.org/author/noriko-oshiro-rapley/" }, { "id": "grace-y-liu", "name": "Grace Y. Liu", "corpus_name": "Liu GY", "orcid": "0000-0001-5463-3055", "lab": "Vance Lab, University of California, Berkeley (Berkeley, California, USA)", "lab_url": "https://vancelab.berkeley.edu/2023/03/17/welcome-to-grace-liu/", "role": "Wrote with David Sabatini a major 2020 review of mTOR in nutrition, growth and ageing, and in the Sabatini lab studied how mTORC1 senses nutrients such as serine", "studies": [ "LIU2020", "GU2017" ], "url": "https://mtor-atlas.org/author/grace-y-liu/" }, { "id": "kendall-j-condon", "name": "Kendall J. Condon", "corpus_name": "Condon KJ", "orcid": "0000-0002-9515-8892", "lab": "PhD (Sabatini lab), MIT Department of Biology (Cambridge, Massachusetts, USA)", "lab_url": "https://biology.mit.edu/event/thesis-defense-kendall-condon/", "role": "Ran genome-wide CRISPR screens revealing how mitochondrial stress signals to mTORC1", "studies": [ "WOL2017", "SHE2018", "CON2021", "GU2017" ], "url": "https://mtor-atlas.org/author/kendall-j-condon/" }, { "id": "sonia-m-scaria", "name": "Sonia M. Scaria", "corpus_name": "Scaria SM", "orcid": null, "lab": "Tward Lab alumni record, UCSF Otolaryngology–Head and Neck Surgery (San Francisco, California, USA)", "lab_url": "https://twardlab.ucsf.edu/people-1", "role": "Contributed, as an MIT undergraduate in the Sabatini lab, to the discovery of CASTOR1 as the arginine sensor and SAMTOR as the SAM sensor of the mTORC1 pathway", "studies": [ "WOL2015", "CHA2014", "WOL2017", "CHA2016", "GU2017" ], "url": "https://mtor-atlas.org/author/sonia-m-scaria/" }, { "id": "mathieu-laplante", "name": "Mathieu Laplante", "corpus_name": "Laplante M", "orcid": null, "lab": "Institut universitaire de cardiologie et de pneumologie de Québec – Université Laval (Quebec City, Quebec, Canada)", "lab_url": "https://www.iucpq.ca/chercheurs-et-chercheuses/dr-mathieu-laplante/", "role": "Co-wrote with David Sabatini one of the field's most cited reviews of mTOR in growth and disease, and his Laval lab studies how mTORC1 and DEPTOR control fat tissue and metabolism", "studies": [ "LAP2012", "SEN2010", "PET2009" ], "url": "https://mtor-atlas.org/author/mathieu-laplante/" }, { "id": "j-silvio-gutkind", "name": "J. Silvio Gutkind", "corpus_name": "Gutkind JS", "orcid": "0000-0002-5150-4482", "lab": "Gutkind Lab, UC San Diego Moores Cancer Center (La Jolla, California, USA)", "lab_url": "https://gutkindlab.org/about-us/j-silvio-gutkind-phd/", "role": "Showed that persistent mTOR activation exhausts epidermal stem cells and accelerates skin ageing, and targets PI3K–mTOR signalling in head-and-neck cancer, including to make tumours respond to immunotherapy", "studies": [ "CAS2009", "NAT2026" ], "url": "https://mtor-atlas.org/author/j-silvio-gutkind/" }, { "id": "matthew-r-janes", "name": "Matthew R. Janes", "corpus_name": "Janes MR", "orcid": null, "lab": "Wellspring Biosciences, Inc. (San Diego, California, USA)", "lab_url": "http://www.wellspringbiosciences.com/", "role": "Showed, as first author in David Fruman's lab, that a dual TORC1/2 kinase inhibitor kills leukemia cells with much weaker effects on normal lymphocytes than rapamycin", "studies": [ "HSI2012", "JAN2010" ], "url": "https://mtor-atlas.org/author/matthew-r-janes/" }, { "id": "andrew-c-hsieh", "name": "Andrew C. Hsieh", "corpus_name": "Hsieh AC", "orcid": null, "lab": "Hsieh Lab, Fred Hutchinson Cancer Center (Seattle, Washington, USA)", "lab_url": "https://research.fredhutch.org/hsieh/en.html", "role": "Showed, as first author in Davide Ruggero's lab, that oncogenic mTOR drives cancer metastasis by selectively translating a specific pro-invasion mRNA program", "studies": [ "HSI2012", "HSI2010" ], "url": "https://mtor-atlas.org/author/andrew-c-hsieh/" }, { "id": "mikhail-v-blagosklonny", "name": "Mikhail V. Blagosklonny", "corpus_name": "Blagosklonny MV", "orcid": null, "lab": "In memoriam / Aging (Aging-US) editor profile (Buffalo, New York, USA)", "lab_url": "https://www.aging-us.com/mikhail-blagosklonny", "role": "Proposed the hyperfunction theory of ageing: TOR signalling that builds a young body never fully switches off, and drives its ageing instead", "studies": [ "ANI2011", "BLA2006", "DEM2009" ], "url": "https://mtor-atlas.org/author/mikhail-v-blagosklonny/" }, { "id": "gerta-hoxhaj", "name": "Gerta Hoxhaj", "corpus_name": "Hoxhaj G", "orcid": "0000-0001-6179-3583", "lab": "Children's Medical Center Research Institute (CRI), UT Southwestern Medical Center (Dallas, Texas, USA)", "lab_url": "https://cri.utsw.edu/faculty/gerta-hoxhaj/", "role": "Studies how growth signalling through PI3K, AKT and mTOR rewires cell metabolism; as a Manning-lab postdoc she co-authored work on how metformin inhibits mTORC1 in the liver", "studies": [ "HOX2019", "BEN2016", "HOW2017", "MEN2014" ], "url": "https://mtor-atlas.org/author/gerta-hoxhaj/" }, { "id": "carmine-settembre", "name": "Carmine Settembre", "corpus_name": "Settembre C", "orcid": "0000-0002-5829-8589", "lab": "Settembre Lab, TIGEM (Telethon Institute of Genetics and Medicine) (Naples, Italy)", "lab_url": "https://www.tigem.it/research/research-faculty/settembre", "role": "Showed, as first author in Andrea Ballabio's lab, that TFEB drives autophagy as well as lysosome production, and, in parallel with other groups, that mTORC1 phosphorylates TFEB at the lysosome to keep this program switched off when nutrients are plentiful", "studies": [ "SET2012", "SET2011", "SET2013" ], "url": "https://mtor-atlas.org/author/carmine-settembre/" }, { "id": "michael-d-frost", "name": "Michael D. Frost", "corpus_name": "Frost M", "orcid": null, "lab": "Minnesota Epilepsy Group (St. Paul, Minnesota, USA)", "lab_url": "https://mnepilepsy.org/our-team/michael-d-frost-md/", "role": "Co-investigator on the EXIST-1 and EXIST-2 trials showing that the mTOR inhibitor everolimus shrinks tuberous sclerosis tumours in the brain and kidney", "studies": [ "BIS2013", "FRA2013" ], "url": "https://mtor-atlas.org/author/michael-d-frost/" }, { "id": "john-j-bissler", "name": "John J. Bissler", "corpus_name": "Bissler JJ", "orcid": "0000-0001-9685-9183", "lab": "St. Jude Children's Research Hospital (Memphis, Tennessee, USA)", "lab_url": "https://www.stjude.org/directory/b/john-bissler.html", "role": "Led the first clinical trial showing that the mTOR inhibitor sirolimus shrinks kidney angiomyolipomas in tuberous sclerosis, and the EXIST-2 trial of everolimus for the same tumours", "studies": [ "BIS2013", "BIS2008" ], "url": "https://mtor-atlas.org/author/john-j-bissler/" }, { "id": "david-n-franz", "name": "David N. Franz", "corpus_name": "Franz DN", "orcid": null, "lab": "Tuberous Sclerosis Clinic, Cincinnati Children's Hospital Medical Center (Cincinnati, Ohio, USA)", "lab_url": "https://www.cincinnatichildrens.org/bio/f/david-franz", "role": "Led the EXIST-1 trial showing that the mTOR inhibitor everolimus shrinks the brain tumours (SEGAs) of tuberous sclerosis, and helped run the first sirolimus trial for its kidney tumours", "studies": [ "KRU2010", "BIS2008", "FRA2006", "FRE2016", "FRA2013" ], "url": "https://mtor-atlas.org/author/david-n-franz/" }, { "id": "pankaj-kapahi", "name": "Pankaj Kapahi", "corpus_name": "Kapahi P", "orcid": "0000-0002-5629-4947", "lab": "Kapahi Lab, Buck Institute for Research on Aging (Novato, California, USA)", "lab_url": "https://www.buckinstitute.org/lab/kapahi-lab/", "role": "Showed that reducing TOR signalling extends fruit-fly lifespan, and that the translation repressor 4E-BP is needed for dietary restriction to extend it", "studies": [ "LAB2015", "FLY2013", "KAP2004", "ZID2009" ], "url": "https://mtor-atlas.org/author/pankaj-kapahi/" }, { "id": "vanessa-s-rodrik-outmezguine", "name": "Vanessa S. Rodrik-Outmezguine", "corpus_name": "Rodrik-Outmezguine VS", "orcid": null, "lab": "Clinical Biomarker Development, Loxo Oncology at Eli Lilly and Company (formerly Rosen Lab, Memorial Sloan Kettering) (Stamford, Connecticut, USA)", "lab_url": "https://www.lilly.com/", "role": "Showed that tumours reactivate AKT after mTOR kinase inhibition, and that the third-generation inhibitor RapaLink-1 overcomes mTOR resistance mutations", "studies": [ "ROD2011", "ROD2016" ], "url": "https://mtor-atlas.org/author/vanessa-s-rodrik-outmezguine/" }, { "id": "neal-rosen", "name": "Neal Rosen", "corpus_name": "Rosen N", "orcid": null, "lab": "Rosen Lab (Member Emeritus), Memorial Sloan Kettering Cancer Center (New York, New York, USA)", "lab_url": "https://www.mskcc.org/research-areas/labs/members/neal-rosen", "role": "Showed that blocking mTORC1 releases a feedback brake on receptor tyrosine kinases and AKT, explaining how tumours escape mTOR and PI3K inhibitors and shaping how these drugs are combined in the clinic", "studies": [ "ORE2006", "ROD2011", "ROD2016" ], "url": "https://mtor-atlas.org/author/neal-rosen/" }, { "id": "brian-c-grabiner", "name": "Brian C. Grabiner", "corpus_name": "Grabiner BC", "orcid": null, "lab": "Sabatini Lab, Whitehead Institute / MIT (HHMI) (Cambridge, Massachusetts, USA)", "lab_url": "https://www.davidsabatinilab.com", "role": "Catalogued cancer-associated MTOR mutations and showed that many of them hyperactivate the kinase and can predict sensitivity to rapamycin; he also contributed to the discovery of GATOR1", "studies": [ "BAR2013", "WAG2014", "GRA2014" ], "url": "https://mtor-atlas.org/author/brian-c-grabiner/" }, { "id": "yakir-guri", "name": "Yakir Guri", "corpus_name": "Guri Y", "orcid": "0000-0003-4273-4603", "lab": "Hall Lab, Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": "https://www.biozentrum.unibas.ch/research/research-groups/research-groups-a-z/overview/unit/research-group-michael-n-hall", "role": "Showed mTORC2 drives liver cancer by rewiring lipid and sphingolipid synthesis", "studies": [ "GUR2017", "GUR2016" ], "url": "https://mtor-atlas.org/author/yakir-guri/" }, { "id": "robbie-loewith", "name": "Robbie Loewith", "corpus_name": "Loewith R", "orcid": "0000-0002-2482-603X", "lab": "Loewith Lab, University of Geneva (Geneva, Switzerland)", "lab_url": "https://www.loewithlab.org/", "role": "Showed, as first author in Michael Hall's lab, that yeast TOR exists as two distinct complexes, the basis of the TORC1/TORC2 framework", "studies": [ "FEL2009", "JAC2004", "LOE2002", "KAR2017", "WUL2006" ], "url": "https://mtor-atlas.org/author/robbie-loewith/" }, { "id": "haijuan-yang", "name": "Haijuan Yang", "corpus_name": "Yang H", "orcid": "0009-0004-5033-1147", "lab": "Pavletich Lab, Structural Biology Program, Memorial Sloan Kettering Cancer Center (New York, New York, USA)", "lab_url": "https://www.mskcc.org/research/ski/labs/nikola-pavletich/members", "role": "Solved, as first author in the Pavletich lab, the crystal structure of the mTOR kinase and the structure of mTORC1 activated by RHEB", "studies": [ "YAN2013", "YAN2017" ], "url": "https://mtor-atlas.org/author/haijuan-yang/" }, { "id": "chong-chen", "name": "Chong Chen", "corpus_name": "Chen C", "orcid": null, "lab": "The Chen-Liu Lab, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University (Chengdu, Sichuan, China)", "lab_url": "https://www.chenliulab.org/", "role": "Showed that blood stem cells need TSC to keep mTOR in check in order to stay dormant and self-renew, and that rapamycin restores the function of aged blood stem cells in mice", "studies": [ "CHE2008", "CHE2009" ], "url": "https://mtor-atlas.org/author/chong-chen/" }, { "id": "pan-zheng", "name": "Pan Zheng", "corpus_name": "Zheng P", "orcid": "0000-0003-2598-3544", "lab": "OncoC4, Inc. (Rockville, Maryland, USA)", "lab_url": "https://oncoc4.com/en/about-us/founders-and-board/pan-zheng-md-phd-fab/", "role": "Showed as senior author that blood stem cells need TSC to keep mTOR in check in order to stay dormant, and that rapamycin restores the function of aged blood stem cells in mice", "studies": [ "CHE2008", "CHE2009" ], "url": "https://mtor-atlas.org/author/pan-zheng/" }, { "id": "benoit-viollet", "name": "Benoit Viollet", "corpus_name": "Viollet B", "orcid": "0000-0002-0121-0224", "lab": "Institut Cochin (INSERM/CNRS/Université Paris Cité) (Paris, France)", "lab_url": "https://institutcochin.fr/en/equipes/physiopathology-ampk-and-ampk-related-protein-kinase-diabetes-and-obesity", "role": "Showed that metformin still lowers liver glucose production without AMPK or LKB1, pointing instead to a drop in cellular energy charge", "studies": [ "EGA2010", "KAL2010", "FOR2010", "KIM2011" ], "url": "https://mtor-atlas.org/author/benoit-viollet/" }, { "id": "joungmok-kim", "name": "Joungmok Kim", "corpus_name": "Kim J", "orcid": null, "lab": "Kyung Hee University (Seoul, South Korea)", "lab_url": "https://khu.elsevierpure.com/en/persons/joungmok-kim", "role": "Showed as a Guan-lab postdoc that AMPK and mTORC1 control autophagy by phosphorylating ULK1 at different sites, with mTORC1's mark on Ser757 blocking activation by AMPK", "studies": [ "KIM2019", "RUS2013", "KIM2011" ], "url": "https://mtor-atlas.org/author/joungmok-kim/" }, { "id": "constantinos-demetriades", "name": "Constantinos Demetriades", "corpus_name": "Demetriades C", "orcid": "0000-0001-7813-7726", "lab": "Demetriades Lab, European Research Institute for the Biology of Ageing (ERIBA), UMCG (Groningen, Netherlands)", "lab_url": "https://eriba.umcg.nl/people/costas-demetriades/", "role": "Showed as a postdoc in Aurelio Teleman's lab that starvation and other stresses pull TSC2 to the lysosome to switch mTORC1 off. His group, at the Max Planck Institute for Biology of Ageing in Cologne from 2017 and at ERIBA in Groningen since 2025, studies how cells sense nutrients and stress through mTORC1 and how this changes with age", "studies": [ "DEM2016", "FER2024", "PRE2021", "FER2025", "DEM2014", "NIC2023", "GOL2022" ], "url": "https://mtor-atlas.org/author/constantinos-demetriades/" }, { "id": "aurelio-a-teleman", "name": "Aurelio A. Teleman", "corpus_name": "Teleman AA", "orcid": "0000-0002-4237-9368", "lab": "Division of Signal Transduction in Cancer and Metabolism, DKFZ (Heidelberg, Germany)", "lab_url": "https://www.dkfz.de/en/signal-transduction-in-cancer-and-metabolism", "role": "Uses fruit-fly genetics and human cells to study how growth signalling through TOR controls cell and body size. His lab showed that starvation and other stresses move TSC2 to the lysosome to switch mTORC1 off", "studies": [ "DEM2016", "PRE2021", "FER2025", "DEM2014", "NIC2023" ], "url": "https://mtor-atlas.org/author/aurelio-a-teleman/" }, { "id": "andrew-l-markhard", "name": "Andrew L. Markhard", "corpus_name": "Markhard AL", "orcid": null, "lab": "Long Lab, Stanford (formerly Mootha Lab, Broad/MGH) (Stanford, California, USA)", "lab_url": "https://longlabstanford.org/people-1", "role": "Contributed, as a Sabatini-lab researcher, to the discovery that Ragulator docks mTORC1 on the lysosome, and now studies metabolite signals that tell the body it has eaten", "studies": [ "SAR2006", "SAN2010" ], "url": "https://mtor-atlas.org/author/andrew-l-markhard/" }, { "id": "peggy-p-hsu", "name": "Peggy P. Hsu", "corpus_name": "Hsu PP", "orcid": null, "lab": "Hsu Lab, University of Michigan Rogel Cancer Center (Ann Arbor, Michigan, USA)", "lab_url": "https://www.uofmhealth.org/profile/1972941136/peggy-ping-hsu", "role": "Identified, in parallel with Yonghao Yu's group, Grb10 as an mTORC1 substrate that feeds back to dampen insulin and growth-factor signalling, and now studies the earliest steps of lung cancer as a physician-scientist", "studies": [ "SAR2006", "HSU2011" ], "url": "https://mtor-atlas.org/author/peggy-p-hsu/" }, { "id": "shomit-sengupta", "name": "Shomit Sengupta", "corpus_name": "Sengupta S", "orcid": null, "lab": "Atavistik Bio (Boston, Massachusetts, USA)", "lab_url": "https://atavistikbio.com/team/shomit-sengupta/", "role": "Showed that mTORC1 controls whether the liver makes ketone bodies during fasting, and now leads biology for drug discovery at a metabolic-disease biotech", "studies": [ "SAR2006", "YIL2012", "SEN2010" ], "url": "https://mtor-atlas.org/author/shomit-sengupta/" }, { "id": "dan-ehninger", "name": "Dan Ehninger", "corpus_name": "Ehninger D", "orcid": null, "lab": "Translational Biogerontology Group, DZNE Bonn (Bonn, Germany)", "lab_url": "https://www.dzne.de/en/research/research-areas/fundamental-research/research-groups/ehninger", "role": "Showed that rapamycin reverses learning deficits in adult mice carrying a tuberous sclerosis mutation, and later tested carefully whether rapamycin's lifespan effect reflects a true slowing of ageing", "studies": [ "EHN2008", "NEF2013" ], "url": "https://mtor-atlas.org/author/dan-ehninger/" }, { "id": "daniel-f-egan", "name": "Daniel F. Egan", "corpus_name": "Egan DF", "orcid": null, "lab": "Shaw Lab, Salk Institute (where this work was done) (La Jolla, California, USA)", "lab_url": "https://shaw.salk.edu/", "role": "Showed as first author that AMPK directly phosphorylates ULK1, linking low cellular energy to autophagy and mitophagy, and contributed to the finding that AMPK brakes mTORC1 by phosphorylating raptor", "studies": [ "GWI2008", "EGA2010" ], "url": "https://mtor-atlas.org/author/daniel-f-egan/" }, { "id": "gregory-a-wyant", "name": "Gregory A. Wyant", "corpus_name": "Wyant GA", "orcid": "0000-0002-4665-2405", "lab": "Wyant Lab, MGH Cardiovascular Research Center (Boston, Massachusetts, USA)", "lab_url": "https://cvrc.massgeneral.org/gregory-a-wyant-phd/", "role": "Showed that the lysosomal protein SLC38A9 exports leucine and other essential amino acids out of the lysosome, letting cells grow on proteins they have taken up and broken down there", "studies": [ "WYA2018", "WOL2017", "WYA2017", "WAN2015", "CHA2016" ], "url": "https://mtor-atlas.org/author/gregory-a-wyant/" }, { "id": "kacper-b-rogala", "name": "Kacper B. Rogala", "corpus_name": "Rogala KB", "orcid": "0000-0001-5997-7770", "lab": "Rogala Lab, Stanford University (Stanford, California, USA)", "lab_url": "https://rogala.stanford.edu/", "role": "Solved the near-atomic cryo-EM structure that shows how mTORC1 physically docks at the lysosome by reading the Rag GTPases", "studies": [ "SHE2019", "VAL2022", "ANA2019", "ROG2019" ], "url": "https://mtor-atlas.org/author/kacper-b-rogala/" }, { "id": "yonghao-yu", "name": "Yonghao Yu", "corpus_name": "Yu Yonghao", "orcid": "0000-0002-7289-7748", "lab": "Yu Lab, Columbia University Irving Medical Center (New York, New York, USA)", "lab_url": "https://www.pharmacology.cuimc.columbia.edu/research/yu-lab", "role": "Used phosphoproteomics to show that mTORC1 phosphorylates and stabilises Grb10, which then acts as a feedback brake on insulin and IGF-1 signalling", "studies": [ "YUX2011" ], "url": "https://mtor-atlas.org/author/yonghao-yu/" }, { "id": "shawn-m-ferguson", "name": "Shawn M. Ferguson", "corpus_name": "Ferguson SM", "orcid": "0000-0002-3092-7718", "lab": "Ferguson Lab, Yale School of Medicine (New Haven, Connecticut, USA)", "lab_url": "https://medicine.yale.edu/lab/ferguson/", "role": "Showed that mTORC1 phosphorylates TFEB to keep the lysosome-building program switched off, and that folliculin is required at the lysosome for amino acids to recruit and activate mTORC1", "studies": [ "ROC2012", "PET2013" ], "url": "https://mtor-atlas.org/author/shawn-m-ferguson/" }, { "id": "natalia-podlutskaya", "name": "Natalia Podlutskaya", "corpus_name": "Podlutskaya N", "orcid": null, "lab": "BLaST Program, University of Alaska Fairbanks (Fairbanks, Alaska, USA)", "lab_url": "https://www.uaf.edu/news/blast-podlutskaya.php", "role": "Contributed, at the Barshop Institute in San Antonio, to mouse studies showing that rapamycin prevents Alzheimer's-like memory loss and improves cognition in normal ageing", "studies": [ "HAL2012", "SPI2010" ], "url": "https://mtor-atlas.org/author/natalia-podlutskaya/" }, { "id": "veronica-galvan", "name": "Veronica Galvan", "corpus_name": "Galvan V", "orcid": null, "lab": "Galvan Lab, University of Oklahoma Health Sciences Center (Oklahoma City, Oklahoma, USA)", "lab_url": "https://www.galvanlab.org/", "role": "Led mouse studies showing that rapamycin prevents Alzheimer's-like memory loss and amyloid build-up, and improves learning in normally ageing mice", "studies": [ "HAL2012", "SPI2010" ], "url": "https://mtor-atlas.org/author/veronica-galvan/" }, { "id": "andrei-v-budanov", "name": "Andrei V. Budanov", "corpus_name": "Budanov AV", "orcid": "0000-0002-7943-1000", "lab": "Budanov Lab, Trinity College Dublin (Dublin, Ireland)", "lab_url": "https://www.tcd.ie/Biochemistry/people/budanova/", "role": "Helped identify the Sestrins as stress-induced proteins and was among the groups that showed they inhibit mTORC1 through the GATOR complex, a brake that protects against age-related disease", "studies": [ "PAR2014", "LEE2010", "BUD2008" ], "url": "https://mtor-atlas.org/author/andrei-v-budanov/" }, { "id": "charles-betz", "name": "Charles Betz", "corpus_name": "Betz C", "orcid": "0000-0002-9837-6916", "lab": "Michael N. Hall Lab, Biozentrum, University of Basel (where these studies were done) (Basel, Switzerland)", "lab_url": "https://www.biozentrum.unibas.ch/research/research-groups/research-groups-a-z/overview/unit/research-group-michael-n-hall", "role": "Traced mTORC2 to a specific address inside the cell — the mitochondria-ER contact site", "studies": [ "HAG2012", "BETZ2013", "BET2013" ], "url": "https://mtor-atlas.org/author/charles-betz/" }, { "id": "greg-m-delgoffe", "name": "Greg M. Delgoffe", "corpus_name": "Delgoffe GM", "orcid": "0000-0002-2957-8135", "lab": "Delgoffe Lab, UPMC Hillman Cancer Center / University of Pittsburgh (Pittsburgh, Pennsylvania, USA)", "lab_url": "http://www.delgoffe-lab.com/", "role": "Showed as a graduate student in Jonathan Powell's lab that T cells lacking mTOR become regulatory rather than effector T cells, and that mTORC1 and mTORC2 steer different helper-T-cell fates", "studies": [ "POL2015", "DEL2011", "DEL2009" ], "url": "https://mtor-atlas.org/author/greg-m-delgoffe/" }, { "id": "rosalie-e-lawrence", "name": "Rosalie E. Lawrence", "corpus_name": "Lawrence RE", "orcid": "0000-0003-3386-7391", "lab": "Lawrence Lab, UCLA David Geffen School of Medicine (Los Angeles, California, USA)", "lab_url": "https://biolchem.ucla.edu/people/rosalie-lawrence-phd", "role": "Working in Roberto Zoncu's lab, uncovered the nutrient-driven affinity switch and the FLCN checkpoint that gate mTORC1 activation at the lysosome", "studies": [ "LAW2019", "LAW2018" ], "url": "https://mtor-atlas.org/author/rosalie-e-lawrence/" }, { "id": "tim-wang", "name": "Tim Wang", "corpus_name": "Wang T", "orcid": null, "lab": "Sabatini Lab, Whitehead Institute / MIT Biology (at time of both featured studies) (Cambridge, Massachusetts, USA)", "lab_url": null, "role": "Co-developed genome-wide CRISPR screening in human cells (reported in parallel by Feng Zhang's lab) as a graduate student with David Sabatini and Eric Lander, and contributed to studies showing that the 4E-BPs mediate mTORC1's control of translation and that CASTOR1 senses arginine", "studies": [ "TSU2013", "SAX2015", "WAN2015", "CHA2016", "THO2012" ], "url": "https://mtor-atlas.org/author/tim-wang/" }, { "id": "juan-m-garcia-martinez", "name": "Juan M. García-Martínez", "corpus_name": "Garcia-Martinez JM", "orcid": null, "lab": "MRC Protein Phosphorylation Unit, University of Dundee (at time of both featured studies) (Dundee, Scotland, United Kingdom)", "lab_url": null, "role": "Discovered mTORC2 activates SGK1 and co-developed Ku-0063794, one of the first selective ATP-competitive mTOR inhibitors", "studies": [ "GAR2009", "GAR2008" ], "url": "https://mtor-atlas.org/author/juan-m-garcia-martinez/" }, { "id": "roger-l-williams", "name": "Roger L. Williams", "corpus_name": "Williams RL", "orcid": "0000-0001-7754-4207", "lab": "MRC Laboratory of Molecular Biology (LMB), Cambridge (Cambridge, England, United Kingdom)", "lab_url": "https://www2.mrc-lmb.cam.ac.uk/groups/rlw/", "role": "Solved structures showing how the Rag GTPases bind mTORC1 and how TOR forms a dimer, working at the MRC Laboratory of Molecular Biology", "studies": [ "BAR2016", "ANA2019" ], "url": "https://mtor-atlas.org/author/roger-l-williams/" }, { "id": "hongbo-chi", "name": "Hongbo Chi", "corpus_name": "Chi H", "orcid": "0000-0002-9997-2496", "lab": "St. Jude Children's Research Hospital, Department of Immunology (Memphis, Tennessee, USA)", "lab_url": "https://www.stjude.org/research/labs/chi-lab.html", "role": "Showed that regulatory T cells need mTORC1 signalling to fuel their suppressive function, and studies how mTOR-driven metabolism steers T-cell fate", "studies": [ "CHI2012", "ZEN2013", "WAN2011" ], "url": "https://mtor-atlas.org/author/hongbo-chi/" }, { "id": "robert-t-abraham", "name": "Robert T. Abraham", "corpus_name": "Abraham RT", "orcid": null, "lab": "Engine Biosciences (San Francisco, California, USA)", "lab_url": "https://www.enginebio.com", "role": "Co-discovered the mammalian target of rapamycin in 1995, giving it the name mTOR, and showed that it directly phosphorylates the translation repressor 4E-BP1 (PHAS-I)", "studies": [ "SAB1995", "GIN1999", "BRU1997" ], "url": "https://mtor-atlas.org/author/robert-t-abraham/" }, { "id": "timm-maier", "name": "Timm Maier", "corpus_name": "Maier T", "orcid": "0000-0002-7459-1363", "lab": "Maier Lab, Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": "https://www.biozentrum.unibas.ch/research/researchgroups/overview/unit/maier", "role": "Solved some of the first cryo-EM structures of human mTORC1 (with Nenad Ban's group) and mTORC2, including a high-resolution map of mTORC2", "studies": [ "BAT2022", "SCA2020", "AYL2015", "STU2018" ], "url": "https://mtor-atlas.org/author/timm-maier/" }, { "id": "issam-ben-sahra", "name": "Issam Ben-Sahra", "corpus_name": "Ben-Sahra I", "orcid": "0000-0001-9333-4162", "lab": "Ben-Sahra Lab, Northwestern University Feinberg School of Medicine (Chicago, Illinois, USA)", "lab_url": "https://www.bensahralab.org", "role": "Showed as a postdoc in Brendan Manning's lab that mTORC1 drives both pyrimidine and purine synthesis, through two different mechanisms. His Northwestern lab has extended this to bicarbonate import, SAM synthesis and ERK control of purine production", "studies": [ "VIL2021", "ALI2020", "BEN2013", "BEN2016", "ALI2022" ], "url": "https://mtor-atlas.org/author/issam-ben-sahra/" }, { "id": "viktor-i-korolchuk", "name": "Viktor I. Korolchuk", "corpus_name": "Korolchuk VI", "orcid": "0000-0002-4071-592X", "lab": "Korolchuk Lab, Biosciences Institute, Newcastle University (Newcastle upon Tyne, England, United Kingdom)", "lab_url": "https://www.ncl.ac.uk/medical-sciences/people/profile/viktorkorolchuk.html", "role": "Showed that where lysosomes sit inside the cell tunes mTORC1 activity to nutrient supply. His Newcastle lab found that senescent cells can no longer switch mTORC1 off when nutrients or growth factors are withdrawn, and studies how autophagy and mitophagy decline with age", "studies": [ "KOR2011", "PRE2021", "KEL2024", "CAR2017", "COR2018" ], "url": "https://mtor-atlas.org/author/viktor-i-korolchuk/" }, { "id": "yoshiaki-kamada", "name": "Yoshiaki Kamada", "corpus_name": "Kamada Y", "orcid": "0000-0001-7395-660X", "lab": "National Institute for Basic Biology, Okazaki (Okazaki, Japan)", "lab_url": "https://www.nibb.ac.jp/en/sections/members/kamada_yoshiaki.html", "role": "Showed as first author that TOR keeps autophagy switched off in yeast by controlling the Atg1 (Apg1) kinase complex, and has studied TOR's control of autophagy ever since", "studies": [ "KAM2000" ], "url": "https://mtor-atlas.org/author/yoshiaki-kamada/" }, { "id": "yoshinori-ohsumi", "name": "Yoshinori Ohsumi", "corpus_name": "Ohsumi Y", "orcid": null, "lab": "Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo (Tokyo, Japan)", "lab_url": "http://www.rcb.iir.titech.ac.jp/en/lab_ohsumi.html", "role": "Found the genes that make autophagy work, and with them the link from TOR to the autophagy machinery", "studies": [ "KAM2000" ], "url": "https://mtor-atlas.org/author/yoshinori-ohsumi/" }, { "id": "maya-p-byfield", "name": "Maya P. Byfield", "corpus_name": "Byfield MP", "orcid": null, "lab": "Department of Molecular Pharmacology, Albert Einstein College of Medicine (affiliation on BYF2005) (Bronx, New York, USA)", "lab_url": null, "role": "Showed as first author that the lipid kinase hVps34 is regulated by nutrients and is needed for amino acids to activate S6 kinase through mTOR, in parallel with a study from George Thomas's group", "studies": [ "BYF2005", "NOB2005" ], "url": "https://mtor-atlas.org/author/maya-p-byfield/" }, { "id": "jonathan-m-backer", "name": "Jonathan M. Backer", "corpus_name": "Backer JM", "orcid": null, "lab": "Backer Lab, Department of Molecular Pharmacology, Albert Einstein College of Medicine (Bronx, New York, USA)", "lab_url": "https://einsteinmed.edu/faculty/283/jonathan-m-backer", "role": "Showed that the class III PI 3-kinase hVps34, best known for its role in autophagy, is regulated by nutrients and is needed for amino acids to activate S6 kinase through mTOR, in parallel with George Thomas's group", "studies": [ "BYF2005", "NOB2005" ], "url": "https://mtor-atlas.org/author/jonathan-m-backer/" }, { "id": "takahiro-nobukuni", "name": "Takahiro Nobukuni", "corpus_name": "Nobukuni T", "orcid": null, "lab": "Tohoku Medical Megabank Organization, Tohoku University (Sendai, Japan)", "lab_url": "https://www.r-info.tohoku.ac.jp/en/7c0ea723668c0757e2b393387b517f75.html", "role": "Showed as first author that amino acids activate mTOR through the lipid kinase hVps34, by a route separate from insulin signalling through TSC, in parallel with a study from Jonathan Backer's laboratory", "studies": [ "GAR2003", "NOB2005", "GUL2008" ], "url": "https://mtor-atlas.org/author/takahiro-nobukuni/" }, { "id": "malene-hansen", "name": "Malene Hansen", "corpus_name": "Hansen M", "orcid": null, "lab": "Hansen Lab, Buck Institute for Research on Aging (Novato, California, USA)", "lab_url": "https://www.buckinstitute.org/lab/hansen-lab/", "role": "Showed in worms, alongside a 2007 report from Beth Levine's laboratory, that autophagy is required for dietary restriction to extend lifespan", "studies": [ "EGA2010", "HAN2007", "HAN2008" ], "url": "https://mtor-atlas.org/author/malene-hansen/" }, { "id": "cynthia-kenyon", "name": "Cynthia Kenyon", "corpus_name": "Kenyon C", "orcid": "0000-0003-3446-2636", "lab": "Calico Life Sciences (South San Francisco, California, USA)", "lab_url": "https://www.calicolabs.com/people/cynthia-kenyon/", "role": "Showed in 1993 that a single-gene change doubles the lifespan of the worm C. elegans, which opened the study of nutrient-sensing pathways as ageing pathways", "studies": [ "HAN2007", "HAN2008" ], "url": "https://mtor-atlas.org/author/cynthia-kenyon/" }, { "id": "tobias-eisenberg", "name": "Tobias Eisenberg", "corpus_name": "Eisenberg T", "orcid": "0000-0003-3559-1130", "lab": "Institute of Molecular Biosciences, University of Graz (Graz, Austria)", "lab_url": "https://molekularbiologie.uni-graz.at/en/our-research/alterung-und-zelltod/", "role": "Showed as first author that the dietary polyamine spermidine extends lifespan by inducing autophagy, and later that it protects the heart in an autophagy-dependent way", "studies": [ "EIS2016", "EIS2009" ], "url": "https://mtor-atlas.org/author/tobias-eisenberg/" }, { "id": "frank-madeo", "name": "Frank Madeo", "corpus_name": "Madeo F", "orcid": "0000-0002-5070-1329", "lab": "Ageing and Cell Death Laboratory, Institute of Molecular Biosciences, University of Graz (Graz, Austria)", "lab_url": "https://molekularbiologie.uni-graz.at/en/our-research/alterung-und-zelltod/", "role": "Established spermidine as a dietary compound that extends lifespan in yeast, worms, flies and mice, and showed that the effect depends on autophagy", "studies": [ "EIS2016", "EIS2009" ], "url": "https://mtor-atlas.org/author/frank-madeo/" }, { "id": "masako-narita", "name": "Masako Narita", "corpus_name": "Narita Masako", "orcid": "0000-0002-9774-4908", "lab": "Narita Group, Cancer Research UK Cambridge Institute (Cambridge, England, United Kingdom)", "lab_url": "https://www.cruk.cam.ac.uk/research-groups/narita-group/", "role": "Discovered, as first author, the TASCC, a compartment in senescent cells where mTOR and autophagy work side by side to fuel the secretion of inflammatory proteins", "studies": [ "NAR2011" ], "url": "https://mtor-atlas.org/author/masako-narita/" }, { "id": "masashi-narita", "name": "Masashi Narita", "corpus_name": "Narita Masashi", "orcid": "0000-0001-7764-577X", "lab": "Narita Group, Cancer Research UK Cambridge Institute (Cambridge, England, United Kingdom)", "lab_url": "https://www.cruk.cam.ac.uk/research-groups/narita-group/", "role": "Studies what senescent cells do to the tissue around them, and showed that mTOR position, not just mTOR activity, sets their secretory output", "studies": [ "NAR2011" ], "url": "https://mtor-atlas.org/author/masashi-narita/" }, { "id": "esperanza-arias-perez", "name": "Esperanza Arias-Perez", "corpus_name": "Arias E", "orcid": "0000-0002-7836-5072", "lab": "Albert Einstein College of Medicine (Bronx, New York, USA)", "lab_url": "https://einsteinmed.edu/faculty/11666/esperanza-arias-perez", "role": "Showed that mTORC2, working with PHLPP1 and Akt at the lysosome, regulates chaperone-mediated autophagy", "studies": [ "ARI2015" ], "url": "https://mtor-atlas.org/author/esperanza-arias-perez/" }, { "id": "ana-maria-cuervo", "name": "Ana Maria Cuervo", "corpus_name": "Cuervo AM", "orcid": "0000-0002-0771-700X", "lab": "Cuervo Lab, Institute for Geroscience, Albert Einstein College of Medicine (Bronx, New York, USA)", "lab_url": "https://einsteinmed.edu/faculty/8784/ana-maria-cuervo", "role": "Worked out much of the machinery of chaperone-mediated autophagy, a pathway first described in Fred Dice's laboratory, and showed it declines with age", "studies": [ "ARI2015" ], "url": "https://mtor-atlas.org/author/ana-maria-cuervo/" }, { "id": "monther-abu-remaileh", "name": "Monther Abu-Remaileh", "corpus_name": "Abu-Remaileh M", "orcid": "0000-0003-3772-0477", "lab": "Abu-Remaileh Lab, Stanford University (Stanford, California, USA)", "lab_url": "https://www.abu-remaileh.com/", "role": "Worked out how to isolate lysosomes fast enough to measure what is inside them, and found that mTOR controls what gets out", "studies": [ "WYA2018", "WOL2017", "WYA2017", "ROG2019", "ABU2017" ], "url": "https://mtor-atlas.org/author/monther-abu-remaileh/" }, { "id": "junichi-sadoshima", "name": "Junichi Sadoshima", "corpus_name": "Sadoshima J", "orcid": "0000-0003-3724-4132", "lab": "Sadoshima Lab, Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School (Newark, New Jersey, USA)", "lab_url": "https://www.sadoshimalab.org/dr-sadoshima", "role": "Studies how mTOR, autophagy and mitophagy protect the heart under stress and in ageing, and contributed to the finding that spermidine protects the heart", "studies": [ "SCI2014", "EIS2016" ], "url": "https://mtor-atlas.org/author/junichi-sadoshima/" }, { "id": "sabrina-buttner", "name": "Sabrina Büttner", "corpus_name": "Buettner S", "orcid": null, "lab": "Büttner Lab, Institute of Integrative Cell Biology and Physiology, University of Münster (Münster, North Rhine-Westphalia, Germany)", "lab_url": "https://www.uni-muenster.de/CiM-IMPRS/research/projects/buettner.html", "role": "Studies how organelles communicate inside cells and how that communication breaks down with age, and contributed to the Graz studies showing that spermidine extends lifespan by inducing autophagy", "studies": [ "EIS2016", "EIS2009" ], "url": "https://mtor-atlas.org/author/sabrina-buttner/" }, { "id": "frauke-neff", "name": "Frauke Neff", "corpus_name": "Neff F", "orcid": null, "lab": "Institute of Pathology and German Mouse Clinic, Helmholtz Zentrum München (Neuherberg (Munich), Germany)", "lab_url": null, "role": "First author of the study that separated what rapamycin does to lifespan from what it does to ageing itself", "studies": [ "EIS2016", "NEF2013" ], "url": "https://mtor-atlas.org/author/frauke-neff/" }, { "id": "didac-carmona-gutierrez", "name": "Didac Carmona-Gutierrez", "corpus_name": "Carmona-Gutierrez D", "orcid": "0000-0001-7548-7771", "lab": "Institute of Molecular Biosciences, University of Graz (Graz, Austria)", "lab_url": "https://molekularbiologie.uni-graz.at/en/our-research/alterung-und-zelltod/", "role": "Studies how cell death and autophagy shape ageing at the University of Graz, and contributed to the studies showing that spermidine extends lifespan through autophagy", "studies": [ "EIS2016", "EIS2009" ], "url": "https://mtor-atlas.org/author/didac-carmona-gutierrez/" }, { "id": "david-c-rubinsztein", "name": "David C. Rubinsztein", "corpus_name": "Rubinsztein DC", "orcid": null, "lab": "Rubinsztein Lab, Cambridge Institute for Medical Research · UK Dementia Research Institute (Cambridge, England, United Kingdom)", "lab_url": "https://www.ukdri.ac.uk/labs/rubinsztein-lab", "role": "Showed that rapamycin induces autophagy to clear the toxic protein of Huntington's disease, and that where lysosomes sit inside a cell helps set mTORC1 activity", "studies": [ "KOR2011", "BER2006" ], "url": "https://mtor-atlas.org/author/david-c-rubinsztein/" }, { "id": "nathalie-bouquier", "name": "Nathalie Bouquier", "corpus_name": "Bouquier N", "orcid": "0000-0002-4827-7303", "lab": "Perroy Team, Institut de Génomique Fonctionnelle (IGF), CNRS/INSERM/Université de Montpellier (Montpellier, France)", "lab_url": "https://www.igf.cnrs.fr/equipes/equipe-perroy/", "role": "Built AIMTOR, a glowing biosensor that lets researchers watch mTOR activity move around inside a living cell in real time", "studies": [ "BOU2020" ], "url": "https://mtor-atlas.org/author/nathalie-bouquier/" }, { "id": "vincent-ollendorff", "name": "Vincent Ollendorff", "corpus_name": "Ollendorff V", "orcid": "0000-0001-9751-2202", "lab": "DMEM (Dynamique Musculaire et Métabolisme), INRAE · Université de Montpellier (Montpellier, France)", "lab_url": "https://dmem.montpellier.hub.inrae.fr/", "role": "Co-led the Montpellier team that built AIMTOR, a light-emitting biosensor for watching mTOR activity inside living cells, as part of his work on muscle metabolism", "studies": [ "BOU2020" ], "url": "https://mtor-atlas.org/author/vincent-ollendorff/" }, { "id": "sebastian-i-arriola-apelo", "name": "Sebastian I. Arriola Apelo", "corpus_name": "Arriola Apelo SI", "orcid": "0000-0003-0274-5367", "lab": "Arriola Apelo Lab, Department of Animal and Dairy Sciences, University of Wisconsin–Madison (Madison, Wisconsin, USA)", "lab_url": "https://arriolaapelolab.andysci.wisc.edu/", "role": "Showed that giving rapamycin intermittently rather than daily lessens its effects on glucose metabolism and the immune system in mice", "studies": [ "ARR2015", "ARR2016" ], "url": "https://mtor-atlas.org/author/sebastian-i-arriola-apelo/" }, { "id": "james-h-hurley", "name": "James H. Hurley", "corpus_name": "Hurley JH", "orcid": "0000-0001-5054-5445", "lab": "Hurley Lab, UC Berkeley (Berkeley, California, USA)", "lab_url": "https://membrane.berkeley.edu/", "role": "Structural biologist who uses cryo-EM to show how protein machines assembled on membranes control autophagy and nutrient signalling. His lab solved structures of the Rag–Ragulator complex and of the whole mTORC1–TFEB–Rag–Ragulator assembly on the lysosome", "studies": [ "ESP2026", "LAW2019", "CUI2025", "JAN2025", "SUX2017", "CUI2023", "LAW2018" ], "url": "https://mtor-atlas.org/author/james-h-hurley/" }, { "id": "ian-g-ganley", "name": "Ian G. Ganley", "corpus_name": "Ganley IG", "orcid": "0000-0003-1481-9407", "lab": "Ganley Lab, MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee (Dundee, Scotland, United Kingdom)", "lab_url": "https://www.ppu.mrc.ac.uk/research/principal-investigator/ian-ganley", "role": "Showed, in one of three 2009 studies (alongside the Mizushima and Kim laboratories), that the ULK1–ATG13–FIP200 complex relays mTOR signalling to start autophagy, and studies how cells select damaged mitochondria for destruction", "studies": [ "GAN2009" ], "url": "https://mtor-atlas.org/author/ian-g-ganley/" }, { "id": "jack-m-parent", "name": "Jack M. Parent", "corpus_name": "Parent JM", "orcid": null, "lab": "Parent Lab, University of Michigan (Ann Arbor, Michigan, USA)", "lab_url": "https://www.jackparentlab.com/", "role": "Neurologist and stem-cell researcher who rebuilds human epilepsies in patient-derived neurons to find what goes wrong", "studies": [ "TID2026" ], "url": "https://mtor-atlas.org/author/jack-m-parent/" }, { "id": "andrew-m-tidball", "name": "Andrew M. Tidball", "corpus_name": "Tidball AM", "orcid": null, "lab": "Tidball Lab, University of Michigan (Ann Arbor, Michigan, USA)", "lab_url": "https://tidball-lab.weebly.com/", "role": "Stem-cell neuroscientist who builds human neuron and organoid models to find the genes behind brain malformations", "studies": [ "TID2026" ], "url": "https://mtor-atlas.org/author/andrew-m-tidball/" }, { "id": "holly-m-brown-borg", "name": "Holly M. Brown-Borg", "corpus_name": "Brown-Borg HM", "orcid": null, "lab": "Brown-Borg Lab, University of North Dakota School of Medicine & Health Sciences (Grand Forks, North Dakota, USA)", "lab_url": "https://med.und.edu/labs/brown-borg/", "role": "Physiologist who measures how reduced growth-hormone signalling changes lifespan and what keeps long-lived mutant mice healthy", "studies": [ "BRO1996" ], "url": "https://mtor-atlas.org/author/holly-m-brown-borg/" }, { "id": "andrzej-bartke", "name": "Andrzej Bartke", "corpus_name": "Bartke A", "orcid": null, "lab": "Bartke Laboratory, Southern Illinois University School of Medicine (Springfield, Illinois, USA)", "lab_url": "https://www.siumed.edu/andrzej-bartke", "role": "Endocrinologist who showed that Ames dwarf mice, which lack growth hormone because of a single-gene mutation, live much longer than normal mice", "studies": [ "BRO1996" ], "url": "https://mtor-atlas.org/author/andrzej-bartke/" }, { "id": "yi-liu", "name": "Yi Liu", "corpus_name": "Liu Yi", "orcid": null, "lab": "Kumquat Biosciences (San Diego, California, USA)", "lab_url": "https://kumquatbiosciences.com/team_members/yi-liu-ph-d/", "role": "Drug-discovery scientist who builds selective kinase inhibitors, including the active-site mTOR inhibitor INK128", "studies": [ "HSI2012" ], "url": "https://mtor-atlas.org/author/yi-liu/" }, { "id": "yu-liu", "name": "Yu Liu", "corpus_name": "Liu Yu", "orcid": null, "lab": "Chen-Liu Lab, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University (Chengdu, Sichuan, China)", "lab_url": "https://www.chenliulab.org/", "role": "Cancer biologist working on how tumour-suppressor loss and epigenetic state decide whether a cell stays differentiated", "studies": [ "CHE2008" ], "url": "https://mtor-atlas.org/author/yu-liu/" }, { "id": "sabrina-schroeder", "name": "Sabrina Schroeder", "corpus_name": "Schroeder S", "orcid": null, "lab": "Madeo group (Cell Ageing and Cell Death), Institute of Molecular Biosciences, University of Graz (Graz, Austria)", "lab_url": "https://molekularbiologie.uni-graz.at/en/our-research/alterung-und-zelltod/", "role": "Researcher in Frank Madeo's group at Graz who has contributed to the spermidine studies from the first yeast longevity experiments to work in mice", "studies": [ "EIS2016", "EIS2009" ], "url": "https://mtor-atlas.org/author/sabrina-schroeder/" }, { "id": "christoph-magnes", "name": "Christoph Magnes", "corpus_name": "Magnes C", "orcid": "0000-0002-5153-7444", "lab": "Bioanalytics and Metabolomics, HEALTH – Institute for Biomedicine and Health Sciences, Joanneum Research (Graz, Austria)", "lab_url": "https://www.joanneum.at/en/health/the-institute/research-groups/bioanalysis-and-metabolomics/", "role": "Analytical chemist at Joanneum Research whose group contributed the mass-spectrometry measurements of polyamines in the Graz spermidine studies", "studies": [ "EIS2016", "EIS2009" ], "url": "https://mtor-atlas.org/author/christoph-magnes/" }, { "id": "christoph-ruckenstuhl", "name": "Christoph Ruckenstuhl", "corpus_name": "Ruckenstuhl C", "orcid": "0000-0002-4338-4679", "lab": "Ruckenstuhl group, Institute of Molecular Biosciences, University of Graz (Graz, Austria)", "lab_url": "https://molekularbiologie.uni-graz.at/en/our-research/alterung-und-zelltod/", "role": "Yeast geneticist who works out how amino-acid restriction and vacuole acidity set lifespan", "studies": [ "EIS2016", "EIS2009" ], "url": "https://mtor-atlas.org/author/christoph-ruckenstuhl/" }, { "id": "alessandro-bitto", "name": "Alessandro Bitto", "corpus_name": "Bitto A", "orcid": null, "lab": "Department of Laboratory Medicine and Pathology, University of Washington (Seattle, Washington, USA)", "lab_url": "https://halo.dlmp.uw.edu/people/alessandro-bitto", "role": "Showed that a short, three-month course of rapamycin in middle-aged mice can extend lifespan and improve healthspan", "studies": [ "BIT2016" ], "url": "https://mtor-atlas.org/author/alessandro-bitto/" }, { "id": "stacy-a-hussong", "name": "Stacy A. Hussong", "corpus_name": "Hussong SA", "orcid": "0000-0003-1957-9086", "lab": "Galvan Lab, University of Oklahoma Health Sciences Center (Oklahoma City, Oklahoma, USA)", "lab_url": "https://www.galvanlab.org/stacy-hussong-ph-d", "role": "Studies how mTOR damages the brain's blood vessels, and how blocking it restores blood flow, the blood-brain barrier and memory in aging and Alzheimer's models", "studies": [ "HAL2012" ], "url": "https://mtor-atlas.org/author/stacy-a-hussong/" }, { "id": "jayanta-debnath", "name": "Jayanta Debnath", "corpus_name": "Debnath J", "orcid": "0000-0002-8745-4069", "lab": "Debnath Lab, UC San Francisco (San Francisco, California, USA)", "lab_url": "https://debnathlab.ucsf.edu/", "role": "Physician-scientist who studies how autophagy - the cell's self-digestion system - keeps epithelial tissue healthy and how tumours hijack it", "studies": [ "SPI2010" ], "url": "https://mtor-atlas.org/author/jayanta-debnath/" }, { "id": "noboru-mizushima", "name": "Noboru Mizushima", "corpus_name": "Mizushima N", "orcid": null, "lab": "Mizushima Laboratory, Department of Biochemistry and Molecular Biology, University of Tokyo (Tokyo, Japan)", "lab_url": "https://molbiolut.jp/en/", "role": "Built much of the molecular map of autophagy in mammals - the ATG proteins that make an autophagosome, and the signals, including mTORC1, that decide when one is made", "studies": [ "HOS2009" ], "url": "https://mtor-atlas.org/author/noboru-mizushima/" }, { "id": "thomas-weichhart", "name": "Thomas Weichhart", "corpus_name": "Weichhart T", "orcid": "0000-0002-4349-0797", "lab": "Weichhart Lab, Center for Pathobiochemistry and Genetics, Medical University of Vienna (Vienna, Austria)", "lab_url": "https://www.weichhart-lab.com/", "role": "Immunologist who showed that mTOR sets the tone of the innate immune response, and now studies how macrophage metabolism drives granulomatous disease", "studies": [ "WEI2008" ], "url": "https://mtor-atlas.org/author/thomas-weichhart/" }, { "id": "nada-y-kalaany", "name": "Nada Y. Kalaany", "corpus_name": "Kalaany NY", "orcid": null, "lab": "Kalaany Lab, Boston Children's Hospital / Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://www.kalaanylab.org/", "role": "Studies how a tumour's metabolism depends on the metabolic state of the whole body, and hunts for nutrient dependencies that can be turned into treatments", "studies": [ "GUE2006" ], "url": "https://mtor-atlas.org/author/nada-y-kalaany/" }, { "id": "mondira-kundu", "name": "Mondira Kundu", "corpus_name": "Kundu M", "orcid": null, "lab": "Kundu Lab, St. Jude Children's Research Hospital (Memphis, Tennessee, USA)", "lab_url": "https://www.stjude.org/research/labs/kundu-lab.html", "role": "Physician-scientist who works out what the autophagy-initiating kinases ULK1 and ULK2 actually do when a cell runs short of fuel", "studies": [ "LOF2011", "EGA2010", "KIM2011" ], "url": "https://mtor-atlas.org/author/mondira-kundu/" }, { "id": "sajad-zalzala", "name": "Sajad Zalzala", "corpus_name": "Zalzala S", "orcid": null, "lab": "AgelessRx (Ann Arbor, Michigan, USA)", "lab_url": "https://agelessrx.com/", "role": "Family physician who co-founded AgelessRx and, as senior author, co-led PEARL, a year-long randomised trial of low-dose intermittent rapamycin in healthy older adults", "studies": [ "MOE2025" ], "url": "https://mtor-atlas.org/author/sajad-zalzala/" }, { "id": "mauricio-moel", "name": "Mauricio Moel", "corpus_name": "Moel M", "orcid": null, "lab": "AgelessRx (Ann Arbor, Michigan, USA)", "lab_url": "https://agelessrx.com/", "role": "Analyses trial and real-world data on repurposed longevity drugs at AgelessRx and led the reporting of the PEARL rapamycin trial", "studies": [ "MOE2025" ], "url": "https://mtor-atlas.org/author/mauricio-moel/" }, { "id": "girish-harinath", "name": "Girish Harinath", "corpus_name": "Harinath G", "orcid": null, "lab": "Division of Research and Applied Sciences, AgelessRx (Ann Arbor, Michigan, USA)", "lab_url": "https://agelessrx.com/research/", "role": "Designs, analyses and writes up human studies of repurposed drugs such as rapamycin at a longevity telehealth company, turning trial and real-world prescription data into peer-reviewed evidence", "studies": [ "MOE2025" ], "url": "https://mtor-atlas.org/author/girish-harinath/" }, { "id": "eunus-s-ali", "name": "Eunus S. Ali", "corpus_name": "Ali ES", "orcid": "0000-0002-9477-3500", "lab": "Ali Lab (Metabolism & Signaling), Department of Toxicology and Cancer Biology, University of Kentucky College of Medicine (Lexington, Kentucky, USA)", "lab_url": "https://eal-metabolab.com/", "role": "Showed as a Ben-Sahra-lab postdoc that ERK2 directly activates the purine-synthesis enzyme PFAS, and that mTORC1 increases bicarbonate import through SLC4A7 to fuel nucleotide synthesis. His Kentucky lab studies how growth signals control nucleotide metabolism in cancer", "studies": [ "VIL2021", "ALI2020", "ALI2022" ], "url": "https://mtor-atlas.org/author/eunus-s-ali/" }, { "id": "umakant-sahu", "name": "Umakant Sahu", "corpus_name": "Sahu U", "orcid": "0000-0002-7269-4430", "lab": "Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi (New Delhi, India)", "lab_url": "https://beb.iitd.ac.in/umakant.html", "role": "Showed that the building blocks of RNA also tell mitochondria how fast to burn fuel", "studies": [ "VIL2021", "ALI2020" ], "url": "https://mtor-atlas.org/author/umakant-sahu/" }, { "id": "brendan-p-ohara", "name": "Brendan P. O'Hara", "corpus_name": "O'Hara BP", "orcid": null, "lab": "Ben-Sahra Lab, Northwestern University Feinberg School of Medicine (Chicago, Illinois, USA)", "lab_url": null, "role": "As lab manager of Issam Ben-Sahra's lab at Northwestern, contributed to its studies of how mTORC1 and ERK control nucleotide synthesis, SAM production and bicarbonate import", "studies": [ "VIL2021", "ALI2020", "ALI2022" ], "url": "https://mtor-atlas.org/author/brendan-p-ohara/" }, { "id": "sen-hong", "name": "Sen Hong", "corpus_name": "Hong S", "orcid": null, "lab": "Hobbs Lab & Li (Xiaochun) Lab, UT Southwestern Medical Center (Dallas, Texas, USA)", "lab_url": null, "role": "First-authored the cryo-EM structure identifying TM6SF1 as a lysosomal cholesterol-binding protein involved in regulating mTORC1 signalling", "studies": [ "HON2026" ], "url": "https://mtor-atlas.org/author/sen-hong/" }, { "id": "xiaochun-li", "name": "Xiaochun Li", "corpus_name": "Li X", "orcid": "0000-0002-0177-0803", "lab": "Li (Xiaochun) Lab, UT Southwestern (Dallas, Texas, USA)", "lab_url": "https://labs.utsouthwestern.edu/li-xiaochun-lab", "role": "Solves cryo-EM structures of cholesterol-sensing membrane proteins, including the new mTORC1 regulator TM6SF1", "studies": [ "HON2026" ], "url": "https://mtor-atlas.org/author/xiaochun-li/" }, { "id": "jessica-l-halle", "name": "Jessica L. Halle", "corpus_name": "Halle JL", "orcid": "0000-0002-3174-5713", "lab": "Miller Lab, Oklahoma Medical Research Foundation (Oklahoma City, Oklahoma, USA)", "lab_url": "https://millerlab.omrf.org/", "role": "Muscle-biology researcher studying how cancer, chemotherapy and cachexia disrupt skeletal-muscle protein turnover and autophagy", "studies": [ "HAL2026" ], "url": "https://mtor-atlas.org/author/jessica-l-halle/" }, { "id": "james-a-carson", "name": "James A. Carson", "corpus_name": "Carson JA", "orcid": "0000-0003-3733-8796", "lab": "Integrative Muscle Biology Laboratory, Texas A&M University (College Station, Texas, USA)", "lab_url": "https://directory.education.tamu.edu/view/jamescarson", "role": "Muscle physiologist studying cancer-associated cachexia and how chemotherapy and exercise remodel skeletal-muscle metabolism", "studies": [ "HAL2026" ], "url": "https://mtor-atlas.org/author/james-a-carson/" }, { "id": "yang-yang", "name": "Yang Yang", "corpus_name": "Yang Y", "orcid": null, "lab": "State Key Laboratory of Medical Proteomics, Academy of Military Medical Sciences, Beijing (Beijing, China)", "lab_url": null, "role": "Showed as first author that the liver-secreted protein hepassocin protects against age-related liver senescence and helps the liver regenerate", "studies": [ "YAN2026B" ], "url": "https://mtor-atlas.org/author/yang-yang/" }, { "id": "xiaoming-yang", "name": "Xiaoming Yang", "corpus_name": "Yang X", "orcid": "0000-0003-3629-0946", "lab": "State Key Laboratory of Medical Proteomics, Academy of Military Medical Sciences, Beijing (Beijing, China)", "lab_url": null, "role": "Showed as senior author that the liver-secreted protein hepassocin protects against age-related liver senescence and helps the liver regenerate", "studies": [ "YAN2026B" ], "url": "https://mtor-atlas.org/author/xiaoming-yang/" }, { "id": "liangbo-sun", "name": "Liangbo Sun", "corpus_name": "Sun L", "orcid": "0000-0001-7405-451X", "lab": "Department of Clinical Biochemistry, Army Medical University (Third Military Medical University) (Chongqing, China)", "lab_url": null, "role": "Researcher studying phosphorylation-based control of autophagy initiation and its role in metabolic liver disease", "studies": [ "SUN2026B" ], "url": "https://mtor-atlas.org/author/liangbo-sun/" }, { "id": "jiqin-lian", "name": "Jiqin Lian", "corpus_name": "Lian J", "orcid": "0000-0002-8708-6171", "lab": "Department of Clinical Biochemistry, Army Medical University (Third Military Medical University) (Chongqing, China)", "lab_url": null, "role": "Biochemist studying deubiquitinase signalling in autophagy and metabolic disease", "studies": [ "SUN2026B" ], "url": "https://mtor-atlas.org/author/jiqin-lian/" }, { "id": "roman-v-kondratov", "name": "Roman V. Kondratov", "corpus_name": "Kondratov RV", "orcid": "0000-0003-3449-745X", "lab": "Kondratov Lab, Center for Gene Regulation in Health and Disease, Cleveland State University (Cleveland, Ohio, USA)", "lab_url": "https://www.csuohio.edu/grhd/faculty/roman-kondratov", "role": "Showed the circadian clock protein BMAL1 gates TOR/mTOR signaling to control aging, and that calorie restriction's lifespan benefits require a working circadian clock", "studies": [ "VEL2026", "KHA2014" ], "url": "https://mtor-atlas.org/author/roman-v-kondratov/" }, { "id": "nikkhil-velingkaar", "name": "Nikkhil Velingkaar", "corpus_name": "Velingkaar N", "orcid": "0000-0003-1571-0833", "lab": "Kondratov Lab, Cleveland State University (where this work was done) (Cleveland, Ohio, USA)", "lab_url": "https://www.csuohio.edu/grhd/faculty/roman-kondratov", "role": "Postdoctoral fellow studying how the circadian clock times caloric restriction's effects on liver mTOR signaling and metabolism", "studies": [ "VEL2026" ], "url": "https://mtor-atlas.org/author/nikkhil-velingkaar/" }, { "id": "mandeep-singh", "name": "Mandeep Singh", "corpus_name": "Singh M", "orcid": "0000-0002-9750-746X", "lab": "Mayo Clinic, Department of Cardiovascular Diseases (Rochester, Minnesota, USA)", "lab_url": "https://www.mayoclinic.org/biographies/singh-mandeep-m-d/bio-20054077", "role": "Interventional cardiologist and professor of medicine at Mayo Clinic; corresponding author on a 2026 trial of low-dose rapamycin in frail older adults with heart failure with preserved ejection fraction (HFpEF)", "studies": [ "LAN2026" ], "url": "https://mtor-atlas.org/author/mandeep-singh/" }, { "id": "luca-marchetti", "name": "Luca Marchetti", "corpus_name": "Marchetti L", "orcid": "0000-0001-9043-7705", "lab": "Laboratory of Computational Modeling, CIBIO, University of Trento / COSBI (Trento, Italy)", "lab_url": "https://www.cibio.unitn.it/1321/laboratory-of-computational-modeling", "role": "Computational biologist building quantitative systems-pharmacology and disease models; senior author on a 2026 survival analysis of the RAP-ALS rapamycin trial", "studies": [ "DEN2026B" ], "url": "https://mtor-atlas.org/author/luca-marchetti/" }, { "id": "elena-rainero", "name": "Elena Rainero", "corpus_name": "Rainero E", "orcid": "0000-0003-1402-8701", "lab": "Rainero Lab, School of Biosciences, University of Sheffield (Sheffield, England, United Kingdom)", "lab_url": "https://sheffield.ac.uk/biosciences/people/academic-staff/elena-rainero", "role": "Studies how cancer cells use the extracellular matrix as a nutrient and signaling source; senior author on a 2026 study linking collagen I to mTORC1 activation in cancer cells", "studies": [ "NAZ2026" ], "url": "https://mtor-atlas.org/author/elena-rainero/" }, { "id": "simon-raffel", "name": "Simon Raffel", "corpus_name": "Raffel S", "orcid": null, "lab": "AG Raffel, Heidelberg University Hospital (Heidelberg, Germany)", "lab_url": "https://www.klinikum.uni-heidelberg.de/kliniken-institute/kliniken/department-fuer-innere-medizin-krehl-klinik/innere-medizin-v-haematologie-onkologie-und-rheumatologie/forschung/emmy-noether-ag-raffel", "role": "Studies metabolic vulnerabilities of leukemia stem cells; senior author on a 2026 Blood paper on IDH3, citrate and mTORC1 in AML stem cell drug resistance", "studies": [ "DEM2026" ], "url": "https://mtor-atlas.org/author/simon-raffel/" }, { "id": "xin-zhou", "name": "Xin Zhou", "corpus_name": "Zhou X", "orcid": null, "lab": "Jin Zhang Lab, UC San Diego (La Jolla, California, USA)", "lab_url": null, "role": "Built TORCAR, an early genetically encoded FRET reporter that lets mTORC1 activity be watched in living cells", "studies": [ "ZHO2015" ], "url": "https://mtor-atlas.org/author/xin-zhou/" }, { "id": "hiroyuki-kubota", "name": "Hiroyuki Kubota", "corpus_name": "Kubota H", "orcid": null, "lab": "Division of Integrated Omics, Kyushu University (Fukuoka, Japan)", "lab_url": "https://www.bioreg.kyushu-u.ac.jp/labo/omics/", "role": "Systems biologist who showed that the insulin pathway carries different messages in the timing of its signal, and that S6K, the mTORC1 target, reads only the fast part", "studies": [ "KUB2012", "KUB2018" ], "url": "https://mtor-atlas.org/author/hiroyuki-kubota/" }, { "id": "shinya-kuroda", "name": "Shinya Kuroda", "corpus_name": "Kuroda S", "orcid": "0000-0001-5059-8299", "lab": "Kuroda Lab (Systems Biology), University of Tokyo (Tokyo, Japan)", "lab_url": "https://kurodalab.bs.s.u-tokyo.ac.jp/en/top_en/", "role": "Leads a systems biology lab that studies how cells decode the timing of hormone signals, with insulin and mTORC1-S6K as the main test case", "studies": [ "KUB2012", "KUB2018" ], "url": "https://mtor-atlas.org/author/shinya-kuroda/" }, { "id": "jin-zhang", "name": "Jin Zhang", "corpus_name": "Zhang J", "orcid": null, "lab": "Jin Zhang Lab, UC San Diego (La Jolla, California, USA)", "lab_url": "https://jinzhanglab.ucsd.edu/", "role": "Builds fluorescent biosensors that show where and when signalling enzymes are active inside living cells; senior author of TORCAR, an early live-cell reporter of mTORC1", "studies": [ "ZHO2015" ], "url": "https://mtor-atlas.org/author/jin-zhang/" }, { "id": "natalia-bobok", "name": "Natalia Bobok", "corpus_name": "Bobok N", "orcid": null, "lab": "INSTYTUTUM AG (Zug, Switzerland)", "lab_url": null, "role": "Physician-scientist and founder of a Swiss longevity/skincare company; author of a 2026 review situating mTOR as an integrative signaling hub across the hallmarks of aging", "studies": [ "BOB2026" ], "url": "https://mtor-atlas.org/author/natalia-bobok/" }, { "id": "hongliang-li", "name": "Hongliang Li", "corpus_name": "Li H", "orcid": null, "lab": "State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Medical University (Ganzhou, China)", "lab_url": null, "role": "Vice President of Gannan Medical University and Executive Director of its State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases; researcher of cardiovascular and metabolic diseases", "studies": [ "HU2026" ], "url": "https://mtor-atlas.org/author/hongliang-li/" }, { "id": "yufeng-hu", "name": "Yufeng Hu", "corpus_name": "Hu Y", "orcid": null, "lab": "Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University (Ganzhou, China)", "lab_url": null, "role": "First author of a 2026 Circulation study identifying LAPTM4A as a novel mTORC1 activator driving pathological cardiac hypertrophy", "studies": [ "HU2026" ], "url": "https://mtor-atlas.org/author/yufeng-hu/" }, { "id": "haojie-huang", "name": "Haojie Huang", "corpus_name": "Huang H", "orcid": null, "lab": "Huang Lab, Mayo Clinic (Rochester, Minnesota, USA)", "lab_url": null, "role": "Senior/corresponding author of a 2026 Nature Communications study identifying the SPOP–ZMYND8–NEK7 mechanism of mTOR-inhibitor resistance in kidney cancer", "studies": [ "TAN2026" ], "url": "https://mtor-atlas.org/author/haojie-huang/" }, { "id": "zongzhao-zhai", "name": "Zongzhao Zhai", "corpus_name": "Zhai Z", "orcid": null, "lab": "Zhai Lab, Hunan Normal University (Changsha, China)", "lab_url": null, "role": "Senior author of a 2026 Nature study identifying Lsp2 as a rapamycin-resistant mTORC1 effector that extends lifespan in Drosophila when removed", "studies": [ "WAN2026" ], "url": "https://mtor-atlas.org/author/zongzhao-zhai/" }, { "id": "thomas-l-li", "name": "Thomas L. Li", "corpus_name": "Li TL", "orcid": null, "lab": "Bateup Lab, Department of Molecular and Cell Biology, University of California, Berkeley (Berkeley, California, USA)", "lab_url": "https://bateuplab.berkeley.edu/", "role": "Co-first author of a 2026 Nature study showing mTORC1 hyperactivity drives reactive astrocytes as a primary, seizure-independent consequence of TSC2 loss, implicating glial dysfunction as a driver of tuberous sclerosis pathology", "studies": [ "LI2026C" ], "url": "https://mtor-atlas.org/author/thomas-l-li/" }, { "id": "helen-s-bateup", "name": "Helen S. Bateup", "corpus_name": "Bateup HS", "orcid": "0000-0002-0135-0972", "lab": "Bateup Lab, UC Berkeley (Berkeley, California, USA)", "lab_url": "https://bateuplab.berkeley.edu/", "role": "Senior/corresponding author of a 2026 Nature study showing mTORC1 hyperactivity drives cell-autonomous astrocyte reactivity in tuberous sclerosis", "studies": [ "BAT2013", "LI2026C" ], "url": "https://mtor-atlas.org/author/helen-s-bateup/" }, { "id": "loren-kell", "name": "Loren Kell", "corpus_name": "Kell L", "orcid": "0000-0003-1322-2027", "lab": "Cox Lab of Ageing and Cell Senescence, University of Oxford (Oxford, England, United Kingdom)", "lab_url": "https://coxlab.web.ox.ac.uk/", "role": "First author identifying a direct genoprotective effect of rapamycin against DNA damage in ageing human immune cells", "studies": [ "KEL2026" ], "url": "https://mtor-atlas.org/author/loren-kell/" }, { "id": "ghada-alsaleh", "name": "Ghada Alsaleh", "corpus_name": "Alsaleh G", "orcid": "0000-0002-4211-3420", "lab": "Alsaleh Group, Kennedy Institute of Rheumatology, University of Oxford (Oxford, England, United Kingdom)", "lab_url": "https://www.kennedy.ox.ac.uk/team/ghada-alsaleh", "role": "Senior author studying autophagy and immune-cell ageing; identified a genoprotective mechanism for rapamycin", "studies": [ "KEL2026" ], "url": "https://mtor-atlas.org/author/ghada-alsaleh/" }, { "id": "alex-zaufel", "name": "Alex Zaufel", "corpus_name": "Zaufel A", "orcid": null, "lab": "Division of Gastroenterology and Hepatology, Medical University of Graz (Graz, Austria)", "lab_url": null, "role": "Researcher studying bile acid metabolism and mTORC1 signaling in liver disease", "studies": [ "ZAU2026" ], "url": "https://mtor-atlas.org/author/alex-zaufel/" }, { "id": "tarek-moustafa", "name": "Tarek Moustafa", "corpus_name": "Moustafa T", "orcid": "0000-0002-6755-4687", "lab": "Division of Gastroenterology and Hepatology, Medical University of Graz (Graz, Austria)", "lab_url": null, "role": "Researcher in hepatic metabolism and bile acid signaling", "studies": [ "ZAU2026" ], "url": "https://mtor-atlas.org/author/tarek-moustafa/" }, { "id": "lyvia-neves-rebello-alves-nolasco", "name": "Lyvia Neves Rebello Alves Nolasco", "corpus_name": "Nolasco LNRA", "orcid": null, "lab": "Núcleo de Genética Humana e Molecular, Universidade Federal do Espírito Santo (Vitória, Brazil)", "lab_url": null, "role": "Postdoctoral researcher in human molecular genetics", "studies": [ "NOL2026" ], "url": "https://mtor-atlas.org/author/lyvia-neves-rebello-alves-nolasco/" }, { "id": "iuri-drumond-louro", "name": "Iúri Drumond Louro", "corpus_name": "Louro ID", "orcid": null, "lab": "Núcleo de Genética Humana e Molecular, Universidade Federal do Espírito Santo (Vitória, Brazil)", "lab_url": null, "role": "Professor of human and molecular genetics", "studies": [ "NOL2026" ], "url": "https://mtor-atlas.org/author/iuri-drumond-louro/" }, { "id": "john-g-albeck", "name": "John G. Albeck", "corpus_name": "Albeck JG", "orcid": null, "lab": "Albeck Lab, UC Davis (Davis, California, USA)", "lab_url": "https://albeck.faculty.ucdavis.edu/", "role": "Measures mTORC1, AMPK and other metabolic signals in single living cells, following how they change over minutes and hours", "studies": [ "SPA2023", "PAU2025" ], "url": "https://mtor-atlas.org/author/john-g-albeck/" }, { "id": "andreas-milias-argeitis", "name": "Andreas Milias-Argeitis", "corpus_name": "Milias-Argeitis A", "orcid": "0000-0002-4291-4228", "lab": "Milias-Argeitis Lab, Molecular Systems Biology, University of Groningen (Groningen, Netherlands)", "lab_url": "https://sites.google.com/rug.nl/milias-argeitis-lab", "role": "Follows TORC1 activity through the cell cycle in single yeast cells and builds light-controlled tools to perturb it", "studies": [ "GUE2022" ], "url": "https://mtor-atlas.org/author/andreas-milias-argeitis/" }, { "id": "steven-d-cappell", "name": "Steven D. Cappell", "corpus_name": "Cappell SD", "orcid": null, "lab": "Cappell Lab, Laboratory of Cancer Biology and Genetics, NCI (Bethesda, Maryland, USA)", "lab_url": "https://ccr.cancer.gov/staff-directory/steven-d-cappell", "role": "Studies how single cells commit to dividing; showed that mTOR briefly switches off the APC/C to give cells a pulse of glycolysis at cell cycle entry", "studies": [ "PAU2025" ], "url": "https://mtor-atlas.org/author/steven-d-cappell/" }, { "id": "david-t-scadden", "name": "David T. Scadden", "corpus_name": "Scadden DT", "orcid": null, "lab": "Scadden Lab, Massachusetts General Hospital & Harvard Stem Cell Institute (Boston, Massachusetts, USA)", "lab_url": "https://scaddenlab.com/", "role": "Stem cell and leukaemia biologist whose lab imaged mTORC1 activity in live mice and showed that well-timed mTORC1 inhibition kills more leukaemia cells", "studies": [ "OKI2021" ], "url": "https://mtor-atlas.org/author/david-t-scadden/" }, { "id": "nicholas-t-ktistakis", "name": "Nicholas T. Ktistakis", "corpus_name": "Ktistakis NT", "orcid": null, "lab": "Ktistakis Group, Signalling Programme, Babraham Institute (Cambridge, England, United Kingdom)", "lab_url": "https://www.babraham.ac.uk/our-research/signalling/nicholas-ktistakis", "role": "Uses live imaging to follow the first minutes of autophagy and of mTORC1 activation", "studies": [ "MAN2016" ], "url": "https://mtor-atlas.org/author/nicholas-t-ktistakis/" }, { "id": "laure-bally-cuif", "name": "Laure Bally-Cuif", "corpus_name": "Bally-Cuif L", "orcid": null, "lab": "Zebrafish Neurogenetics Unit, Institut Pasteur (Paris, France)", "lab_url": "https://research.pasteur.fr/en/team/zebrafish-neurogenetics/", "role": "Studies how adult neural stem cells in the zebrafish brain move between dormancy and activation", "studies": [ "THE2026" ], "url": "https://mtor-atlas.org/author/laure-bally-cuif/" }, { "id": "julie-perroy", "name": "Julie Perroy", "corpus_name": "Perroy J", "orcid": null, "lab": "Perroy Team, Institut de Génomique Fonctionnelle (IGF) (Montpellier, France)", "lab_url": "https://www.igf.cnrs.fr/en/teams/team-perroy/", "role": "Neurobiologist who co-led AIMTOR, a biosensor for watching mTOR activity live in single cells and in separate parts of the cell", "studies": [ "BOU2020" ], "url": "https://mtor-atlas.org/author/julie-perroy/" }, { "id": "tomohide-kinoshita", "name": "Tomohide Kinoshita", "corpus_name": "Kinoshita T", "orcid": null, "lab": "Hori Lab (Laboratory of Immunology and Microbiology), The University of Tokyo (Tokyo, Japan)", "lab_url": null, "role": "First author identifying how TCR-driven mTORC1 signaling epigenetically locks in Foxp3 expression in regulatory T cells", "studies": [ "KIN2026" ], "url": "https://mtor-atlas.org/author/tomohide-kinoshita/" }, { "id": "shohei-hori", "name": "Shohei Hori", "corpus_name": "Hori S", "orcid": null, "lab": "Hori Lab (Laboratory of Immunology and Microbiology), The University of Tokyo (Tokyo, Japan)", "lab_url": null, "role": "Senior author; laboratory head studying regulatory T cell differentiation and immune tolerance", "studies": [ "KIN2026" ], "url": "https://mtor-atlas.org/author/shohei-hori/" }, { "id": "beatrice-rivalta", "name": "Beatrice Rivalta", "corpus_name": "Rivalta B", "orcid": null, "lab": "Clinical Immunology and Vaccinology Unit, Bambino Gesù Children's Hospital (Rome, Italy)", "lab_url": null, "role": "First author of a multicenter registry analysis comparing rapamycin and leniolisib in a rare immune disorder", "studies": [ "RIV2026" ], "url": "https://mtor-atlas.org/author/beatrice-rivalta/" }, { "id": "maria-elena-maccari", "name": "Maria Elena Maccari", "corpus_name": "Maccari ME", "orcid": null, "lab": "Institute for Immunodeficiency, Center for Chronic Immunodeficiency, University of Freiburg Medical Center (Freiburg, Germany)", "lab_url": null, "role": "Senior author studying primary immunodeficiencies and their treatment", "studies": [ "RIV2026" ], "url": "https://mtor-atlas.org/author/maria-elena-maccari/" }, { "id": "alessandra-esposito", "name": "Alessandra Esposito", "corpus_name": "Esposito A", "orcid": null, "lab": "Napolitano / Ballabio lab, TIGEM (Naples, Italy)", "lab_url": null, "role": "Lysosomal signalling and TFEB regulation", "studies": [ "ESP2026", "NAP2020", "CUI2025", "CUI2023" ], "url": "https://mtor-atlas.org/author/alessandra-esposito/" }, { "id": "gennaro-napolitano", "name": "Gennaro Napolitano", "corpus_name": "Napolitano G", "orcid": null, "lab": "Napolitano lab, TIGEM (Naples, Italy)", "lab_url": null, "role": "mTORC1-TFEB lysosomal signalling", "studies": [ "ESP2026", "NAP2020", "CUI2025", "CUI2023" ], "url": "https://mtor-atlas.org/author/gennaro-napolitano/" }, { "id": "krystle-c-kalafut", "name": "Krystle C. Kalafut", "corpus_name": "Kalafut KC", "orcid": null, "lab": "Manning lab, Harvard T.H. Chan School of Public Health (Boston, Massachusetts, USA)", "lab_url": null, "role": "Hepatic mTORC1 and nutrient signalling", "studies": [ "KAL2026", "LAP2026" ], "url": "https://mtor-atlas.org/author/krystle-c-kalafut/" }, { "id": "kate-e-creevy", "name": "Kate E. Creevy", "corpus_name": "Creevy KE", "orcid": null, "lab": "Dog Aging Project, Texas A&M University College of Veterinary Medicine & Biomedical Sciences (College Station, Texas, USA)", "lab_url": "https://dogagingproject.org/", "role": "Runs the veterinary side of the Dog Aging Project and leads TRIAD, the trial testing whether rapamycin extends lifespan in pet dogs", "studies": [ "URF2017", "BAR2023", "COL2025" ], "url": "https://mtor-atlas.org/author/kate-e-creevy/" }, { "id": "amanda-erickson-coleman", "name": "Amanda Erickson Coleman", "corpus_name": "Coleman AE", "orcid": null, "lab": "Cardiology Service, University of Georgia College of Veterinary Medicine (Athens, Georgia, USA)", "lab_url": "https://vet.uga.edu/person/amanda_erickson/", "role": "Veterinary cardiologist and first author of the design paper for TRIAD, the lifespan trial of rapamycin in pet dogs", "studies": [ "COL2025" ], "url": "https://mtor-atlas.org/author/amanda-erickson-coleman/" }, { "id": "brian-g-barnett", "name": "Brian G. Barnett", "corpus_name": "Barnett BG", "orcid": null, "lab": "Department of Small Animal Medicine and Surgery, University of Georgia College of Veterinary Medicine (Athens, Georgia, USA)", "lab_url": null, "role": "First author of the six-month, placebo-controlled trial of low-dose rapamycin in healthy pet dogs", "studies": [ "BAR2023" ], "url": "https://mtor-atlas.org/author/brian-g-barnett/" }, { "id": "marco-ferniani", "name": "Marco Ferniani", "corpus_name": "Ferniani M", "orcid": null, "lab": "Ballabio Lab, Telethon Institute of Genetics and Medicine (TIGEM) / Baylor College of Medicine (Houston, Texas, USA)", "lab_url": null, "role": "First author of the study showing mTORC1 hyperactivation, not TFEB/TFE3 activity itself, is the primary driver of kidney cystogenesis and tumorigenesis in mouse models of Birt-Hogg-Dubé and Tuberous Sclerosis", "studies": [ "FER2026" ], "url": "https://mtor-atlas.org/author/marco-ferniani/" }, { "id": "edward-t-chouchani", "name": "Edward T. Chouchani", "corpus_name": "Chouchani ET", "orcid": null, "lab": "Chouchani Lab, Dana-Farber Cancer Institute / Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": null, "role": "Senior/corresponding author on a bioRxiv preprint showing dietary restriction licenses autophagy through oxidation of a single cysteine (Cys19) on the core autophagy protein ATG5", "studies": [ "SHI2026" ], "url": "https://mtor-atlas.org/author/edward-t-chouchani/" }, { "id": "john-m-asara", "name": "John M. Asara", "corpus_name": "Asara JM", "orcid": null, "lab": "Mass Spectrometry Core, Division of Signal Transduction, Beth Israel Deaconess Medical Center and Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://research.bidmc.org/mass-spectrometry-core", "role": "Mass-spectrometry specialist whose core facility supplied metabolomics and proteomics for several mTOR studies, including measurements of purine, pyrimidine and SAM metabolism downstream of mTORC1.", "studies": [ "VIL2021", "ALI2020", "EGA2010", "BEN2013", "VAL2017", "DIB2012", "LIP2015", "BEN2016", "ALI2022" ], "url": "https://mtor-atlas.org/author/john-m-asara/" }, { "id": "ralf-baumeister", "name": "Ralf Baumeister", "corpus_name": "Baumeister R", "orcid": null, "lab": "Baumeister Lab, Bioinformatics and Molecular Genetics, Institute of Biology III, University of Freiburg (Freiburg, Germany)", "lab_url": "https://celegans.biologie.uni-freiburg.de/?page_id=391", "role": "Head of the Freiburg department that hosted the Thedieck group during the mTOR network modelling work; co-author on the dynamic mTOR model and the G3BP–TSC study.", "studies": [ "PRE2021", "DAL2012" ], "url": "https://mtor-atlas.org/author/ralf-baumeister/" }, { "id": "lara-m-boyle", "name": "Lara M. Boyle", "corpus_name": "Boyle LM", "orcid": null, "lab": "Psychiatry Residency (Research Track), Perelman School of Medicine, University of Pennsylvania (Philadelphia, Pennsylvania, USA)", "lab_url": "https://www.med.upenn.edu/psychres/research_track_residents.html", "role": "Research assistant at Boston Children's Hospital who co-authored both studies linking mTOR to the clock protein BMAL1, including the tuberous sclerosis study where she was second author.", "studies": [ "LIP2015", "LIP2017" ], "url": "https://mtor-atlas.org/author/lara-m-boyle/" }, { "id": "alessia-calcagni", "name": "Alessia Calcagnì", "corpus_name": "Calcagnì A", "orcid": null, "lab": "Ballabio Lab, Telethon Institute of Genetics and Medicine (TIGEM) (Pozzuoli, Campania, Italy)", "lab_url": "https://ballabio.tigem.it/lab-members", "role": "TIGEM researcher on the TFEB/TFE3 side of mTORC1 signalling; co-author on the lysosomal stress route to TFEB activation and on mouse models separating mTORC1 from TFEB/TFE3 in kidney cysts and tumours.", "studies": [ "ESP2026", "NAP2020", "FER2026" ], "url": "https://mtor-atlas.org/author/alessia-calcagni/" }, { "id": "bernadette-carroll", "name": "Bernadette Carroll", "corpus_name": "Carroll B", "orcid": "0000-0001-5673-9371", "lab": "Carroll Lab, School of Biochemistry and Biomedical Sciences, University of Bristol (Bristol, England, United Kingdom)", "lab_url": "https://www.carroll-lab.com/people", "role": "First author of the study showing why mTORC1 stays switched on in senescent cells, and co-author on G3BP–TSC and senescence-mitophagy work; her own lab studies how nutrient sensing breaks down in ageing cells.", "studies": [ "PRE2021", "KEL2024", "CAR2017" ], "url": "https://mtor-atlas.org/author/bernadette-carroll/" }, { "id": "madi-y-cisse", "name": "Madi Y. Cissé", "corpus_name": "Cissé MY", "orcid": null, "lab": "Manning Lab, Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health (Boston, Massachusetts, USA)", "lab_url": "https://hsph.harvard.edu/profile/madi-y-cisse/", "role": "Research associate in the Manning lab and co-author on the two 2026 mouse studies showing which feeding signals switch on mTORC1 in liver and in skeletal muscle.", "studies": [ "KAL2026", "LAP2026" ], "url": "https://mtor-atlas.org/author/madi-y-cisse/" }, { "id": "yann-cormerais", "name": "Yann Cormerais", "corpus_name": "Cormerais Y", "orcid": null, "lab": "Manning Lab, Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health (Boston, Massachusetts, USA)", "lab_url": "https://hsph.harvard.edu/profile/yann-cormerais/", "role": "Research scientist in the Manning lab who works on how PI3K–AKT–TSC2 signalling controls mTORC1 in living tissues, using mouse models in which TSC2 cannot be phosphorylated by AKT.", "studies": [ "KAL2026", "LAP2026" ], "url": "https://mtor-atlas.org/author/yann-cormerais/" }, { "id": "zhicheng-cui", "name": "Zhicheng Cui", "corpus_name": "Cui Z", "orcid": null, "lab": "Cui Lab, Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz School of Medicine (Aurora, Colorado, USA)", "lab_url": "http://www.thecuilab.com", "role": "Structural biologist who solved cryo-EM structures of the mTORC1–TFEB–Rag–Ragulator megacomplex and of mTORC1 switched on by RHEB and the Rags on a lipid membrane.", "studies": [ "CUI2025", "CUI2023" ], "url": "https://mtor-atlas.org/author/zhicheng-cui/" }, { "id": "piero-dalle-pezze", "name": "Piero Dalle Pezze", "corpus_name": "Dalle Pezze P", "orcid": null, "lab": "Genomics England (London, England, United Kingdom)", "lab_url": null, "role": "First author of two Atlas modelling studies: the dynamic insulin–mTOR network model (TSC-independent mTORC2) and the systems study of concurrent AMPK and mTOR activation by amino acids.", "studies": [ "DAL2016", "DAL2012" ], "url": "https://mtor-atlas.org/author/piero-dalle-pezze/" }, { "id": "fred-c-davis", "name": "Fred C. Davis", "corpus_name": "Davis F", "orcid": null, "lab": "Davis Lab, Department of Biology, Northeastern University (Boston, Massachusetts, USA)", "lab_url": "http://www.northeastern.edu/cos/faculty/frederick-davis/", "role": "Circadian biologist from Northeastern University who brought expertise on the brain's master clock to two studies linking mTOR and the clock protein BMAL1.", "studies": [ "LIP2015", "LIP2017" ], "url": "https://mtor-atlas.org/author/fred-c-davis/" }, { "id": "claudio-de-virgilio", "name": "Claudio De Virgilio", "corpus_name": "De Virgilio C", "orcid": "0000-0001-8826-4323", "lab": "De Virgilio Lab, Department of Biology, University of Fribourg (Fribourg, Canton of Fribourg, Switzerland)", "lab_url": "https://www.unifr.ch/directory/en/people/4480/3a13b", "role": "Yeast geneticist whose lab found the EGO/Rag GTPase complex that activates TORC1 and showed that the SEACIT complex (Iml1–Npr2–Npr3) switches TORC1 off by acting as a GAP for the Rag GTPase Gtr1.", "studies": [ "NIC2023", "BON2012", "PAN2013" ], "url": "https://mtor-atlas.org/author/claudio-de-virgilio/" }, { "id": "jorn-dengjel", "name": "Jörn Dengjel", "corpus_name": "Dengjel J", "orcid": "0000-0002-9453-4614", "lab": "Dengjel Lab, Department of Biology, University of Fribourg (Fribourg, Canton of Fribourg, Switzerland)", "lab_url": "https://www.unifr.ch/directory/en/people/185772/e39eb", "role": "Mass-spectrometry proteomics specialist in autophagy and protein homeostasis; co-author on the TBK1/ULK1–TFEB lysosomal stress pathway and on the spermidine lifespan and cardioprotection study.", "studies": [ "ESP2026", "EIS2016", "NAZ2013" ], "url": "https://mtor-atlas.org/author/jorn-dengjel/" }, { "id": "stephanie-a-fernandes", "name": "Stephanie A. Fernandes", "corpus_name": "Fernandes SA", "orcid": null, "lab": "Fernandes Group (Muscle Metabolism and Ageing), Max Planck Institute for Biology of Ageing (Cologne, North Rhine-Westphalia, Germany)", "lab_url": "https://www.age.mpg.de/fernandes", "role": "First author of the study showing that lysosomal and cytoplasmic pools of mTORC1 respond to different amino acid sources and phosphorylate different substrates.", "studies": [ "FER2024", "FER2025", "NIC2023" ], "url": "https://mtor-atlas.org/author/stephanie-a-fernandes/" }, { "id": "peng-gao", "name": "Peng Gao", "corpus_name": "Gao P", "orcid": null, "lab": "Metabolomics Core Facility, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine (Chicago, Illinois, USA)", "lab_url": "https://www.feinberg.northwestern.edu/research/cores/units/metabolomics.html", "role": "Directs the Northwestern metabolomics core that supplied mass-spectrometry metabolite measurements for three Ben-Sahra lab studies on how mTORC1 and ERK signalling drive nucleotide and SAM synthesis.", "studies": [ "VIL2021", "ALI2020", "GAO2026", "ALI2022" ], "url": "https://mtor-atlas.org/author/peng-gao/" }, { "id": "peter-gollwitzer", "name": "Peter Gollwitzer", "corpus_name": "Gollwitzer P", "orcid": null, "lab": "Frezza Lab, CECAD Cluster of Excellence, University of Cologne (Cologne, North Rhine-Westphalia, Germany)", "lab_url": "https://frezza.cecad-labs.uni-koeln.de/lab-members", "role": "First author of the 'Rag dimer code' study showing that the four Rag GTPase paralogues are not interchangeable: RagC/D sets substrate choice and RagA/B sets the response to amino acid withdrawal.", "studies": [ "FER2024", "NIC2023", "GOL2022" ], "url": "https://mtor-atlas.org/author/peter-gollwitzer/" }, { "id": "karen-e-inouye", "name": "Karen E. Inouye", "corpus_name": "Inouye KE", "orcid": null, "lab": "Hotamışlıgil Lab and Sabri Ülker Center, Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health (Boston, Massachusetts, USA)", "lab_url": "https://gsh.hsph.harvard.edu/directory/karen-inouye", "role": "Metabolic physiologist who runs the Hotamışlıgil lab’s physiology facility, which specialises in glucose clamps, and co-authored two 2026 mouse studies on how feeding controls mTORC1 in liver and muscle.", "studies": [ "KAL2026", "LAP2026" ], "url": "https://mtor-atlas.org/author/karen-e-inouye/" }, { "id": "samuel-c-lapp", "name": "Samuel C. Lapp", "corpus_name": "Lapp SC", "orcid": null, "lab": "Manning Lab, Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health (Boston, Massachusetts, USA)", "lab_url": "https://hsph.harvard.edu/profile/samuel-chrisitan-lapp/", "role": "First author of the muscle study showing that feeding-induced mTORC1 activation through AKT–TSC2 drives postprandial protein synthesis but is not needed to build or keep muscle mass.", "studies": [ "KAL2026", "LAP2026" ], "url": "https://mtor-atlas.org/author/samuel-c-lapp/" }, { "id": "jonathan-o-lipton", "name": "Jonathan O. Lipton", "corpus_name": "Lipton JO", "orcid": null, "lab": "Lipton Lab, F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital and Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://www.liptonlab.com", "role": "First author of the two studies that tie mTOR signalling to the circadian clock protein BMAL1: S6K1 phosphorylates BMAL1 to drive translation, and constant mTOR activity in tuberous sclerosis disturbs the clock.", "studies": [ "LIP2015", "LIP2017" ], "url": "https://mtor-atlas.org/author/jonathan-o-lipton/" }, { "id": "satomi-miwa", "name": "Satomi Miwa", "corpus_name": "Miwa S", "orcid": null, "lab": "Biosciences Institute, Newcastle University (Newcastle upon Tyne, England, United Kingdom)", "lab_url": "https://www.ncl.ac.uk/medical-sciences/people/profile/satomimiwa.html", "role": "Mitochondrial biologist who contributed to Newcastle studies on rapamycin in NF-κB-driven ageing mice and on basal mitophagy as a brake on cellular senescence.", "studies": [ "KEL2024", "COR2018" ], "url": "https://mtor-atlas.org/author/satomi-miwa/" }, { "id": "jlenia-monfregola", "name": "Jlenia Monfregola", "corpus_name": "Monfregola J", "orcid": null, "lab": "Ballabio Lab, Telethon Institute of Genetics and Medicine (TIGEM) (Pozzuoli, Campania, Italy)", "lab_url": "https://ballabio.tigem.it/lab-members", "role": "TIGEM postdoc and co-author on the cryo-EM structure of the mTORC1–TFEB–Rag–Ragulator megacomplex and on the TBK1/ULK1 lysosomal stress route to TFEB.", "studies": [ "ESP2026", "NAP2020", "CUI2023" ], "url": "https://mtor-atlas.org/author/jlenia-monfregola/" }, { "id": "ashwin-nathan", "name": "Ashwin Nathan", "corpus_name": "Nathan A", "orcid": null, "lab": "Sahin Lab, F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital (Boston, Massachusetts, USA)", "lab_url": null, "role": "Co-author on both Boston Children's Hospital studies linking mTOR signalling to the circadian clock protein BMAL1.", "studies": [ "LIP2015", "LIP2017" ], "url": "https://mtor-atlas.org/author/ashwin-nathan/" }, { "id": "julian-nuchel", "name": "Julian Nüchel", "corpus_name": "Nüchel J", "orcid": null, "lab": "Nüchel Lab, Center for Biochemistry, Medical Faculty, University of Cologne (Cologne, North Rhine-Westphalia, Germany)", "lab_url": "https://biochemie-med.uni-koeln.de/en/research/research-groups/nuechel-lab", "role": "Co-author on two Demetriades-lab mTORC1 papers from Cologne: the spatial split of mTORC1 signalling by amino acid source and malonyl-CoA as a direct mTORC1 inhibitor.", "studies": [ "FER2024", "FER2025", "NIC2023" ], "url": "https://mtor-atlas.org/author/julian-nuchel/" }, { "id": "mirja-tamara-prentzell", "name": "Mirja Tamara Prentzell", "corpus_name": "Prentzell MT", "orcid": "0000-0002-9659-9825", "lab": "Opitz Lab (Division of Metabolic Crosstalk in Cancer), German Cancer Research Center DKFZ (Heidelberg, Germany)", "lab_url": "https://www.dkfz.de/en/brain-cancer-metabolism/staff.html", "role": "First author of the study showing that G3BP proteins anchor the TSC complex to lysosomes, a physical brake on mTORC1; earlier co-author on the dynamic insulin–mTOR network model.", "studies": [ "PRE2021", "DAL2012" ], "url": "https://mtor-atlas.org/author/mirja-tamara-prentzell/" }, { "id": "mustafa-sahin", "name": "Mustafa Sahin", "corpus_name": "Sahin M", "orcid": null, "lab": "Sahin Lab, Rosamund Stone Zander and Hansjoerg Wyss Translational Neuroscience Center, Department of Neurology, Boston Children's Hospital and Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://research.childrenshospital.org/researchers/mustafa-sahin", "role": "Senior author of the studies showing that mTOR signalling reaches the circadian clock through BMAL1, and a physician-scientist focused on tuberous sclerosis, the classic disease of overactive mTOR.", "studies": [ "LIP2015", "TSA2012", "LIP2017" ], "url": "https://mtor-atlas.org/author/mustafa-sahin/" }, { "id": "julian-r-sampson", "name": "Julian R. Sampson", "corpus_name": "Sampson JR", "orcid": null, "lab": "Institute of Medical Genetics, Division of Cancer and Genetics, School of Medicine, Cardiff University (Cardiff, Wales, United Kingdom)", "lab_url": "https://profiles.cardiff.ac.uk/staff/sampson", "role": "Clinical geneticist who led the consortium that identified the TSC2 gene and led trials of mTOR inhibitors in tuberous sclerosis, including the TRON trial of everolimus for cognition.", "studies": [ "PRE2021", "SAX2026" ], "url": "https://mtor-atlas.org/author/julian-r-sampson/" }, { "id": "daryl-p-shanley", "name": "Daryl P. Shanley", "corpus_name": "Shanley DP", "orcid": "0000-0003-3096-6386", "lab": "Shanley Lab, Biosciences Institute / Centre for Integrated Systems Biology of Ageing and Nutrition (CISBAN), Newcastle University (Newcastle upon Tyne, England, United Kingdom)", "lab_url": "https://www.ncl.ac.uk/bns/people/profile/darylshanley.html", "role": "Systems biologist of ageing whose Newcastle modelling group built, with the Thedieck lab, the dynamic models of mTOR signalling in the Atlas.", "studies": [ "DAL2016", "DAL2012" ], "url": "https://mtor-atlas.org/author/daryl-p-shanley/" }, { "id": "annika-g-sonntag", "name": "Annika G. Sonntag", "corpus_name": "Sonntag AG", "orcid": null, "lab": "Baumeister Lab, Bioinformatics and Molecular Genetics, Institute of Biology III, University of Freiburg, at the time of the studies (Freiburg, Germany)", "lab_url": null, "role": "Experimental researcher in the Thedieck group who contributed cell data to the dynamic mTOR network model and the AMPK–mTOR amino acid study.", "studies": [ "DAL2016", "DAL2012" ], "url": "https://mtor-atlas.org/author/annika-g-sonntag/" }, { "id": "kathrin-thedieck", "name": "Kathrin Thedieck", "corpus_name": "Thedieck K", "orcid": null, "lab": "Lab for Metabolic Signaling (Thedieck Lab), Department Metabolism, Senescence and Autophagy, Faculty of Medicine, University of Duisburg-Essen (Essen, North Rhine-Westphalia, Germany)", "lab_url": "https://www.uni-due.de/crc1430/kathrin_thedieck", "role": "Senior author of three Atlas studies that treat mTOR signalling as a dynamic network: TSC-independent mTORC2 activation, concurrent AMPK and mTOR activation by amino acids, and G3BP tethering of TSC to lysosomes.", "studies": [ "PRE2021", "DAL2016", "DAL2012" ], "url": "https://mtor-atlas.org/author/kathrin-thedieck/" }, { "id": "benjamin-e-turk", "name": "Benjamin E. Turk", "corpus_name": "Turk BE", "orcid": "0000-0001-9275-4069", "lab": "Turk Lab, Department of Pharmacology, Yale School of Medicine (New Haven, Connecticut, USA)", "lab_url": "https://medicine.yale.edu/lab/turk", "role": "Kinase biochemist who studies how protein kinases choose their substrates; co-author on the discovery that AMPK phosphorylates raptor and on the study showing that mTORC1 sites differ in intrinsic substrate quality.", "studies": [ "GWI2008", "KAN2013" ], "url": "https://mtor-atlas.org/author/benjamin-e-turk/" }, { "id": "shinsuke-uda", "name": "Shinsuke Uda", "corpus_name": "Uda S", "orcid": null, "lab": "Information and Data Science Education Center, Yamaguchi University (Yamaguchi, Yamaguchi Prefecture, Japan)", "lab_url": "https://www.bioreg.kyushu-u.ac.jp/labo/omics/uda.html", "role": "Systems biologist who uses information theory and modelling. He co-authored the studies showing that the insulin–AKT pathway encodes insulin’s timing pattern, and that S6K, downstream of mTORC1, reads only the fast, pulse-like part.", "studies": [ "KUB2012", "KUB2018" ], "url": "https://mtor-atlas.org/author/shinsuke-uda/" }, { "id": "elodie-villa", "name": "Elodie Villa", "corpus_name": "Villa E", "orcid": null, "lab": "Ben-Sahra Lab, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine (Chicago, Illinois, USA)", "lab_url": "https://www.bensahralab.org/about-5", "role": "First author of the study showing that mTORC1 raises production of the methyl donor SAM through MAT2A and boosts m6A mRNA methylation to support protein synthesis and cell growth.", "studies": [ "VIL2021", "ALI2020" ], "url": "https://mtor-atlas.org/author/elodie-villa/" }, { "id": "sabine-wilhelm", "name": "Sabine Wilhelm", "corpus_name": "Wilhelm S", "orcid": null, "lab": "Demetriades Lab, Max Planck Institute for Biology of Ageing (Cologne, North Rhine-Westphalia, Germany)", "lab_url": "https://www.age.mpg.de/demetriades", "role": "Co-author on two Demetriades-lab studies of amino acid sensing by mTORC1: the Rag GTPase dimer code and the spatial split of mTORC1 signalling.", "studies": [ "FER2024", "FER2025", "GOL2022" ], "url": "https://mtor-atlas.org/author/sabine-wilhelm/" }, { "id": "elizabeth-d-yuan", "name": "Elizabeth D. Yuan", "corpus_name": "Yuan ED", "orcid": null, "lab": "Sahin Lab, F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital (Boston, Massachusetts, USA)", "lab_url": null, "role": "Second author on the study showing that S6K1 phosphorylates BMAL1 to link mTOR signalling with circadian protein synthesis, and co-author on the follow-up in tuberous sclerosis models.", "studies": [ "LIP2015", "WAN2015", "LIP2017" ], "url": "https://mtor-atlas.org/author/elizabeth-d-yuan/" }, { "id": "thomas-von-zglinicki", "name": "Thomas von Zglinicki", "corpus_name": "von Zglinicki T", "orcid": null, "lab": "von Zglinicki Lab, Biosciences Institute, Newcastle University (Newcastle upon Tyne, England, United Kingdom)", "lab_url": "https://www.ncl.ac.uk/medical-sciences/people/profile/tvonzglinicki.html", "role": "Cell-senescence researcher who co-authored the Newcastle studies on stuck-on mTORC1 in senescent cells and on loss of basal mitophagy as a driver of cellular ageing.", "studies": [ "KEL2024", "CAR2017" ], "url": "https://mtor-atlas.org/author/thomas-von-zglinicki/" }, { "id": "tatiana-m-moreno", "name": "Tatiana M. Moreno", "corpus_name": "Moreno TM", "orcid": null, "lab": "Kumsta Lab, Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California, USA)", "lab_url": "https://sites.google.com/view/kumstalab/team", "role": "First author of a healthy-aging cohort study showing that human autophagy flux is remodeled with age in a sex- and cell type-specific way, uncoupled from autophagy-gene transcription, and responsive to a mild exercise intervention", "studies": [ "MOR2026" ], "url": "https://mtor-atlas.org/author/tatiana-m-moreno/" }, { "id": "caroline-kumsta", "name": "Caroline Kumsta", "corpus_name": "Kumsta C", "orcid": null, "lab": "Kumsta Lab, Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California, USA)", "lab_url": "https://sbpdiscovery.org/scientists/caroline-kumsta-phd/", "role": "Senior author of a healthy-aging cohort study measuring autophagy flux directly across human cell types, showing it is sex- and cell type-specific and linked to physical function in older adults", "studies": [ "MOR2026" ], "url": "https://mtor-atlas.org/author/caroline-kumsta/" }, { "id": "ke-hu", "name": "Ke Hu", "corpus_name": "Hu K", "orcid": null, "lab": "Feske Lab, NYU Grossman School of Medicine (New York, New York, USA)", "lab_url": "http://feskelab.org/", "role": "First author identifying SLC4A7/NBCn1 as a pH regulator required for mTORC1 activity and antibody-secreting cell differentiation", "studies": [ "HU2026B" ], "url": "https://mtor-atlas.org/author/ke-hu/" }, { "id": "stefan-feske", "name": "Stefan Feske", "corpus_name": "Feske S", "orcid": null, "lab": "Feske Lab, NYU Grossman School of Medicine (New York, New York, USA)", "lab_url": "http://feskelab.org/", "role": "Senior author identifying intracellular pH regulation via SLC4A7/NBCn1 as required for mTORC1 activity and antibody-secreting cell differentiation", "studies": [ "HU2026B" ], "url": "https://mtor-atlas.org/author/stefan-feske/" }, { "id": "hitesha-trivedi", "name": "Hitesha Trivedi", "corpus_name": "Trivedi H", "orcid": null, "lab": "Department of Pharmacology, Zydus Medical College and Hospital (Dahod, Gujarat, India)", "lab_url": null, "role": "First author of a 2026 PRISMA-guided systematic review of senolytic, senomorphic and anti-ageing drug trials in humans.", "studies": [ "TRI2026" ], "url": "https://mtor-atlas.org/author/hitesha-trivedi/" }, { "id": "sohel-shaikh", "name": "Sohel Shaikh", "corpus_name": "Shaikh S", "orcid": null, "lab": "Department of Pharmacology, Zydus Medical College and Hospital (Dahod, Gujarat, India)", "lab_url": null, "role": "Senior author of the same 2026 systematic review of senolytic and anti-ageing drug trials in humans.", "studies": [ "TRI2026" ], "url": "https://mtor-atlas.org/author/sohel-shaikh/" }, { "id": "meiling-lai", "name": "Meiling Lai", "corpus_name": "Lai M", "orcid": null, "lab": "Institute of Advanced Biotechnology & Institute of Homeostatic Medicine, Southern University of Science and Technology (Shenzhen, China)", "lab_url": null, "role": "First author of a 2026 study of immune aging across the canine lifespan and short-term responses to rapamycin.", "studies": [ "LAI2026" ], "url": "https://mtor-atlas.org/author/meiling-lai/" }, { "id": "yu-xuan-lyu", "name": "Yu-Xuan Lyu", "corpus_name": "Lyu YX", "orcid": null, "lab": "Institute of Advanced Biotechnology & Institute of Homeostatic Medicine, Southern University of Science and Technology (Shenzhen, China)", "lab_url": null, "role": "Corresponding/senior author of the same 2026 canine immune-aging and geroprotective-intervention study.", "studies": [ "LAI2026" ], "url": "https://mtor-atlas.org/author/yu-xuan-lyu/" }, { "id": "valter-d-longo", "name": "Valter D. Longo", "corpus_name": "Longo VD", "orcid": null, "lab": "Longo Lab, USC Leonard Davis School of Gerontology & USC Longevity Institute, University of Southern California (Los Angeles, California, USA)", "lab_url": "https://gero.usc.edu/labs/longolab", "role": "Studies how nutrient-sensing pathways (including TOR and GH/IGF-1) and diet shape ageing and resistance to stress and disease, from yeast to mice and people.", "studies": [ "FON2010" ], "url": "https://mtor-atlas.org/author/valter-d-longo/" }, { "id": "cherie-ann-o-nathan", "name": "Cherie-Ann O. Nathan", "corpus_name": "Nathan CO", "orcid": null, "lab": "Head and Neck Cancer Research, Department of Otolaryngology-Head and Neck Surgery, LSU Health Shreveport (Shreveport, Louisiana, USA)", "lab_url": "https://www.lsuhs.edu/departments/school-of-medicine/otolaryngology-head-and-neck-surgery/research", "role": "Head and neck surgeon and cancer researcher who tests whether drugs such as the mTOR inhibitor everolimus can help patients whose tumours resist immunotherapy.", "studies": [ "NAT2026" ], "url": "https://mtor-atlas.org/author/cherie-ann-o-nathan/" }, { "id": "christian-sell", "name": "Christian Sell", "corpus_name": "Sell C", "orcid": null, "lab": "Sell Lab, Department of Biochemistry and Molecular Biology, Drexel University College of Medicine (Philadelphia, Pennsylvania, USA)", "lab_url": "https://drexel.edu/medicine/academics/graduate-school/molecular-cell-biology-genetics/student-faculty-highlights/christian-sell", "role": "Studies the basic biology of ageing, especially how mTOR, rapamycin, cellular metabolism and senescence are connected.", "studies": [ "CHU2019" ], "url": "https://mtor-atlas.org/author/christian-sell/" }, { "id": "michael-j-lenardo", "name": "Michael J. Lenardo", "corpus_name": "Lenardo MJ", "orcid": null, "lab": "Molecular Development of the Immune System Section, Laboratory of Immunology, NIAID, National Institutes of Health (Bethesda, Maryland, USA)", "lab_url": "https://www.niaid.nih.gov/node/17072", "role": "Immunologist known for work on how immune cells die and are controlled; his lab also showed that mTOR reactivation ends autophagy and rebuilds lysosomes.", "studies": [ "YUX2010" ], "url": "https://mtor-atlas.org/author/michael-j-lenardo/" }, { "id": "xian-chang-li", "name": "Xian Chang Li", "corpus_name": "Li XC", "orcid": null, "lab": "Immunobiology and Transplant Science Center, Department of Surgery, Houston Methodist (Houston, Texas, USA)", "lab_url": "https://scholars.houstonmethodist.org/en/persons/xian-chang-li/", "role": "Transplant immunologist who studies how the immune system rejects or tolerates transplants, and how drugs such as mTOR inhibitors act on immune cells.", "studies": [ "HEN2026" ], "url": "https://mtor-atlas.org/author/xian-chang-li/" }, { "id": "giulio-superti-furga", "name": "Giulio Superti-Furga", "corpus_name": "Superti-Furga G", "orcid": null, "lab": "Superti-Furga Lab, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Vienna, Austria)", "lab_url": "https://superti-furga-lab.at/", "role": "Systems biologist who maps how proteins and drugs interact in cells, with a focus on solute carrier (SLC) membrane transporters; his group helped identify SLC38A9 as a lysosomal amino-acid sensor for mTORC1.", "studies": [ "REB2015" ], "url": "https://mtor-atlas.org/author/giulio-superti-furga/" }, { "id": "luis-f-parada", "name": "Luis F. Parada", "corpus_name": "Parada LF", "orcid": null, "lab": "Parada Lab, Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center (New York, New York, USA)", "lab_url": "https://www.mskcc.org/research/ski/labs/luis-parada", "role": "Uses genetically engineered mouse models to study nervous system tumours such as glioblastoma and neurofibromatosis-related tumours, and the brain effects of PTEN loss.", "studies": [ "ZHO2009" ], "url": "https://mtor-atlas.org/author/luis-f-parada/" }, { "id": "david-j-kwiatkowski", "name": "David J. Kwiatkowski", "corpus_name": "Kwiatkowski DJ", "orcid": null, "lab": "Kwiatkowski Lab, Division of Translational Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=3198", "role": "Geneticist and physician who studies tuberous sclerosis complex (TSC) and the TSC1/TSC2 genes that restrain mTORC1.", "studies": [ "BOU2026", "KWI2002", "VAL2017", "EHN2008", "DIB2012", "MEI2008", "TEE2002" ], "url": "https://mtor-atlas.org/author/david-j-kwiatkowski/" }, { "id": "marikki-laiho", "name": "Marikki Laiho", "corpus_name": "Laiho M", "orcid": null, "lab": "Laiho Lab, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine (Baltimore, Maryland, USA)", "lab_url": "https://hopkinsmedicine.org/profiles/details/marikki-laiho", "role": "Studies DNA damage, the nucleolar stress response and how RNA polymerase I (which makes ribosomal RNA) can be targeted in cancer.", "studies": [ "FAN2026" ], "url": "https://mtor-atlas.org/author/marikki-laiho/" }, { "id": "adrian-l-harris", "name": "Adrian L. Harris", "corpus_name": "Harris AL", "orcid": null, "lab": "Department of Oncology, University of Oxford; formerly CRUK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine (Oxford, England, United Kingdom)", "lab_url": "https://www.oncology.ox.ac.uk/team/adrian-harris", "role": "Medical oncologist who studies hypoxia, tumour blood-vessel growth and the metabolic response of breast cancer cells.", "studies": [ "GOB2016" ], "url": "https://mtor-atlas.org/author/adrian-l-harris/" }, { "id": "william-r-sellers", "name": "William R. Sellers", "corpus_name": "Sellers WR", "orcid": null, "lab": "Sellers Lab, Cancer Program, Broad Institute of MIT and Harvard (Cambridge, Massachusetts, USA)", "lab_url": "https://www.broadinstitute.org/bios/william-sellers", "role": "Cancer biologist and physician-scientist whose work spans cancer genomics and cancer therapeutics, including how the PI3K/AKT/mTOR pathway drives tumours and how to target it.", "studies": [ "MAJ2004" ], "url": "https://mtor-atlas.org/author/william-r-sellers/" }, { "id": "robin-j-mockett", "name": "Robin J. Mockett", "corpus_name": "Mockett RJ", "orcid": null, "lab": "Mockett Lab, Department of Biomedical Sciences, University of South Alabama (Mobile, Alabama, USA)", "lab_url": "https://coe.southalabama.edu/colleges/alliedhealth/biomedical/resources/mockett.pdf", "role": "Studies ageing in the fruit fly Drosophila melanogaster, including how rapamycin and diet change lifespan.", "studies": [ "JAC2026" ], "url": "https://mtor-atlas.org/author/robin-j-mockett/" }, { "id": "christian-behrends", "name": "Christian Behrends", "corpus_name": "Behrends C", "orcid": null, "lab": "Behrends Lab, Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-Universität München (Munich, Germany)", "lab_url": "https://www.behrendslab.com", "role": "Studies autophagy and ubiquitin pathways, and in 2015 reported SLC38A9 as a member of the Rag-Ragulator complex that relays amino acid availability to mTORC1.", "studies": [ "JUN2015" ], "url": "https://mtor-atlas.org/author/christian-behrends/" }, { "id": "douglas-r-green", "name": "Douglas R. Green", "corpus_name": "Green DR", "orcid": "0000-0002-7332-1417", "lab": "Green Lab, Department of Immunology, St. Jude Children's Research Hospital (Memphis, Tennessee, USA)", "lab_url": "https://www.stjude.org/directory/g/douglas-green.html", "role": "Cell death researcher known for work on apoptosis and the immune system, whose group also showed that the transcription factor Myc drives the metabolic switch of activated T cells.", "studies": [ "WAN2011" ], "url": "https://mtor-atlas.org/author/douglas-r-green/" }, { "id": "william-g-kaelin-jr", "name": "William G. Kaelin Jr.", "corpus_name": "Kaelin WG", "orcid": null, "lab": "Kaelin Lab, Dana-Farber Cancer Institute and Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://labs.dana-farber.org/kaelinlab/william-kaelin", "role": "Cancer researcher who worked out how cells sense oxygen through the VHL and HIF proteins, work recognised by the 2019 Nobel Prize in Physiology or Medicine.", "studies": [ "BRU2004" ], "url": "https://mtor-atlas.org/author/william-g-kaelin-jr/" }, { "id": "dale-d-o-martin", "name": "Dale D. O. Martin", "corpus_name": "Martin DDO", "orcid": null, "lab": "NeurdyPhagy Lab, Department of Biology, University of Waterloo (Waterloo, Ontario, Canada)", "lab_url": "https://uwaterloo.ca/biology/profile/d36marti", "role": "Studies protein mislocalization and disturbed protein recycling (proteostasis) in Huntington disease and ALS.", "studies": [ "ABR2026" ], "url": "https://mtor-atlas.org/author/dale-d-o-martin/" }, { "id": "amanda-c-foks", "name": "Amanda C. Foks", "corpus_name": "Foks AC", "orcid": "0000-0002-9747-3458", "lab": "Aging and Immunity group, Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University (Leiden, Netherlands)", "lab_url": "https://www.universiteitleiden.nl/medewerkers/amanda-foks", "role": "Studies how the immune system drives atherosclerosis and how it changes with age, including how rapamycin reshapes immune cells in aged atherosclerotic mice.", "studies": [ "JIN2026C" ], "url": "https://mtor-atlas.org/author/amanda-c-foks/" }, { "id": "shigehiro-ohdo", "name": "Shigehiro Ohdo", "corpus_name": "Ohdo S", "orcid": null, "lab": "Faculty of Pharmaceutical Sciences, Kyushu University (Fukuoka, Japan)", "lab_url": "https://hyoka.ofc.kyushu-u.ac.jp/search/details/K000034/english.html", "role": "Works on the body clock and drug timing (chronopharmacology), including how circadian rhythms control mTOR in cancer cells.", "studies": [ "OKA2013" ], "url": "https://mtor-atlas.org/author/shigehiro-ohdo/" }, { "id": "david-b-solit", "name": "David B. Solit", "corpus_name": "Solit DB", "orcid": null, "lab": "Solit Lab, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center (New York, New York, USA)", "lab_url": "https://www.sloankettering.edu/research-areas/labs/david-solit", "role": "Physician-scientist who used whole-genome sequencing of an exceptional responder to show that TSC1 mutations can predict sensitivity of bladder cancer to the mTOR inhibitor everolimus.", "studies": [ "IYE2012" ], "url": "https://mtor-atlas.org/author/david-b-solit/" }, { "id": "judith-campisi", "name": "Judith Campisi", "corpus_name": "Campisi J", "orcid": null, "lab": "Campisi Lab, Buck Institute for Research on Aging (Novato, California, USA)", "lab_url": "https://www.buckinstitute.org/?p=11856", "role": "Pioneer of research on cellular senescence and the senescence-associated secretory phenotype (SASP); her 2015 paper showed that mTOR drives the inflammatory SASP.", "studies": [ "LAB2015" ], "url": "https://mtor-atlas.org/author/judith-campisi/" }, { "id": "kristian-kjr-vissing", "name": "Kristian Kjær Vissing", "corpus_name": "Vissing K", "orcid": "0000-0001-5810-5241", "lab": "Department of Public Health, Sport Science, Aarhus University (Aarhus, Denmark)", "lab_url": "https://www.au.dk/en/vissing@ph.au.dk/", "role": "Studies the control of protein balance in skeletal muscle and how this knowledge might counter muscle loss.", "studies": [ "KRISTIANSEN2026" ], "url": "https://mtor-atlas.org/author/kristian-kjr-vissing/" }, { "id": "bruce-c-trapnell", "name": "Bruce C. Trapnell", "corpus_name": "Trapnell BC", "orcid": null, "lab": "Translational Pulmonary Science Center, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center (Cincinnati, Ohio, USA)", "lab_url": "https://www.cincinnatichildrens.org/bio/t/bruce-trapnell", "role": "Pulmonologist-scientist who directs the Rare Lung Diseases Clinical Research Consortium whose MILES trial led to approval of sirolimus for lymphangioleiomyomatosis (LAM); also known for work on pulmonary alveolar proteinosis.", "studies": [ "MCC2011" ], "url": "https://mtor-atlas.org/author/bruce-c-trapnell/" }, { "id": "beatrix-m-ueberheide", "name": "Beatrix M. Ueberheide", "corpus_name": "Ueberheide B", "orcid": null, "lab": "Proteomics Resource Center, Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine (New York, New York, USA)", "lab_url": "https://med.nyu.edu/faculty/beatrix-m-ueberheide", "role": "Mass spectrometry and proteomics specialist who directs NYU's proteomics core and contributed the protein profiling to the Down syndrome hippocampus mTOR study.", "studies": [ "NOR2026" ], "url": "https://mtor-atlas.org/author/beatrix-m-ueberheide/" }, { "id": "francesco-cecconi", "name": "Francesco Cecconi", "corpus_name": "Cecconi F", "orcid": null, "lab": "Cell Stress and Survival group, Danish Cancer Institute (Copenhagen, Denmark), and Department of Biology, University of Rome Tor Vergata (Rome, Italy)", "lab_url": "https://www.cancer.dk/danish-cancer-institute/research-groups/cell-stress-and-survival/", "role": "Discovered AMBRA1, a regulator of autophagy, and showed how mTOR restrains autophagy by acting on AMBRA1 and ULK1.", "studies": [ "NAZ2013" ], "url": "https://mtor-atlas.org/author/francesco-cecconi/" }, { "id": "outi-kummu", "name": "Outi Kummu", "corpus_name": "Kummu O", "orcid": "0000-0003-0327-3496", "lab": "Research Unit of Biomedicine and Internal Medicine, Pharmacology and Toxicology, Faculty of Medicine, University of Oulu (Oulu, Finland)", "lab_url": "https://www.oulu.fi/en/researchers/outi-kummu", "role": "Studies how chemicals activate the nuclear receptor PXR and disturb metabolism; co-author of the study linking PXR-driven liver growth to the AKT-mTOR pathway.", "studies": [ "LASSILA2026" ], "url": "https://mtor-atlas.org/author/outi-kummu/" }, { "id": "joao-f-passos", "name": "João F. Passos", "corpus_name": "Passos JF", "orcid": null, "lab": "Cell and Molecular Aging Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic (Rochester, Minnesota, USA)", "lab_url": "https://www.mayo.edu/research/labs/cell-molecular-aging", "role": "Studies how senescent cells, mitochondria and telomeres contribute to ageing and age-related disease.", "studies": [ "COR2018" ], "url": "https://mtor-atlas.org/author/joao-f-passos/" }, { "id": "wenyi-wei", "name": "Wenyi Wei", "corpus_name": "Wei W", "orcid": "0000-0003-0512-3811", "lab": "Wei Lab, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": null, "role": "Studies how protein stability and cell signalling, including the PI3K-mTOR-AKT network, are controlled in cancer cells.", "studies": [ "LIU2015" ], "url": "https://mtor-atlas.org/author/wenyi-wei/" }, { "id": "rosa-puertollano", "name": "Rosa Puertollano", "corpus_name": "Puertollano R", "orcid": null, "lab": "Protein Trafficking and Organelle Biology, National Heart, Lung, and Blood Institute, NIH (Bethesda, Maryland, USA)", "lab_url": "https://irp.nih.gov/pi/rosa-puertollano", "role": "Studies how lysosomes are regulated, including how mTORC1 controls the transcription factors TFEB and TFE3 that switch on autophagy and lysosome genes.", "studies": [ "MAR2012", "MAR2013" ], "url": "https://mtor-atlas.org/author/rosa-puertollano/" }, { "id": "sourav-bandyopadhyay", "name": "Sourav Bandyopadhyay", "corpus_name": "Bandyopadhyay S", "orcid": null, "lab": "Bandyopadhyay Lab, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco (San Francisco, California, USA)", "lab_url": "http://cancersignaling.net/", "role": "Uses functional genomics, drug screens and proteomics to understand why breast and lung cancers become resistant to drugs, including drugs that target the mTOR pathway.", "studies": [ "MEN2023" ], "url": "https://mtor-atlas.org/author/sourav-bandyopadhyay/" }, { "id": "tamir-gonen", "name": "Tamir Gonen", "corpus_name": "Gonen T", "orcid": null, "lab": "Gonen Lab, Departments of Biological Chemistry and Physiology, David Geffen School of Medicine, University of California, Los Angeles (Los Angeles, California, USA)", "lab_url": "https://cryoem.ucla.edu/", "role": "Determines the 3D structures of membrane proteins and pioneered microcrystal electron diffraction (MicroED); in the mTOR field he solved the structure of the lysosomal arginine transporter SLC38A9.", "studies": [ "LEI2018" ], "url": "https://mtor-atlas.org/author/tamir-gonen/" }, { "id": "george-d-yancopoulos", "name": "George D. Yancopoulos", "corpus_name": "Yancopoulos GD", "orcid": null, "lab": "Regeneron Pharmaceuticals (Tarrytown, New York, USA)", "lab_url": "https://investor.regeneron.com/board-directors-management/george-yancopoulos", "role": "Industry scientist who co-founded Regeneron and led drug discovery there; in this Atlas he is senior author of an early paper showing that Akt/mTOR signalling controls muscle size.", "studies": [ "BOD2001", "ROM2001" ], "url": "https://mtor-atlas.org/author/george-d-yancopoulos/" }, { "id": "toren-finkel", "name": "Toren Finkel", "corpus_name": "Finkel T", "orcid": null, "lab": "Aging Institute, UPMC and University of Pittsburgh (Pittsburgh, Pennsylvania, USA)", "lab_url": "https://aging.pitt.edu/", "role": "Studies the biology of aging, including how mTOR levels and mitochondria influence lifespan and healthspan in mammals.", "studies": [ "WUX2013", "SCH2006" ], "url": "https://mtor-atlas.org/author/toren-finkel/" }, { "id": "christiane-berger-schaffitzel", "name": "Christiane Berger-Schaffitzel", "corpus_name": "Schaffitzel C", "orcid": "0000-0002-1516-9760", "lab": "Berger-Schaffitzel Lab, School of Biochemistry and Biomedical Sciences, University of Bristol (Bristol, England, United Kingdom)", "lab_url": "https://research-information.bris.ac.uk/en/persons/christiane-h-berger-schaffitzel", "role": "Structural biologist who uses cryo-electron microscopy to study ribosomes and translation machinery; co-senior author of the first cryo-EM structure of yeast TORC2.", "studies": [ "KAR2017" ], "url": "https://mtor-atlas.org/author/christiane-berger-schaffitzel/" }, { "id": "patrick-c-phillips", "name": "Patrick C. Phillips", "corpus_name": "Phillips PC", "orcid": null, "lab": "Phillips Lab, Institute of Ecology and Evolution, University of Oregon (Eugene, Oregon, USA)", "lab_url": "https://pages.uoregon.edu/pphil/", "role": "Evolutionary geneticist who uses the nematode C. elegans to study aging, including how insulin/IGF-1 signalling, a pathway tightly connected to mTOR, shapes lifespan.", "studies": [ "ALS2026" ], "url": "https://mtor-atlas.org/author/patrick-c-phillips/" }, { "id": "rafi-ahmed", "name": "Rafi Ahmed", "corpus_name": "Ahmed R", "orcid": null, "lab": "Ahmed Laboratory, Emory Vaccine Center, Department of Microbiology and Immunology, Emory University (Atlanta, Georgia, USA)", "lab_url": "https://vaccines.emory.edu/faculty/primary-faculty/ahmed-rafi.html", "role": "Immunologist who studies T-cell and B-cell memory and showed that mTOR is a major regulator of memory CD8 T-cell formation.", "studies": [ "ARA2009" ], "url": "https://mtor-atlas.org/author/rafi-ahmed/" }, { "id": "ernst-hafen", "name": "Ernst Hafen", "corpus_name": "Hafen E", "orcid": null, "lab": "Hafen Group, Institute of Molecular Systems Biology, ETH Zurich (Zurich, Switzerland)", "lab_url": "https://www.ae-info.org/ae/User/Hafen_Ernst", "role": "Developmental geneticist who used Drosophila to work out how insulin and TOR signalling control cell and body size, including the role of Rheb.", "studies": [ "MON1999", "OLD2000", "GAR2003", "BRU2004", "STO2003" ], "url": "https://mtor-atlas.org/author/ernst-hafen/" }, { "id": "vincent-giguere", "name": "Vincent Giguère", "corpus_name": "Giguère V", "orcid": null, "lab": "Giguère Lab, Department of Biochemistry, Goodman Cancer Institute, McGill University (Montreal, Quebec, Canada)", "lab_url": "https://vincent-giguere.lab.mcgill.ca/", "role": "Studies how nuclear receptors, especially the estrogen-related receptors (ERRs), control energy metabolism, and showed that mTOR and ERRα share target genes involved in lipid and TCA-cycle metabolism", "studies": [ "BCH2026" ], "url": "https://mtor-atlas.org/author/vincent-giguere/" }, { "id": "salvatore-oddo", "name": "Salvatore Oddo", "corpus_name": "Oddo S", "orcid": null, "lab": "Oddo Lab, University of Messina (Messina, Italy)", "lab_url": null, "role": "Alzheimer's disease researcher who showed that amyloid-beta raises mTOR activity and that lowering mTOR with rapamycin cuts amyloid and Tau pathology in mice through autophagy", "studies": [ "MAJ2012", "CAC2010" ], "url": "https://mtor-atlas.org/author/salvatore-oddo/" }, { "id": "gabriel-n-hortobagyi", "name": "Gabriel N. Hortobagyi", "corpus_name": "Hortobagyi GN", "orcid": null, "lab": "Department of Breast Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center (Houston, Texas, USA)", "lab_url": "https://faculty.mdanderson.org/profiles/gabriel_n_hortobagyi.html", "role": "Breast cancer physician-scientist and senior author of BOLERO-2, the phase 3 trial that showed adding the mTOR inhibitor everolimus improves outcomes in advanced hormone-receptor-positive breast cancer", "studies": [ "BAS2012", "PIC2014" ], "url": "https://mtor-atlas.org/author/gabriel-n-hortobagyi/" }, { "id": "stanley-fields", "name": "Stanley Fields", "corpus_name": "Fields S", "orcid": null, "lab": "Fields Lab, Department of Genome Sciences, University of Washington (Seattle, Washington, USA)", "lab_url": "https://www.gs.washington.edu/about/directory/faculty/stanley-fields/", "role": "Technology-driven geneticist whose yeast screens helped show that lowering TOR signaling extends chronological lifespan in yeast", "studies": [ "KAE2005", "POW2006" ], "url": "https://mtor-atlas.org/author/stanley-fields/" }, { "id": "hyeon-soo-kim", "name": "Hyeon Soo Kim", "corpus_name": "Kim HS", "orcid": null, "lab": "Myokine Research Center, Department of Anatomy, Korea University College of Medicine (Seoul, South Korea)", "lab_url": "https://myokinemrc.korea.ac.kr/members/group_view.html?no=1", "role": "Muscle biologist working on muscle-secreted factors and treatments for sarcopenia and muscle wasting, and senior author of a study on a leucine-like drug that activates mTORC1 through Sestrin2", "studies": [ "SHIM2026" ], "url": "https://mtor-atlas.org/author/hyeon-soo-kim/" }, { "id": "alejandro-ocampo", "name": "Alejandro Ocampo", "corpus_name": "Ocampo A", "orcid": null, "lab": "Ocampo Lab, University of Lausanne (Lausanne, Switzerland)", "lab_url": null, "role": "Aging researcher known for work on partial cellular reprogramming as a way to rejuvenate tissues, and senior author of a cross-species platform for screening lifespan-extending compounds", "studies": [ "PEREZ2026" ], "url": "https://mtor-atlas.org/author/alejandro-ocampo/" }, { "id": "won-suk-chung", "name": "Won-Suk Chung", "corpus_name": "Chung WS", "orcid": null, "lab": "Glia Biology Lab, Department of Biological Sciences, KAIST and Center for Vascular Research, Institute for Basic Science (Daejeon, South Korea)", "lab_url": "https://www.kaistglia.org", "role": "Neuroscientist who studies how glial cells (astrocytes and microglia) shape synapses, and senior author of the 2026 study linking neuronal ERBB4 and mTOR signaling to early Alzheimer's disease changes in mice", "studies": [ "LEE2026" ], "url": "https://mtor-atlas.org/author/won-suk-chung/" }, { "id": "ronjon-chakraverty", "name": "Ronjon Chakraverty", "corpus_name": "Chakraverty R", "orcid": null, "lab": "Chakraverty Group, Weatherall Institute of Molecular Medicine, University of Oxford (Oxford, England, United Kingdom)", "lab_url": "https://www.imm.ox.ac.uk/people/ronjon-chakraverty", "role": "Haematologist and transplant immunologist who studies why T cell immunotherapies succeed or fail, including how tuning T cell metabolism through mTORC1 changes their function.", "studies": [ "SIL2026" ], "url": "https://mtor-atlas.org/author/ronjon-chakraverty/" }, { "id": "ai-ling-lin", "name": "Ai-Ling Lin", "corpus_name": "Lin AL", "orcid": null, "lab": "Lin Lab, Department of Radiology, University of Missouri (Columbia, Missouri, USA)", "lab_url": "https://www.medicine.missouri.edu/faculty/ai-ling-lin-phd", "role": "Neuroimaging scientist who studies brain blood flow and metabolism in ageing and Alzheimer's risk, including the effect of rapamycin in people who carry APOE4.", "studies": [ "AWARE2026" ], "url": "https://mtor-atlas.org/author/ai-ling-lin/" }, { "id": "klemens-budde", "name": "Klemens Budde", "corpus_name": "Budde K", "orcid": "0000-0002-7929-5942", "lab": "Department of Internal Medicine, with a focus on Nephrology and Internal Intensive Care, Charité – Universitätsmedizin Berlin (Berlin, Germany)", "lab_url": "https://sciencemediacenter.de/en/angebote/forschende/prof-dr-klemens-budde-161d5106-5d43-603c-5d2a-62a88c617efc", "role": "Kidney and transplant physician who took part as an investigator in the EXIST-2 trial of everolimus for kidney tumours in tuberous sclerosis and LAM; clinician-investigator rather than a bench mTOR researcher.", "studies": [ "BIS2013" ], "url": "https://mtor-atlas.org/author/klemens-budde/" }, { "id": "andrew-c-liu", "name": "Andrew C. Liu", "corpus_name": "Liu AC", "orcid": "0000-0003-1927-0900", "lab": "Liu Lab, Department of Physiology and Aging, College of Medicine, University of Florida (Gainesville, Florida, USA)", "lab_url": "https://cicmd.center.ufl.edu/profile/liu-andrew/", "role": "Circadian biologist who studies how the body clock works at the molecular level and how it connects with metabolism and signalling pathways such as mTOR.", "studies": [ "RAM2018" ], "url": "https://mtor-atlas.org/author/andrew-c-liu/" }, { "id": "timothy-a-bolger", "name": "Timothy A. Bolger", "corpus_name": "Bolger TA", "orcid": null, "lab": "Bolger Lab, Department of Biochemistry and Molecular Biology, University of Georgia (Athens, Georgia, USA)", "lab_url": "https://www.bmb.uga.edu/research/lab/bolger", "role": "Studies how RNA helicases such as yeast Ded1 and human DDX3X control protein production under stress, including after TORC1 inhibition.", "studies": [ "SWA2026" ], "url": "https://mtor-atlas.org/author/timothy-a-bolger/" }, { "id": "helene-knvelsrud", "name": "Helene Knævelsrud", "corpus_name": "Knævelsrud H", "orcid": null, "lab": "Autophagy regulation in development and disease, Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, and Institute of Basic Medical Sciences, University of Oslo (Oslo, Norway)", "lab_url": "https://ous-research.no/cellstress", "role": "Autophagy researcher who studies how cells recycle their own material and how this process is regulated in development and disease, including cancer.", "studies": [ "ULL2026" ], "url": "https://mtor-atlas.org/author/helene-knvelsrud/" }, { "id": "jon-clardy", "name": "Jon Clardy", "corpus_name": "Clardy J", "orcid": null, "lab": "Clardy Lab, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://clardy.hms.harvard.edu/", "role": "Chemist who solved the crystal structure of the FKBP12-rapamycin-FRB (mTOR) complex, showing how rapamycin acts as a molecular glue between two proteins.", "studies": [ "CHO1996" ], "url": "https://mtor-atlas.org/author/jon-clardy/" }, { "id": "timothy-j-sargeant", "name": "Timothy J. Sargeant", "corpus_name": "Sargeant TJ", "orcid": null, "lab": "Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute (Adelaide, South Australia, Australia)", "lab_url": "https://sahmri.org.au/people/tim-sargeant", "role": "Studies lysosomal recycling and autophagy in ageing and Alzheimer's disease, and develops ways to measure autophagy flux in people.", "studies": [ "SIN2026" ], "url": "https://mtor-atlas.org/author/timothy-j-sargeant/" }, { "id": "bing-su", "name": "Bing Su", "corpus_name": "Su B", "orcid": null, "lab": "Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine (Shanghai, China)", "lab_url": "https://www.shsmu.edu.cn/english/info/1267/1867.htm", "role": "Immunologist who studies how mTOR and MAPK signaling shape immune regulation and vascular function, and senior author of the study showing that SIN1 is a core part of mTORC2.", "studies": [ "JAC2006", "LIU2015", "FAC2008", "GAN2011" ], "url": "https://mtor-atlas.org/author/bing-su/" }, { "id": "mauro-costa-mattioli", "name": "Mauro Costa-Mattioli", "corpus_name": "Costa-Mattioli M", "orcid": null, "lab": "MCM Lab, Department of Neuroscience, Baylor College of Medicine (Houston, Texas, USA)", "lab_url": "https://costamattiolilab.org/", "role": "Neuroscientist who studies how mTOR signaling and protein synthesis control learning, memory and brain function, including the role of mTORC2 in long-term memory.", "studies": [ "HUA2013", "COS2009" ], "url": "https://mtor-atlas.org/author/mauro-costa-mattioli/" }, { "id": "david-a-fruman", "name": "David A. Fruman", "corpus_name": "Fruman DA", "orcid": null, "lab": "Fruman Lab, Department of Molecular Biology and Biochemistry, University of California, Irvine (Irvine, California, USA)", "lab_url": "https://faculty.sites.uci.edu/frumanlab/", "role": "Immunologist and cancer biologist who studies PI3K and mTOR signaling in lymphocytes and leukemia cells and the drugs that target them.", "studies": [ "JAN2010" ], "url": "https://mtor-atlas.org/author/david-a-fruman/" }, { "id": "helen-m-blau", "name": "Helen M. Blau", "corpus_name": "Blau HM", "orcid": "0000-0001-6503-5480", "lab": "Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Stanford University School of Medicine (Stanford, California, USA)", "lab_url": "https://med.stanford.edu/blau-lab.html", "role": "Stem cell biologist known for work on muscle stem cells, regeneration, cell reprogramming and rejuvenation, including how aging muscle loses strength.", "studies": [ "ANC2026" ], "url": "https://mtor-atlas.org/author/helen-m-blau/" }, { "id": "michael-karin", "name": "Michael Karin", "corpus_name": "Karin M", "orcid": null, "lab": "Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, UC San Diego School of Medicine (La Jolla, California, USA)", "lab_url": "https://profiles.ucsd.edu/michael.karin", "role": "Cell biologist best known for discovering AP-1 and JNK signaling and the IKK-NF-kB inflammation pathway, whose lab also co-led the study of Sestrin as a feedback inhibitor of TOR.", "studies": [ "PAR2014", "LEE2010", "BUD2008" ], "url": "https://mtor-atlas.org/author/michael-karin/" }, { "id": "blake-b-rasmussen", "name": "Blake B. Rasmussen", "corpus_name": "Rasmussen BB", "orcid": null, "lab": "Rasmussen Lab, Department of Cellular & Integrative Physiology, Long School of Medicine, UT Health San Antonio (San Antonio, Texas, USA)", "lab_url": "https://labs.uthscsa.edu/rasmussen/", "role": "Muscle physiologist who studies how mTORC1 and nutrient signaling control muscle growth and loss in people, including during exercise and aging.", "studies": [ "MARCHANT2026", "DRU2009", "MAR2026B" ], "url": "https://mtor-atlas.org/author/blake-b-rasmussen/" }, { "id": "dominic-winter", "name": "Dominic Winter", "corpus_name": "Winter D", "orcid": null, "lab": "AG Winter, Lysosomal Proteome Dynamics, Research Center One Health Ruhr, University of Duisburg-Essen (Essen, North Rhine-Westphalia, Germany)", "lab_url": "https://www.ibmb.uni-bonn.de/forschung/ag-winter", "role": "Proteomics researcher who uses mass spectrometry to map lysosomal proteins and their modifications, including phosphorylation, in health and disease.", "studies": [ "MUT2026" ], "url": "https://mtor-atlas.org/author/dominic-winter/" }, { "id": "t-keith-blackwell", "name": "T. Keith Blackwell", "corpus_name": "Blackwell TK", "orcid": null, "lab": "Blackwell Lab, Joslin Diabetes Center, Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://joslin.theopenscholar.com/blackwelllab", "role": "Geneticist who uses the worm C. elegans to study how the SKN-1/Nrf stress-response factor, insulin signaling and TOR shape stress resistance and lifespan.", "studies": [ "ROB2012" ], "url": "https://mtor-atlas.org/author/t-keith-blackwell/" }, { "id": "ronald-s-duman", "name": "Ronald S. Duman", "corpus_name": "Duman RS", "orcid": null, "lab": "Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale School of Medicine (New Haven, Connecticut, USA)", "lab_url": null, "role": "Psychiatric neuroscientist who showed that ketamine's rapid antidepressant effect depends on mTOR signaling and the growth of new synapses in the prefrontal cortex.", "studies": [ "LIX2010" ], "url": "https://mtor-atlas.org/author/ronald-s-duman/" }, { "id": "martin-pass", "name": "Martin Pass", "corpus_name": "Pass M", "orcid": null, "lab": "Oncology drug discovery, AstraZeneca (Cheshire, England, United Kingdom)", "lab_url": "https://amphista.com/our-people/martin-pass/", "role": "Pharmaceutical drug-discovery leader who worked on AstraZeneca's oncology small-molecule programs, including the ATP-competitive mTOR kinase inhibitor AZD8055.", "studies": [ "CHR2009" ], "url": "https://mtor-atlas.org/author/martin-pass/" }, { "id": "jamie-h-d-cate", "name": "Jamie H. D. Cate", "corpus_name": "Cate JHD", "orcid": null, "lab": "Cate Lab, Departments of Molecular and Cell Biology and of Chemistry, University of California, Berkeley (Berkeley, California, USA)", "lab_url": "https://sites.google.com/berkeley.edu/cate-lab/home", "role": "Structural and molecular biologist who studies how ribosomes and the initiation factor eIF3 control which mRNAs are translated into protein.", "studies": [ "PLEDGER2026" ], "url": "https://mtor-atlas.org/author/jamie-h-d-cate/" }, { "id": "nenad-ban", "name": "Nenad Ban", "corpus_name": "Ban N", "orcid": null, "lab": "Ban Group, Institute of Molecular Biology and Biophysics, ETH Zurich (Zurich, Switzerland)", "lab_url": "https://bangroup.ethz.ch/", "role": "Structural biologist known for atomic structures of the ribosome and for work on how cells make, fold and sort proteins.", "studies": [ "SCA2020", "AYL2015", "STU2018" ], "url": "https://mtor-atlas.org/author/nenad-ban/" }, { "id": "xingrong-du", "name": "Xingrong Du", "corpus_name": "Du X", "orcid": null, "lab": "Du Group, Institute of Metabolism and Integrative Biology, Fudan University (Shanghai, China)", "lab_url": "https://imib.fudan.edu.cn/imiben/32/ab/c23203a275115/page.htm", "role": "Studies how cellular metabolism and signaling shape the function of T cells, regulatory T cells and dendritic cells in tumor immunity, autoimmunity and immunodeficiency.", "studies": [ "WANG2026" ], "url": "https://mtor-atlas.org/author/xingrong-du/" }, { "id": "michele-pagano", "name": "Michele Pagano", "corpus_name": "Pagano M", "orcid": null, "lab": "Pagano Laboratory, Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine (New York, New York, USA)", "lab_url": "https://med.nyu.edu/faculty/michele-pagano", "role": "Studies ubiquitin ligases, the enzymes that tag proteins for destruction, including how the S6K1 kinase triggers degradation of the translation brake PDCD4.", "studies": [ "DOR2006" ], "url": "https://mtor-atlas.org/author/michele-pagano/" }, { "id": "sean-p-cregan", "name": "Sean P. Cregan", "corpus_name": "Cregan SP", "orcid": null, "lab": "Cregan Laboratory, Robarts Research Institute and Neuroscience Program, Western University (London, Ontario, Canada)", "lab_url": "https://rri-www.schulich.uwo.ca/research/scientists/cregan_sean.html", "role": "Studies the molecular pathways that trigger neuron death, aiming to find drug targets that protect neurons in stroke and in diseases such as Parkinson, Alzheimer and Huntington.", "studies": [ "DEMMINGS2026" ], "url": "https://mtor-atlas.org/author/sean-p-cregan/" }, { "id": "doreen-a-cantrell", "name": "Doreen A. Cantrell", "corpus_name": "Cantrell DA", "orcid": null, "lab": "Cantrell Group, Cell Signalling and Immunology, School of Life Sciences, University of Dundee (Dundee, Scotland, United Kingdom)", "lab_url": "https://www.dundee.ac.uk/people/doreen-cantrell", "role": "Studies how signaling and metabolism control T-cell fate, including how amino-acid uptake and mTORC1 steer T-cell differentiation.", "studies": [ "SIN2013" ], "url": "https://mtor-atlas.org/author/doreen-a-cantrell/" }, { "id": "alcino-j-silva", "name": "Alcino J. Silva", "corpus_name": "Silva AJ", "orcid": null, "lab": "Silva Lab, Department of Neurobiology and Integrative Center for Learning and Memory, University of California, Los Angeles (Los Angeles, California, USA)", "lab_url": "https://www.psych.ucla.edu/faculty-page/silvaa", "role": "Studies the molecular and cellular basis of learning and memory, including how overactive mTOR signaling in tuberous sclerosis impairs memory and how rapamycin can reverse it in mice.", "studies": [ "EHN2008" ], "url": "https://mtor-atlas.org/author/alcino-j-silva/" }, { "id": "surendra-nath-sehgal", "name": "Surendra Nath Sehgal", "corpus_name": "Sehgal SN", "orcid": null, "lab": "Ayerst Research Laboratories (later Wyeth) (Montreal, Quebec, Canada)", "lab_url": "https://en.wikipedia.org/wiki/Surendra_Nath_Sehgal", "role": "Led the team at Ayerst that isolated rapamycin from an Easter Island soil bacterium and kept the program alive until the drug reached the clinic.", "studies": [ "VEZ1975" ], "url": "https://mtor-atlas.org/author/surendra-nath-sehgal/" }, { "id": "andrea-b-maier", "name": "Andrea B. Maier", "corpus_name": "Maier AB", "orcid": "0000-0001-7206-1724", "lab": "Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore (Singapore)", "lab_url": "https://medicine.nus.edu.sg/trp/healthy-longevity/about-us/our-people/", "role": "Geriatrician-researcher who studies biological ageing and healthy longevity, including a systematic review of what rapamycin and its derivatives do in humans.", "studies": [ "LEE2024" ], "url": "https://mtor-atlas.org/author/andrea-b-maier/" }, { "id": "dominic-j-withers", "name": "Dominic J. Withers", "corpus_name": "Withers DJ", "orcid": null, "lab": "Metabolic Signalling Group, MRC Laboratory of Medical Sciences, Imperial College London (London, England, United Kingdom)", "lab_url": "https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Professor-Dominic-Withers-0014987", "role": "Studies how hormone and nutrient signaling pathways control metabolism and ageing, including the finding that loss of S6K1 extends lifespan in mice.", "studies": [ "SEL2009" ], "url": "https://mtor-atlas.org/author/dominic-j-withers/" }, { "id": "yong-keun-jung", "name": "Yong-Keun Jung", "corpus_name": "Jung YK", "orcid": null, "lab": "Laboratory of Apoptosis & Molecular Disease, School of Biological Sciences, Seoul National University (Seoul, South Korea)", "lab_url": "https://biosci.snu.ac.kr/ykjung/en/professor", "role": "Studies programmed cell death and autophagy and their roles in ageing and disease, including mice with extra copies of the autophagy gene Atg5 that live longer.", "studies": [ "PYO2013" ], "url": "https://mtor-atlas.org/author/yong-keun-jung/" }, { "id": "keishi-fujio", "name": "Keishi Fujio", "corpus_name": "Fujio K", "orcid": null, "lab": "Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo (Tokyo, Japan)", "lab_url": "https://www.u-tokyo.ac.jp/focus/en/people/people002439.html", "role": "Rheumatologist and immunologist who studies how self-tolerance breaks down in autoimmune disease, including lupus, and how nutrient sensing by CASTOR1 shapes B-cell responses.", "studies": [ "KUS2026" ], "url": "https://mtor-atlas.org/author/keishi-fujio/" }, { "id": "dean-l-kellogg-jr", "name": "Dean L. Kellogg Jr.", "corpus_name": "Kellogg DL", "orcid": null, "lab": "Kellogg Lab, Division of Geriatrics, Gerontology & Palliative Medicine, Department of Medicine, UT Health San Antonio (San Antonio, Texas, USA)", "lab_url": "https://directory.uthscsa.edu/academics/profile/kelloggd", "role": "A geriatrician who co-leads clinical trials of rapamycin in older adults at the Barshop Institute, with a focus on safety and cardiovascular effects.", "studies": [ "KRA2018" ], "url": "https://mtor-atlas.org/author/dean-l-kellogg-jr/" }, { "id": "lloyd-b-klickstein", "name": "Lloyd B. Klickstein", "corpus_name": "Klickstein LB", "orcid": "0000-0002-4108-9123", "lab": "New Indications Discovery Unit, Novartis Institutes for BioMedical Research (Cambridge, Massachusetts, USA)", "lab_url": "https://timothyspringer.org/people/lloyd-klickstein-md-phd", "role": "A physician-scientist who led the clinical studies at Novartis showing that low-dose mTOR inhibitors can boost immune function and cut infections in older adults.", "studies": [ "MAN2014", "MAN2018" ], "url": "https://mtor-atlas.org/author/lloyd-b-klickstein/" }, { "id": "bruce-a-edgar", "name": "Bruce A. Edgar", "corpus_name": "Edgar BA", "orcid": null, "lab": "Edgar Lab, Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah (Salt Lake City, Utah, USA)", "lab_url": "https://uofuhealth.utah.edu/huntsman/labs/edgar", "role": "A Drosophila geneticist who studies how cells and tissues control their growth, including the role of Rheb in the insulin/TOR network.", "studies": [ "SAU2003" ], "url": "https://mtor-atlas.org/author/bruce-a-edgar/" }, { "id": "gerald-r-crabtree", "name": "Gerald R. Crabtree", "corpus_name": "Crabtree GR", "orcid": null, "lab": "Crabtree Lab, Departments of Pathology and Developmental Biology, Stanford University School of Medicine (Stanford, California, USA)", "lab_url": "http://crablab.stanford.edu/", "role": "Helped define the calcineurin-NFAT pathway behind cyclosporine and FK506, and showed in 1992 that rapamycin blocks IL-2 activation of p70 S6 kinase.", "studies": [ "CHU1992", "KUO1992" ], "url": "https://mtor-atlas.org/author/gerald-r-crabtree/" }, { "id": "jonathan-e-rosenberg", "name": "Jonathan E. Rosenberg", "corpus_name": "Rosenberg JE", "orcid": null, "lab": "Genitourinary Oncology Service, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center (New York, New York, USA)", "lab_url": "https://www.mskcc.org/cancer-care/doctors/jonathan-rosenberg", "role": "A bladder and urothelial cancer oncologist whose clinical trial work includes the case of an exceptional responder to everolimus with activating MTOR mutations.", "studies": [ "WAG2014" ], "url": "https://mtor-atlas.org/author/jonathan-e-rosenberg/" }, { "id": "kjell-oberg", "name": "Kjell Öberg", "corpus_name": "Oberg K", "orcid": null, "lab": "Endocrine Oncology, Department of Medical Sciences, Uppsala University (Uppsala, Sweden)", "lab_url": "https://www.uu.se/en/contact-and-organisation/staff?query=N96-5147", "role": "A leading figure in neuroendocrine tumor research and care, and a co-author of the RADIANT-3 trial that supported everolimus for pancreatic neuroendocrine tumors.", "studies": [ "YAO2011" ], "url": "https://mtor-atlas.org/author/kjell-oberg/" }, { "id": "ming-o-li", "name": "Ming O. Li", "corpus_name": "Li MO", "orcid": null, "lab": "Ming Li Lab, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center (New York, New York, USA)", "lab_url": "https://www.sloankettering.edu/research/ski/labs/ming-li", "role": "An immunologist who studies how tumors trigger immune responses and who found that SZT2 organizes the GATOR complexes controlling mTORC1.", "studies": [ "PEN2017" ], "url": "https://mtor-atlas.org/author/ming-o-li/" }, { "id": "beth-levine", "name": "Beth Levine", "corpus_name": "Levine B", "orcid": null, "lab": "Center for Autophagy Research, UT Southwestern Medical Center (Dallas, Texas, USA)", "lab_url": "https://www.utsouthwestern.edu/ctplus/stories/2020/dr-beth-levine.html", "role": "Discovered beclin 1, the first mammalian autophagy gene, and showed that autophagy matters for lifespan, tumor suppression and defense against viruses.", "studies": [ "MEL2003" ], "url": "https://mtor-atlas.org/author/beth-levine/" }, { "id": "almut-schulze", "name": "Almut Schulze", "corpus_name": "Schulze A", "orcid": null, "lab": "Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ) (Heidelberg, Germany)", "lab_url": "https://www.dkfz.de/en/tumour-metabolism-and-microenvironment", "role": "Studies how growth signaling, including PI3K/Akt and mTORC1, drives the metabolism that cancer cells need, notably fat synthesis through SREBP.", "studies": [ "POR2008" ], "url": "https://mtor-atlas.org/author/almut-schulze/" }, { "id": "sergiusz-jozwiak", "name": "Sergiusz Jóźwiak", "corpus_name": "Jozwiak S", "orcid": null, "lab": "Department of Child Neurology, Medical University of Warsaw (Warsaw, Poland)", "lab_url": "https://neurologiadziecieca.wum.edu.pl/en", "role": "A child neurologist known for work on tuberous sclerosis complex and a senior author of the EXIST-1 trial of everolimus.", "studies": [ "FRA2013" ], "url": "https://mtor-atlas.org/author/sergiusz-jozwiak/" }, { "id": "ingrid-e-scheffer", "name": "Ingrid E. Scheffer", "corpus_name": "Scheffer IE", "orcid": null, "lab": "Epilepsy research, The Florey Institute of Neuroscience and Mental Health / Austin Health, University of Melbourne (Melbourne, Victoria, Australia)", "lab_url": "https://royalsociety.org/people/ingrid-scheffer-13841/", "role": "Paediatric neurologist and epilepsy researcher who defined new epilepsy syndromes and helped identify epilepsy genes, including DEPDC5, a GATOR1 gene that connects inherited focal epilepsy to the mTOR pathway.", "studies": [ "DIB2013B" ], "url": "https://mtor-atlas.org/author/ingrid-e-scheffer/" }, { "id": "eric-ravussin", "name": "Eric Ravussin", "corpus_name": "Ravussin E", "orcid": null, "lab": "Pennington Biomedical Research Center, Louisiana State University System (Baton Rouge, Louisiana, USA)", "lab_url": "https://www.pbrc.edu/news/media/2018/Profile-Eric-Ravussin-PhD.aspx", "role": "Human energy-metabolism researcher who studies why people differ in how they burn energy and what long-term calorie restriction does to the body, including in the CALERIE trial.", "studies": [ "ROM2016" ], "url": "https://mtor-atlas.org/author/eric-ravussin/" }, { "id": "pere-puigserver", "name": "Pere Puigserver", "corpus_name": "Puigserver P", "orcid": null, "lab": "Puigserver Lab, Department of Cell Biology and Cancer Biology, Harvard Medical School and Dana-Farber Cancer Institute (Boston, Massachusetts, USA)", "lab_url": "https://labs.dana-farber.org/puigserverlab", "role": "Metabolism researcher who studies how mitochondrial energy production and nutrient metabolism are controlled, including the finding that mTOR drives mitochondrial gene activity through YY1 and PGC-1alpha.", "studies": [ "CUN2007" ], "url": "https://mtor-atlas.org/author/pere-puigserver/" }, { "id": "sara-c-kozma", "name": "Sara C. Kozma", "corpus_name": "Kozma SC", "orcid": null, "lab": "Kozma Laboratory, Department of Cancer and Cell Biology, Genome Research Institute, University of Cincinnati (Cincinnati, Ohio, USA)", "lab_url": "https://researchdirectory.uc.edu/p/kozmasc", "role": "Studies the S6K/mTOR pathway and how it controls cell growth, ribosome production, diabetes and cancer, including mTOR signalling in liver cancer.", "studies": [ "MON1999", "DEN2001", "PEN2000", "UMX2004", "GAR2003", "KAL2010", "COT2006", "CAR2008", "SHI1998", "SEL2009", "DEL2009", "GUL2008" ], "url": "https://mtor-atlas.org/author/sara-c-kozma/" }, { "id": "simon-melov", "name": "Simon Melov", "corpus_name": "Melov S", "orcid": null, "lab": "Melov Lab, Buck Institute for Research on Aging (Novato, California, USA)", "lab_url": "https://www.buckinstitute.org/lab/melov-lab/", "role": "Geroscientist who studies how cells and tissues change with age or drug treatment, including the finding that late-life rapamycin improves heart function in old mice.", "studies": [ "FLY2013" ], "url": "https://mtor-atlas.org/author/simon-melov/" }, { "id": "tony-hunter", "name": "Tony Hunter", "corpus_name": "Hunter T", "orcid": null, "lab": "Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies (La Jolla, California, USA)", "lab_url": "http://hunter.salk.edu/", "role": "Cell biologist who showed that tyrosine phosphorylation is a master on/off switch for proteins, work that informed cancer drugs such as Gleevec; his lab also studied the TSC/Rheb/mTOR/S6K feedback to insulin signalling.", "studies": [ "SHA2004" ], "url": "https://mtor-atlas.org/author/tony-hunter/" }, { "id": "xuejun-jiang", "name": "Xuejun Jiang", "corpus_name": "Jiang X", "orcid": null, "lab": "Xuejun Jiang Lab, Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center (New York, New York, USA)", "lab_url": "https://www.mskcc.org/research-areas/labs/xuejun-jiang", "role": "Cell biologist who studies autophagy and programmed cell death, including the ULK1-ATG13-FIP200 complex that links mTOR signalling to autophagy.", "studies": [ "GAN2009" ], "url": "https://mtor-atlas.org/author/xuejun-jiang/" }, { "id": "dianqing-dan-wu", "name": "Dianqing (Dan) Wu", "corpus_name": "Wu D", "orcid": "0000-0002-7342-5961", "lab": "Department of Pharmacology, Yale School of Medicine (New Haven, Connecticut, USA)", "lab_url": "https://medicine.yale.edu/cancer/profile/dianqing-wu/", "role": "Signalling biologist who studies Wnt signalling and receptor-driven cell migration, and who showed that PIP3 can directly stimulate mTORC2 kinase activity.", "studies": [ "GAN2011" ], "url": "https://mtor-atlas.org/author/dianqing-dan-wu/" }, { "id": "vojo-deretic", "name": "Vojo Deretic", "corpus_name": "Deretic V", "orcid": null, "lab": "Deretic Laboratory, Autophagy, Inflammation and Metabolism (AIM) Center, Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center (Albuquerque, New Mexico, USA)", "lab_url": "https://hsc.unm.edu/directory/deretic-vojo.html", "role": "Studies how autophagy shapes infection, immunity and inflammation, including early work showing that autophagy restricts Mycobacterium tuberculosis, and how galectins and TRIM proteins control mTOR and AMPK.", "studies": [ "KOR2011" ], "url": "https://mtor-atlas.org/author/vojo-deretic/" }, { "id": "robert-j-motzer", "name": "Robert J. Motzer", "corpus_name": "Motzer RJ", "orcid": null, "lab": "Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center (New York, New York, USA)", "lab_url": "https://www.mskcc.org/cancer-care/doctors/robert-motzer", "role": "Kidney-cancer oncologist who led the RECORD-1 phase III trial showing that the mTOR inhibitor everolimus extends progression-free survival in metastatic renal cell carcinoma.", "studies": [ "MOT2008", "HUD2007" ], "url": "https://mtor-atlas.org/author/robert-j-motzer/" }, { "id": "martine-j-piccart", "name": "Martine J. Piccart", "corpus_name": "Piccart M", "orcid": null, "lab": "Institut Jules Bordet, Université libre de Bruxelles (Brussels, Belgium)", "lab_url": "https://www.esmo.org/Profiles/Martine-Piccart", "role": "Breast cancer oncologist who co-founded the Breast International Group and has led or co-led major academic trials such as HERA, MINDACT and ALTTO.", "studies": [ "BAS2012", "PIC2014" ], "url": "https://mtor-atlas.org/author/martine-j-piccart/" }, { "id": "vamsi-k-mootha", "name": "Vamsi K. Mootha", "corpus_name": "Mootha VK", "orcid": null, "lab": "Mootha Laboratory, Department of Molecular Biology, Massachusetts General Hospital; Department of Systems Biology, Harvard Medical School; Broad Institute (Boston, Massachusetts, USA)", "lab_url": "https://mootha.med.harvard.edu/index.html", "role": "Studies how mitochondria are built and work and how their genes cause disease, including the MitoCarta inventory of the mitochondrial proteome and the mitochondrial calcium uniporter.", "studies": [ "CUN2007" ], "url": "https://mtor-atlas.org/author/vamsi-k-mootha/" }, { "id": "james-brugarolas", "name": "James Brugarolas", "corpus_name": "Brugarolas J", "orcid": null, "lab": "Kidney Cancer Program, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center (Dallas, Texas, USA)", "lab_url": "https://profiles.utsouthwestern.edu/profile/80679/james-brugarolas.html", "role": "First author of the 2004 study showing that hypoxia switches off mTOR through REDD1 and the TSC1/TSC2 complex; now directs a kidney cancer research program studying signalling and resistance to targeted drugs.", "studies": [ "PEN2011", "MAJ2004", "BRU2004" ], "url": "https://mtor-atlas.org/author/james-brugarolas/" }, { "id": "luigi-fontana", "name": "Luigi Fontana", "corpus_name": "Fontana L", "orcid": "0000-0001-8500-5537", "lab": "Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney (Sydney, New South Wales, Australia)", "lab_url": "https://profiles.sydney.edu.au/luigi.fontana", "role": "Studies how diet and calorie restriction affect human ageing and metabolic health, and co-wrote a widely cited Science review linking dietary restriction to nutrient-sensing pathways such as mTOR", "studies": [ "FON2010" ], "url": "https://mtor-atlas.org/author/luigi-fontana/" }, { "id": "gokhan-s-hotamslgil", "name": "Gökhan S. Hotamışlıgil", "corpus_name": "Hotamışlıgil GS", "orcid": null, "lab": "Hotamışlıgil Lab, Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health (Boston, Massachusetts, USA)", "lab_url": "https://www.hsph.harvard.edu/profile/gokhan-s-hotamisligil/", "role": "Leads a Harvard laboratory on metabolic disease and was elected to the US National Academy of Sciences in 2026 for achievements in metabolic research", "studies": [ "KAL2026" ], "url": "https://mtor-atlas.org/author/gokhan-s-hotamslgil/" }, { "id": "peter-s-rabinovitch", "name": "Peter S. Rabinovitch", "corpus_name": "Rabinovitch PS", "orcid": null, "lab": "Rabinovitch Lab, Department of Laboratory Medicine and Pathology, University of Washington (Seattle, Washington, USA)", "lab_url": "https://dlmp.uw.edu/faculty/rabinovitch", "role": "Uses mouse models to study how improving mitochondrial function changes lifespan and healthspan, including catalase-overexpressing mice and the drug elamipretide (SS-31)", "studies": [ "JOH2013" ], "url": "https://mtor-atlas.org/author/peter-s-rabinovitch/" }, { "id": "matthew-meyerson", "name": "Matthew Meyerson", "corpus_name": "Meyerson M", "orcid": null, "lab": "Meyerson Lab, Center for Cancer Genomics, Dana-Farber Cancer Institute (Boston, Massachusetts, USA)", "lab_url": "http://meyersonlab.dana-farber.org/", "role": "Cancer geneticist whose group has helped identify key genes mutated in lung cancer, and who contributed the cancer-genome analysis to the discovery that GATOR1 is a tumour suppressor acting on mTORC1", "studies": [ "BAR2013" ], "url": "https://mtor-atlas.org/author/matthew-meyerson/" }, { "id": "nicholas-t-ingolia", "name": "Nicholas T. Ingolia", "corpus_name": "Ingolia NT", "orcid": null, "lab": "Ingolia Lab, Department of Molecular and Cell Biology, University of California, Berkeley (Berkeley, California, USA)", "lab_url": "http://www.ingolia-lab.org/", "role": "Known for ribosome profiling, a method that reads out which messenger RNAs ribosomes are translating across a whole genome; the study in the Atlas used this approach to map mTOR-controlled translation in prostate cancer.", "studies": [ "HSI2012" ], "url": "https://mtor-atlas.org/author/nicholas-t-ingolia/" }, { "id": "zachary-a-knight", "name": "Zachary A. Knight", "corpus_name": "Knight ZA", "orcid": null, "lab": "Knight Lab (The Neurobiology of Homeostasis), Department of Physiology, University of California San Francisco (San Francisco, California, USA)", "lab_url": "https://knightlab.ucsf.edu/", "role": "Neuroscientist whose lab studies the brain mechanisms behind appetite, thirst and body-temperature preference; he is a co-author of the 2009 study that introduced the TORKinibs PP242 and PP30.", "studies": [ "FEL2009" ], "url": "https://mtor-atlas.org/author/zachary-a-knight/" }, { "id": "luca-scorrano", "name": "Luca Scorrano", "corpus_name": "Scorrano L", "orcid": "0000-0002-8515-8928", "lab": "Scorrano Lab, Department of Biology, University of Padova (Padova, Italy)", "lab_url": "https://www.unipd.it/en/erc-scorrano-integrate", "role": "Mitochondrial biologist known for showing how the shape of mitochondria and their inner folds (cristae) control energy production and cell death.", "studies": [ "EIS2016" ], "url": "https://mtor-atlas.org/author/luca-scorrano/" }, { "id": "arkaitz-carracedo", "name": "Arkaitz Carracedo", "corpus_name": "Carracedo A", "orcid": null, "lab": "Cancer Cell Signaling and Metabolism Laboratory, CIC bioGUNE (Bilbao, Spain)", "lab_url": "https://www.cicbiogune.es/people/acarracedo", "role": "Cancer biologist who, as first author in 2008, showed that blocking mTORC1 can switch on the MAPK pathway through a PI3K-dependent feedback loop.", "studies": [ "CAR2008" ], "url": "https://mtor-atlas.org/author/arkaitz-carracedo/" }, { "id": "kresimir-krnjevic", "name": "Krešimir Krnjević", "corpus_name": "Krnjevic K", "orcid": null, "lab": "Department of Physiology, McGill University (Montreal, Quebec, Canada)", "lab_url": "https://www.mcgill.ca/channels/node/170006", "role": "Neurophysiologist who helped identify glutamate and GABA as the brain's main excitatory and inhibitory transmitters and described slow modulatory actions of acetylcholine in the cortex.", "studies": [ "HUA2013" ], "url": "https://mtor-atlas.org/author/kresimir-krnjevic/" }, { "id": "lukas-a-huber", "name": "Lukas A. Huber", "corpus_name": "Huber LA", "orcid": "0000-0003-1116-2120", "lab": "Huber Laboratory, Institute of Cell Biology, Medical University of Innsbruck (Innsbruck, Tyrol, Austria)", "lab_url": "https://cellbiology.i-med.ac.at/research-groups/the-huber-laboratory/", "role": "Cell biologist who studied the p14-MP1 scaffold on late endosomes, a complex later recognised as part of Ragulator (LAMTOR), the lysosomal platform that holds mTORC1 in place", "studies": [ "NAP2020", "PRE2021", "REB2015", "CUI2023" ], "url": "https://mtor-atlas.org/author/lukas-a-huber/" }, { "id": "nektarios-tavernarakis", "name": "Nektarios Tavernarakis", "corpus_name": "Tavernarakis N", "orcid": null, "lab": "Neurogenetics and Ageing Laboratory, Medical School, University of Crete and Institute of Molecular Biology and Biotechnology, FORTH (Heraklion, Crete, Greece)", "lab_url": "https://tavernarakislab.gr/en/members/head/", "role": "Geneticist who uses the roundworm C. elegans to study how ageing, neurodegeneration, necrotic cell death, autophagy and protein turnover are controlled", "studies": [ "EIS2009" ], "url": "https://mtor-atlas.org/author/nektarios-tavernarakis/" }, { "id": "johannes-l-hans-bos", "name": "Johannes L. (Hans) Bos", "corpus_name": "Bos JL", "orcid": null, "lab": "Group Bos, Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht (Utrecht, Netherlands)", "lab_url": "https://www.umcutrecht.nl/en/group-bos", "role": "Cancer biologist known for work on Ras mutations and for the small GTPase Rap1 and its activator Epac, a cAMP-regulated switch for cell adhesion", "studies": [ "GAR2003", "NOB2005" ], "url": "https://mtor-atlas.org/author/johannes-l-hans-bos/" }, { "id": "rachel-green", "name": "Rachel Green", "corpus_name": "Green R", "orcid": null, "lab": "Green Lab, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine (Baltimore, Maryland, USA)", "lab_url": "https://greenlabjhmi.org/", "role": "Biochemist who studies how the ribosome works and how cells detect and rescue stalled or colliding ribosomes, including links to the integrated stress response", "studies": [ "FAN2026" ], "url": "https://mtor-atlas.org/author/rachel-green/" }, { "id": "barry-d-kahan", "name": "Barry D. Kahan", "corpus_name": "Kahan BD (Rapamune US Study Group)", "orcid": null, "lab": "Division of Immunology and Organ Transplantation, Department of Surgery, McGovern Medical School, University of Texas Health Science Center (Houston, Texas, USA)", "lab_url": "https://www.asts.org/about-asts/chimera-chronicles/barry-kahan", "role": "Transplant surgeon-scientist who was the named author of the large US trial that made sirolimus (rapamycin) an approved immunosuppressant for kidney transplant patients", "studies": [ "KAH2000" ], "url": "https://mtor-atlas.org/author/barry-d-kahan/" }, { "id": "michael-b-yaffe", "name": "Michael B. Yaffe", "corpus_name": "Yaffe MB", "orcid": null, "lab": "Yaffe Lab, Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology (Cambridge, Massachusetts, USA)", "lab_url": "https://yaffelab.mit.edu/", "role": "Cancer biologist and physician-scientist known for working out how phosphorylation creates binding sites on proteins, including the 14-3-3 family of phosphoserine/threonine-binding proteins, and how kinases choose their targets.", "studies": [ "HSU2011", "KAN2013" ], "url": "https://mtor-atlas.org/author/michael-b-yaffe/" }, { "id": "dirk-hockemeyer", "name": "Dirk Hockemeyer", "corpus_name": "Hockemeyer D", "orcid": "0000-0002-5598-5092", "lab": "Hockemeyer Lab, Department of Molecular and Cell Biology, University of California, Berkeley (Berkeley, California, USA)", "lab_url": "https://hockemeyerlab.berkeley.edu/index.html", "role": "Stem-cell biologist whose laboratory builds engineered human stem-cell and mouse models of disease, using genome editing and functional genomics screens.", "studies": [ "LI2026C" ], "url": "https://mtor-atlas.org/author/dirk-hockemeyer/" }, { "id": "john-b-hogenesch", "name": "John B. Hogenesch", "corpus_name": "Hogenesch JB", "orcid": null, "lab": "Hogenesch Lab, Division of Human Genetics, Cincinnati Children's Hospital Medical Center (Cincinnati, Ohio, USA)", "lab_url": "https://hogeneschlab.org/", "role": "Circadian-rhythm geneticist who uses genome-wide methods to map which genes the body clock controls in each tissue.", "studies": [ "RAM2018" ], "url": "https://mtor-atlas.org/author/john-b-hogenesch/" }, { "id": "francis-x-mccormack", "name": "Francis X. McCormack", "corpus_name": "McCormack FX", "orcid": null, "lab": "Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati (Cincinnati, Ohio, USA)", "lab_url": "https://researchdirectory.uc.edu/p/mccormfx", "role": "Pulmonologist who led the MILES trial, which showed that sirolimus (rapamycin) halts the decline in lung function in lymphangioleiomyomatosis, a rare mTOR-driven lung disease.", "studies": [ "BIS2008", "MCC2011" ], "url": "https://mtor-atlas.org/author/francis-x-mccormack/" }, { "id": "martin-hrabe-de-angelis", "name": "Martin Hrabě de Angelis", "corpus_name": "de Angelis MH", "orcid": null, "lab": "Institute of Experimental Genetics, Helmholtz Munich, and Chair of Experimental Genetics, Technical University of Munich (Munich, Germany)", "lab_url": "https://www.helmholtz-munich.de/en/ieg/martin-hrabe-de-angelis", "role": "Mouse geneticist who directs large-scale phenotyping of mouse mutants and the German Mouse Clinic, a platform that tests how genes affect health and disease.", "studies": [ "EIS2016" ], "url": "https://mtor-atlas.org/author/martin-hrabe-de-angelis/" }, { "id": "w-michael-kuehl", "name": "W. Michael Kuehl", "corpus_name": "Kuehl WM", "orcid": null, "lab": "Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health (Bethesda, Maryland, USA)", "lab_url": "https://ccr.cancer.gov/news/article/in-memoriam-w-michael-kuehl-md", "role": "Physician-scientist who spent decades working out the genetic and molecular biology of multiple myeloma and its precursor condition MGUS.", "studies": [ "PET2009" ], "url": "https://mtor-atlas.org/author/w-michael-kuehl/" }, { "id": "guido-kroemer", "name": "Guido Kroemer", "corpus_name": "Kroemer G", "orcid": null, "lab": "Metabolism, Cancer and Immunity team, Cordeliers Research Centre (Inserm) & Gustave Roussy (Paris, France)", "lab_url": "https://www.gustaveroussy.fr/en/node/5207", "role": "Cell biologist known for work on programmed cell death, mitochondria and autophagy, and for linking autophagy to ageing and cancer immunity.", "studies": [ "EIS2009" ], "url": "https://mtor-atlas.org/author/guido-kroemer/" }, { "id": "samuel-f-berkovic", "name": "Samuel F. Berkovic", "corpus_name": "Berkovic SF", "orcid": null, "lab": "Epilepsy Research Centre, Austin Health & Department of Medicine, University of Melbourne (Melbourne, Victoria, Australia)", "lab_url": "https://www.epilepsyresearch.org.au/erc-team", "role": "Neurologist who helped establish the genetic causes of many epilepsies, including the discovery that DEPDC5 mutations, which affect the mTORC1 brake GATOR1, cause familial focal epilepsy.", "studies": [ "DIB2013B" ], "url": "https://mtor-atlas.org/author/samuel-f-berkovic/" }, { "id": "eric-j-brown", "name": "Eric J. Brown", "corpus_name": "Brown EJ", "orcid": null, "lab": "Brown Lab, Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania (Philadelphia, Pennsylvania, USA)", "lab_url": "https://www.med.upenn.edu/apps/faculty/index.php/g20002940/p2585468", "role": "Co-discoverer of mTOR: as first author he isolated the mammalian protein bound by the rapamycin-FKBP12 complex (FRAP) and cloned its gene in 1994.", "studies": [ "BRO1994" ], "url": "https://mtor-atlas.org/author/eric-j-brown/" }, { "id": "monica-driscoll", "name": "Monica Driscoll", "corpus_name": "Driscoll M", "orcid": null, "lab": "Driscoll Lab, Department of Molecular Biology and Biochemistry, Rutgers University (Piscataway, New Jersey, USA)", "lab_url": "https://sites.rutgers.edu/driscoll-lab/", "role": "Studies the biology of ageing in the roundworm C. elegans, including interventions that extend healthspan and the mechanisms that protect neurons from damage.", "studies": [ "HAN2008" ], "url": "https://mtor-atlas.org/author/monica-driscoll/" }, { "id": "joseph-heitman", "name": "Joseph Heitman", "corpus_name": "Heitman J", "orcid": null, "lab": "Heitman Lab, Department of Molecular Genetics and Microbiology, Duke University School of Medicine (Durham, North Carolina, USA)", "lab_url": "https://mgm.duke.edu/heitman-lab", "role": "Co-discovered the TOR genes in yeast in 1991 as a first author with Rao Movva and Michael Hall, the genetic identification of what became known as mTOR in mammals", "studies": [ "HEI1991" ], "url": "https://mtor-atlas.org/author/joseph-heitman/" }, { "id": "jose-baselga", "name": "José Baselga", "corpus_name": "Baselga J", "orcid": null, "lab": "Division of Hematology/Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School (affiliation on BAS2012) (Boston, Massachusetts, USA)", "lab_url": "https://ascopost.com/issues/april-10-2021/towering-figure-in-cancer-drug-development-josé-baselga-md-phd-fasco-dies-at-age-61/", "role": "Breast cancer oncologist who led the BOLERO-2 trial showing that the mTOR inhibitor everolimus added to hormone therapy lengthens progression-free survival", "studies": [ "ORE2006", "ROD2011", "BAS2012", "CAR2008", "PIC2014" ], "url": "https://mtor-atlas.org/author/jose-baselga/" }, { "id": "james-l-kirkland", "name": "James L. Kirkland", "corpus_name": "Kirkland JL", "orcid": null, "lab": "Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center (Los Angeles, California, USA)", "lab_url": "https://www.cedars-sinai.org/stories-and-insights/innovation-and-research/the-future-of-aging-research", "role": "Founder of the field of senolytics, drugs that clear senescent cells, and a leader of clinical trials of ageing-targeted therapies", "studies": [ "STR2012", "LAN2026" ], "url": "https://mtor-atlas.org/author/james-l-kirkland/" }, { "id": "seymour-benzer", "name": "Seymour Benzer", "corpus_name": "Benzer S", "orcid": null, "lab": "Benzer Laboratory, Division of Biology, California Institute of Technology (Pasadena, California, USA)", "lab_url": null, "role": "Pioneer of fine-structure gene mapping in phage and founder of neurogenetics, whose Drosophila work found the first circadian-rhythm mutants", "studies": [ "KAP2004", "ZID2009" ], "url": "https://mtor-atlas.org/author/seymour-benzer/" }, { "id": "anne-claude-gingras", "name": "Anne-Claude Gingras", "corpus_name": "Gingras AC", "orcid": null, "lab": "Gingras Lab, Lunenfeld-Tanenbaum Research Institute, Sinai Health; Department of Molecular Genetics, University of Toronto (Toronto, Ontario, Canada)", "lab_url": "https://gingraslab.org", "role": "Showed in 1999 that mTOR phosphorylates 4E-BP1 in a priming two-step mechanism, and now leads work on interaction proteomics (including BioID) that maps how cells read signals such as mTORC1", "studies": [ "TAN2002", "GIN1999" ], "url": "https://mtor-atlas.org/author/anne-claude-gingras/" }, { "id": "william-b-mair", "name": "William B. Mair", "corpus_name": "Mair WB", "orcid": null, "lab": "Mair Lab, Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health (Boston, Massachusetts, USA)", "lab_url": "https://hsph.harvard.edu/research/mair-lab/", "role": "Studies how nutrient and energy sensors, and dietary restriction, control the rate of ageing, using models from yeast to mammals", "studies": [ "SHI2026" ], "url": "https://mtor-atlas.org/author/william-b-mair/" }, { "id": "jenna-l-jewell", "name": "Jenna L. Jewell", "corpus_name": "Jewell JL", "orcid": null, "lab": "Jewell Lab, Department of Molecular Biology, UT Southwestern Medical Center (Dallas, Texas, USA)", "lab_url": "https://profiles.utsouthwestern.edu/profile/162357/jenna-jewell.html", "role": "Studies how cells sense nutrients such as amino acids to control growth and metabolism through mTORC1", "studies": [ "JEW2015" ], "url": "https://mtor-atlas.org/author/jenna-l-jewell/" }, { "id": "dana-m-gwinn", "name": "Dana M. Gwinn", "corpus_name": "Gwinn DM", "orcid": null, "lab": "Shaw Lab, Salk Institute for Biological Studies, at the time of the study (La Jolla, California, USA)", "lab_url": null, "role": "First author of the 2008 study showing that the energy sensor AMPK switches off mTORC1 by phosphorylating raptor", "studies": [ "GWI2008", "EGA2010" ], "url": "https://mtor-atlas.org/author/dana-m-gwinn/" }, { "id": "maria-m-mihaylova", "name": "Maria M. Mihaylova", "corpus_name": "Mihaylova MM", "orcid": null, "lab": "Mihaylova Lab, Department of Biological Chemistry and Pharmacology, The Ohio State University (Columbus, Ohio, USA)", "lab_url": "https://www.pew.org/en/projects/pew-biomedical-scholars/directory-of-pew-scholars/2022/maria-m-mihaylova", "role": "Studies how intestinal stem cells change with age and how diet shapes their metabolism", "studies": [ "GWI2008", "EGA2010" ], "url": "https://mtor-atlas.org/author/maria-m-mihaylova/" }, { "id": "emilie-vander-haar", "name": "Emilie Vander Haar", "corpus_name": "Vander Haar E", "orcid": null, "lab": "Kim Lab, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, at the time of the study (Minneapolis, Minnesota, USA)", "lab_url": null, "role": "First author of the 2007 study identifying PRAS40 as the link that carries insulin signals from Akt to mTOR", "studies": [ "VAN2007" ], "url": "https://mtor-atlas.org/author/emilie-vander-haar/" }, { "id": "diane-c-fingar", "name": "Diane C. Fingar", "corpus_name": "Fingar DC", "orcid": null, "lab": "Fingar Lab, Department of Cell and Developmental Biology, University of Michigan Medical School (Ann Arbor, Michigan, USA)", "lab_url": "https://medschool.umich.edu/profile/1417/diane-c-fingar", "role": "Studies how mTORC1 and mTORC2 are regulated, especially through site-specific phosphorylation", "studies": [ "SCH2003", "FIN2002", "TEE2002" ], "url": "https://mtor-atlas.org/author/diane-c-fingar/" }, { "id": "darcy-a-krueger", "name": "Darcy A. Krueger", "corpus_name": "Krueger DA", "orcid": null, "lab": "Tuberous Sclerosis Clinic, Cincinnati Children's Hospital Medical Center (Cincinnati, Ohio, USA)", "lab_url": "https://www.reachmd.com/profiles/darcy-a-krueger-md-phd/jGbbxV/biography/", "role": "Child neurologist who led the first trial of an mTOR inhibitor for brain tumours in tuberous sclerosis complex", "studies": [ "KRU2010" ], "url": "https://mtor-atlas.org/author/darcy-a-krueger/" }, { "id": "brinda-ravikumar", "name": "Brinda Ravikumar", "corpus_name": "Ravikumar B", "orcid": null, "lab": "Rubinsztein Lab, Cambridge Institute for Medical Research, University of Cambridge, at the time of the study (Cambridge, England, United Kingdom)", "lab_url": null, "role": "First author of the 2004 study showing that switching off mTOR clears the toxic protein of Huntington disease by autophagy", "studies": [ "BER2006", "RAV2004" ], "url": "https://mtor-atlas.org/author/brinda-ravikumar/" }, { "id": "colin-selman", "name": "Colin Selman", "corpus_name": "Selman C", "orcid": null, "lab": "School of Molecular Biosciences, University of Glasgow (Glasgow, Scotland, United Kingdom)", "lab_url": "https://www.gla.ac.uk/schools/molecularbiosciences/staff/colinselman", "role": "Biogerontologist who studies how diet and nutrient-sensing pathways such as insulin/IGF-1 and mTOR set the pace of ageing", "studies": [ "SEL2009" ], "url": "https://mtor-atlas.org/author/colin-selman/" }, { "id": "ivana-bjedov", "name": "Ivana Bjedov", "corpus_name": "Bjedov I", "orcid": null, "lab": "UCL Cancer Institute, University College London (London, England, United Kingdom)", "lab_url": null, "role": "Studies DNA repair and protein synthesis in ageing; showed that rapamycin extends lifespan in fruit flies", "studies": [ "BJE2010" ], "url": "https://mtor-atlas.org/author/ivana-bjedov/" }, { "id": "greg-m-findlay", "name": "Greg M. Findlay", "corpus_name": "Findlay GM", "orcid": null, "lab": "MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee (Dundee, Scotland, United Kingdom)", "lab_url": "https://www.ppu.mrc.ac.uk/research/principal-investigator/biography/greg-findlay", "role": "Uses pluripotent stem cells to study how faulty signalling by protein kinases causes intellectual disability", "studies": [ "HAR2004" ], "url": "https://mtor-atlas.org/author/greg-m-findlay/" }, { "id": "laura-s-harrington", "name": "Laura S. Harrington", "corpus_name": "Harrington LS", "orcid": null, "lab": "Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, at the time of the study (London, England, United Kingdom)", "lab_url": null, "role": "First author of the 2004 study showing that TSC1-2 loss blunts insulin signalling through S6K1-driven feedback on IRS proteins", "studies": [ "HAR2004" ], "url": "https://mtor-atlas.org/author/laura-s-harrington/" }, { "id": "richard-f-lamb", "name": "Richard F. Lamb", "corpus_name": "Lamb RF", "orcid": null, "lab": "School of Health Sciences, Liverpool Hope University (Liverpool, England, United Kingdom)", "lab_url": null, "role": "Studied how amino acids and growth signals reach mTOR, including the IRS feedback loop and nutrient signalling through MAP4K3", "studies": [ "HAR2004" ], "url": "https://mtor-atlas.org/author/richard-f-lamb/" }, { "id": "jennifer-hong", "name": "Jennifer Hong", "corpus_name": "Hong J", "orcid": null, "lab": "Departments of Surgery and Molecular and Systems Biology, Geisel School of Medicine at Dartmouth (Hanover, New Hampshire, USA)", "lab_url": "https://geiselmed.dartmouth.edu/faculty/facultydb/view.php/?uid=7031", "role": "Neurosurgeon-scientist who studies peripheral nerve regeneration and epilepsy", "studies": [ "EVA2026" ], "url": "https://mtor-atlas.org/author/jennifer-hong/" }, { "id": "yi-ji", "name": "Yi Ji", "corpus_name": "Ji Y", "orcid": null, "lab": "Division of Oncology, Department of Pediatric Surgery, West China Hospital, Sichuan University (Chengdu, Sichuan, China)", "lab_url": "https://wchscu.cn/details/63935.html", "role": "Paediatric surgeon whose team studies sirolimus treatment of kaposiform hemangioendothelioma in children", "studies": [ "XU2026" ], "url": "https://mtor-atlas.org/author/yi-ji/" }, { "id": "marcus-d-saemann", "name": "Marcus D. Säemann", "corpus_name": "Säemann MD", "orcid": null, "lab": "Chair of Nephrology, Sigmund Freud University Vienna (Vienna, Austria)", "lab_url": "https://sfu.ac.at/en/person/saeemann-marcus", "role": "Nephrologist who showed that the TSC-mTOR pathway controls the innate inflammatory response", "studies": [ "WEI2008" ], "url": "https://mtor-atlas.org/author/marcus-d-saemann/" }, { "id": "pierrick-bedouch", "name": "Pierrick Bedouch", "corpus_name": "Bedouch P", "orcid": null, "lab": "ThEMAS team, TIMC laboratory (CNRS UMR 5525), Université Grenoble Alpes, and Pharmacy Department, CHU Grenoble Alpes (Grenoble, France)", "lab_url": "https://www.timc.fr/en/pierrick-bedouch", "role": "Clinical pharmacist who studies the prevention of adverse drug events and pharmacoepidemiology", "studies": [ "LANDOAS2026" ], "url": "https://mtor-atlas.org/author/pierrick-bedouch/" }, { "id": "justin-g-meyerowitz", "name": "Justin G. Meyerowitz", "corpus_name": "Meyerowitz JG", "orcid": null, "lab": "Revolution Medicines (Redwood City, California, USA)", "lab_url": null, "role": "Industry scientist on the team that developed RMC-5552, a bi-steric inhibitor selective for mTORC1", "studies": [ "SCH2025" ], "url": "https://mtor-atlas.org/author/justin-g-meyerowitz/" }, { "id": "hsin-sheng-yang", "name": "Hsin-Sheng Yang", "corpus_name": "Yang HS", "orcid": null, "lab": "Department of Toxicology and Cancer Biology and Markey Cancer Center, University of Kentucky College of Medicine (Lexington, Kentucky, USA)", "lab_url": "https://medicine.uky.edu/departments/toxicology/users/hyang3", "role": "Studies translational control of genes that drive tumour invasion and metastasis, centred on the tumour suppressor Pdcd4", "studies": [ "WANG2026B" ], "url": "https://mtor-atlas.org/author/hsin-sheng-yang/" }, { "id": "peter-bai", "name": "Peter Bai", "corpus_name": "Bai P", "orcid": null, "lab": "Department of Medical Chemistry, Faculty of Medicine, University of Debrecen (Debrecen, Hungary)", "lab_url": "https://tudoster.unideb.hu/en/szerzok/376", "role": "Biochemist who studies PARP enzymes, mitochondria and metabolism", "studies": [ "RAUCH2026" ], "url": "https://mtor-atlas.org/author/peter-bai/" }, { "id": "antonio-carlos-de-freitas", "name": "Antonio Carlos de Freitas", "corpus_name": "de Freitas AC", "orcid": null, "lab": "Laboratory of Molecular Studies and Experimental Therapy (LEMTE), Department of Genetics, Federal University of Pernambuco (Recife, Brazil)", "lab_url": "https://bv.fapesp.br/en/pesquisador/53124/URL", "role": "Geneticist who studies human papillomavirus, HPV vaccines and diagnostics, and links between HPV and breast and lung cancer", "studies": [ "DEOLIVEIRA2026" ], "url": "https://mtor-atlas.org/author/antonio-carlos-de-freitas/" }, { "id": "antoine-fraissenon", "name": "Antoine Fraissenon", "corpus_name": "Fraissenon A", "orcid": null, "lab": "Pediatric and Fetal Imaging, Hôpital Femme Mère Enfant, Hospices Civils de Lyon; INSERM U1151, Institut Necker-Enfants Malades, Paris (Lyon, France)", "lab_url": null, "role": "Paediatric radiologist who works on vascular anomalies and PIK3CA-related overgrowth", "studies": [ "GUIB2026" ], "url": "https://mtor-atlas.org/author/antoine-fraissenon/" }, { "id": "fredrick-j-rosario", "name": "Fredrick J. Rosario", "corpus_name": "Rosario FJ", "orcid": null, "lab": "Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus (Aurora, Colorado, USA)", "lab_url": "https://medschool.cuanschutz.edu/ob-gyn/divisions/division-of-reproductive-sciences/our-faculty/fredrick-rosario-joseph-phd", "role": "Studies how mTOR signalling in the placenta controls the transport of amino acids and folate to the fetus", "studies": [ "SHIMADA2026" ], "url": "https://mtor-atlas.org/author/fredrick-j-rosario/" }, { "id": "moises-santillan", "name": "Moisés Santillán", "corpus_name": "Santillán M", "orcid": null, "lab": "Unidad Monterrey, Centro de Investigación y de Estudios Avanzados del IPN (Cinvestav) (Apodaca, Nuevo León, Mexico)", "lab_url": "https://loop.frontiersin.org/people/8553/publications", "role": "Builds mathematical models of biological regulation, including how the circadian clock and mTORC1 influence each other", "studies": [ "GUE2020" ], "url": "https://mtor-atlas.org/author/moises-santillan/" }, { "id": "maureen-r-horton", "name": "Maureen R. Horton", "corpus_name": "Horton MR", "orcid": null, "lab": "Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine (Baltimore, Maryland, USA)", "lab_url": "https://the-asci.org/controllers/asci/AsciProfileController.php?pid=501524", "role": "Pulmonary physician-scientist who studies immune mechanisms of lung inflammation and fibrosis", "studies": [ "DEL2011", "POW2011" ], "url": "https://mtor-atlas.org/author/maureen-r-horton/" }, { "id": "manuel-carcao", "name": "Manuel Carcao", "corpus_name": "Carcao M", "orcid": null, "lab": "Division of Haematology/Oncology, The Hospital for Sick Children (SickKids), and Institute of Medical Science, University of Toronto (Toronto, Ontario, Canada)", "lab_url": "https://ims.utoronto.ca/faculty/manuel-carcao", "role": "Paediatric haematologist specialising in bleeding disorders", "studies": [ "MCNEILL2026" ], "url": "https://mtor-atlas.org/author/manuel-carcao/" }, { "id": "cheng-hu", "name": "Cheng Hu", "corpus_name": "Hu C", "orcid": null, "lab": "Shanghai Diabetes Institute, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine (Shanghai, China)", "lab_url": "https://www.shsmu.edu.cn/english/info/1343/2860.htm", "role": "Studies the genetics and causes of diabetes and obesity", "studies": [ "XIA2026" ], "url": "https://mtor-atlas.org/author/cheng-hu/" }, { "id": "jaume-capdevila", "name": "Jaume Capdevila", "corpus_name": "Capdevila J", "orcid": null, "lab": "Gastrointestinal and Endocrine Tumors Group, Vall d'Hebron Institute of Oncology (VHIO) (Barcelona, Spain)", "lab_url": "https://vhio.net/biosketch-jaume-capdevila/", "role": "Medical oncologist specialising in neuroendocrine and endocrine tumours", "studies": [ "WALTER2026", "YAO2011" ], "url": "https://mtor-atlas.org/author/jaume-capdevila/" }, { "id": "wen-xing-ding", "name": "Wen-Xing Ding", "corpus_name": "Ding WX", "orcid": null, "lab": "Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center (Kansas City, Kansas, USA)", "lab_url": "https://www.kumc.edu/wxding.html", "role": "Studies autophagy and mitophagy in liver injury and the roles of Nrf2 and mTOR in liver disease and cancer", "studies": [ "ZHANG2026" ], "url": "https://mtor-atlas.org/author/wen-xing-ding/" }, { "id": "barbara-e-bierer", "name": "Barbara E. Bierer", "corpus_name": "Bierer BE", "orcid": null, "lab": "Brigham and Women's Hospital and Harvard Medical School; Multi-Regional Clinical Trials Center (Boston, Massachusetts, USA)", "lab_url": "https://bioethics.hms.harvard.edu/faculty-staff/barbara-bierer", "role": "Haematologist-oncologist and research-ethics leader whose early lab work helped show how rapamycin acts on immune cells", "studies": [ "PRI1992" ], "url": "https://mtor-atlas.org/author/barbara-e-bierer/" }, { "id": "max-l-valenstein", "name": "Max L. Valenstein", "corpus_name": "Valenstein ML", "orcid": null, "lab": "Internal Medicine Residency, Massachusetts General Hospital (Boston, Massachusetts, USA)", "lab_url": null, "role": "First author of the cryo-EM structures of GATOR2, the hub that tells mTORC1 whether amino acids are present, alone and bound to the sensors Sestrin2 and CASTOR1", "studies": [ "VAL2022", "VAL2025", "SHE2018" ], "url": "https://mtor-atlas.org/author/max-l-valenstein/" }, { "id": "pranav-v-lalgudi", "name": "Pranav V. Lalgudi", "corpus_name": "Lalgudi PV", "orcid": null, "lab": "Department of Genetics, Stanford University School of Medicine (Stanford, California, USA)", "lab_url": "https://profiles.stanford.edu/pranav-lalgudi", "role": "Co-author of the cryo-EM structures of GATOR2, the nutrient-sensing hub of mTORC1, in 2022 and of GATOR2 bound to Sestrin2 and CASTOR1 in 2025", "studies": [ "VAL2022", "VAL2025" ], "url": "https://mtor-atlas.org/author/pranav-v-lalgudi/" }, { "id": "rachel-m-jansen", "name": "Rachel M. Jansen", "corpus_name": "Jansen RM", "orcid": null, "lab": "Hurley Lab, UC Berkeley (Berkeley, California, USA)", "lab_url": "https://membrane.berkeley.edu/", "role": "First author of the cryo-EM structure showing how the arginine sensor CASTOR1 binds the GATOR2 cage when arginine is low and is released when arginine returns", "studies": [ "ESP2026", "JAN2025" ], "url": "https://mtor-atlas.org/author/rachel-m-jansen/" }, { "id": "christopher-j-potter", "name": "Christopher J. Potter", "corpus_name": "Potter CJ", "orcid": null, "lab": "Potter Lab, Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine (Baltimore, Maryland, USA)", "lab_url": "https://potterlab.johnshopkins.edu/", "role": "As a PhD student with Tian Xu at Yale, showed in Drosophila that Akt directly phosphorylates Tsc2 and breaks up the Tsc1-Tsc2 complex, one of several 2002 papers that connected insulin-Akt signalling to TSC. He now studies insect olfaction", "studies": [ "POT2002" ], "url": "https://mtor-atlas.org/author/christopher-j-potter/" }, { "id": "tian-xu", "name": "Tian Xu", "corpus_name": "Xu T", "orcid": null, "lab": "Xu Lab, Westlake University (Hangzhou, Zhejiang, China)", "lab_url": "https://westlake.edu.cn/faculty/tian-xu.html", "role": "Drosophila geneticist whose Yale lab helped show that Akt controls growth by phosphorylating the tumour suppressor Tsc2, linking the insulin pathway to TSC", "studies": [ "POT2002" ], "url": "https://mtor-atlas.org/author/tian-xu/" }, { "id": "duojia-pan", "name": "Duojia Pan", "corpus_name": "Pan D", "orcid": null, "lab": "Pan Lab, Department of Physiology, UT Southwestern Medical Center (Dallas, Texas, USA)", "lab_url": "https://profiles.utsouthwestern.edu/profile/37929/", "role": "Fly geneticist best known for work on the Hippo organ-size pathway. In 2002 his group reported that the Tsc1 and Tsc2 tumour suppressors act upstream of TOR to restrain S6K activity, in flies and mammalian cells", "studies": [ "GAO2002" ], "url": "https://mtor-atlas.org/author/duojia-pan/" }, { "id": "patrick-b-dennis", "name": "Patrick B. Dennis", "corpus_name": "Dennis PB", "orcid": null, "lab": "Materials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base (Dayton, Ohio, USA)", "lab_url": null, "role": "As a postdoc in George Thomas's lab at the Friedrich Miescher Institute, was first author on the 2001 study proposing that mTOR responds to cellular ATP levels independently of amino acids", "studies": [ "DEN2001" ], "url": "https://mtor-atlas.org/author/patrick-b-dennis/" }, { "id": "jacques-montagne", "name": "Jacques Montagne", "corpus_name": "Montagne J", "orcid": null, "lab": "CNRS, Institut de Génomique Fonctionnelle de Lyon, ENS de Lyon (Lyon, France)", "lab_url": null, "role": "Drosophila geneticist who, working in George Thomas's group, showed that flies lacking S6 kinase are small because their cells are small, not fewer, and helped characterise fly TOR", "studies": [ "MON1999", "OLD2000" ], "url": "https://mtor-atlas.org/author/jacques-montagne/" }, { "id": "thomas-p-neufeld", "name": "Thomas P. Neufeld", "corpus_name": "Neufeld TP", "orcid": null, "lab": "Neufeld Lab, Department of Genetics, Cell Biology and Development, University of Minnesota (Minneapolis, Minnesota, USA)", "lab_url": "https://cbs.umn.edu/directory/thomas-neufeld", "role": "Uses Drosophila to study how TOR signalling controls cell growth and autophagy; his group was one of two that described the fly TOR gene in 2000", "studies": [ "ZHA2000" ], "url": "https://mtor-atlas.org/author/thomas-p-neufeld/" }, { "id": "michael-n-corradetti", "name": "Michael N. Corradetti", "corpus_name": "Corradetti MN", "orcid": null, "lab": "Radiation Oncology, Providence Queen of the Valley Medical Center (Napa, California, USA)", "lab_url": "https://providence.org/doctors/radiation-oncology/ca/napa/michael-corradetti-1093977621", "role": "As an MD-PhD student at the University of Michigan, was first author on the 2004 study linking the LKB1 tumour suppressor to TSC2 through AMPK. He is now a radiation oncologist", "studies": [ "COR2004" ], "url": "https://mtor-atlas.org/author/michael-n-corradetti/" }, { "id": "m-phillip-deyoung", "name": "M. Phillip DeYoung", "corpus_name": "DeYoung MP", "orcid": null, "lab": "Ellisen Lab, Massachusetts General Hospital Cancer Center (Boston, Massachusetts, USA)", "lab_url": null, "role": "As a research fellow in Leif Ellisen's lab, was first author on the 2008 study showing that hypoxia switches off mTORC1 through REDD1 releasing TSC2 from 14-3-3 proteins", "studies": [ "DEY2008" ], "url": "https://mtor-atlas.org/author/m-phillip-deyoung/" }, { "id": "leif-w-ellisen", "name": "Leif W. Ellisen", "corpus_name": "Ellisen LW", "orcid": null, "lab": "Ellisen Lab, Mass General Cancer Center, Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://researchers.mgh.harvard.edu/profile/3660991/Leif-Ellisen", "role": "Physician-scientist whose lab studies REDD1, a stress-induced inhibitor of mTORC1, and showed how hypoxia uses REDD1 to release TSC2 from 14-3-3 proteins", "studies": [ "DEY2008" ], "url": "https://mtor-atlas.org/author/leif-w-ellisen/" }, { "id": "russell-g-jones", "name": "Russell G. Jones", "corpus_name": "Jones RG", "orcid": null, "lab": "Jones Lab, Department of Metabolism and Nutritional Programming, Van Andel Institute (Grand Rapids, Michigan, USA)", "lab_url": "https://russelljoneslab.vai.org/", "role": "Studies how nutrient and energy sensing by AMPK and mTOR shapes cell metabolism, especially in T cells and cancer. As a postdoc with Craig Thompson he showed that AMPK triggers a p53-dependent glucose checkpoint in the cell cycle", "studies": [ "JON2005", "PEA2009" ], "url": "https://mtor-atlas.org/author/russell-g-jones/" }, { "id": "craig-b-thompson", "name": "Craig B. Thompson", "corpus_name": "Thompson CB", "orcid": null, "lab": "Thompson Lab, Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center (New York, New York, USA)", "lab_url": "https://www.mskcc.org/research/ski/labs/craig-thompson", "role": "Cancer biologist whose lab studies how growth signals control the uptake and use of nutrients; senior author of the study that described an AMPK- and p53-dependent glucose checkpoint in the cell cycle", "studies": [ "JON2005" ], "url": "https://mtor-atlas.org/author/craig-b-thompson/" }, { "id": "angela-alexander", "name": "Angela Alexander", "corpus_name": "Alexander A", "orcid": null, "lab": "Morgan Welch Inflammatory Breast Cancer Research Program, Department of Breast Medical Oncology, MD Anderson Cancer Center (Houston, Texas, USA)", "lab_url": null, "role": "First author of the study showing that the DNA-damage kinase ATM also works in the cytoplasm, where it switches on TSC2 in response to reactive oxygen species and so turns mTORC1 down", "studies": [ "ALE2010" ], "url": "https://mtor-atlas.org/author/angela-alexander/" }, { "id": "cheryl-lyn-walker", "name": "Cheryl Lyn Walker", "corpus_name": "Walker CL", "orcid": null, "lab": "Center for Precision Environmental Health, Baylor College of Medicine (Houston, Texas, USA)", "lab_url": "https://www.bcm.edu/academic-centers/precision-environmental-health/faculty/leadership", "role": "Cancer biologist and toxicologist who studies how environmental exposures reprogram the epigenome and target tumour suppressor genes; senior author of the study linking ATM to TSC2 and mTORC1 in the response to oxidative stress", "studies": [ "ALE2010" ], "url": "https://mtor-atlas.org/author/cheryl-lyn-walker/" }, { "id": "charles-l-sawyers", "name": "Charles L. Sawyers", "corpus_name": "Sawyers CL", "orcid": null, "lab": "Sawyers Lab, Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center (New York, New York, USA)", "lab_url": "https://www.mskcc.org/research/lab/charles-sawyers", "role": "Physician-scientist known for targeted cancer drugs (ABL inhibitors in leukaemia, antiandrogens in prostate cancer); his UCLA lab helped show that PTEN-deficient tumour cells depend more on mTOR", "studies": [ "NES2001", "POD2001" ], "url": "https://mtor-atlas.org/author/charles-l-sawyers/" }, { "id": "katrina-podsypanina", "name": "Katrina Podsypanina", "corpus_name": "Podsypanina K", "orcid": null, "lab": "Manoury team, Institut Necker Enfants Malades, INSERM U1151 / Université Paris Cité (Paris, France)", "lab_url": "https://www.institut-necker-enfants-malades.fr/en-gb/node/3291", "role": "First author of the study showing that an mTOR inhibitor reduced tumour growth and S6 kinase activity in Pten+/- mice; later moved from cancer genetics to tumour immunology", "studies": [ "POD2001" ], "url": "https://mtor-atlas.org/author/katrina-podsypanina/" }, { "id": "ramon-parsons", "name": "Ramon Parsons", "corpus_name": "Parsons R", "orcid": null, "lab": "Parsons Lab, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai (New York, New York, USA)", "lab_url": "https://profiles.icahn.mssm.edu/ramon-parsons", "role": "Cancer geneticist whose Columbia group identified the PTEN tumour suppressor gene in 1997, in parallel with another team; his lab then studied what goes wrong downstream of PTEN loss, including mTOR", "studies": [ "POD2001" ], "url": "https://mtor-atlas.org/author/ramon-parsons/" }, { "id": "tatsuhiro-sato", "name": "Tatsuhiro Sato", "corpus_name": "Sato T", "orcid": null, "lab": "Department of Tumor Control, Aichi Cancer Center Research Institute (Nagoya, Aichi, Japan)", "lab_url": "https://cancer-c.pref.aichi.jp/research-staff/1190/", "role": "First author of the study that found single amino-acid changes in mTOR, taken from cancer genome databases, that keep mTOR signalling on during nutrient starvation", "studies": [ "SAT2010" ], "url": "https://mtor-atlas.org/author/tatsuhiro-sato/" }, { "id": "fuyuhiko-tamanoi", "name": "Fuyuhiko Tamanoi", "corpus_name": "Tamanoi F", "orcid": null, "lab": "Tamanoi Lab, Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University (Kyoto, Japan)", "lab_url": "https://www.icems.kyoto-u.ac.jp/en/people/1413/", "role": "Biochemist who studied protein farnesylation and the Rheb–TOR pathway in fission yeast and mammalian cells; senior author of the study that found activating mTOR mutations in human cancer data", "studies": [ "SAT2010" ], "url": "https://mtor-atlas.org/author/fuyuhiko-tamanoi/" }, { "id": "katrin-duvel", "name": "Katrin Düvel", "corpus_name": "Düvel K", "orcid": null, "lab": "Research Compliance and Integrity, Wyss Institute for Biologically Inspired Engineering at Harvard University (Boston, Massachusetts, USA)", "lab_url": "https://wyss.harvard.edu/team/administration-operations/katrin-duevel", "role": "First author of the study showing that mTORC1 switches on a metabolic gene program through HIF1α and SREBP, driving glycolysis, the pentose phosphate pathway and lipid synthesis", "studies": [ "DUV2010" ], "url": "https://mtor-atlas.org/author/katrin-duvel/" }, { "id": "gregory-bonfils", "name": "Grégory Bonfils", "corpus_name": "Bonfils G", "orcid": null, "lab": "De Virgilio Lab, Department of Biology, University of Fribourg (Fribourg, Canton of Fribourg, Switzerland)", "lab_url": "https://www.unifr.ch/directory/en/people/4480/3a13b", "role": "First author of the yeast study proposing that leucyl-tRNA synthetase passes the leucine signal to TORC1 by binding the Rag GTPase Gtr1", "studies": [ "BON2012" ], "url": "https://mtor-atlas.org/author/gregory-bonfils/" }, { "id": "pawan-gulati", "name": "Pawan Gulati", "corpus_name": "Gulati P", "orcid": null, "lab": "Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, University of Cambridge (Cambridge, England, United Kingdom)", "lab_url": null, "role": "First author of the study proposing that amino acids activate mTORC1 through a rise in intracellular calcium and calmodulin binding to hVps34, and later of work linking the obesity gene FTO to amino-acid sensing by mTORC1", "studies": [ "GUL2008" ], "url": "https://mtor-atlas.org/author/pawan-gulati/" }, { "id": "valeria-facchinetti", "name": "Valeria Facchinetti", "corpus_name": "Facchinetti V", "orcid": null, "lab": "Department of Immunology, MD Anderson Cancer Center (Houston, Texas, USA)", "lab_url": null, "role": "First author of the study showing that mTORC2 phosphorylates the turn motif of Akt and conventional PKC as the proteins are made, which helps them fold and stay stable", "studies": [ "FAC2008" ], "url": "https://mtor-atlas.org/author/valeria-facchinetti/" }, { "id": "mario-pende", "name": "Mario Pende", "corpus_name": "Pende M", "orcid": null, "lab": "Cell Growth Control by Nutrients team, Institut Necker Enfants Malades, INSERM (Paris, France)", "lab_url": "https://www.institut-necker-enfants-malades.fr/en-gb/node/3040", "role": "Studies how nutrients and growth factors set cell size and metabolism through mTOR and S6 kinase; as a student in George Thomas's lab he helped show that mice lacking S6K1 have small pancreatic beta-cells and low insulin.", "studies": [ "PEN2000", "SHI1998" ], "url": "https://mtor-atlas.org/author/mario-pende/" }, { "id": "oded-meyuhas", "name": "Oded Meyuhas", "corpus_name": "Meyuhas O", "orcid": null, "lab": "Meyuhas Lab, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Hebrew University of Jerusalem (Jerusalem, Israel)", "lab_url": "https://medicine.ekmd.huji.ac.il/en/research/odedm", "role": "Studies how mRNAs with a 5'TOP motif, which encode ribosomal proteins, are controlled, and what phosphorylation of ribosomal protein S6 does in the cell; his lab built the knock-in mouse in which rpS6 cannot be phosphorylated.", "studies": [ "RUV2005" ], "url": "https://mtor-atlas.org/author/oded-meyuhas/" }, { "id": "harold-jefferies", "name": "Harold Jefferies", "corpus_name": "Jefferies HB", "orcid": null, "lab": "Molecular Cell Biology of Autophagy Laboratory (Tooze lab), The Francis Crick Institute (London, England, United Kingdom)", "lab_url": "https://www.crick.ac.uk/research/find-a-researcher/harold-jefferies", "role": "Biochemist who worked on S6 kinase and 5'TOP mRNA translation in George Thomas's lab and has studied the molecular machinery of autophagy in Sharon Tooze's lab since 2003.", "studies": [ "JEF1997" ], "url": "https://mtor-atlas.org/author/harold-jefferies/" }, { "id": "ola-larsson", "name": "Ola Larsson", "corpus_name": "Larsson O", "orcid": "0000-0003-1412-1308", "lab": "Translational Control of Cancer group, Department of Oncology-Pathology, Karolinska Institutet (Stockholm, Sweden)", "lab_url": "https://ki.se/en/research/groups/translational-control-of-cancer-ola-larssons-group", "role": "Studies how mRNA translation is altered in cancer and develops methods to measure genome-wide translation; helped show that metformin changes which mRNAs cancer cells translate, through the mTORC1/4E-BP pathway.", "studies": [ "LAR2012" ], "url": "https://mtor-atlas.org/author/ola-larsson/" }, { "id": "stefan-m-schieke", "name": "Stefan M. Schieke", "corpus_name": "Schieke SM", "orcid": null, "lab": "Department of Dermatology, Georgetown University Medical Center and MedStar Health (Washington, District of Columbia, USA)", "lab_url": "https://www.medstarhealth.org/doctors/stefan-m-schieke-md", "role": "Physician-scientist who, as a postdoc at the NHLBI, helped show that mTOR-raptor activity tracks mitochondrial oxygen consumption in human cells; his lab now studies the metabolism of lymphoid cancers.", "studies": [ "SCH2006" ], "url": "https://mtor-atlas.org/author/stefan-m-schieke/" }, { "id": "edmond-y-w-chan", "name": "Edmond Y. W. Chan", "corpus_name": "Chan EY", "orcid": null, "lab": "Chan Lab, Department of Biomedical and Molecular Sciences, Queen's University (Kingston, Ontario, Canada)", "lab_url": "https://dbms.queensu.ca/faculty/edmond-chan/chan-lab", "role": "Studies how nutrient-sensing kinases, including ULK1, mTORC1 and AMPK, control autophagy and mitochondrial stress responses; in Sharon Tooze's lab he helped identify ULK1 as a kinase needed for starvation-induced autophagy in human cells.", "studies": [ "CHA2007" ], "url": "https://mtor-atlas.org/author/edmond-y-w-chan/" }, { "id": "sharon-a-tooze", "name": "Sharon A. Tooze", "corpus_name": "Tooze SA", "orcid": null, "lab": "Molecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute (London, England, United Kingdom)", "lab_url": "https://www.crick.ac.uk/research/find-a-researcher/sharon-tooze", "role": "Cell biologist who studies how autophagosomes are built in mammalian cells; her lab has identified several mammalian Atg proteins and helped show that ULK1 is needed for starvation-induced autophagy.", "studies": [ "CHA2007" ], "url": "https://mtor-atlas.org/author/sharon-a-tooze/" }, { "id": "ryan-c-russell", "name": "Ryan C. Russell", "corpus_name": "Russell RC", "orcid": null, "lab": "Russell Lab, Department of Cellular and Molecular Medicine, University of Ottawa (Ottawa, Ontario, Canada)", "lab_url": "https://www.uottawa.ca/faculty-medicine/dr-ryan-russell", "role": "Studies how the nutrient-sensing kinases mTORC1, ULK1 and AMPK control the autophagy machinery; as a postdoc with Kun-Liang Guan he showed that ULK1 phosphorylates Beclin-1 to switch on the autophagy-specific VPS34 complex.", "studies": [ "RUS2013" ], "url": "https://mtor-atlas.org/author/ryan-c-russell/" }, { "id": "marco-sardiello", "name": "Marco Sardiello", "corpus_name": "Sardiello M", "orcid": "0000-0001-6484-0250", "lab": "Sardiello Lab, Division of Genetics and Genomic Medicine, Department of Pediatrics, Washington University School of Medicine (St. Louis, Missouri, USA)", "lab_url": "https://pediatricgeneticsgenomics.wustl.edu/items/sardiello-lab/", "role": "Geneticist who, in Andrea Ballabio's group, helped show that lysosomal genes share a promoter motif and are switched on together by the transcription factor TFEB; his lab now works on lysosomal storage diseases, especially the neuronal ceroid lipofuscinoses.", "studies": [ "SAR2009" ], "url": "https://mtor-atlas.org/author/marco-sardiello/" }, { "id": "samuel-pena-llopis", "name": "Samuel Peña-Llopis", "corpus_name": "Peña-Llopis S", "orcid": null, "lab": "Translational Genomics group, Department of Ophthalmology, University Hospital Essen (Essen, North Rhine-Westphalia, Germany)", "lab_url": "https://augenklinik.uk-essen.de/ag-translationale-genomik/", "role": "Cancer geneticist who, in James Brugarolas's lab, found that mTORC1 controls expression of lysosomal V-ATPase genes through TFEB; his group now studies BAP1-mutant uveal melanoma, kidney cancer and cholangiocarcinoma.", "studies": [ "PEN2011" ], "url": "https://mtor-atlas.org/author/samuel-pena-llopis/" }, { "id": "jose-a-martina", "name": "José A. Martina", "corpus_name": "Martina JA", "orcid": null, "lab": "Puertollano group, Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, NIH (Bethesda, Maryland, USA)", "lab_url": "https://irp.nih.gov/pi/rosa-puertollano", "role": "Cell biologist in Rosa Puertollano's group at the NHLBI who works on how mTORC1 and the Rag GTPases control the lysosomal transcription factors TFEB and TFE3.", "studies": [ "MAR2013" ], "url": "https://mtor-atlas.org/author/jose-a-martina/" }, { "id": "calvin-k-yip", "name": "Calvin K. Yip", "corpus_name": "Yip CK", "orcid": null, "lab": "Yip Lab, Department of Biochemistry and Molecular Biology and Life Sciences Institute, University of British Columbia (Vancouver, British Columbia, Canada)", "lab_url": "https://biochem.ubc.ca/person/calvin-yip/", "role": "Structural biologist who uses electron microscopy to study large protein machines; as a postdoc at Harvard Medical School he determined a cryo-EM structure of human mTORC1, and his lab now studies the autophagy machinery.", "studies": [ "YIP2010" ], "url": "https://mtor-atlas.org/author/calvin-k-yip/" }, { "id": "rong-wang", "name": "Rong Wang", "corpus_name": "Wang Rong", "orcid": null, "lab": "Pérez Lab, Linus Pauling Institute, Oregon State University (affiliation on WAN2017) (Corvallis, Oregon, USA)", "lab_url": "https://lpi.oregonstate.edu/viviana-perez", "role": "Researcher in Viviana Pérez's group at the Linus Pauling Institute who studied how rapamycin holds back cellular senescence, and first author of work separating its effect on the senescence secretory profile from its Nrf2-dependent effect on cell-cycle arrest", "studies": [ "WAN2017" ], "url": "https://mtor-atlas.org/author/rong-wang/" }, { "id": "viviana-i-perez", "name": "Viviana I. Pérez", "corpus_name": "Perez VI", "orcid": null, "lab": "Division of Aging Biology, National Institute on Aging, NIH (Bethesda, Maryland, USA)", "lab_url": "https://www.nia.nih.gov/research/dab", "role": "Aging biologist who studied protein homeostasis in long-lived species and how rapamycin and dietary restriction act in mice, and who now directs the National Institute on Aging's Division of Aging Biology", "studies": [ "WAN2017" ], "url": "https://mtor-atlas.org/author/viviana-i-perez/" }, { "id": "vladimir-n-anisimov", "name": "Vladimir N. Anisimov", "corpus_name": "Anisimov VN", "orcid": null, "lab": "In memoriam / Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology (St. Petersburg, Russia)", "lab_url": "https://www.niioncologii.ru/en/science/cangen", "role": "Russian gerontologist and oncologist who studied the links between ageing and cancer, and whose group tested drugs such as metformin and rapamycin for effects on lifespan and spontaneous tumours in mice", "studies": [ "ANI2011" ], "url": "https://mtor-atlas.org/author/vladimir-n-anisimov/" }, { "id": "kathleen-e-fischer", "name": "Kathleen E. Fischer", "corpus_name": "Fischer KE", "orcid": null, "lab": "Department of Biology, University of Alabama at Birmingham (Birmingham, Alabama, USA)", "lab_url": "https://www.uab.edu/cas/biology/people/affiliated-faculty/kathleen-e-fischer", "role": "Comparative biologist of ageing who studies why ageing rates differ between sexes, strains and species, and who led a long-term study of how lifelong rapamycin affects health measures in mice", "studies": [ "FIS2015" ], "url": "https://mtor-atlas.org/author/kathleen-e-fischer/" }, { "id": "steven-n-austad", "name": "Steven N. Austad", "corpus_name": "Austad SN", "orcid": null, "lab": "Austad Lab, Department of Biology, University of Alabama at Birmingham (Birmingham, Alabama, USA)", "lab_url": "https://www.uab.edu/cas/biology/people/faculty/steven-n-austad", "role": "Comparative biologist of ageing who studies why some species and one sex live longer than others, and who directs the UAB Nathan Shock Center; senior author of a study of how lifelong rapamycin affects health in mice", "studies": [ "FIS2015" ], "url": "https://mtor-atlas.org/author/steven-n-austad/" }, { "id": "smita-majumder", "name": "Smita Majumder", "corpus_name": "Majumder S", "orcid": null, "lab": "Department of Physiology, University of Texas Health Science Center at San Antonio (affiliation on MAJ2012) (San Antonio, Texas, USA)", "lab_url": null, "role": "First author of a mouse study in Salvatore Oddo's group showing that rapamycin started early in life, but not in middle age, protected against age-related memory decline", "studies": [ "MAJ2012" ], "url": "https://mtor-atlas.org/author/smita-majumder/" }, { "id": "omer-h-yilmaz", "name": "Ömer H. Yilmaz", "corpus_name": "Yilmaz ÖH", "orcid": null, "lab": "Yilmaz Lab, Koch Institute for Integrative Cancer Research and Department of Biology, MIT (Cambridge, Massachusetts, USA)", "lab_url": "https://yilmaz-lab.mit.edu/", "role": "Pathologist and stem-cell biologist who studies how diet and nutrient sensing control intestinal stem cells; as a postdoc with David Sabatini he showed that calorie restriction acts on the stem-cell niche through mTORC1 in Paneth cells", "studies": [ "YIL2012" ], "url": "https://mtor-atlas.org/author/omer-h-yilmaz/" }, { "id": "erika-l-pearce", "name": "Erika L. Pearce", "corpus_name": "Pearce EL", "orcid": null, "lab": "Pearce Lab, Department of Oncology and Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University (Baltimore, Maryland, USA)", "lab_url": "https://bdp.jhu.edu/bd-professors/erika-pearce/", "role": "Immunologist who studies how metabolism controls T-cell fate. As a postdoc at Penn she showed in mice that drugs that raise fatty acid oxidation, metformin and rapamycin, increase CD8 memory T cells", "studies": [ "PEA2009" ], "url": "https://mtor-atlas.org/author/erika-l-pearce/" }, { "id": "yongwon-choi", "name": "Yongwon Choi", "corpus_name": "Choi Y", "orcid": null, "lab": "Choi Lab, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania (Philadelphia, Pennsylvania, USA)", "lab_url": "https://pathology.med.upenn.edu/node/405", "role": "Immunologist who studies TRAF6 and RANKL (TRANCE) signalling at the junction of the immune and skeletal systems; senior author of the study linking TRAF6 and fatty acid oxidation to CD8 T-cell memory", "studies": [ "PEA2009" ], "url": "https://mtor-atlas.org/author/yongwon-choi/" }, { "id": "rajesh-r-rao", "name": "Rajesh R. Rao", "corpus_name": "Rao RR", "orcid": null, "lab": "Shrikant Lab, Department of Immunology, Roswell Park Cancer Institute (affiliation on RAO2010) (Buffalo, New York, USA)", "lab_url": null, "role": "First author of mouse studies in Protul Shrikant's group showing that mTOR activity decides between effector and memory fates in CD8 T cells by controlling T-bet and Eomesodermin", "studies": [ "RAO2010" ], "url": "https://mtor-atlas.org/author/rajesh-r-rao/" }, { "id": "protul-a-shrikant", "name": "Protul A. Shrikant", "corpus_name": "Shrikant PA", "orcid": null, "lab": "Shrikant Lab, Department of Immunobiology, University of Arizona College of Medicine (Tucson, Arizona, USA)", "lab_url": "https://cancerscholars.arizona.edu/person/protul-shrikant-phd", "role": "Tumour immunologist whose Roswell Park group showed in mouse CD8 T cells that mTOR activity, driven by IL-12, decides between effector and memory fates through T-bet and Eomesodermin", "studies": [ "RAO2010" ], "url": "https://mtor-atlas.org/author/protul-a-shrikant/" }, { "id": "ryan-d-michalek", "name": "Ryan D. Michalek", "corpus_name": "Michalek RD", "orcid": null, "lab": "Metabolon, Inc. (Durham, North Carolina, USA)", "lab_url": "https://vumc.org/jeff-rathmell-lab/people", "role": "T-cell metabolism researcher who, as a postdoc with Jeffrey Rathmell, showed that effector CD4 T cells rely on glycolysis while regulatory T cells rely on lipid oxidation, which ties the pro-Treg effect of rapamycin to fatty acid oxidation; he later moved into metabolomics in industry", "studies": [ "MIC2011" ], "url": "https://mtor-atlas.org/author/ryan-d-michalek/" }, { "id": "jeffrey-c-rathmell", "name": "Jeffrey C. Rathmell", "corpus_name": "Rathmell JC", "orcid": null, "lab": "Rathmell Lab, Ben May Department for Cancer Research, University of Chicago (Chicago, Illinois, USA)", "lab_url": "https://benmay.uchicago.edu/faculty/jeffrey-rathmell", "role": "Studies how nutrients and metabolic pathways control lymphocyte growth, differentiation and function; his lab helped show that effector and regulatory CD4 T cells rely on different fuel programmes, glycolysis versus lipid oxidation (in mouse cells).", "studies": [ "MIC2011" ], "url": "https://mtor-atlas.org/author/jeffrey-c-rathmell/" }, { "id": "antoine-marcais", "name": "Antoine Marçais", "corpus_name": "Marcais A", "orcid": null, "lab": "NK cell immunometabolism group, LYACTS team, Centre International de Recherche en Infectiologie (CIRI), INSERM / ENS de Lyon (Lyon, France)", "lab_url": "https://ciri.ens-lyon.fr/teams/lyacts/presentation", "role": "Studies how mTOR and cell metabolism control natural killer (NK) cells; first author of the mouse study showing that NK cells need mTOR to respond to IL-15 during their development and activation.", "studies": [ "MAR2014" ], "url": "https://mtor-atlas.org/author/antoine-marcais/" }, { "id": "thierry-walzer", "name": "Thierry Walzer", "corpus_name": "Walzer T", "orcid": null, "lab": "LYACTS team (Walzer lab), Centre International de Recherche en Infectiologie (CIRI), INSERM / ENS de Lyon (Lyon, France)", "lab_url": "https://ciri.ens-lyon.fr/teams/lyacts/presentation", "role": "Studies how natural killer (NK) cells develop and become active; his team showed in mice that IL-15 signalling through mTOR is needed for NK-cell maturation and activation.", "studies": [ "MAR2014" ], "url": "https://mtor-atlas.org/author/thierry-walzer/" }, { "id": "steven-j-bensinger", "name": "Steven J. Bensinger", "corpus_name": "Bensinger SJ", "orcid": null, "lab": "Bensinger Lab, Department of Immunology and Immune Therapeutics, Keck School of Medicine of USC (Los Angeles, California, USA)", "lab_url": "https://keck.usc.edu/faculty-search/steven-j-bensinger/", "role": "Studies how lipid metabolism shapes innate and adaptive immunity; his lab showed in mice that activated CD8 T cells need SREBP-driven cholesterol and fatty-acid synthesis, switched on through mTOR, in order to grow and divide.", "studies": [ "KID2013" ], "url": "https://mtor-atlas.org/author/steven-j-bensinger/" }, { "id": "roger-geiger", "name": "Roger Geiger", "corpus_name": "Geiger R", "orcid": null, "lab": "Systems Immunology group, Institute for Research in Biomedicine (IRB), Università della Svizzera italiana (Bellinzona, Switzerland)", "lab_url": "https://irb.usi.ch/irb-people/geiger-roger/?id=8996", "role": "Studies how metabolism regulates T-cell responses against tumours; first author of the study showing that raising L-arginine shifts human T cells towards oxidative metabolism and longer survival, an effect the authors found to be independent of mTOR.", "studies": [ "GEI2016" ], "url": "https://mtor-atlas.org/author/roger-geiger/" }, { "id": "antonio-lanzavecchia", "name": "Antonio Lanzavecchia", "corpus_name": "Lanzavecchia A", "orcid": null, "lab": "Lanzavecchia Lab, Human Immunology Program, Istituto Nazionale di Genetica Molecolare (INGM) (Milan, Italy)", "lab_url": "https://ingm.org/en/lanzavecchia-lab-antonio-lanzavecchia/antonio-lanzavecchia/", "role": "Human immunologist known for work on antigen presentation, memory T and B cells and methods for isolating human monoclonal antibodies; senior author of the study showing that L-arginine changes T-cell metabolism and survival independently of mTOR.", "studies": [ "GEI2016" ], "url": "https://mtor-atlas.org/author/antonio-lanzavecchia/" }, { "id": "shao-jun-tang", "name": "Shao-Jun Tang", "corpus_name": "Tang SJ", "orcid": null, "lab": "Tang Lab, Department of Anesthesiology, Renaissance School of Medicine at Stony Brook University (Stony Brook, New York, USA)", "lab_url": "https://renaissance.stonybrookmedicine.edu/anesthesiology/faculty/tang", "role": "Neuroscientist who, as a postdoc in Erin Schuman's group at Caltech, helped show that a rapamycin-sensitive mTOR pathway is needed for the protein-synthesis-dependent late phase of hippocampal LTP; his lab now studies chronic pain.", "studies": [ "TAN2002" ], "url": "https://mtor-atlas.org/author/shao-jun-tang/" }, { "id": "erin-m-schuman", "name": "Erin M. Schuman", "corpus_name": "Schuman EM", "orcid": "0000-0002-7053-1005", "lab": "Department of Synaptic Plasticity, Max Planck Institute for Brain Research (Frankfurt am Main, Germany)", "lab_url": "https://brain.mpg.de/schuman", "role": "Studies how neurons make and break down proteins locally in dendrites and axons; her group helped tie a rapamycin-sensitive mTOR pathway to the protein-synthesis-dependent phase of synaptic plasticity.", "studies": [ "TAN2002" ], "url": "https://mtor-atlas.org/author/erin-m-schuman/" }, { "id": "christos-g-gkogkas", "name": "Christos G. Gkogkas", "corpus_name": "Gkogkas CG", "orcid": "0000-0001-6281-3419", "lab": "Gkogkas Lab, Biomedical Research Institute, Foundation for Research and Technology – Hellas (FORTH) (Ioannina, Greece)", "lab_url": "https://www.bri.forth.gr/en/research/Christos-G-Gkogkas.5/", "role": "Studies how protein synthesis is controlled in the brain; first author of the mouse study linking loss of the translational repressor 4E-BP2, downstream of mTORC1, to autism-like behaviour through increased neuroligin translation.", "studies": [ "GKO2013" ], "url": "https://mtor-atlas.org/author/christos-g-gkogkas/" }, { "id": "daniela-cota", "name": "Daniela Cota", "corpus_name": "Cota D", "orcid": null, "lab": "Energy Balance and Obesity team, Neurocentre Magendie, INSERM U1215, University of Bordeaux (Bordeaux, France)", "lab_url": "https://www.bordeaux-neurocampus.fr/en/?p=79944", "role": "Studies how the brain senses nutrients and hormones to control food intake and body weight; as a postdoc in Cincinnati she was first author of the rat study that tied hypothalamic mTOR signalling to food intake and leptin action.", "studies": [ "COT2006" ], "url": "https://mtor-atlas.org/author/daniela-cota/" }, { "id": "randy-j-seeley", "name": "Randy J. Seeley", "corpus_name": "Seeley RJ", "orcid": null, "lab": "Seeley Lab, Department of Surgery, University of Michigan Medical School (Ann Arbor, Michigan, USA)", "lab_url": "https://medresearch.umich.edu/labs-departments/labs/seeley-lab", "role": "Studies how gut and brain signals control appetite, body weight and blood sugar, including why bariatric surgery works; his Cincinnati lab was senior on the rat study linking hypothalamic mTOR to food intake.", "studies": [ "COT2006" ], "url": "https://mtor-atlas.org/author/randy-j-seeley/" }, { "id": "peter-t-tsai", "name": "Peter T. Tsai", "corpus_name": "Tsai PT", "orcid": null, "lab": "Tsai Lab, Department of Neurology, UT Southwestern Medical Center (Dallas, Texas, USA)", "lab_url": "https://labs.utsouthwestern.edu/tsai-lab", "role": "Child neurologist and neuroscientist who studies how the cerebellum contributes to autism; first author of the mouse study showing that loss of Tsc1 in Purkinje cells causes autism-like behaviour that rapamycin can prevent.", "studies": [ "TSA2012", "LIP2017" ], "url": "https://mtor-atlas.org/author/peter-t-tsai/" }, { "id": "bernardo-l-sabatini", "name": "Bernardo L. Sabatini", "corpus_name": "Sabatini BL", "orcid": null, "lab": "Sabatini Lab, Department of Neurobiology, Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://sabatini.hms.harvard.edu/", "role": "Neurobiologist who studies how synapses and circuits change during development and learning; his lab showed that loss of Tsc1 in mouse hippocampal neurons weakens inhibitory input and tips circuits toward hyperexcitability.", "studies": [ "BAT2013" ], "url": "https://mtor-atlas.org/author/bernardo-l-sabatini/" }, { "id": "michael-b-atkins", "name": "Michael B. Atkins", "corpus_name": "Atkins MB", "orcid": null, "lab": "Georgetown Lombardi Comprehensive Cancer Center, Georgetown University Medical Center (Washington, District of Columbia, USA)", "lab_url": "https://www.medstarhealth.org/doctor/dr-michael-benjamin-atkins-md/", "role": "Medical oncologist specialising in kidney cancer and melanoma; led the randomised phase II dose study of temsirolimus (CCI-779) in advanced kidney cancer that supported taking the 25 mg weekly dose forward.", "studies": [ "ATK2004" ], "url": "https://mtor-atlas.org/author/michael-b-atkins/" }, { "id": "matthew-l-sherman", "name": "Matthew L. Sherman", "corpus_name": "Sherman ML", "orcid": null, "lab": "Deciphera Pharmaceuticals (Waltham, Massachusetts, USA)", "lab_url": "https://www.deciphera.com/leadership/matthew-l-sherman-md", "role": "Oncologist and drug developer who led clinical programmes at Wyeth, including the sponsor side of the phase II temsirolimus (CCI-779) dose study in kidney cancer.", "studies": [ "ATK2004" ], "url": "https://mtor-atlas.org/author/matthew-l-sherman/" }, { "id": "kerry-r-crone", "name": "Kerry R. Crone", "corpus_name": "Crone KR", "orcid": null, "lab": "Department of Neurosurgery, University of Cincinnati College of Medicine (Cincinnati, Ohio, USA)", "lab_url": "https://med.uc.edu/neurosurgery/directory/faculty/Index/Pubs/cronek/", "role": "Pediatric neurosurgeon in Cincinnati; senior author of the small case series in which oral rapamycin shrank brain astrocytomas in patients with tuberous sclerosis complex.", "studies": [ "FRA2006" ], "url": "https://mtor-atlas.org/author/kerry-r-crone/" }, { "id": "ling-hui-zeng", "name": "Ling-Hui Zeng", "corpus_name": "Zeng LH", "orcid": null, "lab": "Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University (Hangzhou, Zhejiang, China)", "lab_url": null, "role": "Pharmacologist who studies mTOR signalling in epilepsy; as a researcher in Michael Wong's group she was first author of the mouse study showing that rapamycin prevents epilepsy in a tuberous sclerosis model.", "studies": [ "ZEN2008" ], "url": "https://mtor-atlas.org/author/ling-hui-zeng/" }, { "id": "michael-wong", "name": "Michael Wong", "corpus_name": "Wong M", "orcid": null, "lab": "Wong Lab, Department of Neurology, Washington University School of Medicine (St. Louis, Missouri, USA)", "lab_url": "https://wonglab.wustl.edu/", "role": "Pediatric epileptologist whose lab studies how epilepsy develops, with a focus on mTOR in tuberous sclerosis complex and brain injury; senior author of the mouse study in which rapamycin prevented epilepsy in a TSC model.", "studies": [ "ZEN2008" ], "url": "https://mtor-atlas.org/author/michael-wong/" }, { "id": "jacqueline-a-french", "name": "Jacqueline A. French", "corpus_name": "French JA", "orcid": null, "lab": "Comprehensive Epilepsy Center, NYU Grossman School of Medicine (New York, New York, USA)", "lab_url": "https://nyulangone.org/doctors/1689606832/jacqueline-a-french", "role": "Epilepsy clinical-trial specialist; first author of EXIST-3, the placebo-controlled phase 3 trial in which everolimus reduced treatment-resistant seizures in tuberous sclerosis complex.", "studies": [ "FRE2016" ], "url": "https://mtor-atlas.org/author/jacqueline-a-french/" }, { "id": "adam-b-salmon", "name": "Adam B. Salmon", "corpus_name": "Salmon AB", "orcid": null, "lab": "Salmon Lab, Barshop Institute for Longevity and Aging Studies, UT Health San Antonio (San Antonio, Texas, USA)", "lab_url": "https://nathanshockcenters.org/", "role": "Biologist of aging at UT Health San Antonio whose work in this Atlas spans rapamycin in mice and in common marmosets. He is a co-author on the Interventions Testing Program reports from the San Antonio site and on the marmoset rapamycin studies on blood markers, epigenetic age and the salivary gland", "studies": [ "ABD2026", "HOR2021", "SIL2018", "TAR2014", "LAM2012", "FOK2014", "STR2022", "ROS2015", "MAR2026B", "MIL2014", "LEL2016" ], "url": "https://mtor-atlas.org/author/adam-b-salmon/" }, { "id": "parveez-ahamed-abdul-azees", "name": "Parveez Ahamed Abdul-Azees", "corpus_name": "Abdul-Azees PA", "orcid": null, "lab": "Center for Regenerative Sciences and Department of Comprehensive Dentistry, School of Dentistry, UT Health San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "Oral biology researcher at the UT Health San Antonio School of Dentistry who works on dental caries, oral biofilms and salivary gland ageing, and first author of the marmoset study of rapamycin and the ageing salivary gland", "studies": [ "ABD2026" ], "url": "https://mtor-atlas.org/author/parveez-ahamed-abdul-azees/" }, { "id": "chih-ko-yeh", "name": "Chih-Ko Yeh", "corpus_name": "Yeh CK", "orcid": null, "lab": "Center for Regenerative Sciences and Department of Comprehensive Dentistry, School of Dentistry, UT Health San Antonio (San Antonio, Texas, USA)", "lab_url": "https://directory.uthscsa.edu/academics/profile/yeh", "role": "Professor of Comprehensive Dentistry at UT Health San Antonio who studies how ageing changes saliva and the salivary glands, and how damaged glands might be repaired", "studies": [ "ABD2026" ], "url": "https://mtor-atlas.org/author/chih-ko-yeh/" }, { "id": "sze-ham-chan", "name": "Sze Ham Chan", "corpus_name": "Chan SH", "orcid": null, "lab": "Whitehead Institute for Biomedical Research (Cambridge, Massachusetts, USA)", "lab_url": null, "role": "Researcher at the Whitehead Institute who contributed to studies of lysosome contents, nutrient sensing and cancer metabolism, mostly from David Sabatini's lab", "studies": [ "WYA2018", "ABU2017" ], "url": "https://mtor-atlas.org/author/sze-ham-chan/" }, { "id": "elizaveta-freinkman", "name": "Elizaveta Freinkman", "corpus_name": "Freinkman E", "orcid": null, "lab": "Whitehead Institute for Biomedical Research (Cambridge, Massachusetts, USA)", "lab_url": null, "role": "Chemist and mass-spectrometry specialist at the Whitehead Institute who measured metabolites for many studies of nutrient sensing and cancer metabolism, including the lysosome amino acid work behind two Atlas papers", "studies": [ "WYA2017", "ABU2017" ], "url": "https://mtor-atlas.org/author/elizaveta-freinkman/" }, { "id": "choah-kim", "name": "Choah Kim", "corpus_name": "Kim C", "orcid": null, "lab": "Sabatini Lab, Whitehead Institute for Biomedical Research (Cambridge, Massachusetts, USA)", "lab_url": null, "role": "Researcher in David Sabatini's lab at the Whitehead Institute who contributed to three studies on how amino acids at the lysosome are sensed by mTORC1", "studies": [ "TSU2013", "WAN2015", "ABU2017" ], "url": "https://mtor-atlas.org/author/choah-kim/" }, { "id": "nouf-n-laqtom", "name": "Nouf N. Laqtom", "corpus_name": "Laqtom NN", "orcid": null, "lab": "Subcellular Metabolism and Disease Lab, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (Thuwal, Saudi Arabia)", "lab_url": "https://kaust.edu.sa/en/study/faculty/nouf-laqtom", "role": "Cell biologist who helped develop methods to purify intact lysosomes and used them to find what the Batten disease gene CLN3 does, and who now runs a lab at KAUST on lysosome and endoplasmic reticulum defects in rare brain and metabolic diseases", "studies": [ "WYA2018", "ROG2019", "ABU2017" ], "url": "https://mtor-atlas.org/author/nouf-n-laqtom/" }, { "id": "rose-s-al-saadi", "name": "Rose S. Al-Saadi", "corpus_name": "Al-Saadi RS", "orcid": null, "lab": "Phillips Lab, Institute of Ecology and Evolution, University of Oregon (Eugene, Oregon, USA)", "lab_url": null, "role": "Doctoral student in Patrick Phillips' lab at the University of Oregon who studies how ageing differs between the sexes, using male C. elegans", "studies": [ "ALS2026" ], "url": "https://mtor-atlas.org/author/rose-s-al-saadi/" }, { "id": "madhanagopal-anandapadamanaban", "name": "Madhanagopal Anandapadamanaban", "corpus_name": "Anandapadamanaban M", "orcid": null, "lab": "Roger Williams group, MRC Laboratory of Molecular Biology (Cambridge, England, United Kingdom)", "lab_url": "https://crukcambridgecentre.org.uk/user/13904", "role": "Structural biologist at the MRC Laboratory of Molecular Biology who solved the structure of the human Rag GTPases bound to mTORC1, showing how amino acids bring mTORC1 to the lysosome", "studies": [ "ANA2019" ], "url": "https://mtor-atlas.org/author/madhanagopal-anandapadamanaban/" }, { "id": "alex-berndt", "name": "Alex Berndt", "corpus_name": "Berndt A", "orcid": null, "lab": "Roger Williams group, MRC Laboratory of Molecular Biology (Cambridge, England, United Kingdom)", "lab_url": null, "role": "Protein scientist in Roger Williams' group at the MRC Laboratory of Molecular Biology who helped solve structures of PI3K enzymes and of mTOR and its partners", "studies": [ "BAR2016", "ANA2019" ], "url": "https://mtor-atlas.org/author/alex-berndt/" }, { "id": "christopher-johnson", "name": "Christopher Johnson", "corpus_name": "Johnson CM", "orcid": null, "lab": "Biophysics Facility, MRC Laboratory of Molecular Biology (Cambridge, England, United Kingdom)", "lab_url": null, "role": "Biophysicist who built and ran the Biophysics Facility at the MRC Laboratory of Molecular Biology, measuring how proteins fold, bind and change shape for dozens of research groups", "studies": [ "BAR2016", "ANA2019" ], "url": "https://mtor-atlas.org/author/christopher-johnson/" }, { "id": "sara-ancel", "name": "Sara Ancel", "corpus_name": "Ancel S", "orcid": null, "lab": "Center for Cardiovascular and Muscular Diseases, Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California, USA)", "lab_url": null, "role": "Muscle stem-cell biologist at Sanford Burnham Prebys, trained at Nestle Research and EPFL in Lausanne, who studies why muscle repair fails with age", "studies": [ "ANC2026" ], "url": "https://mtor-atlas.org/author/sara-ancel/" }, { "id": "koichi-araki", "name": "Koichi Araki", "corpus_name": "Araki K", "orcid": null, "lab": "Department of Microbiology and Immunology and Emory Vaccine Center, Emory University (Atlanta, Georgia, USA)", "lab_url": null, "role": "Immunologist in Rafi Ahmed's group at Emory who discovered that rapamycin improves memory killer T cells, a finding that linked mTOR to vaccine design", "studies": [ "ARA2009" ], "url": "https://mtor-atlas.org/author/koichi-araki/" }, { "id": "emma-l-baar", "name": "Emma L. Baar", "corpus_name": "Baar EL", "orcid": null, "lab": "Lamming Lab, Department of Medicine, University of Wisconsin-Madison (Madison, Wisconsin, USA)", "lab_url": null, "role": "Researcher in Dudley Lamming's group at the University of Wisconsin-Madison who mapped how mTOR signalling changes with age in different mouse tissues and helped test gentler rapamycin dosing schedules", "studies": [ "ARR2015", "ARR2016" ], "url": "https://mtor-atlas.org/author/emma-l-baar/" }, { "id": "nicole-e-cummings", "name": "Nicole E. Cummings", "corpus_name": "Cummings NE", "orcid": null, "lab": "Lamming Lab, Department of Medicine, University of Wisconsin-Madison (Madison, Wisconsin, USA)", "lab_url": null, "role": "Graduate researcher in Dudley Lamming's lab at the University of Wisconsin-Madison and first author of a 2017 study reporting that eating fewer branched-chain amino acids restores metabolic health", "studies": [ "ARR2015", "ARR2016" ], "url": "https://mtor-atlas.org/author/nicole-e-cummings/" }, { "id": "cassidy-p-pumper", "name": "Cassidy P. Pumper", "corpus_name": "Pumper CP", "orcid": null, "lab": "Lamming Lab, Department of Medicine, University of Wisconsin-Madison (Madison, Wisconsin, USA)", "lab_url": null, "role": "Member of Dudley Lamming's group at the University of Wisconsin-Madison who contributed to the intermittent rapamycin studies in mice", "studies": [ "ARR2015", "ARR2016" ], "url": "https://mtor-atlas.org/author/cassidy-p-pumper/" }, { "id": "chetan-aware", "name": "Chetan Aware", "corpus_name": "Aware C", "orcid": null, "lab": "Lin Lab, Department of Radiology and NextGen Precision Health, University of Missouri (Columbia, Missouri, USA)", "lab_url": null, "role": "Researcher in Ai-Ling Lin's group at the University of Missouri who studies how rapamycin and the gut microbiome affect brain blood flow and metabolism in people and mice at genetic risk of Alzheimer's disease", "studies": [ "AWARE2026" ], "url": "https://mtor-atlas.org/author/chetan-aware/" }, { "id": "christopher-aylett", "name": "Christopher Aylett", "corpus_name": "Aylett CH", "orcid": null, "lab": "Aylett Group, Section for Structural and Synthetic Biology, Department of Infectious Disease, Imperial College London (London, England, United Kingdom)", "lab_url": null, "role": "Structural biologist who solved the first cryo-EM architecture of human mTORC1 at ETH Zurich and now leads a cryo-EM group at Imperial College London", "studies": [ "AYL2015", "STU2018" ], "url": "https://mtor-atlas.org/author/christopher-aylett/" }, { "id": "daniel-boehringer", "name": "Daniel Boehringer", "corpus_name": "Boehringer D", "orcid": null, "lab": "Cryo-EM Knowledge Hub, ETH Zurich (Zurich, Switzerland)", "lab_url": null, "role": "Electron microscopy specialist at ETH Zurich whose cryo-EM work underpins the Atlas structures of human mTORC1 and mTORC2", "studies": [ "SCA2020", "AYL2015", "STU2018" ], "url": "https://mtor-atlas.org/author/daniel-boehringer/" }, { "id": "stefan-imseng", "name": "Stefan Imseng", "corpus_name": "Imseng S", "orcid": null, "lab": "Maier Lab, Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": null, "role": "Structural biologist from Timm Maier's group at the Biozentrum Basel who helped solve the first detailed structures of human mTORC1 and mTORC2 and then worked on a drug to block mTORC1 specifically", "studies": [ "SCA2020", "AYL2015", "STU2018" ], "url": "https://mtor-atlas.org/author/stefan-imseng/" }, { "id": "evelyn-sauer", "name": "Evelyn Sauer", "corpus_name": "Sauer E", "orcid": null, "lab": "Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": null, "role": "Structural biologist at the Biozentrum Basel who worked on the structure of the mTOR kinase and contributed to the cryo-EM structures of human mTORC1 and mTORC2", "studies": [ "AYL2015", "STU2018" ], "url": "https://mtor-atlas.org/author/evelyn-sauer/" }, { "id": "reji-babygirija", "name": "Reji Babygirija", "corpus_name": "Babygirija R", "orcid": null, "lab": "Lamming Lab, Department of Medicine, University of Wisconsin-Madison (Madison, Wisconsin, USA)", "lab_url": null, "role": "Researcher in Dudley Lamming's lab at the University of Wisconsin-Madison who studies how restricting single amino acids in the diet affects metabolism, memory and Alzheimer's disease in mice", "studies": [ "BAB2025" ], "url": "https://mtor-atlas.org/author/reji-babygirija/" }, { "id": "bailey-a-knopf", "name": "Bailey A. Knopf", "corpus_name": "Knopf BA", "orcid": null, "lab": "Lamming Lab, Department of Medicine, University of Wisconsin-Madison (Madison, Wisconsin, USA)", "lab_url": "https://lamminglab.medicine.wisc.edu/lab-members/", "role": "Graduate student in Dudley Lamming's lab at the University of Wisconsin-Madison and first author of a 2026 review that sets out the hallmarks of protein and amino acid restriction in aging", "studies": [ "KNO2026", "BAB2025" ], "url": "https://mtor-atlas.org/author/bailey-a-knopf/" }, { "id": "chandrayee-banerjee", "name": "Chandrayee Banerjee", "corpus_name": "Banerjee C", "orcid": null, "lab": "Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy (Moga, Punjab, India)", "lab_url": null, "role": "Pharmacology researcher at ISF College of Pharmacy in Punjab who writes reviews on signalling pathways and repurposed drugs for multiple sclerosis and other brain diseases", "studies": [ "BANERJEE2026" ], "url": "https://mtor-atlas.org/author/chandrayee-banerjee/" }, { "id": "manoj-tongra", "name": "Manoj Tongra", "corpus_name": "Tongra M", "orcid": null, "lab": "Celagenex Research (Thane, Mumbai, India)", "lab_url": null, "role": "Chief Scientific Officer of Celagenex Research in Mumbai, senior author of reviews and animal studies that link the PI3K/Akt/mTOR pathway to brain and immune disorders", "studies": [ "BANERJEE2026" ], "url": "https://mtor-atlas.org/author/manoj-tongra/" }, { "id": "domagoj-baretic", "name": "Domagoj Baretić", "corpus_name": "Baretic D", "orcid": null, "lab": "Sir William Dunn School of Pathology, University of Oxford (Oxford, England, United Kingdom)", "lab_url": null, "role": "Structural biologist who, while at the MRC Laboratory of Molecular Biology, solved early cryo-EM structures of Tor and its relatives, and now works on ADP-ribosylation enzymes at Oxford", "studies": [ "BAR2016" ], "url": "https://mtor-atlas.org/author/domagoj-baretic/" }, { "id": "howard-a-burris", "name": "Howard A Burris", "corpus_name": "Burris HA", "orcid": null, "lab": "Sarah Cannon Research Institute (Nashville, Tennessee, USA)", "lab_url": null, "role": "Medical oncologist who led the Sarah Cannon Research Institute in Nashville as President and Chief Medical Officer, has run hundreds of early-phase cancer drug trials, including the first trial of the mTORC1-selective inhibitor RMC-5552, and was ASCO President in 2019–2020", "studies": [ "SCH2025", "PIC2014" ], "url": "https://mtor-atlas.org/author/howard-a-burris/" }, { "id": "stefania-battaglioni", "name": "Stefania Battaglioni", "corpus_name": "Battaglioni S", "orcid": null, "lab": "Hall Lab, Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": null, "role": "Cell biologist in Michael Hall's group at the Biozentrum Basel, first author of a 2022 Cell review that catalogued the direct substrates of mTOR", "studies": [ "BAT2022" ], "url": "https://mtor-atlas.org/author/stefania-battaglioni/" }, { "id": "wafa-bchir", "name": "Wafa B'chir", "corpus_name": "B'chir W", "orcid": null, "lab": "Vincent Giguère laboratory, Goodman Cancer Institute, McGill University (Montreal, Quebec, Canada)", "lab_url": null, "role": "Metabolism researcher in Vincent Giguère's laboratory at McGill who studies how the nuclear receptor ERR-alpha controls fat handling in the liver, including the fatty liver caused by rapamycin", "studies": [ "BCH2026" ], "url": "https://mtor-atlas.org/author/wafa-bchir/" }, { "id": "c-florian-bentzinger", "name": "C. Florian Bentzinger", "corpus_name": "Bentzinger CF", "orcid": "0000-0003-0422-9622", "lab": "Bentzinger Lab, Department of Pharmacology-Physiology, Université de Sherbrooke (Sherbrooke, Quebec, Canada)", "lab_url": "https://www.usherbrooke.ca/recherche/fr/specialistes/details/cf.bentzinger", "role": "Muscle stem cell biologist at the Université de Sherbrooke who, as a PhD student in Basel, showed that mTORC1 but not mTORC2 is essential for healthy skeletal muscle", "studies": [ "BEN2008" ], "url": "https://mtor-atlas.org/author/c-florian-bentzinger/" }, { "id": "jessica-j-howell", "name": "Jessica J. Howell", "corpus_name": "Howell JJ", "orcid": null, "lab": "Spark Therapeutics (Philadelphia, Pennsylvania, USA)", "lab_url": null, "role": "Metabolism biologist who, as a postdoc in Brendan Manning's lab at Harvard, worked out how the diabetes drug metformin switches off mTORC1 in the liver, and who later moved into drug and gene-therapy research in industry", "studies": [ "HOW2017" ], "url": "https://mtor-atlas.org/author/jessica-j-howell/" }, { "id": "zdenek-berger", "name": "Zdenek Berger", "corpus_name": "Berger Z", "orcid": null, "lab": "Rubinsztein Lab, Cambridge Institute for Medical Research, University of Cambridge (Cambridge, England, United Kingdom)", "lab_url": null, "role": "Neuroscientist who, in David Rubinsztein's lab in Cambridge, showed that rapamycin-induced autophagy lowers the toxicity of several disease proteins that form clumps, including tau in fruit flies", "studies": [ "BER2006" ], "url": "https://mtor-atlas.org/author/zdenek-berger/" }, { "id": "petrus-j-de-vries", "name": "Petrus J. de Vries", "corpus_name": "de Vries PJ", "orcid": null, "lab": "Division of Child and Adolescent Psychiatry and Centre for Autism Research in Africa, University of Cape Town (Cape Town, South Africa)", "lab_url": "https://health.uct.ac.za/cara/articles/2019-10-17-tsc-associated-neuropsychiatric-disorders", "role": "Child and adolescent psychiatrist at the University of Cape Town known for work on TAND, the behavioural, learning and mental-health problems of tuberous sclerosis complex, and co-author of major everolimus trials in TSC", "studies": [ "FRE2016", "SAX2026" ], "url": "https://mtor-atlas.org/author/petrus-j-de-vries/" }, { "id": "david-j-glass", "name": "David J. Glass", "corpus_name": "Glass DJ", "orcid": null, "lab": "Regeneron Pharmaceuticals (Tarrytown, New York, USA)", "lab_url": null, "role": "Muscle biologist and Regeneron vice president for ageing research, member of the US National Academy of Sciences, who helped discover the muscle-wasting enzymes MuRF1 and MAFbx and co-authored the first trials of low-dose mTOR inhibition in older people", "studies": [ "MAN2014", "MAN2018" ], "url": "https://mtor-atlas.org/author/david-j-glass/" }, { "id": "antonella-caccamo", "name": "Antonella Caccamo", "corpus_name": "Caccamo A", "orcid": null, "lab": "Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina (Messina, Italy)", "lab_url": null, "role": "Neuroscientist who, with Salvatore Oddo, showed in Alzheimer's model mice that amyloid-beta and mTOR feed each other in a loop that rapamycin can break", "studies": [ "CAC2010" ], "url": "https://mtor-atlas.org/author/antonella-caccamo/" }, { "id": "zhi-lie-cao", "name": "Zhi-Lie Cao", "corpus_name": "Cao ZL", "orcid": null, "lab": "Department of Urology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University (Taizhou, China)", "lab_url": null, "role": "Urologist in Zhejiang who works with colleagues on inherited endocrine tumour syndromes and wrote a review re-examining how FLCN loss changes mTORC1 signalling in Birt-Hogg-Dube syndrome", "studies": [ "CAO2026" ], "url": "https://mtor-atlas.org/author/zhi-lie-cao/" }, { "id": "wei-ying-chen", "name": "Wei-Ying Chen", "corpus_name": "Chen WY", "orcid": null, "lab": "Department of Urology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University (Taizhou, China)", "lab_url": null, "role": "Urologist at Taizhou Hospital in Zhejiang and senior author of a review on why FLCN loss affects mTORC1 selectively in Birt-Hogg-Dube syndrome", "studies": [ "CAO2026" ], "url": "https://mtor-atlas.org/author/wei-ying-chen/" }, { "id": "peng-cao", "name": "Peng Cao", "corpus_name": "Cao P", "orcid": null, "lab": "Burn and Trauma Treatment Center, Affiliated Hospital of Jiangnan University (Wuxi, China)", "lab_url": null, "role": "Wound-repair researcher at the Burn and Trauma Treatment Center in Wuxi who tests natural compounds against scarring and diabetic wound inflammation", "studies": [ "CAO2026B" ], "url": "https://mtor-atlas.org/author/peng-cao/" }, { "id": "guozhong-lyu", "name": "Guozhong Lyu", "corpus_name": "Lyu G", "orcid": null, "lab": "Burn and Trauma Treatment Center, Affiliated Hospital of Jiangnan University (Wuxi, China)", "lab_url": null, "role": "Burn and wound-repair specialist in Wuxi whose group studies natural compounds, biomaterials and devices that improve healing and reduce scarring", "studies": [ "CAO2026B" ], "url": "https://mtor-atlas.org/author/guozhong-lyu/" }, { "id": "penny-lovat", "name": "Penny Lovat", "corpus_name": "Lovat P", "orcid": null, "lab": "Translational and Clinical Research Institute, Newcastle University (Newcastle upon Tyne, England, United Kingdom)", "lab_url": null, "role": "Professor of Cellular Dermatology and Oncology at Newcastle University who studies autophagy in melanoma, and whose work on the autophagy protein AMBRA1 and the skin protein loricrin underlies a test, developed with AMLo Biosciences, to identify early melanomas at low risk of spreading", "studies": [ "KEL2024", "CAR2017" ], "url": "https://mtor-atlas.org/author/penny-lovat/" }, { "id": "glyn-nelson", "name": "Glyn Nelson", "corpus_name": "Nelson G", "orcid": null, "lab": "Bioimaging Unit, Newcastle University (Newcastle upon Tyne, England, United Kingdom)", "lab_url": "https://www.ncl.ac.uk/bioimaging/staff/profile/glynnelson.html", "role": "Microscopy specialist who manages Newcastle University's Bioimaging Unit and has worked for many years on the signalling networks that keep senescent cells in their arrested state", "studies": [ "KEL2024", "CAR2017" ], "url": "https://mtor-atlas.org/author/glyn-nelson/" }, { "id": "rogerio-m-castilho", "name": "Rogerio M Castilho", "corpus_name": "Castilho RM", "orcid": null, "lab": "Castilho Lab, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan (Ann Arbor, Michigan, USA)", "lab_url": "https://media.dent.umich.edu/labs/castilho/", "role": "Dentist and cell biologist who showed, as a postdoc at the US National Institutes of Health, that Wnt signalling wears out skin stem cells through mTOR and that rapamycin can prevent it, and whose University of Michigan lab now studies how histone marks control epithelial healing and treatment resistance in head and neck cancer", "studies": [ "CAS2009" ], "url": "https://mtor-atlas.org/author/rogerio-m-castilho/" }, { "id": "brian-m-castellano", "name": "Brian M. Castellano", "corpus_name": "Castellano BM", "orcid": null, "lab": "Zoncu Lab, Department of Molecular and Cell Biology, University of California, Berkeley (Berkeley, California, USA)", "lab_url": null, "role": "Cell biologist who, in Roberto Zoncu's lab at UC Berkeley, showed that cholesterol inside the lysosome switches on mTORC1 through the SLC38A9 and NPC1 proteins", "studies": [ "CAS2017" ], "url": "https://mtor-atlas.org/author/brian-m-castellano/" }, { "id": "douglas-f-covey", "name": "Douglas F. Covey", "corpus_name": "Covey DF", "orcid": null, "lab": "Department of Developmental Biology and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine (St. Louis, Missouri, USA)", "lab_url": null, "role": "Medicinal chemist and Andrew C and Barbara B Taylor Distinguished Professor of Psychiatry at Washington University in St. Louis who designs synthetic steroids and sterols to study neurosteroids, GABA-A receptors and cholesterol sensing, including in two Atlas studies on cholesterol and mTORC1", "studies": [ "SHI2022", "CAS2017" ], "url": "https://mtor-atlas.org/author/douglas-f-covey/" }, { "id": "oliver-b-davis", "name": "Oliver B. Davis", "corpus_name": "Davis OB", "orcid": null, "lab": "Zoncu Lab, Department of Molecular and Cell Biology, University of California, Berkeley (Berkeley, California, USA)", "lab_url": null, "role": "Cell biologist who did a PhD in Roberto Zoncu's lab at UC Berkeley on how lysosomal cholesterol controls mTORC1, and first author of a 2020 study proposing NPC1-mTORC1 signalling as a drug target in Niemann-Pick type C disease", "studies": [ "SHI2022", "CAS2017" ], "url": "https://mtor-atlas.org/author/oliver-b-davis/" }, { "id": "ofer-moldavski", "name": "Ofer Moldavski", "corpus_name": "Moldavski O", "orcid": null, "lab": "Zoncu Lab, Department of Molecular and Cell Biology, University of California, Berkeley (Berkeley, California, USA)", "lab_url": null, "role": "Researcher who worked on lysosomes and lipid signalling in Roberto Zoncu's lab at UC Berkeley and was first author of a 2021 study on how the oxysterol 4beta-hydroxycholesterol switches on fat-making genes", "studies": [ "CAS2017", "LAW2018" ], "url": "https://mtor-atlas.org/author/ofer-moldavski/" }, { "id": "daniel-k-nomura", "name": "Daniel K. Nomura", "corpus_name": "Nomura DK", "orcid": null, "lab": "Nomura Lab, Departments of Chemistry and of Molecular and Cell Biology, University of California, Berkeley (Berkeley, California, USA)", "lab_url": "https://chemistry.berkeley.edu/node/849", "role": "Chemical biologist and professor at UC Berkeley who uses chemoproteomics to find druggable sites on proteins, including covalent handles that turn ordinary drug molecules into protein degraders", "studies": [ "SHI2022", "CAS2017" ], "url": "https://mtor-atlas.org/author/daniel-k-nomura/" }, { "id": "rushika-m-perera", "name": "Rushika M. Perera", "corpus_name": "Perera RM", "orcid": null, "lab": "Perera Lab, Department of Anatomy, University of California San Francisco (San Francisco, California, USA)", "lab_url": "http://www.rushikapereralab.com", "role": "Professor of Anatomy at UCSF whose lab studies how autophagy and the lysosome, the cell's recycling centre, help cancer cells cope with stress, and a co-author of two Science papers on how lysosomal cholesterol switches on mTORC1", "studies": [ "SHI2022", "CAS2017" ], "url": "https://mtor-atlas.org/author/rushika-m-perera/" }, { "id": "ashley-m-thelen", "name": "Ashley M. Thelen", "corpus_name": "Thelen AM", "orcid": null, "lab": "Greenberg Lab, Fred Hutchinson Cancer Center (Seattle, Washington, USA)", "lab_url": null, "role": "Cell biologist who did graduate work in Roberto Zoncu's lysosome lab at UC Berkeley, first author of a 2017 review on the lysosome's roles in lipid metabolism, and later a postdoctoral scholar in Philip Greenberg's lab at Fred Hutch", "studies": [ "LAW2019", "CAS2017" ], "url": "https://mtor-atlas.org/author/ashley-m-thelen/" }, { "id": "jose-m-orozco", "name": "Jose M. Orozco", "corpus_name": "Orozco JM", "orcid": null, "lab": "Sabatini Laboratory, Whitehead Institute for Biomedical Research (Cambridge, Massachusetts, USA)", "lab_url": null, "role": "Researcher trained in David Sabatini's laboratory at the Whitehead Institute and MIT who showed that mTORC1 senses glucose through the glycolysis metabolite DHAP", "studies": [ "CHA2014", "WOL2017", "CON2021", "GU2017" ], "url": "https://mtor-atlas.org/author/jose-m-orozco/" }, { "id": "eric-spooner", "name": "Eric Spooner", "corpus_name": "Spooner E", "orcid": null, "lab": "Proteomics Core Facility, Whitehead Institute for Biomedical Research (Cambridge, Massachusetts, USA)", "lab_url": null, "role": "Manager of the Whitehead Institute's Proteomics Core Facility, whose mass spectrometry work identified proteins in complexes for many Whitehead studies, including two on amino acid sensing upstream of mTORC1", "studies": [ "TSU2013", "CHA2014" ], "url": "https://mtor-atlas.org/author/eric-spooner/" }, { "id": "xizi-chen", "name": "Xizi Chen", "corpus_name": "Chen Xizi", "orcid": null, "lab": "Yanhui Xu laboratory, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University (Shanghai, China)", "lab_url": null, "role": "Structural biologist in Yanhui Xu's group at Fudan University who was first author of the 2018 cryo-EM structure of human mTORC2 and co-first author of an earlier structure of human mTORC1", "studies": [ "CHE2018" ], "url": "https://mtor-atlas.org/author/xizi-chen/" }, { "id": "kewei-chen", "name": "Kewei Chen", "corpus_name": "Chen K", "orcid": null, "lab": "Department of Plastic Surgery, The First Affiliated Hospital of Wenzhou Medical University (Wenzhou, China)", "lab_url": null, "role": "Researcher in plastic surgery at Wenzhou Medical University and first author of a mouse study on engineered stem-cell exosomes that speed wound healing by changing fibroblast metabolism", "studies": [ "CHEN2026" ], "url": "https://mtor-atlas.org/author/kewei-chen/" }, { "id": "xianglong-chen", "name": "Xianglong Chen", "corpus_name": "Chen Xianglong", "orcid": null, "lab": "Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (Wuhan, Hubei, China)", "lab_url": null, "role": "Orthopedic researcher at Union Hospital, Wuhan, and first author of a 2026 study that found a new route by which failing autophagy switches on mTORC1 and drives spinal disc degeneration", "studies": [ "CHEN2026C" ], "url": "https://mtor-atlas.org/author/xianglong-chen/" }, { "id": "christina-lee-chung", "name": "Christina Lee Chung", "corpus_name": "Chung CL", "orcid": null, "lab": "Montgomery Dermatology and Lankenau Institute for Medical Research (Wynnewood, Pennsylvania, USA)", "lab_url": null, "role": "Dermatologist specialising in skin disease of organ transplant recipients, and first author of a small randomised trial showing that topical rapamycin lowers a senescence marker in aging human skin", "studies": [ "CHU2019" ], "url": "https://mtor-atlas.org/author/christina-lee-chung/" }, { "id": "clara-correia-melo", "name": "Clara Correia-Melo", "corpus_name": "Correia-Melo C", "orcid": null, "lab": "Leibniz Institute on Aging, Fritz Lipmann Institute (Jena, Thuringia, Germany)", "lab_url": null, "role": "Ageing biologist who showed with João Passos in Newcastle that rapamycin can improve healthspan in mice without lowering inflammation, and later studied metabolite sharing between cells in Markus Ralser's lab", "studies": [ "COR2018" ], "url": "https://mtor-atlas.org/author/clara-correia-melo/" }, { "id": "christine-m-chresta", "name": "Christine M. Chresta", "corpus_name": "Chresta CM", "orcid": null, "lab": "Oncology iMed, AstraZeneca, Alderley Park (Macclesfield, England, United Kingdom)", "lab_url": null, "role": "Cancer biologist at AstraZeneca who led the preclinical description of AZD8055, one of the first ATP-competitive mTOR kinase inhibitors to reach clinical testing", "studies": [ "CHR2009" ], "url": "https://mtor-atlas.org/author/christine-m-chresta/" }, { "id": "sabina-cosulich", "name": "Sabina Cosulich", "corpus_name": "Cosulich S", "orcid": null, "lab": "Oncology R&D, AstraZeneca (Cambridge, England, United Kingdom)", "lab_url": null, "role": "Cancer drug discovery scientist at AstraZeneca whose work spans PI3K and mTOR pathway inhibitors, PARP1 inhibitors and phosphoinositide lipid signalling", "studies": [ "ROD2016" ], "url": "https://mtor-atlas.org/author/sabina-cosulich/" }, { "id": "mariana-de-araujo", "name": "Mariana de Araujo", "corpus_name": "de Araujo MEG", "orcid": null, "lab": "Huber Lab, Institute of Cell Biology, Biocenter, Medical University of Innsbruck (Innsbruck, Tyrol, Austria)", "lab_url": null, "role": "Cell biologist in Lukas Huber's group in Innsbruck who solved the crystal structure of the Ragulator (LAMTOR) complex, the lysosomal platform on which mTORC1 is switched on", "studies": [ "NAP2020", "PRE2021", "CUI2023" ], "url": "https://mtor-atlas.org/author/mariana-de-araujo/" }, { "id": "xiaoli-cui", "name": "Xiaoli Cui", "corpus_name": "Cui X", "orcid": null, "lab": "Department of Pharmacology, College of Pharmacy, Beihua University (Jilin, China)", "lab_url": null, "role": "Pharmacologist at Beihua University who studies how plant-derived compounds protect the kidney and heart from damage caused by high blood pressure in mice", "studies": [ "CUI2026" ], "url": "https://mtor-atlas.org/author/xiaoli-cui/" }, { "id": "john-t-cunningham", "name": "John T. Cunningham", "corpus_name": "Cunningham JT", "orcid": null, "lab": "Department of Cancer Biology, University of Cincinnati (Cincinnati, Ohio, USA)", "lab_url": null, "role": "Cancer biologist who showed in Puigserver's lab at Dana-Farber that mTOR controls mitochondrial activity, later worked on protein synthesis and nucleotide metabolism in cancer in Davide Ruggero's lab at UCSF, and now works at the University of Cincinnati", "studies": [ "CUN2007" ], "url": "https://mtor-atlas.org/author/john-t-cunningham/" }, { "id": "alexander-m-heberle", "name": "Alexander M Heberle", "corpus_name": "Heberle AM", "orcid": null, "lab": "Institute of Biochemistry, University of Innsbruck (Innsbruck, Tyrol, Austria)", "lab_url": "https://uibk.ac.at/biochemistry/people/heberle", "role": "Cell biologist and Junior Group Leader at the University of Innsbruck who studies how mTOR balances growth signalling and metabolism when cells are under stress, trained in Kathrin Thedieck's systems-biology group", "studies": [ "PRE2021", "DAL2016" ], "url": "https://mtor-atlas.org/author/alexander-m-heberle/" }, { "id": "bjorn-stork", "name": "Björn Stork", "corpus_name": "Stork B", "orcid": null, "lab": "Molecular Biology of Cellular Stress Responses group, Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University (Düsseldorf, North Rhine-Westphalia, Germany)", "lab_url": "https://www.uniklinik-duesseldorf.de/patienten-besucher/klinikeninstitutezentren/institut-fuer-molekulare-medizin-i/forschung/ag-stork-signaltransduktion-der-autophagie", "role": "Heisenberg Professor for the molecular biology of cellular stress responses at Heinrich Heine University Düsseldorf, who studies the ULK1 complex, the switch that starts autophagy, and how it is wired to the energy sensor AMPK and to mTOR", "studies": [ "LOF2011" ], "url": "https://mtor-atlas.org/author/bjorn-stork/" }, { "id": "lufeng-dan", "name": "Lufeng Dan", "corpus_name": "Dan L", "orcid": null, "lab": "School of Pharmacy, Chengdu University (Chengdu, Sichuan, China)", "lab_url": null, "role": "Yeast geneticist at Chengdu University who studies reversible mutations that let cells switch drug resistance on and off, using rapamycin resistance in fission yeast as the model", "studies": [ "DAN2026" ], "url": "https://mtor-atlas.org/author/lufeng-dan/" }, { "id": "aykut-demir", "name": "Aykut Demir", "corpus_name": "Demir A", "orcid": null, "lab": "Simon Raffel group, Heidelberg University and Heidelberg University Hospital (Heidelberg, Germany)", "lab_url": null, "role": "Leukaemia researcher at Heidelberg University and first author of the 2026 study showing that the enzyme IDH3 keeps acute myeloid leukaemia stem cells metabolically fit and resistant to venetoclax", "studies": [ "DEM2026" ], "url": "https://mtor-atlas.org/author/aykut-demir/" }, { "id": "nicola-zamboni", "name": "Nicola Zamboni", "corpus_name": "Zamboni N", "orcid": null, "lab": "Zamboni Group, Institute of Molecular Systems Biology, ETH Zurich (Zurich, Switzerland)", "lab_url": null, "role": "Group leader at ETH Zurich's Institute of Molecular Systems Biology who develops mass spectrometry methods to measure hundreds of metabolites at once, used in many collaborations on cell metabolism", "studies": [ "GEI2016", "DEM2026" ], "url": "https://mtor-atlas.org/author/nicola-zamboni/" }, { "id": "matthew-d-demmings", "name": "Matthew D. Demmings", "corpus_name": "Demmings MD", "orcid": null, "lab": "Neuroscience Program, Schulich School of Medicine and Dentistry, University of Western Ontario (London, Ontario, Canada)", "lab_url": null, "role": "Neuroscience researcher in Sean Cregan's lab at Western University who showed that chronic ATF4 stress signalling shuts down mTOR and kills dopamine neurons in models of Parkinson's disease", "studies": [ "DEMMINGS2026" ], "url": "https://mtor-atlas.org/author/matthew-d-demmings/" }, { "id": "alex-de-nardi", "name": "Alex De Nardi", "corpus_name": "De Nardi A", "orcid": null, "lab": "Centre for Computational and Systems Biology (COSBI), Fondazione The Microsoft Research - University of Trento (Rovereto, Italy)", "lab_url": null, "role": "Mathematical modeller in Trento who applies survival and epidemic models to medical data, and first author of the 2026 re-analysis of the RAP-ALS rapamycin trial in ALS", "studies": [ "DEN2026B" ], "url": "https://mtor-atlas.org/author/alex-de-nardi/" }, { "id": "beatriz-eda-de-oliveira-isidio", "name": "Beatriz Eda de Oliveira Isídio", "corpus_name": "de Oliveira Isídio BE", "orcid": null, "lab": "Laboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco (Recife, Brazil)", "lab_url": null, "role": "Researcher in Antonio Carlos de Freitas's laboratory at the Federal University of Pernambuco who studies whether human papillomavirus (HPV) is active in breast tumours", "studies": [ "DEOLIVEIRA2026" ], "url": "https://mtor-atlas.org/author/beatriz-eda-de-oliveira-isidio/" }, { "id": "leanne-m-dibbens", "name": "Leanne M. Dibbens", "corpus_name": "Dibbens LM", "orcid": null, "lab": "Epilepsy Research Group, Australian Centre for Precision Health, University of South Australia (Adelaide, South Australia, Australia)", "lab_url": null, "role": "Epilepsy geneticist at the University of South Australia who found that mutations in DEPDC5, part of the GATOR1 brake on mTORC1, cause familial focal epilepsy", "studies": [ "DIB2013B" ], "url": "https://mtor-atlas.org/author/leanne-m-dibbens/" }, { "id": "n-valerio-dorrello", "name": "N. Valerio Dorrello", "corpus_name": "Dorrello NV", "orcid": null, "lab": "Division of Pediatric Critical Care Medicine and Hospital Medicine, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons (New York, New York, USA)", "lab_url": null, "role": "Pediatric critical care physician-scientist at Columbia University whose training in Michele Pagano's lab at NYU showed how S6K1 removes the translation brake PDCD4, and who now works on repairing injured children's lungs", "studies": [ "DOR2006" ], "url": "https://mtor-atlas.org/author/n-valerio-dorrello/" }, { "id": "micah-j-drummond", "name": "Micah J. Drummond", "corpus_name": "Drummond MJ", "orcid": "0000-0001-5961-8890", "lab": "Drummond Lab, Department of Physical Therapy and Athletic Training, University of Utah (Salt Lake City, Utah, USA)", "lab_url": "https://bioscience.utah.edu/faculty/drummond/", "role": "Muscle physiologist at the University of Utah who studies why older muscle wastes during inactivity and recovers poorly, and who showed that mTORC1 drives part of the protein-building response to exercise in humans", "studies": [ "DRU2009" ], "url": "https://mtor-atlas.org/author/micah-j-drummond/" }, { "id": "raul-v-duran", "name": "Raúl V. Durán", "corpus_name": "Duran RV", "orcid": null, "lab": "Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), CSIC (Seville, Spain)", "lab_url": null, "role": "Cell biologist who showed that glutamine breakdown feeds amino acid signalling to mTORC1, and who now leads research on mTOR, glutamine metabolism and cancer at CABIMER in Seville", "studies": [ "DUR2012" ], "url": "https://mtor-atlas.org/author/raul-v-duran/" }, { "id": "aaron-m-robitaille", "name": "Aaron M. Robitaille", "corpus_name": "Robitaille AM", "orcid": null, "lab": "Thermo Fisher Scientific (San Jose, California, USA)", "lab_url": null, "role": "Mass spectrometry scientist who, as a PhD student in Michael Hall's lab, used phosphoproteomics to show that mTORC1 switches on the cell's production of pyrimidines, and who now works on proteomics applications at Thermo Fisher Scientific", "studies": [ "ROB2013" ], "url": "https://mtor-atlas.org/author/aaron-m-robitaille/" }, { "id": "silvana-duran-ortiz", "name": "Silvana Duran-Ortiz", "corpus_name": "Duran-Ortiz S", "orcid": null, "lab": "Institute for Molecular Medicine and Aging, Heritage College of Osteopathic Medicine, Ohio University (Athens, Ohio, USA)", "lab_url": null, "role": "Researcher in John Kopchick's group at Ohio University who studies how switching off growth hormone action, even in middle age, lengthens life in mice", "studies": [ "DUR2026" ], "url": "https://mtor-atlas.org/author/silvana-duran-ortiz/" }, { "id": "yuji-ikeno", "name": "Yuji Ikeno", "corpus_name": "Ikeno Y", "orcid": null, "lab": "Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "Pathologist at the Barshop Institute for Longevity and Aging Studies in San Antonio whose examinations of tissues from aged mice help ageing studies tell whether an intervention changes disease, especially cancer, late in life", "studies": [ "LAB2015", "DUR2026" ], "url": "https://mtor-atlas.org/author/yuji-ikeno/" }, { "id": "simone-evans", "name": "Simone Evans", "corpus_name": "Evans S", "orcid": null, "lab": "Department of Integrative Neuroscience, Guarini School of Graduate and Advanced Studies, Dartmouth College (Hanover, New Hampshire, USA)", "lab_url": null, "role": "Neuroscience researcher at Dartmouth who studies how growth signals shape the skeleton of sensory nerve fibres, and first author of work showing that PTEN acts on microtubules through mTORC2 rather than mTORC1", "studies": [ "EVA2026" ], "url": "https://mtor-atlas.org/author/simone-evans/" }, { "id": "wenjun-fan", "name": "Wenjun Fan", "corpus_name": "Fan W", "orcid": null, "lab": "Laiho Lab, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine (Baltimore, Maryland, USA)", "lab_url": null, "role": "Cancer biologist in Marikki Laiho's lab at Johns Hopkins who studies ribosome production as a weak point of cancer cells, and who showed how mTOR inhibition helps cells survive when ribosomes run short", "studies": [ "FAN2026" ], "url": "https://mtor-atlas.org/author/wenjun-fan/" }, { "id": "morris-e-feldman", "name": "Morris E. Feldman", "corpus_name": "Feldman ME", "orcid": null, "lab": "Shokat lab, Department of Cellular and Molecular Pharmacology, UCSF and Howard Hughes Medical Institute (San Francisco, California, USA)", "lab_url": null, "role": "Chemical biologist who, in the Shokat lab at UCSF, introduced PP242 and the TORKinib class of drugs that block mTOR's active site and reach the outputs rapamycin misses", "studies": [ "FEL2009" ], "url": "https://mtor-atlas.org/author/morris-e-feldman/" }, { "id": "james-m-flynn", "name": "James M. Flynn", "corpus_name": "Flynn JM", "orcid": null, "lab": "Melov Lab, Buck Institute for Research on Aging (Novato, California, USA)", "lab_url": null, "role": "Aging researcher from Simon Melov's lab at the Buck Institute who showed that a short course of rapamycin late in life can partly reverse heart aging in mice", "studies": [ "FLY2013" ], "url": "https://mtor-atlas.org/author/james-m-flynn/" }, { "id": "vivian-diaz", "name": "Vivian Diaz", "corpus_name": "Diaz V", "orcid": null, "lab": "Barshop Institute for Longevity and Aging Studies, UT Health San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "Aging researcher at the Barshop Institute in San Antonio who has worked for more than a decade on the mouse lifespan studies behind rapamycin's reputation as an anti-aging drug, including the Interventions Testing Program", "studies": [ "FOK2014", "STR2022" ], "url": "https://mtor-atlas.org/author/vivian-diaz/" }, { "id": "wilson-c-fok", "name": "Wilson C. Fok", "corpus_name": "Fok WC", "orcid": null, "lab": "Department of Cellular and Structural Biology and Barshop Institute, UT Health San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "Biologist of aging who, in Viviana Pérez's group in San Antonio, compared rapamycin with dietary restriction in mouse liver and showed that rapamycin's lifespan gain comes with large changes in liver gene activity", "studies": [ "FOK2014" ], "url": "https://mtor-atlas.org/author/wilson-c-fok/" }, { "id": "marc-foretz", "name": "Marc Foretz", "corpus_name": "Foretz M", "orcid": null, "lab": "Institut Cochin, Université Paris Cité, CNRS, Inserm (Paris, France)", "lab_url": null, "role": "Researcher at the Institut Cochin in Paris who studies how the liver controls sugar and fat, and whose 2010 work showed that metformin can lower liver glucose output without AMPK", "studies": [ "FOR2010" ], "url": "https://mtor-atlas.org/author/marc-foretz/" }, { "id": "paolo-curatolo", "name": "Paolo Curatolo", "corpus_name": "Curatolo P", "orcid": null, "lab": "Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University (Rome, Italy)", "lab_url": null, "role": "Child neurologist at Tor Vergata University in Rome who has spent much of a long career on tuberous sclerosis complex, the genetic disease of overactive mTOR, with a focus on epilepsy and brain development in children", "studies": [ "FRE2016" ], "url": "https://mtor-atlas.org/author/paolo-curatolo/" }, { "id": "maria-a-frias", "name": "Maria A Frias", "corpus_name": "Frias MA", "orcid": null, "lab": "Department of Biology, St. Francis College (Brooklyn, New York, USA)", "lab_url": "https://www.sfc.edu/academics/faculty-directory/maria-frias-2", "role": "Cancer biologist who did her doctoral research on mTORC2 in David Sabatini's lab and now teaches biology at St. Francis College in Brooklyn, while continuing work with David Foster on how the lipid phosphatidic acid controls mTOR", "studies": [ "FRI2006" ], "url": "https://mtor-atlas.org/author/maria-a-frias/" }, { "id": "cong-xu", "name": "Cong Xu", "corpus_name": "Xu C", "orcid": null, "lab": "Department of Hematology, The Seventh Affiliated Hospital, Sun Yat-sen University (Shenzhen, China)", "lab_url": null, "role": "Hematologist in Shenzhen who studies drug resistance and drug safety in multiple myeloma, and senior author of a study linking a small RNA fragment to autophagy-driven resistance to bortezomib", "studies": [ "FU2026" ], "url": "https://mtor-atlas.org/author/cong-xu/" }, { "id": "xiaoqing-gan", "name": "Xiaoqing Gan", "corpus_name": "Gan X", "orcid": null, "lab": "Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University (Shanghai, China)", "lab_url": "https://basicmed.fudan.edu.cn/a3/62/c28574a303970/page.htm", "role": "Biochemist at Fudan University who showed as a Yale postdoc that the lipid messenger PIP3 directly switches on mTORC2, and who now studies Wnt and mTORC2 signalling in metabolism", "studies": [ "GAN2011" ], "url": "https://mtor-atlas.org/author/xiaoqing-gan/" }, { "id": "xinsheng-gao", "name": "Xinsheng Gao", "corpus_name": "Gao X", "orcid": null, "lab": "Department of Physiology, University of Texas Southwestern Medical Center (Dallas, Texas, USA)", "lab_url": null, "role": "Geneticist who, in Duojia Pan's lab, used fruit flies and mammalian cells to show that the tumour suppressors Tsc1 and Tsc2 restrain TOR signalling and make it sensitive to amino acids", "studies": [ "GAO2002" ], "url": "https://mtor-atlas.org/author/xinsheng-gao/" }, { "id": "ke-gao", "name": "Ke Gao", "corpus_name": "Gao K", "orcid": null, "lab": "Department of Urology, Xi'an People's Hospital (Xi'an Fourth Hospital), School of Medicine, Northwest University (Xi'an, Shaanxi, China)", "lab_url": null, "role": "Urology researcher at Xi'an People's Hospital and first author of a 2026 multicentre study showing that the fat content of TSC kidney tumours predicts how well they shrink on everolimus", "studies": [ "GAO2026B" ], "url": "https://mtor-atlas.org/author/ke-gao/" }, { "id": "jianxin-ni", "name": "Jianxin Ni", "corpus_name": "Ni J", "orcid": null, "lab": "Department of Urology, Urology and Nephrology Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Northwest University (Xi'an, Shaanxi, China)", "lab_url": null, "role": "Urologist at Xi'an People's Hospital and senior author of a 2026 multicentre study of everolimus for TSC kidney tumours, with further work on prostate cancer", "studies": [ "GAO2026B" ], "url": "https://mtor-atlas.org/author/jianxin-ni/" }, { "id": "attila-garami", "name": "Attila Garami", "corpus_name": "Garami A", "orcid": null, "lab": "Friedrich Miescher Institute for Biomedical Research (Basel, Switzerland)", "lab_url": null, "role": "First author of the 2003 study, from George Thomas's group at the Friedrich Miescher Institute, showing that insulin switches on Rheb and that the TSC1-TSC2 complex switches it off", "studies": [ "GAR2003" ], "url": "https://mtor-atlas.org/author/attila-garami/" }, { "id": "hugo-stocker", "name": "Hugo Stocker", "corpus_name": "Stocker H", "orcid": null, "lab": "Hafen group, Institute of Molecular Systems Biology, ETH Zurich (Zurich, Switzerland)", "lab_url": null, "role": "Drosophila geneticist who worked for nearly two decades in Ernst Hafen's group in Zurich and helped show how insulin and TOR signalling set cell and body size in the fruit fly, including the discovery that Rheb is essential for TOR-S6K driven growth", "studies": [ "STO2003" ], "url": "https://mtor-atlas.org/author/hugo-stocker/" }, { "id": "deborah-c-i-goberdhan", "name": "Deborah C. I. Goberdhan", "corpus_name": "Goberdhan DC", "orcid": null, "lab": "Nuffield Department of Women's and Reproductive Health, University of Oxford (Oxford, England, United Kingdom)", "lab_url": null, "role": "Oxford cell biologist who studies how amino acid transporters and the cell's secretory compartments control growth signalling, often using the fruit fly, and who argued that intracellular transporters mark where mTORC1 is switched on", "studies": [ "GOB2016" ], "url": "https://mtor-atlas.org/author/deborah-c-i-goberdhan/" }, { "id": "claire-goul", "name": "Claire Goul", "corpus_name": "Goul C", "orcid": null, "lab": "Leonetti Group, Chan Zuckerberg Biohub San Francisco (San Francisco, California, USA)", "lab_url": null, "role": "Cell biologist who did graduate work in Roberto Zoncu's lab at UC Berkeley on lysosomes and mTORC1, first author of a major review of how mTORC1 senses nutrients and of a 2026 Nature study on how damaged lysosomes are repaired, now a scientist at CZ Biohub", "studies": [ "GOU2023" ], "url": "https://mtor-atlas.org/author/claire-goul/" }, { "id": "xin-gu", "name": "Xin Gu", "corpus_name": "Gu X", "orcid": null, "lab": "Gu Lab, Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://labs.dana-farber.org/xingulab/team", "role": "Cell biologist who discovered SAMTOR, the sensor that lets mTORC1 read the methyl donor SAM, as a PhD student at MIT, and who now leads a lab at Dana-Farber and Harvard Medical School studying ubiquitin-independent protein destruction by the midnolin-proteasome pathway", "studies": [ "VAL2022", "WOL2017", "ROG2019", "GU2017" ], "url": "https://mtor-atlas.org/author/xin-gu/" }, { "id": "jose-g-guerrero-morin", "name": "José G Guerrero-Morín", "corpus_name": "Guerrero-Morín JG", "orcid": null, "lab": "Unidad Monterrey, Centro de Investigación y de Estudios Avanzados del IPN (Apodaca, Nuevo León, Mexico)", "lab_url": null, "role": "Researcher at the Monterrey unit of Cinvestav in Mexico and first author of a 2020 mathematical model of how mTORC1 could tune the body's daily clock", "studies": [ "GUE2020" ], "url": "https://mtor-atlas.org/author/jose-g-guerrero-morin/" }, { "id": "paolo-guerra", "name": "Paolo Guerra", "corpus_name": "Guerra P", "orcid": null, "lab": "Molecular Systems Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen (Groningen, Netherlands)", "lab_url": null, "role": "Systems biologist who tracked TORC1 and PKA signalling in single yeast cells and showed that their growth signals rise and fall with the cell cycle", "studies": [ "GUE2022" ], "url": "https://mtor-atlas.org/author/paolo-guerra/" }, { "id": "markus-h-heim", "name": "Markus H. Heim", "corpus_name": "Heim MH", "orcid": null, "lab": "Department of Biomedicine, University of Basel, and Clarunis (Basel, Switzerland)", "lab_url": null, "role": "Basel hepatologist who studies how the liver responds to viral infection and how liver cancer develops, and a co-author of the study linking mTORC2 to fat synthesis in liver tumours", "studies": [ "GUR2017" ], "url": "https://mtor-atlas.org/author/markus-h-heim/" }, { "id": "paul-jenoe", "name": "Paul Jenoe", "corpus_name": "Jenoe P", "orcid": null, "lab": "Proteomics Core Facility, Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": null, "role": "Protein chemist who ran mass spectrometry and protein sequencing at the Biozentrum Basel for decades and contributed protein analysis to many mTOR studies from Michael Hall's lab", "studies": [ "GUR2017" ], "url": "https://mtor-atlas.org/author/paul-jenoe/" }, { "id": "suzette-moes", "name": "Suzette Moes", "corpus_name": "Moes S", "orcid": null, "lab": "Proteomics Core Facility, Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": null, "role": "Protein scientist at the Biozentrum Basel's proteomics facility who, with Paul Jenö, carried out mass spectrometry for many mTOR studies from Michael Hall's lab", "studies": [ "GUR2017" ], "url": "https://mtor-atlas.org/author/suzette-moes/" }, { "id": "amany-a-e-ahmed", "name": "Amany A E Ahmed", "corpus_name": "Ahmed AAE", "orcid": null, "lab": "Pharmacology and Toxicology Department, Faculty of Pharmacy, Helwan University (Ein Helwan, Egypt)", "lab_url": null, "role": "Pharmacologist at Helwan University in Cairo who leads animal studies of how existing drugs and natural compounds protect tissues from inflammation, fibrosis and injury", "studies": [ "HAFEZ2026" ], "url": "https://mtor-atlas.org/author/amany-a-e-ahmed/" }, { "id": "saeed-a-hafez", "name": "Saeed A Hafez", "corpus_name": "Hafez SA", "orcid": null, "lab": "Health Holding Company, Aseer Health Cluster, Saudi Ministry of Health (Abha, Saudi Arabia)", "lab_url": null, "role": "Researcher with the Aseer Health Cluster in Abha, Saudi Arabia, and first author of a 2026 mouse study testing the bee-venom peptide melittin against psoriasis-like skin inflammation", "studies": [ "HAFEZ2026" ], "url": "https://mtor-atlas.org/author/saeed-a-hafez/" }, { "id": "asami-hagiwara", "name": "Asami Hagiwara", "corpus_name": "Hagiwara A", "orcid": null, "lab": "Hall Lab, Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": null, "role": "First author of a 2012 mouse study from Michael Hall's lab showing that liver mTORC2 tells the liver that the animal has eaten, by switching on sugar breakdown and fat production", "studies": [ "HAG2012" ], "url": "https://mtor-atlas.org/author/asami-hagiwara/" }, { "id": "pazit-polak", "name": "Pazit Polak", "corpus_name": "Polak P", "orcid": null, "lab": "Hall Lab, Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": null, "role": "Cell biologist from Michael Hall's Basel lab who showed, in mice, that switching off mTORC1 in fat tissue alone makes animals lean and protects them from diet-induced obesity", "studies": [ "POL2008" ], "url": "https://mtor-atlas.org/author/pazit-polak/" }, { "id": "jung-min-han", "name": "Jung Min Han", "corpus_name": "Han JM", "orcid": null, "lab": "College of Pharmacy, Yonsei University (Incheon, South Korea)", "lab_url": null, "role": "Pharmacologist at Yonsei University who found that leucyl-tRNA synthetase, the enzyme that loads leucine onto its tRNA, doubles as the cell's leucine sensor for mTORC1, and who now studies how this enzyme links nutrients to growth signalling", "studies": [ "HAN2012" ], "url": "https://mtor-atlas.org/author/jung-min-han/" }, { "id": "jacob-m-hands", "name": "Jacob M Hands", "corpus_name": "Hands JM", "orcid": null, "lab": "Department of Pathology, University of Southern California (Los Angeles, California, USA)", "lab_url": null, "role": "Researcher in integrative medicine and nutrition science, trained at George Washington University, who wrote a cautious review of whether off-label rapamycin is justified for healthy adults", "studies": [ "HAN2025" ], "url": "https://mtor-atlas.org/author/jacob-m-hands/" }, { "id": "bradley-rosen", "name": "Bradley Rosen", "corpus_name": "Rosen B", "orcid": null, "lab": "MTOR MD (Los Angeles, California, USA)", "lab_url": "https://mtormd.com", "role": "Los Angeles physician, originally trained as a retina specialist, who runs a longevity-medicine practice built around rapamycin and metformin, and senior author of a cautious review of the human evidence for off-label rapamycin in healthy adults", "studies": [ "HAN2025" ], "url": "https://mtor-atlas.org/author/bradley-rosen/" }, { "id": "martin-a-javors", "name": "Martin A. Javors", "corpus_name": "Javors MA", "orcid": null, "lab": "Biological Psychiatry Analytical Laboratory, Department of Psychiatry, University of Texas Health Science Center at San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "Pharmacologist and professor at UT Health San Antonio who directs an analytical laboratory for biochemical and drug measurements, and a co-author of rapamycin studies in mice and in older people", "studies": [ "KRA2018", "STR2022" ], "url": "https://mtor-atlas.org/author/martin-a-javors/" }, { "id": "elizabeth-fernandez", "name": "Elizabeth Fernandez", "corpus_name": "Fernandez E", "orcid": null, "lab": "Barshop Institute for Longevity and Aging Studies, UT Health San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "Aging researcher at the Barshop Institute in San Antonio who has worked on rapamycin studies in mice and common marmosets, including the NIA Interventions Testing Program", "studies": [ "TAR2014", "STR2022", "ROS2015" ], "url": "https://mtor-atlas.org/author/elizabeth-fernandez/" }, { "id": "james-f-nelson", "name": "James F. Nelson", "corpus_name": "Nelson JF", "orcid": null, "lab": "Department of Cellular and Integrative Physiology and Barshop Institute for Longevity and Aging Studies, UT Health San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "Physiologist of aging at UT Health San Antonio who studies how calorie restriction, sex hormones and drugs change mouse lifespan, and a co-investigator on the Interventions Testing Program", "studies": [ "STR2022" ], "url": "https://mtor-atlas.org/author/james-f-nelson/" }, { "id": "john-e-wilkinson", "name": "John E Wilkinson", "corpus_name": "Wilkinson JE", "orcid": null, "lab": "Unit for Laboratory Animal Medicine and Department of Pathology, University of Michigan (Ann Arbor, Michigan, USA)", "lab_url": null, "role": "Pathologist at the University of Michigan who examines animal tissues for aging and cancer studies, and first author of the 2012 paper showing that rapamycin slows many signs of aging in mice", "studies": [ "WIL2012" ], "url": "https://mtor-atlas.org/author/john-e-wilkinson/" }, { "id": "david-b-allison", "name": "David B. Allison", "corpus_name": "Allison DB", "orcid": null, "lab": "Department of Biostatistics, University of Alabama at Birmingham (Birmingham, Alabama, USA)", "lab_url": null, "role": "Biostatistician and obesity researcher, long at the University of Alabama at Birmingham and later dean of public health at Indiana University, known for work on nutrition, obesity and research rigour", "studies": [ "MAT2017" ], "url": "https://mtor-atlas.org/author/david-b-allison/" }, { "id": "yi-he", "name": "Yi He", "corpus_name": "He Y", "orcid": null, "lab": "Xuefeng Yu group, Division of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (Wuhan, Hubei, China)", "lab_url": null, "role": "Endocrinology researcher in Xuefeng Yu's group at Tongji Hospital in Wuhan who studies the liver- and fat-derived hormone ANGPTL8 in aging and diabetes", "studies": [ "HE2026" ], "url": "https://mtor-atlas.org/author/yi-he/" }, { "id": "samson-hennessy-strahs", "name": "Samson Hennessy-Strahs", "corpus_name": "Hennessy-Strahs S", "orcid": null, "lab": "Immunobiology and Transplant Science Center, Houston Methodist Hospital (Houston, Texas, USA)", "lab_url": null, "role": "Researcher who moved from studying heart pumps and blood vessels at Penn to transplant immunology in Houston, and first author of a study showing that the lung's cleaning macrophages need mTOR to survive", "studies": [ "HEN2026" ], "url": "https://mtor-atlas.org/author/samson-hennessy-strahs/" }, { "id": "marina-k-holz", "name": "Marina K. Holz", "corpus_name": "Holz MK", "orcid": null, "lab": "Department of Cell and Molecular Physiology, Graduate School of Biomedical Sciences, New York Medical College (Valhalla, New York, USA)", "lab_url": null, "role": "Cell biologist who, as a postdoc with John Blenis, showed how mTOR and S6K1 trade places on eIF3 to start protein synthesis, and who now studies mTOR in breast cancer and the rare lung disease LAM at New York Medical College", "studies": [ "HOL2005" ], "url": "https://mtor-atlas.org/author/marina-k-holz/" }, { "id": "steve-horvath", "name": "Steve Horvath", "corpus_name": "Horvath S", "orcid": null, "lab": "Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles (Los Angeles, California, USA)", "lab_url": null, "role": "Biostatistician and geneticist who built the first pan-tissue epigenetic clock, a DNA methylation test that estimates biological age, and co-developed the network method WGCNA", "studies": [ "HOR2021" ], "url": "https://mtor-atlas.org/author/steve-horvath/" }, { "id": "julie-a-mattison", "name": "Julie A. Mattison", "corpus_name": "Mattison JA", "orcid": null, "lab": "Translational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health (Baltimore, Maryland, USA)", "lab_url": null, "role": "Primate aging researcher at the US National Institute on Aging who led the NIA study of calorie restriction in rhesus monkeys and its comparison with the Wisconsin study", "studies": [ "HOR2021", "MAT2017" ], "url": "https://mtor-atlas.org/author/julie-a-mattison/" }, { "id": "nao-hosokawa", "name": "Nao Hosokawa", "corpus_name": "Hosokawa N", "orcid": null, "lab": "Department of Physiology and Cell Biology, Tokyo Medical and Dental University (Tokyo, Japan)", "lab_url": null, "role": "Cell biologist who, in Noboru Mizushima's lab, showed how mTORC1 directly holds the autophagy starter complex in check and helped discover the autophagy protein Atg101", "studies": [ "HOS2009" ], "url": "https://mtor-atlas.org/author/nao-hosokawa/" }, { "id": "george-talbott", "name": "George Talbott", "corpus_name": "Talbott G", "orcid": null, "lab": "Manning Lab, Harvard T.H. Chan School of Public Health (Boston, Massachusetts, USA)", "lab_url": null, "role": "Research assistant in Brendan Manning's mTOR lab at Harvard in 2013 and 2014, who contributed to studies on where the TSC complex sits in the cell and how metformin reaches mTORC1", "studies": [ "HOW2017", "MEN2014" ], "url": "https://mtor-atlas.org/author/george-talbott/" }, { "id": "marc-turner", "name": "Marc Turner", "corpus_name": "Turner M", "orcid": null, "lab": "Manning Lab, Harvard T.H. Chan School of Public Health (Boston, Massachusetts, USA)", "lab_url": null, "role": "Research assistant and lab manager in Brendan Manning's mTOR lab at Harvard from 2014 to 2016, who contributed to studies on nucleotide synthesis in tumour cells and on metformin's route to mTORC1", "studies": [ "VAL2017", "HOW2017" ], "url": "https://mtor-atlas.org/author/marc-turner/" }, { "id": "wei-huang", "name": "Wei Huang", "corpus_name": "Huang W", "orcid": null, "lab": "Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine (Baltimore, Maryland, USA)", "lab_url": null, "role": "Neuroscientist trained in Mauro Costa-Mattioli's memory lab at Baylor, first author of the study that showed mTORC2 is needed for long-term memory through control of the actin skeleton", "studies": [ "HUA2013" ], "url": "https://mtor-atlas.org/author/wei-huang/" }, { "id": "congxiu-huang", "name": "Congxiu Huang", "corpus_name": "Huang C", "orcid": null, "lab": "Department of Radiation Oncology, The Affiliated Hospital of Inner Mongolia Medical University (Hohhot, China)", "lab_url": null, "role": "Radiation oncology researcher in Hohhot and first author of a study linking the PIK3CA E545K mutation to faster growth and invasion of cervical cancer through AKT/mTOR signalling", "studies": [ "HUANG2026" ], "url": "https://mtor-atlas.org/author/congxiu-huang/" }, { "id": "gary-hudes", "name": "Gary Hudes", "corpus_name": "Hudes G", "orcid": null, "lab": "Department of Medical Oncology, Fox Chase Cancer Center (Philadelphia, Pennsylvania, USA)", "lab_url": null, "role": "Medical oncologist at Fox Chase Cancer Center who led the phase 3 trial showing that the mTOR inhibitor temsirolimus lengthens survival in poor-prognosis advanced kidney cancer", "studies": [ "HUD2007" ], "url": "https://mtor-atlas.org/author/gary-hudes/" }, { "id": "qian-yang", "name": "Qian Yang", "corpus_name": "Yang Q", "orcid": null, "lab": "Kun-Liang Guan lab, Life Sciences Institute, University of Michigan (Ann Arbor, Michigan, USA)", "lab_url": null, "role": "Researcher in Kun-Liang Guan's Michigan lab and first author of the 2006 study that identified Sin1 as an essential part of mTOR complex 2", "studies": [ "YAN2006" ], "url": "https://mtor-atlas.org/author/qian-yang/" }, { "id": "gopa-iyer", "name": "Gopa Iyer", "corpus_name": "Iyer G", "orcid": null, "lab": "Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center (New York, New York, USA)", "lab_url": "https://www.mskcc.org/cancer-care/doctors/gopa-iyer", "role": "Medical oncologist at Memorial Sloan Kettering who heads its bladder cancer section and studies the genetics behind how bladder tumors respond to drugs", "studies": [ "IYE2012" ], "url": "https://mtor-atlas.org/author/gopa-iyer/" }, { "id": "lauren-n-jackson", "name": "Lauren N. Jackson", "corpus_name": "Jackson LN", "orcid": null, "lab": "Mockett Lab, Department of Biomedical Sciences, University of South Alabama (Mobile, Alabama, USA)", "lab_url": null, "role": "Researcher in Robin Mockett's lab at the University of South Alabama who showed that rapamycin's effect on fruit fly lifespan swings from harmful to helpful depending on the food", "studies": [ "JAC2026" ], "url": "https://mtor-atlas.org/author/lauren-n-jackson/" }, { "id": "young-chul-kim", "name": "Young Chul Kim", "corpus_name": "Kim YC", "orcid": null, "lab": "Vallon Lab, Division of Nephrology and Hypertension, University of California San Diego and VA San Diego Healthcare System (La Jolla, California, USA)", "lab_url": null, "role": "Cell biologist who studied mTOR and autophagy in Kun-Liang Guan's lab at UC San Diego and later moved to kidney research in Volker Vallon's group", "studies": [ "JEW2015" ], "url": "https://mtor-atlas.org/author/young-chul-kim/" }, { "id": "hyun-woo-park", "name": "Hyun Woo Park", "corpus_name": "Park HW", "orcid": null, "lab": "Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University (Seoul, South Korea)", "lab_url": null, "role": "Biochemist at Yonsei University who trained with Kun-Liang Guan on the Hippo-YAP/TAZ growth pathway and now studies how cancer cells change their signalling and metabolism to spread", "studies": [ "JEW2015" ], "url": "https://mtor-atlas.org/author/hyun-woo-park/" }, { "id": "jennifer-jung", "name": "Jennifer Jung", "corpus_name": "Jung J", "orcid": null, "lab": "Behrends Lab, Institute of Biochemistry II, Goethe University School of Medicine (Frankfurt am Main, Germany)", "lab_url": null, "role": "Biochemist from Christian Behrends' group in Frankfurt who showed that the lysosomal amino acid transporter SLC38A9 helps switch on mTORC1, and who studied regulators of autophagy", "studies": [ "JUN2015" ], "url": "https://mtor-atlas.org/author/jennifer-jung/" }, { "id": "peng-jin", "name": "Peng Jin", "corpus_name": "Jin P", "orcid": null, "lab": "College of Pharmaceutical Sciences, Southwest University (Chongqing, China)", "lab_url": null, "role": "Pharmaceutical scientist in Lei Luo's group at Southwest University in Chongqing who studies the drug pump P-glycoprotein, and first author of the study showing that oxidative stress boosts P-glycoprotein production through mTOR", "studies": [ "JIN2026" ], "url": "https://mtor-atlas.org/author/peng-jin/" }, { "id": "lingyan-jin", "name": "Lingyan Jin", "corpus_name": "Jin L", "orcid": null, "lab": "Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University (Xi'an, Shaanxi, China)", "lab_url": null, "role": "Cardiology researcher in Qiangsun Zheng's group in Xi'an who studies how metabolism and aging make the heart's upper chambers prone to atrial fibrillation", "studies": [ "JIN2026B" ], "url": "https://mtor-atlas.org/author/lingyan-jin/" }, { "id": "qiangsun-zheng", "name": "Qiangsun Zheng", "corpus_name": "Zheng Q", "orcid": null, "lab": "Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University (Xi'an, Shaanxi, China)", "lab_url": null, "role": "Cardiologist at the Second Affiliated Hospital of Xi'an Jiaotong University whose group studies atrial fibrillation as a disorder of heart metabolism, in mice and in patients", "studies": [ "JIN2026B" ], "url": "https://mtor-atlas.org/author/qiangsun-zheng/" }, { "id": "jill-de-mol", "name": "Jill de Mol", "corpus_name": "de Mol J", "orcid": "0000-0003-3541-9912", "lab": "Aging and Immunity group (Foks lab), Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University (Leiden, Netherlands)", "lab_url": "https://www.universiteitleiden.nl/en/staffmembers/jill-de-mol", "role": "Immunologist at Leiden University who studies how the aging immune system, especially aged B cells, drives atherosclerosis, and first author of a 2026 study of rapamycin as an immune rejuvenator in old mice", "studies": [ "JIN2026C" ], "url": "https://mtor-atlas.org/author/jill-de-mol/" }, { "id": "simon-c-johnson", "name": "Simon C. Johnson", "corpus_name": "Johnson SC", "orcid": "0000-0002-1942-3674", "lab": "School of Geography and Natural Sciences, Northumbria University (Newcastle upon Tyne, England, United Kingdom)", "lab_url": "https://researchportal.northumbria.ac.uk/en/persons/simon-johnson/", "role": "Biologist of aging and mitochondrial disease, first author with Peter Rabinovitch and Matt Kaeberlein of the 2013 Nature review that made the case for mTOR as a central controller of aging, now a professor at Northumbria University", "studies": [ "JOH2013" ], "url": "https://mtor-atlas.org/author/simon-c-johnson/" }, { "id": "r-wilson-powers", "name": "R Wilson Powers", "corpus_name": "Powers RW", "orcid": null, "lab": "Sterne, Kessler, Goldstein & Fox P.L.L.C. (Washington, DC, USA)", "lab_url": null, "role": "Molecular biologist who, as a PhD student in Seattle, built high-throughput lifespan screens in yeast and showed that lowering TOR signalling extends chronological lifespan, and who later became a patent attorney", "studies": [ "POW2006" ], "url": "https://mtor-atlas.org/author/r-wilson-powers/" }, { "id": "adem-kalender", "name": "Adem Kalender", "corpus_name": "Kalender A", "orcid": null, "lab": "George Thomas group, Metabolic Diseases Institute, University of Cincinnati (Cincinnati, Ohio, USA)", "lab_url": null, "role": "Cell biologist who, in George Thomas's group at the University of Cincinnati, showed that metformin can switch off mTORC1 without AMPK by acting through the Rag GTPases", "studies": [ "KAL2010" ], "url": "https://mtor-atlas.org/author/adem-kalender/" }, { "id": "michael-e-pacold", "name": "Michael E. Pacold", "corpus_name": "Pacold ME", "orcid": null, "lab": "Pacold Lab, Department of Radiation Oncology and Laura and Isaac Perlmutter Cancer Center, NYU Langone Health (New York, New York, USA)", "lab_url": "https://www.pacoldlab.org/members", "role": "Radiation oncologist and chemical biologist at NYU Langone who studies the metabolism of brain tumours, and a co-author of the Sabatini lab's structure of the leucine sensor Sestrin2", "studies": [ "SAX2015" ], "url": "https://mtor-atlas.org/author/michael-e-pacold/" }, { "id": "brian-m-zid", "name": "Brian M. Zid", "corpus_name": "Zid BM", "orcid": null, "lab": "Zid Lab, Department of Chemistry and Biochemistry, University of California San Diego (La Jolla, California, USA)", "lab_url": null, "role": "Biochemist at UC San Diego who studies how cells decide which messenger RNAs to translate under stress, and who showed as a Caltech student that the mTOR target 4E-BP is needed for dietary restriction to lengthen fly lifespan", "studies": [ "ZID2009" ], "url": "https://mtor-atlas.org/author/brian-m-zid/" }, { "id": "manikandan-karuppasamy", "name": "Manikandan Karuppasamy", "corpus_name": "Karuppasamy M", "orcid": null, "lab": "European Molecular Biology Laboratory, Grenoble Outstation (Grenoble, France)", "lab_url": null, "role": "Structural biologist who used cryo-electron microscopy at EMBL Grenoble to solve the first structure of yeast TORC2, explaining why it resists rapamycin", "studies": [ "KAR2017" ], "url": "https://mtor-atlas.org/author/manikandan-karuppasamy/" }, { "id": "george-kelly", "name": "George Kelly", "corpus_name": "Kelly G", "orcid": null, "lab": "Korolchuk Lab, Biosciences Institute, Newcastle University (Newcastle upon Tyne, England, United Kingdom)", "lab_url": null, "role": "Cell biologist from Viktor Korolchuk's group at Newcastle University who showed that the routine clearing of damaged mitochondria fails as human cells become senescent", "studies": [ "KEL2024" ], "url": "https://mtor-atlas.org/author/george-kelly/" }, { "id": "rohini-v-khapre", "name": "Rohini V. Khapre", "corpus_name": "Khapre RV", "orcid": null, "lab": "Kondratov Lab, Center for Gene Regulation in Health and Disease, Cleveland State University (Cleveland, Ohio, USA)", "lab_url": null, "role": "Circadian biologist who did her PhD in Roman Kondratov's lab at Cleveland State University, where she showed that the clock protein BMAL1 acts as a brake on mTORC1 and that feeding times set a daily rhythm in mTORC1 activity", "studies": [ "KHA2014" ], "url": "https://mtor-atlas.org/author/rohini-v-khapre/" }, { "id": "yoko-kidani", "name": "Yoko Kidani", "corpus_name": "Kidani Y", "orcid": null, "lab": "Institute for Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles (Los Angeles, California, USA)", "lab_url": null, "role": "Researcher who, in Steven Bensinger's lab at UCLA, showed that activated killer T cells need SREBP-driven fat and cholesterol synthesis to expand", "studies": [ "KID2013" ], "url": "https://mtor-atlas.org/author/yoko-kidani/" }, { "id": "young-mi-kim", "name": "Young-Mi Kim", "corpus_name": "Kim YM", "orcid": null, "lab": "Do-Hyung Kim Lab, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota (Minneapolis, Minnesota, USA)", "lab_url": null, "role": "mTOR researcher in Do-Hyung Kim's University of Minnesota lab who found SH3BP4 as a brake on the amino acid sensing Rag GTPases and showed that mTORC1 phosphorylates UVRAG to slow autophagy", "studies": [ "KIM2012" ], "url": "https://mtor-atlas.org/author/young-mi-kim/" }, { "id": "adriana-d-benavides", "name": "Adriana D. Benavides", "corpus_name": "Benavides AD", "orcid": null, "lab": "Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "Immunologist who worked at UT Health San Antonio and the Children's Hospital of Philadelphia, and a co-author of the first small safety trial of rapamycin in healthy older people", "studies": [ "KRA2018" ], "url": "https://mtor-atlas.org/author/adriana-d-benavides/" }, { "id": "ellen-kraig", "name": "Ellen Kraig", "corpus_name": "Kraig E", "orcid": null, "lab": "Department of Cell Systems and Anatomy, UT Health San Antonio (San Antonio, Texas, USA)", "lab_url": "https://utsystem.edu/sites/regents-outstanding-teaching-awards/2018/kraig-ellen", "role": "Immunologist at UT Health San Antonio who studies how aging changes immune regulation and who led the first small safety trial of rapamycin in healthy older people at the Barshop Institute", "studies": [ "KRA2018" ], "url": "https://mtor-atlas.org/author/ellen-kraig/" }, { "id": "nicolas-musi", "name": "Nicolas Musi", "corpus_name": "Musi N", "orcid": null, "lab": "Diabetes and Aging Center, Cedars-Sinai Medical Center (Los Angeles, California, USA)", "lab_url": "https://www.cedars-sinai.org/newsroom/nicolas-musi-md-named-inaugural-cypres-chair-in-diabetes-research/", "role": "Endocrinologist and aging researcher who directs the Division of Endocrinology, Diabetes and Metabolism and the Diabetes and Aging Center at Cedars-Sinai, and who studies how aging drives insulin resistance, frailty and senescence", "studies": [ "KRA2018" ], "url": "https://mtor-atlas.org/author/nicolas-musi/" }, { "id": "jonas-boritz-kristiansen", "name": "Jonas Boritz Kristiansen", "corpus_name": "Kristiansen JB", "orcid": null, "lab": "Exercise Biology, Department of Public Health, Aarhus University (Aarhus, Denmark)", "lab_url": null, "role": "Exercise biologist at Aarhus University, working with Kristian Vissing, who studies how aging changes muscle's response to mechanical load and to food", "studies": [ "KRISTIANSEN2026" ], "url": "https://mtor-atlas.org/author/jonas-boritz-kristiansen/" }, { "id": "takeshi-kusuda", "name": "Takeshi Kusuda", "corpus_name": "Kusuda T", "orcid": null, "lab": "Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo (Tokyo, Japan)", "lab_url": null, "role": "Rheumatologist and researcher at the University of Tokyo who studies how B cells go wrong in lupus, and first author of the 2026 study tying the arginine sensor CASTOR1 to mTORC1 in antibody-making cells", "studies": [ "KUS2026" ], "url": "https://mtor-atlas.org/author/takeshi-kusuda/" }, { "id": "remi-martin-laberge", "name": "Remi-Martin Laberge", "corpus_name": "Laberge RM", "orcid": null, "lab": "UNITY Biotechnology (South San Francisco, California, USA)", "lab_url": null, "role": "Biologist of cell senescence, trained in Judith Campisi's lab, who showed how mTOR drives the inflammatory signals of senescent cells and then moved to drug development against senescence at UNITY Biotechnology", "studies": [ "LAB2015" ], "url": "https://mtor-atlas.org/author/remi-martin-laberge/" }, { "id": "conor-m-lane", "name": "Conor M. Lane", "corpus_name": "Lane CM", "orcid": null, "lab": "Department of Cardiovascular Medicine, Mayo Clinic (Rochester, Minnesota, USA)", "lab_url": null, "role": "Cardiologist at Mayo Clinic in Rochester, working in interventional cardiology, and first author of a trial of low-dose rapamycin in frail older adults with heart failure with preserved ejection fraction", "studies": [ "LAN2026" ], "url": "https://mtor-atlas.org/author/conor-m-lane/" }, { "id": "agathe-landoas", "name": "Agathe Landoas", "corpus_name": "Landoas A", "orcid": null, "lab": "Pharmacy Department, Grenoble Alpes University Hospital, Universite Grenoble Alpes (Grenoble, France)", "lab_url": null, "role": "Hospital pharmacist at Grenoble Alpes University Hospital who studies how everolimus is used after lung transplantation and whether it protects the new lungs from long-term rejection", "studies": [ "LANDOAS2026" ], "url": "https://mtor-atlas.org/author/agathe-landoas/" }, { "id": "masahiro-morita", "name": "Masahiro Morita", "corpus_name": "Morita M", "orcid": null, "lab": "Morita Lab, Department of Molecular Medicine and Barshop Institute for Longevity and Aging Studies, UT Health San Antonio (San Antonio, Texas, USA)", "lab_url": "https://directory.uthscsa.edu/academics/profile/moritam", "role": "Biochemist at UT Health San Antonio who studies how mTORC1 controls protein synthesis, mRNA decay and mitochondria, and how these links go wrong in cancer and metabolic disease", "studies": [ "MOR2013" ], "url": "https://mtor-atlas.org/author/masahiro-morita/" }, { "id": "jukka-hakkola", "name": "Jukka Hakkola", "corpus_name": "Hakkola J", "orcid": "0000-0001-5048-4363", "lab": "Research Unit of Biomedicine and Internal Medicine, Pharmacology and Toxicology, University of Oulu (Oulu, Finland)", "lab_url": "https://www.oulu.fi/en/researchers/jukka-hakkola", "role": "Professor of Pharmacology at the University of Oulu who studies the pregnane X receptor (PXR), a liver sensor of drugs and foreign chemicals, and how it changes liver growth and metabolism", "studies": [ "LASSILA2026" ], "url": "https://mtor-atlas.org/author/jukka-hakkola/" }, { "id": "piia-lassila", "name": "Piia Lassila", "corpus_name": "Lassila P", "orcid": null, "lab": "Research Unit of Biomedicine and Internal Medicine, Pharmacology and Toxicology, University of Oulu (Oulu, Finland)", "lab_url": null, "role": "Researcher in Jukka Hakkola's pharmacology group at the University of Oulu who led a clinical and mouse study showing that activating the drug sensor PXR makes the liver grow", "studies": [ "LASSILA2026" ], "url": "https://mtor-atlas.org/author/piia-lassila/" }, { "id": "do-jin-kim", "name": "Do Jin Kim", "corpus_name": "Kim DJ", "orcid": null, "lab": "Denali Therapeutics (South San Francisco, California, USA)", "lab_url": null, "role": "Structural biologist, now at Denali Therapeutics, who worked in James Hurley's lab at UC Berkeley on the protein machines of autophagy and on the Rag-Ragulator complex that brings mTORC1 to the lysosome", "studies": [ "LAW2019", "SUX2017", "LAW2018" ], "url": "https://mtor-atlas.org/author/do-jin-kim/" }, { "id": "chun-yan-lim", "name": "Chun-Yan Lim", "corpus_name": "Lim CY", "orcid": null, "lab": "School of Basic Medical Sciences, Guangzhou National Laboratory, Guangzhou Medical University (Guangzhou, China)", "lab_url": null, "role": "Cell biologist who trained in Roberto Zoncu's lab at UC Berkeley on how cholesterol controls mTORC1, and now publishes as corresponding author from Guangzhou National Laboratory on lysosome signalling in immunity and nutrient sensing", "studies": [ "SHI2022", "LAW2019" ], "url": "https://mtor-atlas.org/author/chun-yan-lim/" }, { "id": "jun-hee-lee", "name": "Jun Hee Lee", "corpus_name": "Lee JH", "orcid": null, "lab": "Department of Molecular and Integrative Physiology, University of Michigan Medical School (Ann Arbor, Michigan, USA)", "lab_url": null, "role": "Physiologist at the University of Michigan who first showed in flies that Sestrin is a feedback brake on TOR that protects against age-related decline, and has since studied Sestrins as stress-induced regulators of mTORC1", "studies": [ "LEE2010" ], "url": "https://mtor-atlas.org/author/jun-hee-lee/" }, { "id": "deborah-j-w-lee", "name": "Deborah J W Lee", "corpus_name": "Lee DJW", "orcid": null, "lab": "Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore (Singapore)", "lab_url": null, "role": "First author of the first systematic review of rapamycin and related drugs given to people for ageing, from the Healthy Longevity Translational Research Program at the National University of Singapore", "studies": [ "LEE2024" ], "url": "https://mtor-atlas.org/author/deborah-j-w-lee/" }, { "id": "se-young-lee", "name": "Se Young Lee", "corpus_name": "Lee SY", "orcid": null, "lab": "Center for Vascular Research, Institute for Basic Science, and Department of Biological Sciences, KAIST (Daejeon, South Korea)", "lab_url": null, "role": "Neuroscientist in Won-Suk Chung's group at KAIST and the Institute for Basic Science who studies how neurons, astrocytes and immune cells interact in Alzheimer's disease, and first author of the 2026 Nature study on ERBB4 in excitatory neurons", "studies": [ "LEE2026" ], "url": "https://mtor-atlas.org/author/se-young-lee/" }, { "id": "hsiang-ting-lei", "name": "Hsiang-Ting Lei", "corpus_name": "Lei HT", "orcid": null, "lab": "Gonen Lab, Howard Hughes Medical Institute, University of California, Los Angeles (Los Angeles, California, USA)", "lab_url": null, "role": "Structural biologist from Tamir Gonen's lab who solved crystal structures of the lysosomal arginine sensor SLC38A9, showing how it holds arginine and how its own tail plugs the binding pocket", "studies": [ "LEI2018" ], "url": "https://mtor-atlas.org/author/hsiang-ting-lei/" }, { "id": "matthew-lelegren", "name": "Matthew Lelegren", "corpus_name": "Lelegren M", "orcid": null, "lab": "Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, and Barshop Institute, UT Health San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "First author of a 2016 study of how rapamycin changes the protein-quality-control machinery in marmoset liver, muscle and fat, carried out in Adam Salmon's group in San Antonio", "studies": [ "LEL2016" ], "url": "https://mtor-atlas.org/author/matthew-lelegren/" }, { "id": "corinna-ross", "name": "Corinna Ross", "corpus_name": "Ross C", "orcid": null, "lab": "Ross Lab, Southwest National Primate Research Center, Texas Biomedical Research Institute (San Antonio, Texas, USA)", "lab_url": "https://texasbiomedical.theopenscholar.com/ross-lab/people/corinna-ross", "role": "Primate biologist at Texas Biomedical Research Institute who uses the common marmoset to test whether drugs such as rapamycin can protect health during aging", "studies": [ "TAR2014", "ROS2015", "LEL2016" ], "url": "https://mtor-atlas.org/author/corinna-ross/" }, { "id": "suzette-tardif", "name": "Suzette Tardif", "corpus_name": "Tardif S", "orcid": null, "lab": "Southwest National Primate Research Center, Texas Biomedical Research Institute (San Antonio, Texas, USA)", "lab_url": null, "role": "Primate biologist who spent more than 30 years developing the common marmoset as a research model, and who led the first studies of rapamycin dosing and safety in this small monkey", "studies": [ "TAR2014", "ROS2015", "LEL2016" ], "url": "https://mtor-atlas.org/author/suzette-tardif/" }, { "id": "zhenhai-wang", "name": "Zhenhai Wang", "corpus_name": "Wang Zhenhai", "orcid": null, "lab": "Neurology Center, General Hospital of Ningxia Medical University (Yinchuan, Ningxia, China)", "lab_url": null, "role": "Neurologist in Yinchuan who leads cell studies of microglia, the brain's immune cells, and of how Brucella bacteria survive inside them", "studies": [ "LI2026B" ], "url": "https://mtor-atlas.org/author/zhenhai-wang/" }, { "id": "xiaoting-liang", "name": "Xiaoting Liang", "corpus_name": "Liang X", "orcid": null, "lab": "Department of Environmental Health, School of Public Health, Shanxi Medical University (Taiyuan, Shanxi, China)", "lab_url": null, "role": "Toxicology and environmental health researcher who found that the long non-coding RNA LINP1 protects skin cells from radiation-induced senescence by binding mTOR", "studies": [ "LIANG2026" ], "url": "https://mtor-atlas.org/author/xiaoting-liang/" }, { "id": "nanxin-li", "name": "Nanxin Li", "corpus_name": "Li N", "orcid": null, "lab": "Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine (New Haven, Connecticut, USA)", "lab_url": null, "role": "Neuroscientist in Ronald Duman's Yale psychiatry lab who showed in rats that ketamine's fast antidepressant effect depends on mTOR switching on new synapse growth in the prefrontal cortex", "studies": [ "LIX2010" ], "url": "https://mtor-atlas.org/author/nanxin-li/" }, { "id": "stephan-wullschleger", "name": "Stephan Wullschleger", "corpus_name": "Wullschleger S", "orcid": null, "lab": "MRC Protein Phosphorylation Unit, University of Dundee (Dundee, Scotland, United Kingdom)", "lab_url": null, "role": "Biochemist trained in Michael Hall's Basel lab on TOR complex 2 in yeast, and first author of the widely cited 2006 Cell review that laid out the two TOR complexes and what each controls", "studies": [ "WUL2006" ], "url": "https://mtor-atlas.org/author/stephan-wullschleger/" }, { "id": "antje-s-loffler", "name": "Antje S. Löffler", "corpus_name": "Löffler AS", "orcid": null, "lab": "Stork group, Institute of Molecular Medicine I, Heinrich Heine University Düsseldorf (Düsseldorf, North Rhine-Westphalia, Germany)", "lab_url": null, "role": "Cell biologist who worked in Björn Stork's group on how the autophagy kinase ULK1 talks back to the energy sensor AMPK", "studies": [ "LOF2011" ], "url": "https://mtor-atlas.org/author/antje-s-loffler/" }, { "id": "shiqi-lv", "name": "Shiqi Lv", "corpus_name": "Lv S", "orcid": null, "lab": "Department of Nephrology, Zhongshan Hospital, Fudan University (Shanghai, China)", "lab_url": null, "role": "Kidney researcher at Zhongshan Hospital, Fudan University, and first author of a 2026 study tracing a chain of enzymes that switches on mTOR and drives scarring in damaged kidneys", "studies": [ "LV2026S" ], "url": "https://mtor-atlas.org/author/shiqi-lv/" }, { "id": "xiaoyan-zhang", "name": "Xiaoyan Zhang", "corpus_name": "Zhang Xiaoyan", "orcid": null, "lab": "Department of Nephrology, Zhongshan Hospital, Fudan University (Shanghai, China)", "lab_url": null, "role": "Nephrologist at Zhongshan Hospital, Fudan University, and senior author of a 2026 study linking the enzyme USP7 to mTOR activation and kidney scarring", "studies": [ "LV2026S" ], "url": "https://mtor-atlas.org/author/xiaoyan-zhang/" }, { "id": "hongxuan-feng", "name": "Hongxuan Feng", "corpus_name": "Feng H", "orcid": null, "lab": "Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou, Jiangsu, China)", "lab_url": null, "role": "Neurologist at Suzhou Municipal Hospital and senior author of a 2026 stroke study proposing PIP4K2A as a protector of brain tissue through AKT/mTOR signalling and autophagy", "studies": [ "MA2026" ], "url": "https://mtor-atlas.org/author/hongxuan-feng/" }, { "id": "bodun-ma", "name": "Bodun Ma", "corpus_name": "Ma B", "orcid": null, "lab": "Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou, Jiangsu, China)", "lab_url": null, "role": "Neurology researcher in Suzhou and first author of a 2026 study on how the enzyme PIP4K2A protects the brain after stroke by restoring autophagy through AKT/mTOR", "studies": [ "MA2026" ], "url": "https://mtor-atlas.org/author/bodun-ma/" }, { "id": "mahmoud-elshal", "name": "Mahmoud Elshal", "corpus_name": "Elshal M", "orcid": null, "lab": "Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University (Mansoura, Egypt)", "lab_url": null, "role": "Pharmacologist at Mansoura University who tests whether existing drugs can protect the brain, liver and other organs in rodent models of disease", "studies": [ "MADKOUR2026" ], "url": "https://mtor-atlas.org/author/mahmoud-elshal/" }, { "id": "ahmed-h-madkour", "name": "Ahmed H. Madkour", "corpus_name": "Madkour AH", "orcid": null, "lab": "Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University (Mansoura, Egypt)", "lab_url": null, "role": "Pharmacologist at Mansoura University who tests approved drugs as protection against seizures and kidney injury in rats", "studies": [ "MADKOUR2026" ], "url": "https://mtor-atlas.org/author/ahmed-h-madkour/" }, { "id": "pradip-k-majumder", "name": "Pradip K. Majumder", "corpus_name": "Majumder PK", "orcid": null, "lab": "Sellers Lab, Department of Medical Oncology, Dana-Farber Cancer Institute (Boston, Massachusetts, USA)", "lab_url": null, "role": "Cancer biologist who, in William Sellers's lab at Dana-Farber, showed that mTOR inhibitors reverse AKT-driven early prostate cancer in mice", "studies": [ "MAJ2004" ], "url": "https://mtor-atlas.org/author/pradip-k-majumder/" }, { "id": "maria-manifava", "name": "Maria Manifava", "corpus_name": "Manifava M", "orcid": null, "lab": "Ktistakis Group, Signalling Programme, Babraham Institute (Cambridge, England, United Kingdom)", "lab_url": null, "role": "Cell biologist in Nicholas Ktistakis's group at the Babraham Institute whose live-cell imaging work spans more than two decades of research on lipid signalling, autophagosome formation and mTORC1", "studies": [ "MAN2016" ], "url": "https://mtor-atlas.org/author/maria-manifava/" }, { "id": "dean-quinn", "name": "Dean Quinn", "corpus_name": "Quinn D", "orcid": null, "lab": "P3 Research (Wellington, New Zealand)", "lab_url": null, "role": "Clinical trial investigator at P3 Research in Wellington, New Zealand, who was a co-author of the resTORbio trials that tested low-dose mTOR inhibitors to strengthen immunity in older adults", "studies": [ "MAN2021", "MAN2018" ], "url": "https://mtor-atlas.org/author/dean-quinn/" }, { "id": "sarb-shergill", "name": "Sarb Shergill", "corpus_name": "Shergill S", "orcid": null, "lab": "resTORbio (Boston, Massachusetts, USA)", "lab_url": null, "role": "Senior author of the 2021 report of resTORbio's phase 2b and phase 3 trials of the mTOR inhibitor RTB101 to protect older adults from respiratory infections", "studies": [ "MAN2021" ], "url": "https://mtor-atlas.org/author/sarb-shergill/" }, { "id": "erik-d-marchant", "name": "Erik D. Marchant", "corpus_name": "Marchant ED", "orcid": null, "lab": "Rasmussen Lab, Department of Cellular and Integrative Physiology, Long School of Medicine, UT Health San Antonio (San Antonio, Texas, USA)", "lab_url": "https://lsom.uthscsa.edu/physiology/team-member/erik-dean-marchant/", "role": "Graduate student in Blake Rasmussen's lab in San Antonio who studies what overactive mTORC1 in skeletal muscle does to metabolism, inflammation and exercise adaptation in aging and overnutrition", "studies": [ "MARCHANT2026", "MAR2026B" ], "url": "https://mtor-atlas.org/author/erik-d-marchant/" }, { "id": "rozalyn-m-anderson", "name": "Rozalyn M. Anderson", "corpus_name": "Anderson RM", "orcid": null, "lab": "Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison (Madison, Wisconsin, USA)", "lab_url": "https://www.medicine.wisc.edu/directory/anderson-rozalyn", "role": "Professor of medicine at the University of Wisconsin-Madison who studies the basic biology of aging and how calorie restriction slows it, and senior author of the 2017 comparison of the two long-running rhesus monkey calorie restriction studies", "studies": [ "MAT2017" ], "url": "https://mtor-atlas.org/author/rozalyn-m-anderson/" }, { "id": "rafael-de-cabo", "name": "Rafael de Cabo", "corpus_name": "de Cabo R", "orcid": null, "lab": "Translational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health (Baltimore, Maryland, USA)", "lab_url": null, "role": "Aging researcher at the US National Institute on Aging who has studied calorie restriction, fasting and drugs that mimic them in mice and rhesus monkeys, including the long-running NIA monkey study", "studies": [ "MAT2017" ], "url": "https://mtor-atlas.org/author/rafael-de-cabo/" }, { "id": "xiaoju-max-ma", "name": "Xiaoju Max Ma", "corpus_name": "Ma XM", "orcid": null, "lab": "Department of Research Oncology Diagnostics, Genentech (South San Francisco, California, USA)", "lab_url": null, "role": "Cell biologist who trained with John Blenis on how mTOR and S6K1 control protein synthesis, wrote a widely used review of mTOR-driven translation, and later worked in cancer research at Genentech", "studies": [ "MAX2009" ], "url": "https://mtor-atlas.org/author/xiaoju-max-ma/" }, { "id": "maggie-mcneill", "name": "Maggie McNeill", "corpus_name": "McNeill M", "orcid": null, "lab": "Division of Hematology-Oncology, Department of Pediatrics, The Hospital for Sick Children (Toronto, Ontario, Canada)", "lab_url": null, "role": "Paediatric haematology researcher at SickKids in Toronto and first author of a 2026 cohort study of sirolimus for Evans syndrome and other autoimmune blood-count disorders in children", "studies": [ "MCNEILL2026" ], "url": "https://mtor-atlas.org/author/maggie-mcneill/" }, { "id": "lynsey-meikle", "name": "Lynsey Meikle", "corpus_name": "Meikle L", "orcid": null, "lab": "Division of Translational Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": null, "role": "Researcher in David Kwiatkowski's tuberous sclerosis lab at Brigham and Women's Hospital who built a mouse model of TSC in the brain and showed that mTOR blockers rescue it", "studies": [ "MEI2008" ], "url": "https://mtor-atlas.org/author/lynsey-meikle/" }, { "id": "alicia-melendez", "name": "Alicia Meléndez", "corpus_name": "Melendez A", "orcid": null, "lab": "Meléndez Lab, Department of Biology, Queens College, City University of New York (New York, New York, USA)", "lab_url": "https://www.qc.cuny.edu/academics/ougr/?p=7188", "role": "Developmental geneticist at Queens College, CUNY, who showed as a postdoc in Beth Levine's lab that autophagy genes are needed for the long life of insulin-signalling mutant worms. Her lab studies autophagy in C. elegans development, from germline stem cells to meiosis", "studies": [ "MEL2003" ], "url": "https://mtor-atlas.org/author/alicia-melendez/" }, { "id": "hani-goodarzi", "name": "Hani Goodarzi", "corpus_name": "Goodarzi H", "orcid": "0000-0002-9648-8949", "lab": "Goodarzi Lab, Department of Biochemistry and Biophysics, University of California, San Francisco (San Francisco, California, USA)", "lab_url": "https://profiles.ucsf.edu/hani.goodarzi", "role": "Systems biologist at UCSF and the Arc Institute who combines computation and experiments to find hidden gene-regulation programs that drive cancer, and a co-author of two Atlas studies on mTORC1 in drug-resistant cancers", "studies": [ "MEN2023", "YAN2026" ], "url": "https://mtor-atlas.org/author/hani-goodarzi/" }, { "id": "delong-meng", "name": "Delong Meng", "corpus_name": "Meng D", "orcid": null, "lab": "Bandyopadhyay Lab, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco (San Francisco, California, USA)", "lab_url": null, "role": "Cancer researcher at UCSF who led the preclinical test of RMC-6272, a drug that blocks mTORC1 much more strongly than mTORC2, in drug-resistant breast cancer", "studies": [ "MEN2023" ], "url": "https://mtor-atlas.org/author/delong-meng/" }, { "id": "yu-chi-yang", "name": "Yu Chi Yang", "corpus_name": "Yang YC", "orcid": null, "lab": "Revolution Medicines (Redwood City, California, USA)", "lab_url": null, "role": "Scientist at Revolution Medicines who worked on the company's bi-steric mTORC1-selective inhibitors, from the breast cancer lab studies of RMC-6272 to the first trial of RMC-5552 in patients", "studies": [ "MEN2023", "SCH2025" ], "url": "https://mtor-atlas.org/author/yu-chi-yang/" }, { "id": "zheng-cao", "name": "Zheng Cao", "corpus_name": "Cao Z", "orcid": null, "lab": "Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University (Harbin, China)", "lab_url": null, "role": "Veterinary toxicologist at Northeast Agricultural University in Harbin whose group studies how pollutants and food toxins damage the kidney, liver and gut in mice", "studies": [ "MIAO2026" ], "url": "https://mtor-atlas.org/author/zheng-cao/" }, { "id": "chenjiao-miao", "name": "Chenjiao Miao", "corpus_name": "Miao C", "orcid": null, "lab": "Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University (Harbin, China)", "lab_url": null, "role": "Researcher in Zheng Cao's group at Northeast Agricultural University who studies how environmental and food toxins damage organs in mice, and first author of the 2026 study tying a screen chemical to kidney disease through mTOR", "studies": [ "MIAO2026" ], "url": "https://mtor-atlas.org/author/chenjiao-miao/" }, { "id": "dirk-mossmann", "name": "Dirk Mossmann", "corpus_name": "Mossmann D", "orcid": null, "lab": "Hall Lab, Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": null, "role": "Biochemist in Michael Hall's Basel lab who studies how mTOR and nutrients rewire metabolism in liver cancer, and first author of the 2023 Cell study showing that arginine drives liver tumour metabolism", "studies": [ "MOS2018" ], "url": "https://mtor-atlas.org/author/dirk-mossmann/" }, { "id": "taras-stasyk", "name": "Taras Stasyk", "corpus_name": "Stasyk T", "orcid": null, "lab": "Huber Lab, Institute of Cell Biology, Biocenter, Medical University of Innsbruck (Innsbruck, Tyrol, Austria)", "lab_url": null, "role": "Protein chemist in Lukas Huber's group in Innsbruck who has spent two decades applying proteomics to the late endosomes and lysosomes where mTORC1 is controlled", "studies": [ "NAP2020", "REB2015" ], "url": "https://mtor-atlas.org/author/taras-stasyk/" }, { "id": "priyatosh-nath", "name": "Priyatosh Nath", "corpus_name": "Nath P", "orcid": null, "lab": "Department of Otolaryngology-Head and Neck Surgery, LSU Health Shreveport (Shreveport, Louisiana, USA)", "lab_url": null, "role": "Cancer researcher in Cherie-Ann Nathan's head and neck cancer group at LSU Health Shreveport, first author of a 2026 study showing that the mTOR inhibitor everolimus can turn immune-cold tumours hot in mice", "studies": [ "NAT2026" ], "url": "https://mtor-atlas.org/author/priyatosh-nath/" }, { "id": "francesca-nazio", "name": "Francesca Nazio", "corpus_name": "Nazio F", "orcid": null, "lab": "Department of Biology, University of Rome Tor Vergata (Rome, Italy)", "lab_url": null, "role": "Cell biologist at the University of Rome Tor Vergata who, in Francesco Cecconi's lab, showed how mTOR keeps autophagy switched off by acting on AMBRA1 and the starter kinase ULK1", "studies": [ "NAZ2013" ], "url": "https://mtor-atlas.org/author/francesca-nazio/" }, { "id": "mona-nazemi", "name": "Mona Nazemi", "corpus_name": "Nazemi M", "orcid": null, "lab": "Rainero Lab, School of Biosciences, University of Sheffield (Sheffield, England, United Kingdom)", "lab_url": null, "role": "Cell biologist in Elena Rainero's lab at the University of Sheffield who studies how the collagen-rich matrix around tumours feeds cancer cells when nutrients run short", "studies": [ "NAZ2026" ], "url": "https://mtor-atlas.org/author/mona-nazemi/" }, { "id": "laura-brohee", "name": "Laura Brohée", "corpus_name": "Brohée L", "orcid": null, "lab": "Max Planck Institute for Biology of Ageing (Cologne, North Rhine-Westphalia, Germany)", "lab_url": null, "role": "Cell biologist who studied how lipid metabolism and the lysosome feed into mTORC1, first at the University of Liège and then at the Max Planck Institute for Biology of Ageing in Cologne", "studies": [ "PRE2021", "NIC2023" ], "url": "https://mtor-atlas.org/author/laura-brohee/" }, { "id": "gianluca-figlia", "name": "Gianluca Figlia", "corpus_name": "Figlia G", "orcid": null, "lab": "Institute of Neuropathology, RWTH Aachen University Hospital (Aachen, North Rhine-Westphalia, Germany)", "lab_url": null, "role": "Cell biologist who studied how mTORC1 senses nutrients in Aurelio Teleman's group at the German Cancer Research Center, including the finding that glutamine is sensed through the kinase GCN2, and who now works at the Institute of Neuropathology in Aachen", "studies": [ "PRE2021", "NIC2023" ], "url": "https://mtor-atlas.org/author/gianluca-figlia/" }, { "id": "raffaele-nicastro", "name": "Raffaele Nicastro", "corpus_name": "Nicastro R", "orcid": null, "lab": "De Virgilio Lab, Department of Biology, University of Fribourg (Fribourg, Canton of Fribourg, Switzerland)", "lab_url": null, "role": "Cell biologist at the University of Fribourg who studies TORC1 signalling in yeast and mammals, and first author of the discovery that malonyl-CoA is a natural mTORC1 inhibitor", "studies": [ "NIC2023" ], "url": "https://mtor-atlas.org/author/raffaele-nicastro/" }, { "id": "hiroki-nojima", "name": "Hiroki Nojima", "corpus_name": "Nojima H", "orcid": null, "lab": "Biosignal Research Center, Kobe University (Kobe, Japan)", "lab_url": null, "role": "First author of the 2003 Kobe study showing that raptor grabs mTOR's targets through a short TOS motif, the docking step that lets mTORC1 reach its substrates", "studies": [ "NOJ2003" ], "url": "https://mtor-atlas.org/author/hiroki-nojima/" }, { "id": "ann-charlotte-granholm", "name": "Ann-Charlotte Granholm", "corpus_name": "Granholm AC", "orcid": null, "lab": "Department of Neurosurgery, University of Colorado Anschutz Medical Campus (Aurora, Colorado, USA)", "lab_url": "https://www.cumedicine.us/providers/neurosurgery/Ann-Charlotte-Granholm-Bentley", "role": "Neuroscientist of aging who has studied Down syndrome and the Alzheimer's disease that often comes with it since the 1990s, now a professor at the University of Colorado Anschutz Medical Campus", "studies": [ "NOR2026" ], "url": "https://mtor-atlas.org/author/ann-charlotte-granholm/" }, { "id": "abigail-nordbeck", "name": "Abigail Nordbeck", "corpus_name": "Nordbeck AJ", "orcid": null, "lab": "Department of Neurosurgery, University of Colorado Anschutz Medical Campus (Aurora, Colorado, USA)", "lab_url": null, "role": "Neuroscience researcher and first author of a 2026 spatial study of the human hippocampus in Down syndrome with Alzheimer's disease, which found mTOR and insulin signalling disturbed in specific cell layers", "studies": [ "NOR2026" ], "url": "https://mtor-atlas.org/author/abigail-nordbeck/" }, { "id": "hiroyuki-okazaki", "name": "Hiroyuki Okazaki", "corpus_name": "Okazaki H", "orcid": null, "lab": "Faculty of Pharmaceutical Sciences, Daiichi University of Pharmacy (Fukuoka, Japan)", "lab_url": null, "role": "Pharmacologist at Daiichi University of Pharmacy in Fukuoka who studies how the body clock sets the daily rhythm of mTOR in tumours and how to time cancer drugs to match it", "studies": [ "OKA2013" ], "url": "https://mtor-atlas.org/author/hiroyuki-okazaki/" }, { "id": "toshihiko-oki", "name": "Toshihiko Oki", "corpus_name": "Oki T", "orcid": null, "lab": "Center for Regenerative Medicine, Massachusetts General Hospital (Boston, Massachusetts, USA)", "lab_url": null, "role": "Hematology researcher who trained at the Institute of Medical Science in Tokyo and in David Scadden's lab at Massachusetts General Hospital, where he imaged mTORC1 activity in leukemia cells inside living mice", "studies": [ "OKI2021" ], "url": "https://mtor-atlas.org/author/toshihiko-oki/" }, { "id": "kathryn-oreilly", "name": "Kathryn O'Reilly", "corpus_name": "O'Reilly KE", "orcid": null, "lab": "Department of Dermatology, New York University School of Medicine (New York, New York, USA)", "lab_url": null, "role": "Physician-scientist who, in Neal Rosen's lab at Memorial Sloan Kettering, showed that blocking mTORC1 with rapamycin-like drugs switches on the survival kinase Akt through a feedback loop, a main reason these drugs worked less well against cancer than hoped", "studies": [ "ORE2006" ], "url": "https://mtor-atlas.org/author/kathryn-oreilly/" }, { "id": "nicolas-panchaud", "name": "Nicolas Panchaud", "corpus_name": "Panchaud N", "orcid": null, "lab": "De Virgilio lab, Department of Biology, Division of Biochemistry, University of Fribourg (Fribourg, Canton of Fribourg, Switzerland)", "lab_url": null, "role": "Biochemist who, during a PhD with Claudio De Virgilio in Fribourg, showed that the yeast SEACIT complex switches off TORC1 when amino acids run out, and who later moved into clinical drug development at Novartis", "studies": [ "PAN2013" ], "url": "https://mtor-atlas.org/author/nicolas-panchaud/" }, { "id": "ji-man-park", "name": "Ji-Man Park", "corpus_name": "Park JM", "orcid": null, "lab": "Do-Hyung Kim Lab, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota (Minneapolis, Minnesota, USA)", "lab_url": null, "role": "Autophagy researcher in Do-Hyung Kim's University of Minnesota lab who mapped how the kinase ULK1 starts autophagy, and lead author of work showing that AMPK can hold ULK1 back under energy stress", "studies": [ "PAR2023" ], "url": "https://mtor-atlas.org/author/ji-man-park/" }, { "id": "debasish-paul", "name": "Debasish Paul", "corpus_name": "Paul D", "orcid": null, "lab": "Cappell Lab, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute (Bethesda, Maryland, USA)", "lab_url": "https://ccr.cancer.gov/staff-directory/debasish-paul", "role": "Postdoctoral fellow in Steven Cappell's lab at the National Cancer Institute who studies how ubiquitin ligases time the start of the cell cycle, and who found that mTOR briefly switches off the APC/C to give cells a burst of glycolysis as they start to divide", "studies": [ "PAU2025" ], "url": "https://mtor-atlas.org/author/debasish-paul/" }, { "id": "min-peng", "name": "Min Peng", "corpus_name": "Peng M", "orcid": null, "lab": "Peng Lab, School of Medicine, Tsinghua University (Beijing, China)", "lab_url": "https://www.iitu.tsinghua.edu.cn/MinPeng/list.htm", "role": "Immunologist at Tsinghua University who, as a postdoc at Memorial Sloan Kettering, identified Sestrins and SZT2 as brakes on mTORC1 and now studies how T cells grow, specialise and remember", "studies": [ "PEN2017" ], "url": "https://mtor-atlas.org/author/min-peng/" }, { "id": "kevin-perez", "name": "Kevin Perez", "corpus_name": "Perez K", "orcid": null, "lab": "EPITERNA SA (Épalinges, Switzerland)", "lab_url": null, "role": "Aging researcher and co-founder of the Swiss company EPITERNA, working with Alejandro Ocampo's lab at the University of Lausanne on screening platforms that look for drugs extending lifespan across several species", "studies": [ "PEREZ2026" ], "url": "https://mtor-atlas.org/author/kevin-perez/" }, { "id": "constance-petit", "name": "Constance Petit", "corpus_name": "Petit CS", "orcid": null, "lab": "Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health (Boston, Massachusetts, USA)", "lab_url": null, "role": "Cell biologist who showed, in Shawn Ferguson's lab at Yale, that folliculin moves onto lysosomes when amino acids run out and is needed to switch on the Rag GTPases", "studies": [ "PET2013" ], "url": "https://mtor-atlas.org/author/constance-petit/" }, { "id": "agnes-roczniak-ferguson", "name": "Agnes Roczniak-Ferguson", "corpus_name": "Roczniak-Ferguson A", "orcid": null, "lab": "Ferguson Lab, Department of Cell Biology, Yale University School of Medicine (New Haven, Connecticut, USA)", "lab_url": null, "role": "Cell biologist in Shawn Ferguson's lab at Yale who showed that mTORC1 phosphorylates the transcription factor TFEB to control lysosome and autophagy genes, and who studies lysosome biology in neurodegenerative disease", "studies": [ "ROC2012" ], "url": "https://mtor-atlas.org/author/agnes-roczniak-ferguson/" }, { "id": "erica-pledger", "name": "Erica Pledger", "corpus_name": "Pledger ES", "orcid": null, "lab": "Cate Lab, Department of Molecular and Cell Biology, University of California, Berkeley (Berkeley, California, USA)", "lab_url": null, "role": "Researcher in Jamie Cate's lab at UC Berkeley who used ribosome profiling to show that exhausted human T cells shut down a key class of growth-related mRNAs even while mTOR is active", "studies": [ "PLEDGER2026" ], "url": "https://mtor-atlas.org/author/erica-pledger/" }, { "id": "thomas-porstmann", "name": "Thomas Porstmann", "corpus_name": "Porstmann T", "orcid": null, "lab": "Gene Expression Analysis Laboratory (Almut Schulze), Cancer Research UK London Research Institute (London, England, United Kingdom)", "lab_url": null, "role": "Cell biologist who, as a researcher in Almut Schulze's laboratory at the Cancer Research UK London Research Institute, showed that the growth kinase Akt drives fat synthesis through SREBP and that this route runs through mTORC1", "studies": [ "POR2008" ], "url": "https://mtor-atlas.org/author/thomas-porstmann/" }, { "id": "morten-poulsen", "name": "Morten Poulsen", "corpus_name": "Poulsen MM", "orcid": null, "lab": "Department of Endocrinology and Internal Medicine, Aarhus University Hospital (Aarhus, Denmark)", "lab_url": null, "role": "Endocrinologist at Aarhus University Hospital who led one of the first careful human trials of high-dose resveratrol, which found no metabolic benefit in obese men", "studies": [ "POU2013" ], "url": "https://mtor-atlas.org/author/morten-poulsen/" }, { "id": "jong-ok-pyo", "name": "Jong-Ok Pyo", "corpus_name": "Pyo JO", "orcid": null, "lab": "Yong-Keun Jung laboratory, School of Biological Sciences and Bio-MAX Institute, Seoul National University (Seoul, South Korea)", "lab_url": null, "role": "Autophagy researcher in Yong-Keun Jung's group in Korea, and first author of the 2013 study in which mice with an extra dose of the autophagy gene Atg5 lived longer", "studies": [ "PYO2013" ], "url": "https://mtor-atlas.org/author/jong-ok-pyo/" }, { "id": "chidambaram-ramanathan", "name": "Chidambaram Ramanathan", "corpus_name": "Ramanathan C", "orcid": null, "lab": "College of Health Sciences, University of Memphis (Memphis, Tennessee, USA)", "lab_url": "https://www.memphis.edu/healthsciences/overview/faculty/chidaramanathan.php", "role": "Circadian biologist at the University of Memphis who showed that mTOR signalling sets the speed and strength of the body's daily clocks", "studies": [ "RAM2018" ], "url": "https://mtor-atlas.org/author/chidambaram-ramanathan/" }, { "id": "xiaodong-feng", "name": "Xiaodong Feng", "corpus_name": "Feng X", "orcid": null, "lab": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University (Chengdu, Sichuan, China)", "lab_url": null, "role": "Researcher at the State Key Laboratory of Oral Diseases in Chengdu whose group studies how cells in the mouth respond to stress, from chemotherapy tolerance in oral cancer to inflammation in gum disease", "studies": [ "RAO2026" ], "url": "https://mtor-atlas.org/author/xiaodong-feng/" }, { "id": "pengcheng-rao", "name": "Pengcheng Rao", "corpus_name": "Rao P", "orcid": null, "lab": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University (Chengdu, Sichuan, China)", "lab_url": null, "role": "Researcher at the West China Hospital of Stomatology in Chengdu who led a genome-wide CRISPR screen showing that switching off mTOR can help cancer cells tolerate cisplatin", "studies": [ "RAO2026" ], "url": "https://mtor-atlas.org/author/pengcheng-rao/" }, { "id": "boglarka-rauch", "name": "Boglarka Rauch", "corpus_name": "Rauch B", "orcid": null, "lab": "Bai Lab, Department of Medical Chemistry, Faculty of Medicine, University of Debrecen (Debrecen, Hungary)", "lab_url": null, "role": "Researcher in Péter Bai's group at the University of Debrecen who studies how ADP-ribosylating enzymes control fat cell development through AMPK and mTOR", "studies": [ "RAUCH2026" ], "url": "https://mtor-atlas.org/author/boglarka-rauch/" }, { "id": "manuele-rebsamen", "name": "Manuele Rebsamen", "corpus_name": "Rebsamen M", "orcid": null, "lab": "Rebsamen Lab, Department of Immunobiology, University of Lausanne (Épalinges, Switzerland)", "lab_url": null, "role": "Cell biologist who found that the lysosomal transporter SLC38A9 is part of the amino acid sensor for mTORC1, and who now leads a group at the University of Lausanne studying transporters in immune signalling and autoimmunity", "studies": [ "REB2015" ], "url": "https://mtor-atlas.org/author/manuele-rebsamen/" }, { "id": "yingxin-ren", "name": "Yingxin Ren", "corpus_name": "Ren Y", "orcid": null, "lab": "Yanfeng Hu group, Department of General Surgery, Nanfang Hospital, Southern Medical University (Guangzhou, China)", "lab_url": null, "role": "Gastric cancer researcher in Yanfeng Hu's surgical group at Nanfang Hospital who studies how tumour bacteria and metabolism shape resistance to immunotherapy", "studies": [ "REN2026" ], "url": "https://mtor-atlas.org/author/yingxin-ren/" }, { "id": "stacey-robida-stubbs", "name": "Stacey Robida-Stubbs", "corpus_name": "Robida-Stubbs S", "orcid": null, "lab": "Blackwell Lab, Joslin Diabetes Center, Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": null, "role": "Researcher in Keith Blackwell's worm lab at the Joslin Diabetes Center who showed that TOR inhibition and rapamycin extend C. elegans lifespan through the protective factors SKN-1/Nrf and DAF-16/FoxO", "studies": [ "ROB2012" ], "url": "https://mtor-atlas.org/author/stacey-robida-stubbs/" }, { "id": "mitsugu-shimobayashi", "name": "Mitsugu Shimobayashi", "corpus_name": "Shimobayashi M", "orcid": null, "lab": "Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven (Leuven, Belgium)", "lab_url": null, "role": "Metabolism researcher who trained with Michael Hall in Basel on mTOR in fat tissue and now leads a group at KU Leuven studying how fat and liver control sugar and lipid storage", "studies": [ "SHI2014", "SCA2020", "ROB2013" ], "url": "https://mtor-atlas.org/author/mitsugu-shimobayashi/" }, { "id": "edward-j-brignole", "name": "Edward J. Brignole", "corpus_name": "Brignole EJ", "orcid": null, "lab": "MIT Cryo-EM Facility, MIT.nano, Massachusetts Institute of Technology (Cambridge, Massachusetts, USA)", "lab_url": null, "role": "Research scientist who directs the cryo-electron microscopy facility at MIT.nano and whose cryo-EM work helped solve the structures of GATOR1, GATOR2 and Raptor docked on the Rag GTPases for the Sabatini lab", "studies": [ "VAL2022", "ROG2019", "SHE2018" ], "url": "https://mtor-atlas.org/author/edward-j-brignole/" }, { "id": "william-e-kraus", "name": "William E. Kraus", "corpus_name": "Kraus WE", "orcid": null, "lab": "Duke Molecular Physiology Institute and Division of Cardiology, Duke University School of Medicine (Durham, North Carolina, USA)", "lab_url": "https://scholars.duke.edu/person/william.kraus", "role": "Preventive cardiologist and exercise physiologist at Duke University who leads long-running trials on how exercise and calorie restriction change human health, and senior author of the CALERIE two-year safety report", "studies": [ "ROM2016" ], "url": "https://mtor-atlas.org/author/william-e-kraus/" }, { "id": "sergei-v-romashkan", "name": "Sergei V. Romashkan", "corpus_name": "Romashkan SV", "orcid": null, "lab": "Division of Geriatrics and Clinical Gerontology, National Institute on Aging, National Institutes of Health (Bethesda, Maryland, USA)", "lab_url": null, "role": "Physician scientist at the National Institute on Aging who oversees clinical trials in older adults and led the safety analysis of CALERIE, the first long-term trial of calorie restriction in healthy people", "studies": [ "ROM2016" ], "url": "https://mtor-atlas.org/author/sergei-v-romashkan/" }, { "id": "igor-ruvinsky", "name": "Igor Ruvinsky", "corpus_name": "Ruvinsky I", "orcid": null, "lab": "Meyuhas Lab, Department of Biochemistry and Molecular Biology, Hebrew University-Hadassah Medical School (Jerusalem, Israel)", "lab_url": null, "role": "Biochemist from Oded Meyuhas's Jerusalem lab who made the mouse in which ribosomal protein S6 cannot be phosphorylated, showing that this mark controls cell size and blood sugar rather than the translation of TOP mRNAs", "studies": [ "RUV2005" ], "url": "https://mtor-atlas.org/author/igor-ruvinsky/" }, { "id": "abdelhafid-saci", "name": "Abdelhafid Saci", "corpus_name": "Saci A", "orcid": null, "lab": "Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": null, "role": "Cell biologist who, in Christopher Carpenter's lab at Beth Israel Deaconess, found that the small GTPase Rac1 binds mTOR and helps set the activity and location of both mTOR complexes", "studies": [ "SAC2011" ], "url": "https://mtor-atlas.org/author/abdelhafid-saci/" }, { "id": "zixin-sang", "name": "Zixin Sang", "corpus_name": "Sang Z", "orcid": null, "lab": "Jie Wang group, Department of Chemistry, Southern University of Science and Technology (Shenzhen, China)", "lab_url": null, "role": "Chemical biologist at SUSTech in Shenzhen who used a light-activated methionine probe to identify PKM2 as a methionine sensor for mTORC1", "studies": [ "SANG2026" ], "url": "https://mtor-atlas.org/author/zixin-sang/" }, { "id": "leslie-j-saucedo", "name": "Leslie J. Saucedo", "corpus_name": "Saucedo LJ", "orcid": null, "lab": "Department of Biology, Pacific Lutheran University (Tacoma, Washington, USA)", "lab_url": "https://plu.edu/biology/staff/leslie-saucedo", "role": "Fruit-fly cell biologist and teacher who, as a postdoc in Bruce Edgar's lab, showed that the small GTPase Rheb drives cell growth in the insulin/TOR pathway", "studies": [ "SAU2003" ], "url": "https://mtor-atlas.org/author/leslie-j-saucedo/" }, { "id": "kevin-e-knockenhauer", "name": "Kevin E. Knockenhauer", "corpus_name": "Knockenhauer KE", "orcid": null, "lab": "Accent Therapeutics (Lexington, Massachusetts, USA)", "lab_url": null, "role": "Structural biologist trained in Thomas Schwartz's MIT lab who helped solve the amino acid sensor structures of Sestrin2 and CASTOR1, and who later moved to drug discovery at Accent Therapeutics", "studies": [ "SAX2016", "SAX2015" ], "url": "https://mtor-atlas.org/author/kevin-e-knockenhauer/" }, { "id": "thomas-u-schwartz", "name": "Thomas U. Schwartz", "corpus_name": "Schwartz TU", "orcid": null, "lab": "Schwartz Lab, Department of Biology, Massachusetts Institute of Technology (Cambridge, Massachusetts, USA)", "lab_url": "https://biology.mit.edu/profile/thomas-u-schwartz/", "role": "MIT structural biologist who studies how molecules pass across the nuclear envelope, and whose crystallography lab helped solve the leucine and arginine sensor structures upstream of mTORC1", "studies": [ "SAX2016", "SAX2015" ], "url": "https://mtor-atlas.org/author/thomas-u-schwartz/" }, { "id": "anurag-saxena", "name": "Anurag Saxena", "corpus_name": "Saxena A", "orcid": null, "lab": "Institute of Medical Genetics, Division of Cancer and Genetics, School of Medicine, Cardiff University (Cardiff, Wales, United Kingdom)", "lab_url": "https://cardiff.ac.uk/people/view/126711-saxena-anurag", "role": "Clinical research fellow at Cardiff University who coordinated TRON, a placebo-controlled trial testing whether everolimus improves memory and thinking in adults with tuberous sclerosis complex", "studies": [ "SAX2026" ], "url": "https://mtor-atlas.org/author/anurag-saxena/" }, { "id": "alain-scaiola", "name": "Alain Scaiola", "corpus_name": "Scaiola A", "orcid": null, "lab": "Ban Lab, Institute of Molecular Biology and Biophysics, ETH Zurich (Zurich, Switzerland)", "lab_url": null, "role": "Structural biologist in Nenad Ban's group at ETH Zurich who solved the 3.2-angstrom cryo-EM structure of human mTORC2 and works on how ribosomes are built and how new proteins are processed", "studies": [ "SCA2020", "STU2018" ], "url": "https://mtor-atlas.org/author/alain-scaiola/" }, { "id": "edward-stuttfeld", "name": "Edward Stuttfeld", "corpus_name": "Stuttfeld E", "orcid": null, "lab": "Maier Lab, Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": null, "role": "Structural biologist who led the 2018 eLife study that gave the first detailed picture of the human mTORC2 core complex, working in Timm Maier's lab in Basel", "studies": [ "SCA2020", "STU2018" ], "url": "https://mtor-atlas.org/author/edward-stuttfeld/" }, { "id": "stefanie-s-schalm", "name": "Stefanie S. Schalm", "corpus_name": "Schalm SS", "orcid": null, "lab": "Kymera Therapeutics (Watertown, Massachusetts, USA)", "lab_url": null, "role": "Cell biologist who, in John Blenis's lab, showed that the TOS motif lets raptor grab 4E-BP1 so mTORC1 can phosphorylate it, and who later moved into cancer drug discovery in the biotech industry", "studies": [ "SCH2003" ], "url": "https://mtor-atlas.org/author/stefanie-s-schalm/" }, { "id": "alison-m-schram", "name": "Alison M. Schram", "corpus_name": "Schram AM", "orcid": null, "lab": "Early Drug Development Service and Gynecologic Medical Oncology, Memorial Sloan Kettering Cancer Center (New York, New York, USA)", "lab_url": "https://www.mskcc.org/cancer-care/doctors/alison-schram", "role": "Medical oncologist at Memorial Sloan Kettering who runs first-in-human cancer drug trials, including the first trial of RMC-5552, an mTORC1-selective inhibitor", "studies": [ "SCH2025" ], "url": "https://mtor-atlas.org/author/alison-m-schram/" }, { "id": "sebastiano-sciarretta", "name": "Sebastiano Sciarretta", "corpus_name": "Sciarretta S", "orcid": null, "lab": "Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, and IRCCS Neuromed (Latina, Italy)", "lab_url": null, "role": "Cardiologist and heart researcher at Sapienza University of Rome who trained with Junichi Sadoshima on how mTOR and autophagy protect or harm the stressed heart", "studies": [ "SCI2014" ], "url": "https://mtor-atlas.org/author/sebastiano-sciarretta/" }, { "id": "o-jameel-shah", "name": "O. Jameel Shah", "corpus_name": "Shah OJ", "orcid": null, "lab": "Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies (La Jolla, California, USA)", "lab_url": null, "role": "Cell biologist in Tony Hunter's lab at the Salk Institute who showed that runaway Rheb-mTOR-S6K signalling destroys the insulin receptor's helper proteins IRS1 and IRS2, one half of the discovery of the S6K-IRS feedback loop", "studies": [ "SHA2004" ], "url": "https://mtor-atlas.org/author/o-jameel-shah/" }, { "id": "rick-k-huang", "name": "Rick K. Huang", "corpus_name": "Huang RK", "orcid": null, "lab": "Howard Hughes Medical Institute, Janelia Research Campus (Ashburn, Virginia, USA)", "lab_url": null, "role": "Cryo-electron microscopy specialist who, at the HHMI Janelia Research Campus, helped solve the 2018 and 2019 structures of the protein machines that pass amino acid signals to mTORC1", "studies": [ "SHE2019", "SHE2018" ], "url": "https://mtor-atlas.org/author/rick-k-huang/" }, { "id": "hijai-r-shin", "name": "Hijai R. Shin", "corpus_name": "Shin HR", "orcid": null, "lab": "Children's Medical Center Research Institute at UT Southwestern, University of Texas Southwestern Medical Center (Dallas, Texas, USA)", "lab_url": null, "role": "Cell biologist who discovered, in Roberto Zoncu's lab at UC Berkeley, that the lysosomal protein LYCHOS senses cholesterol for mTORC1, and who now works at the Children's Medical Center Research Institute at UT Southwestern", "studies": [ "SHI2022" ], "url": "https://mtor-atlas.org/author/hijai-r-shin/" }, { "id": "jae-ho-shim", "name": "Jae Ho Shim", "corpus_name": "Shim JH", "orcid": null, "lab": "Department of Anatomy, Korea University College of Medicine (Seoul, South Korea)", "lab_url": null, "role": "Medicinal chemist in Hyeon Soo Kim's group at the Department of Anatomy, Korea University College of Medicine, who designs small molecules, and first author of the study of the D-leucine prodrug DLMEH that switches on mTORC1 through Sestrin2", "studies": [ "SHIM2026" ], "url": "https://mtor-atlas.org/author/jae-ho-shim/" }, { "id": "hiroshi-shimada", "name": "Hiroshi Shimada", "corpus_name": "Shimada H", "orcid": null, "lab": "Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus (Aurora, Colorado, USA)", "lab_url": null, "role": "Obstetrician-scientist from Sapporo Medical University working in the Colorado placenta group of Thomas Jansson, Theresa Powell and Fredrick Rosario on how mTOR controls nutrient transport to the fetus", "studies": [ "SHIMADA2026" ], "url": "https://mtor-atlas.org/author/hiroshi-shimada/" }, { "id": "aubrey-m-sills", "name": "Aubrey M. Sills", "corpus_name": "Sills AM", "orcid": null, "lab": "Barshop Institute for Longevity and Aging Studies, UT Health San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "Researcher at the Barshop Institute in San Antonio who worked with common marmosets in Adam Salmon's group and led the 2018 study of long-term rapamycin and blood health in these small primates", "studies": [ "SIL2018" ], "url": "https://mtor-atlas.org/author/aubrey-m-sills/" }, { "id": "francesca-sillito", "name": "Francesca Sillito", "corpus_name": "Sillito F", "orcid": null, "lab": "Chakraverty Lab, UCL Cancer Institute, University College London (London, England, United Kingdom)", "lab_url": null, "role": "Haematologist at the Royal Marsden Hospital and University College London with a special interest in CAR-T cell therapy and lymphoma, whose PhD showed that forcing mTORC1 on in CD4+ T cells makes them last longer but tire out", "studies": [ "SIL2026" ], "url": "https://mtor-atlas.org/author/francesca-sillito/" }, { "id": "linda-v-sinclair", "name": "Linda V. Sinclair", "corpus_name": "Sinclair LV", "orcid": null, "lab": "Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee (Dundee, Scotland, United Kingdom)", "lab_url": "https://discovery.dundee.ac.uk/en/persons/linda-sinclair/", "role": "T cell immunologist at the University of Dundee who works out how amino acid supply, through transporters such as SLC7A5, feeds mTORC1 and decides what activated T cells become", "studies": [ "SIN2013" ], "url": "https://mtor-atlas.org/author/linda-v-sinclair/" }, { "id": "sanjna-singh", "name": "Sanjna Singh", "corpus_name": "Singh S", "orcid": null, "lab": "Lysosomal Health in Ageing, South Australian Health and Medical Research Institute (Adelaide, South Australia, Australia)", "lab_url": null, "role": "Autophagy researcher in Timothy Sargeant's group in Adelaide who measures autophagy directly in human blood cells and led a diet trial testing whether eating less protein switches it on in people", "studies": [ "SIN2026" ], "url": "https://mtor-atlas.org/author/sanjna-singh/" }, { "id": "stephen-j-simpson", "name": "Stephen J. Simpson", "corpus_name": "Simpson SJ", "orcid": null, "lab": "Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney (Sydney, New South Wales, Australia)", "lab_url": null, "role": "Biologist who began with how locusts choose their food and is known for the Geometric Framework for nutrition, which shows that the balance of protein, carbohydrate and fat shapes health and lifespan; inaugural academic director of the Charles Perkins Centre", "studies": [ "SOL2014" ], "url": "https://mtor-atlas.org/author/stephen-j-simpson/" }, { "id": "david-a-sinclair", "name": "David A. Sinclair", "corpus_name": "Sinclair DA", "orcid": null, "lab": "Sinclair Lab, Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": "https://sinclair.hms.harvard.edu/", "role": "Geneticist of aging at Harvard Medical School, known for work on sirtuins, NAD+ and the idea that aging stems from a loss of epigenetic information, who appears in this Atlas as a co-author on two mouse lifespan studies", "studies": [ "SOL2014", "STR2012" ], "url": "https://mtor-atlas.org/author/david-a-sinclair/" }, { "id": "samantha-m-solon-biet", "name": "Samantha M. Solon-Biet", "corpus_name": "Solon-Biet SM", "orcid": null, "lab": "Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney (Sydney, New South Wales, Australia)", "lab_url": null, "role": "Nutrition and ageing researcher at the Charles Perkins Centre who uses the Geometric Framework to study how protein, carbohydrate and fat intake affect lifespan, metabolism and reproduction in mice", "studies": [ "SOL2014" ], "url": "https://mtor-atlas.org/author/samantha-m-solon-biet/" }, { "id": "breanne-sparta", "name": "Breanne Sparta", "corpus_name": "Sparta B", "orcid": null, "lab": "Deeds Lab, University of California, Los Angeles (Los Angeles, California, USA)", "lab_url": "https://www.biomedpostdoc.ucla.edu/people/breanne-sparta", "role": "Quantitative cell biologist who trained in John Albeck's lab at UC Davis, where live single-cell imaging showed that the mTORC1-TFEB signalling axis tracks nutrients and growth factors continuously, and then moved to UCLA as a postdoctoral fellow", "studies": [ "SPA2023" ], "url": "https://mtor-atlas.org/author/breanne-sparta/" }, { "id": "patricia-spilman", "name": "Patricia Spilman", "corpus_name": "Spilman P", "orcid": null, "lab": "Drug Discovery Lab, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles (Los Angeles, California, USA)", "lab_url": null, "role": "Neuroscientist who showed, with Veronica Galvan, that long-term rapamycin prevents memory loss in an Alzheimer's mouse model, and who later worked with Dale Bredesen on Alzheimer's drug discovery", "studies": [ "SPI2010" ], "url": "https://mtor-atlas.org/author/patricia-spilman/" }, { "id": "savraj-s-grewal", "name": "Savraj S. Grewal", "corpus_name": "Grewal SS", "orcid": null, "lab": "Grewal Lab, Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary (Calgary, Alberta, Canada)", "lab_url": "https://profiles.ucalgary.ca/savraj-grewal", "role": "Calgary biochemist who uses fruit flies to work out how nutrients and growth signals such as TOR set the size of cells, organs and the whole animal", "studies": [ "SRI2026" ], "url": "https://mtor-atlas.org/author/savraj-s-grewal/" }, { "id": "shrivani-sriskanthadevan-pirahas", "name": "Shrivani Sriskanthadevan-Pirahas", "corpus_name": "Sriskanthadevan-Pirahas S", "orcid": null, "lab": "Grewal Lab, Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary (Calgary, Alberta, Canada)", "lab_url": null, "role": "Fruit fly biologist in Savraj Grewal's Calgary lab who studies how growth signals and mitochondria in one tissue control how fast the whole larva grows", "studies": [ "SRI2026" ], "url": "https://mtor-atlas.org/author/shrivani-sriskanthadevan-pirahas/" }, { "id": "yanhong-su", "name": "Yanhong Su", "corpus_name": "Su Y", "orcid": null, "lab": "Department of Cardiology, Tianjin Medical University (Tianjin, China)", "lab_url": null, "role": "Cardiologist in Tianjin and Cangzhou who studied how a long non-coding RNA drives necroptotic heart-cell death after a blocked artery is reopened", "studies": [ "SU2026" ], "url": "https://mtor-atlas.org/author/yanhong-su/" }, { "id": "jun-zhang", "name": "Jun Zhang", "corpus_name": "Zhang Jun", "orcid": null, "lab": "Department of Cardiology, Cangzhou Central Hospital, Tianjin Medical University (Tianjin, China)", "lab_url": null, "role": "Cardiologist at Cangzhou Central Hospital, a teaching hospital of Tianjin Medical University, and senior author of a study on RNA-driven heart-cell death after reperfusion", "studies": [ "SU2026" ], "url": "https://mtor-atlas.org/author/jun-zhang/" }, { "id": "zexing-sun", "name": "Zexing Sun", "corpus_name": "Sun Z", "orcid": null, "lab": "Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Hangzhou, Zhejiang, China)", "lab_url": null, "role": "Hematology researcher in Hangzhou who studies treatment of bone-marrow failure, including the use of sirolimus (rapamycin) in pure red cell aplasia", "studies": [ "SUN2026" ], "url": "https://mtor-atlas.org/author/zexing-sun/" }, { "id": "ming-yuan-su", "name": "Ming-Yuan Su", "corpus_name": "Su MY", "orcid": null, "lab": "Department of Biochemistry, School of Medicine, Southern University of Science and Technology (Shenzhen, China)", "lab_url": null, "role": "Structural biologist who solved cryo-EM structures of lysosomal complexes in James Hurley's lab at UC Berkeley and now leads cryo-EM studies of mTORC1 regulators as corresponding author at the Southern University of Science and Technology in Shenzhen", "studies": [ "SUX2017" ], "url": "https://mtor-atlas.org/author/ming-yuan-su/" }, { "id": "chikako-suzuki", "name": "Chikako Suzuki", "corpus_name": "Suzuki C", "orcid": null, "lab": "Wagner Lab, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School (Boston, Massachusetts, USA)", "lab_url": null, "role": "Structural biologist from Gerhard Wagner's Harvard lab who showed how the tumour suppressor PDCD4 grabs the helicase eIF4A to block the start of protein synthesis", "studies": [ "SUZ2008" ], "url": "https://mtor-atlas.org/author/chikako-suzuki/" }, { "id": "akanksha-swarup", "name": "Akanksha Swarup", "corpus_name": "Swarup A", "orcid": null, "lab": "Bolger Lab, Department of Biochemistry and Molecular Biology, University of Georgia (Athens, Georgia, USA)", "lab_url": "https://bolgerlab.uga.edu/meet-the-lab", "role": "PhD candidate in Timothy Bolger's lab at the University of Georgia who studies how cancer mutations in the RNA helicase DDX3X change the cell's protein-making response to stress", "studies": [ "SWA2026" ], "url": "https://mtor-atlas.org/author/akanksha-swarup/" }, { "id": "angelia-szwed", "name": "Angelia Szwed", "corpus_name": "Szwed A", "orcid": null, "lab": "Jacinto Lab, Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University (Piscataway, New Jersey, USA)", "lab_url": "https://sites.rutgers.edu/jacinto-lab/?p=1003", "role": "Lead author, from Estela Jacinto's Rutgers lab, of a long Physiological Reviews article on how the two mTOR complexes are controlled and what they do in metabolism", "studies": [ "SZW2021" ], "url": "https://mtor-atlas.org/author/angelia-szwed/" }, { "id": "bo-tang", "name": "Bo Tang", "corpus_name": "Tang B", "orcid": null, "lab": "Department of Urology, Institute of Urology, West China Hospital, Sichuan University (Chengdu, Sichuan, China)", "lab_url": null, "role": "Urology researcher at West China Hospital and first author of a study explaining how kidney cancers escape mTOR inhibitor drugs, and how blocking NEK7 restores their effect", "studies": [ "TAN2026" ], "url": "https://mtor-atlas.org/author/bo-tang/" }, { "id": "jiajie-tao", "name": "Jiajie Tao", "corpus_name": "Tao J", "orcid": null, "lab": "Research Centre of Environmental Ecology and Fish Nutrition, College of Fisheries and Life Science, Shanghai Ocean University (Shanghai, China)", "lab_url": null, "role": "Fish nutrition researcher at Shanghai Ocean University who studies why carnivorous farmed fish such as largemouth bass handle dietary carbohydrate poorly and how this links to mTOR signalling in the liver", "studies": [ "TAO2026" ], "url": "https://mtor-atlas.org/author/jiajie-tao/" }, { "id": "songlin-li", "name": "Songlin Li", "corpus_name": "Li S", "orcid": null, "lab": "Research Centre of Environmental Ecology and Fish Nutrition, College of Fisheries and Life Science, Shanghai Ocean University (Shanghai, China)", "lab_url": null, "role": "Fish nutrition scientist at Shanghai Ocean University who leads research on how largemouth bass and other farmed fish use carbohydrate and other nutrients in their feed", "studies": [ "TAO2026" ], "url": "https://mtor-atlas.org/author/songlin-li/" }, { "id": "ashutosh-tiwari", "name": "Ashutosh Tiwari", "corpus_name": "Tiwari A", "orcid": null, "lab": "Bagchi Lab, Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California, USA)", "lab_url": null, "role": "Cancer biologist in Anindya Bagchi's lab who found that a tiny protein made from the circular RNA circPVT1 keeps MYC levels high through mTORC1", "studies": [ "TIW2026" ], "url": "https://mtor-atlas.org/author/ashutosh-tiwari/" }, { "id": "anindya-bagchi", "name": "Anindya Bagchi", "corpus_name": "Bagchi A", "orcid": null, "lab": "Bagchi Lab, Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California, USA)", "lab_url": "https://sbpdiscovery.org/bagchi", "role": "Cancer geneticist and associate professor at Sanford Burnham Prebys who uses chromosome engineering to find cancer genes, known for showing that MYC-amplified cancers depend on the neighbouring gene PVT1", "studies": [ "TIW2026" ], "url": "https://mtor-atlas.org/author/anindya-bagchi/" }, { "id": "zhi-yang-tsun", "name": "Zhi-Yang Tsun", "corpus_name": "Tsun ZY", "orcid": null, "lab": "Sabatini Lab, Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology (Cambridge, Massachusetts, USA)", "lab_url": null, "role": "Biologist who, as first author in David Sabatini's lab, showed that the tumour suppressor folliculin is a GAP for the RagC and RagD GTPases that carry the amino acid signal to mTORC1", "studies": [ "TSU2013", "WAN2015" ], "url": "https://mtor-atlas.org/author/zhi-yang-tsun/" }, { "id": "halvor-ullern", "name": "Halvor Ullern", "corpus_name": "Ullern H", "orcid": null, "lab": "Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo (Oslo, Norway)", "lab_url": null, "role": "Researcher in Helene Knævelsrud's autophagy group at the University of Oslo and first author of a 2026 study of folliculin loss in Birt-Hogg-Dubé kidney cancer", "studies": [ "ULL2026" ], "url": "https://mtor-atlas.org/author/halvor-ullern/" }, { "id": "sung-hee-um", "name": "Sung Hee Um", "corpus_name": "Um SH", "orcid": null, "lab": "Department of Molecular and Cellular Biology, Sungkyunkwan University School of Medicine (Suwon, South Korea)", "lab_url": null, "role": "Molecular biologist at Sungkyunkwan University School of Medicine whose work centres on the S6 kinases, and first author of the 2004 Nature study showing that mice without S6K1 resist obesity", "studies": [ "UMX2004" ], "url": "https://mtor-atlas.org/author/sung-hee-um/" }, { "id": "silvan-r-urfer", "name": "Silvan R. Urfer", "corpus_name": "Urfer SR", "orcid": null, "lab": "Department of Laboratory Medicine and Pathology, University of Washington (Seattle, Washington, USA)", "lab_url": "https://dlmp.uw.edu/faculty/urfer", "role": "Veterinarian and epidemiologist of aging at the University of Washington who led the first placebo-controlled rapamycin trial in pet dogs, an early step of the Dog Aging Project", "studies": [ "URF2017" ], "url": "https://mtor-atlas.org/author/silvan-r-urfer/" }, { "id": "tibor-vellai", "name": "Tibor Vellai", "corpus_name": "Vellai T", "orcid": null, "lab": "Department of Genetics, Eötvös Loránd University (Budapest, Hungary)", "lab_url": null, "role": "Hungarian geneticist who showed in 2003 that silencing the TOR gene roughly doubles the lifespan of the worm C. elegans, and who studies autophagy and ageing in worms at Eötvös Loránd University in Budapest", "studies": [ "VEL2003" ], "url": "https://mtor-atlas.org/author/tibor-vellai/" }, { "id": "giancarlo-maruri-munaretto", "name": "Giancarlo Maruri Munaretto", "corpus_name": "Munaretto GM", "orcid": null, "lab": "Department of Medicine, Universidade do Contestado (Concordia, Brazil)", "lab_url": null, "role": "Member of the Department of Medicine at Universidade do Contestado in Santa Catarina, Brazil, and senior author of a 2026 meta-analysis of everolimus after heart transplantation", "studies": [ "VITTE2026" ], "url": "https://mtor-atlas.org/author/giancarlo-maruri-munaretto/" }, { "id": "sofia-helena-vitte", "name": "Sofia Helena Vitte", "corpus_name": "Vitte SH", "orcid": null, "lab": "Hospital de Amor Nossa Senhora (Barretos, Brazil)", "lab_url": null, "role": "Brazilian medical researcher who works on evidence synthesis and cardiometabolic studies, and first author of the 2026 meta-analysis of everolimus in heart transplant recipients", "studies": [ "VITTE2026" ], "url": "https://mtor-atlas.org/author/sofia-helena-vitte/" }, { "id": "nikhil-wagle", "name": "Nikhil Wagle", "corpus_name": "Wagle N", "orcid": null, "lab": "Department of Medical Oncology, Dana-Farber Cancer Institute (Boston, Massachusetts, USA)", "lab_url": null, "role": "Medical oncologist and cancer genomics researcher at Dana-Farber who studies why some patients respond exceptionally well to targeted drugs, including a patient whose tumour carried two activating MTOR mutations", "studies": [ "WAG2014" ], "url": "https://mtor-atlas.org/author/nikhil-wagle/" }, { "id": "thomas-walter", "name": "Thomas Walter", "corpus_name": "Walter T", "orcid": null, "lab": "Department of Medical Oncology, Hôpital Édouard Herriot, Hospices Civils de Lyon (Lyon, France)", "lab_url": null, "role": "Medical oncologist in Lyon who specialises in neuroendocrine tumours and led the COMPETE phase 3 trial comparing 177Lu-edotreotide with everolimus", "studies": [ "WALTER2026" ], "url": "https://mtor-atlas.org/author/thomas-walter/" }, { "id": "qing-wang", "name": "Qing Wang", "corpus_name": "Wang Q", "orcid": null, "lab": "Yang Lab, Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky (Lexington, Kentucky, USA)", "lab_url": null, "role": "Cancer biologist in Hsin-Sheng Yang's lab at the University of Kentucky who studies how the tumour suppressor Pdcd4 holds back mTORC2 signalling, protein synthesis and cancer cell invasion", "studies": [ "WANG2026B" ], "url": "https://mtor-atlas.org/author/qing-wang/" }, { "id": "kiryl-d-piatkevich", "name": "Kiryl D. Piatkevich", "corpus_name": "Piatkevich KD", "orcid": null, "lab": "Piatkevich Lab, School of Life Sciences, Westlake University (Hangzhou, Zhejiang, China)", "lab_url": null, "role": "Protein engineer who designs fluorescent proteins and biosensors for imaging cells and brains, trained with Vladislav Verkhusha and Edward Boyden, now running a lab at Westlake University", "studies": [ "WANG2026C" ], "url": "https://mtor-atlas.org/author/kiryl-d-piatkevich/" }, { "id": "xiaoxiao-zhang", "name": "Xiaoxiao Zhang", "corpus_name": "Zhang Xiaoxiao", "orcid": null, "lab": "Guangzhou Aier Eye Hospital, Jinan University (Guangzhou, China)", "lab_url": null, "role": "Eye specialist at Guangzhou Aier Eye Hospital who works on childhood myopia, from school screening and myopia-control lenses to the biology of the sclera in animal models", "studies": [ "WEN2026" ], "url": "https://mtor-atlas.org/author/xiaoxiao-zhang/" }, { "id": "j-julie-wu", "name": "J. Julie Wu", "corpus_name": "Wu JJ", "orcid": null, "lab": "Laboratory of Molecular Biology, Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health (Bethesda, Maryland, USA)", "lab_url": null, "role": "Researcher in Toren Finkel's laboratory at the US National Heart, Lung, and Blood Institute and first author of the 2013 study showing that mice making only a quarter of the normal amount of mTOR live about 20 percent longer", "studies": [ "WUX2013" ], "url": "https://mtor-atlas.org/author/j-julie-wu/" }, { "id": "tianxiong-xiao", "name": "Tianxiong Xiao", "corpus_name": "Xiao T", "orcid": null, "lab": "Key Laboratory of Systems Health Science of Zhejiang Province, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences (Hangzhou, Zhejiang, China)", "lab_url": null, "role": "Researcher at the Hangzhou Institute for Advanced Study and first author of a 2026 review on how nutrient-sensing pathways steer adult stem cells through life", "studies": [ "XIA2026" ], "url": "https://mtor-atlas.org/author/tianxiong-xiao/" }, { "id": "jiayuan-xie", "name": "Jiayuan Xie", "corpus_name": "Xie J", "orcid": null, "lab": "Key Laboratory of Efficient Utilization of Non-grain Feed Resources, College of Animal Science and Technology, Shandong Agricultural University (Tai'an, Shandong, China)", "lab_url": null, "role": "Animal nutrition researcher in Ning Jiao's group at Shandong Agricultural University who studies how feed contaminants damage the pig gut, and first author of the piglet study on glutamine and bisphenol A", "studies": [ "XIE2026" ], "url": "https://mtor-atlas.org/author/jiayuan-xie/" }, { "id": "ning-jiao", "name": "Ning Jiao", "corpus_name": "Jiao N", "orcid": null, "lab": "Key Laboratory of Efficient Utilization of Non-grain Feed Resources, College of Animal Science and Technology, Shandong Agricultural University (Tai'an, Shandong, China)", "lab_url": null, "role": "Animal nutrition scientist at Shandong Agricultural University who studies how feed contaminants such as mould toxins and bisphenol A harm pigs, and how nutrients like glutamine protect the gut", "studies": [ "XIE2026" ], "url": "https://mtor-atlas.org/author/ning-jiao/" }, { "id": "jingting-xu", "name": "Jingting Xu", "corpus_name": "Xu J", "orcid": null, "lab": "Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (Wuhan, Hubei, China)", "lab_url": null, "role": "Researcher in the orthopedics department of Tongji Hospital, Wuhan, and first author of a 2026 review on mTORC2 and its partner RICTOR in immune cells and inflammatory disease", "studies": [ "XU2026B" ], "url": "https://mtor-atlas.org/author/jingting-xu/" }, { "id": "fengjing-guo", "name": "Fengjing Guo", "corpus_name": "Guo F", "orcid": null, "lab": "Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (Wuhan, Hubei, China)", "lab_url": null, "role": "Orthopedic researcher at Tongji Hospital, Wuhan, and senior author of a 2026 review on how mTORC2 and RICTOR shape immune cells and inflammation", "studies": [ "XU2026B" ], "url": "https://mtor-atlas.org/author/fengjing-guo/" }, { "id": "hyo-j-yang", "name": "Hyo J Yang", "corpus_name": "Yang HJ", "orcid": null, "lab": "Structural Biology Program, Memorial Sloan Kettering Cancer Center (New York, New York, USA)", "lab_url": null, "role": "Researcher in Nikola Pavletich's structural biology laboratory at Memorial Sloan Kettering and co-author of the two Nature papers that showed the atomic structure of mTOR and of mTORC1", "studies": [ "YAN2013", "YAN2017" ], "url": "https://mtor-atlas.org/author/hyo-j-yang/" }, { "id": "rui-li", "name": "Rui Li", "corpus_name": "Li R", "orcid": null, "lab": "Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University (Wuhan, Hubei, China)", "lab_url": null, "role": "Toxicologist at Central China Normal University in Wuhan who leads mouse studies of how early-life exposure to microplastics, nanoplastics and plastic additives harms the developing brain", "studies": [ "YANG2026" ], "url": "https://mtor-atlas.org/author/rui-li/" }, { "id": "ge-yang", "name": "Ge Yang", "corpus_name": "Yang G", "orcid": null, "lab": "Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University (Wuhan, Hubei, China)", "lab_url": null, "role": "Researcher in Rui Li's group at Central China Normal University who has led mouse studies on how microplastics, nanoplastics and the plasticiser DEHP affect the young brain", "studies": [ "YANG2026" ], "url": "https://mtor-atlas.org/author/ge-yang/" }, { "id": "james-c-yao", "name": "James C. Yao", "corpus_name": "Yao JC", "orcid": null, "lab": "Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center (Houston, Texas, USA)", "lab_url": null, "role": "Medical oncologist at MD Anderson Cancer Center who led the RADIANT-3 and RADIANT-4 trials that made the mTOR inhibitor everolimus a standard treatment for advanced neuroendocrine tumours", "studies": [ "YAO2011" ], "url": "https://mtor-atlas.org/author/james-c-yao/" }, { "id": "jian-yin", "name": "Jian Yin", "corpus_name": "Yin J", "orcid": null, "lab": "School of Life Sciences, Tsinghua University (Beijing, China)", "lab_url": null, "role": "Structural biologist at Tsinghua University who used cryo-electron microscopy to show how the human amino acid transporter PAT1 (SLC36A1) recognises and moves its cargo", "studies": [ "YIN2026" ], "url": "https://mtor-atlas.org/author/jian-yin/" }, { "id": "jiafeng-yu", "name": "Jiafeng Yu", "corpus_name": "Yu J", "orcid": null, "lab": "Department of Anesthesia, Tianjin Medical University General Hospital, and Tianjin Institute of Anesthesiology (Tianjin, China)", "lab_url": null, "role": "Anesthesiology researcher at Tianjin Medical University General Hospital and first author of a mouse study showing that breathing hydrogen gas protects memory after sepsis by calming mTOR in brain support cells", "studies": [ "YU2026" ], "url": "https://mtor-atlas.org/author/jiafeng-yu/" }, { "id": "yang-yu", "name": "Yang Yu", "corpus_name": "Yu Yang", "orcid": null, "lab": "Department of Anesthesia, Tianjin Medical University General Hospital, and Tianjin Institute of Anesthesiology (Tianjin, China)", "lab_url": null, "role": "Anesthesiologist and researcher at Tianjin Medical University General Hospital who studies hydrogen gas as a treatment for sepsis and its brain damage, and co-senior author of the 2026 study linking hydrogen, mTOR and myelin repair", "studies": [ "YU2026" ], "url": "https://mtor-atlas.org/author/yang-yu/" }, { "id": "li-yu", "name": "Li Yu", "corpus_name": "Yu L", "orcid": null, "lab": "Li Yu Lab, School of Life Sciences, Tsinghua University (Beijing, China)", "lab_url": "https://liyu-lab-tsinghua.github.io/", "role": "Cell biologist at Tsinghua University who, as a postdoc at the NIH, found how cells end autophagy and rebuild their lysosomes, and whose own group later discovered the migrasome, a new organelle left behind by migrating cells", "studies": [ "YUX2010" ], "url": "https://mtor-atlas.org/author/li-yu/" }, { "id": "hu-zeng", "name": "Hu Zeng", "corpus_name": "Zeng H", "orcid": null, "lab": "Zeng Lab, Division of Rheumatology, Department of Medicine, and Department of Immunology, Mayo Clinic (Rochester, Minnesota, USA)", "lab_url": null, "role": "Immunologist at Mayo Clinic who studies how mTOR signalling and cell metabolism shape T cells in autoimmunity, and who showed as a postdoc that regulatory T cells need mTORC1 to work", "studies": [ "ZEN2013" ], "url": "https://mtor-atlas.org/author/hu-zeng/" }, { "id": "gang-li", "name": "Gang Li", "corpus_name": "Li G", "orcid": null, "lab": "College of Life Sciences, Yantai University (Yantai, China)", "lab_url": null, "role": "Researcher at the College of Life Sciences, Yantai University, and senior author of a mouse study of the plant compound pungenin and hair regrowth", "studies": [ "ZHAI2026" ], "url": "https://mtor-atlas.org/author/gang-li/" }, { "id": "wencai-zhai", "name": "Wencai Zhai", "corpus_name": "Zhai W", "orcid": null, "lab": "College of Life Sciences, Yantai University (Yantai, China)", "lab_url": null, "role": "Researcher at Yantai University and first author of a mouse study showing that the plant compound pungenin speeds hair regrowth in hormone-driven hair loss", "studies": [ "ZHAI2026" ], "url": "https://mtor-atlas.org/author/wencai-zhai/" }, { "id": "jingyue-zhang", "name": "Jingyue Zhang", "corpus_name": "Zhang Jingyue", "orcid": null, "lab": "School of Pharmacy, Lanzhou University (Lanzhou, China)", "lab_url": null, "role": "Pharmacy researcher at Lanzhou University working with Wen Li on the chemistry and actions of traditional Chinese medicines, from extracting plant compounds to testing a herbal formula in breast cancer models", "studies": [ "ZHANG2026C" ], "url": "https://mtor-atlas.org/author/jingyue-zhang/" }, { "id": "nan-zhou", "name": "Nan Zhou", "corpus_name": "Zhou N", "orcid": null, "lab": "Department of Oncology, The First Affiliated Hospital of Harbin Medical University (Harbin, China)", "lab_url": null, "role": "Oncology researcher at the First Affiliated Hospital of Harbin Medical University and first author of a 2026 study linking a DNA-demethylating enzyme to PI3K-AKT-mTOR activation in lung adenocarcinoma", "studies": [ "ZHOU2026" ], "url": "https://mtor-atlas.org/author/nan-zhou/" }, { "id": "hongbo-you", "name": "Hongbo You", "corpus_name": "You H", "orcid": null, "lab": "Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (Wuhan, Hubei, China)", "lab_url": null, "role": "Orthopedic researcher at Tongji Hospital, Wuhan, and senior author of a 2026 mouse study showing that the plant compound corilagin slows osteoarthritis by restoring cartilage-cell autophagy", "studies": [ "ZHOU2026B" ], "url": "https://mtor-atlas.org/author/hongbo-you/" }, { "id": "ruijia-zhou", "name": "Ruijia Zhou", "corpus_name": "Zhou R", "orcid": null, "lab": "Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (Wuhan, Hubei, China)", "lab_url": null, "role": "Researcher in the orthopedics department of Tongji Hospital, Wuhan, and first author of a 2026 study on corilagin, a plant polyphenol that protected mouse cartilage by restoring autophagy", "studies": [ "ZHOU2026B" ], "url": "https://mtor-atlas.org/author/ruijia-zhou/" }, { "id": "vittoria-zinzalla", "name": "Vittoria Zinzalla", "corpus_name": "Zinzalla V", "orcid": null, "lab": "Boehringer Ingelheim RCV (Vienna, Austria)", "lab_url": null, "role": "Cell biologist who, in Michael Hall's Basel lab, found that mTORC2 is switched on by binding to ribosomes, and later moved to cancer pharmacology at Boehringer Ingelheim in Vienna", "studies": [ "ZIN2011" ], "url": "https://mtor-atlas.org/author/vittoria-zinzalla/" }, { "id": "christian-bannister", "name": "Christian Bannister", "corpus_name": "Bannister CA", "orcid": null, "lab": "Human Data Sciences (Cardiff, Wales, United Kingdom)", "lab_url": null, "role": "Health data analyst from Craig Currie's group in Cardiff who works with UK primary care records, and first author of the 2014 comparison of survival in people with type 2 diabetes on metformin and people without diabetes", "studies": [ "BAN2014" ], "url": "https://mtor-atlas.org/author/christian-bannister/" }, { "id": "craig-currie", "name": "Craig Currie", "corpus_name": "Currie CJ", "orcid": null, "lab": "Division of Population Medicine, School of Medicine, Cardiff University (Cardiff, Wales, United Kingdom)", "lab_url": null, "role": "Pharmacoepidemiologist at Cardiff University who uses large UK primary care databases to study diabetes treatments and their long-term outcomes, and senior author of the 2014 metformin survival study", "studies": [ "BAN2014" ], "url": "https://mtor-atlas.org/author/craig-currie/" }, { "id": "kathleen-ottina", "name": "Kathleen Ottina", "corpus_name": "Ottina KA", "orcid": null, "lab": "Sabatini Lab, Whitehead Institute for Biomedical Research (Cambridge, Massachusetts, USA)", "lab_url": null, "role": "Researcher in David Sabatini's lab at the Whitehead Institute and HHMI at MIT who contributed to studies of the GATOR1 amino acid off-switch, mTORC1 feedback on growth-factor signalling, and cancer drug resistance", "studies": [ "BAR2013", "HSU2011" ], "url": "https://mtor-atlas.org/author/kathleen-ottina/" }, { "id": "mario-campone", "name": "Mario Campone", "corpus_name": "Campone M", "orcid": null, "lab": "Institut de Cancérologie de l'Ouest (Saint-Herblain, France)", "lab_url": null, "role": "Breast cancer oncologist and general director of the Institut de Cancérologie de l'Ouest, a co-investigator on the BOLERO-2 trial that brought everolimus into breast cancer care", "studies": [ "BAS2012", "PIC2014" ], "url": "https://mtor-atlas.org/author/mario-campone/" }, { "id": "ines-deleu", "name": "Ines Deleu", "corpus_name": "Deleu I", "orcid": null, "lab": "Oncology Department, Vitaz (Sint-Niklaas, Belgium)", "lab_url": null, "role": "Medical oncologist in Sint-Niklaas, Belgium, who enrolled patients in international breast cancer drug trials, including the BOLERO-2 trial of everolimus", "studies": [ "BAS2012", "PIC2014" ], "url": "https://mtor-atlas.org/author/ines-deleu/" }, { "id": "michael-gnant", "name": "Michael Gnant", "corpus_name": "Gnant M", "orcid": "0000-0003-1002-2118", "lab": "Department of Surgery and Comprehensive Cancer Center, Medical University of Vienna (Vienna, Austria)", "lab_url": "https://www.ae-info.org/ae/User/Gnant_Michael", "role": "Surgical oncologist and breast cancer trialist, Professor of Surgery at the Medical University of Vienna and President of the Austrian Breast and Colorectal Cancer Study Group, and a co-author of BOLERO-2, the trial that brought the mTOR inhibitor everolimus into breast cancer treatment", "studies": [ "BAS2012", "PIC2014" ], "url": "https://mtor-atlas.org/author/michael-gnant/" }, { "id": "yoshinori-ito", "name": "Yoshinori Ito", "corpus_name": "Ito Y", "orcid": null, "lab": "Department of Breast Medical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research (Tokyo, Japan)", "lab_url": null, "role": "Breast medical oncologist at the Cancer Institute Hospital in Tokyo and a co-investigator of BOLERO-2, the trial that brought the mTOR inhibitor everolimus into breast cancer treatment", "studies": [ "BAS2012", "PIC2014" ], "url": "https://mtor-atlas.org/author/yoshinori-ito/" }, { "id": "fabienne-lebrun", "name": "Fabienne Lebrun", "corpus_name": "Lebrun F", "orcid": null, "lab": "Institut Jules Bordet, Université Libre de Bruxelles (Brussels, Belgium)", "lab_url": null, "role": "Medical oncologist at the Institut Jules Bordet in Brussels and a co-author of the BOLERO-2 trial reports that brought the mTOR inhibitor everolimus into breast cancer care", "studies": [ "BAS2012", "PIC2014" ], "url": "https://mtor-atlas.org/author/fabienne-lebrun/" }, { "id": "shinzaburo-noguchi", "name": "Shinzaburo Noguchi", "corpus_name": "Noguchi S", "orcid": null, "lab": "Department of Breast and Endocrine Surgery, Osaka University Graduate School of Medicine (Osaka, Japan)", "lab_url": null, "role": "Breast cancer surgeon and researcher at Osaka University and a co-investigator of BOLERO-2, the trial that brought the mTOR inhibitor everolimus into breast cancer treatment", "studies": [ "BAS2012", "PIC2014" ], "url": "https://mtor-atlas.org/author/shinzaburo-noguchi/" }, { "id": "alejandra-perez", "name": "Alejandra Perez", "corpus_name": "Perez A", "orcid": null, "lab": "Breast Medical Oncology, Sylvester Comprehensive Cancer Center, University of Miami (Plantation, Florida, USA)", "lab_url": "https://doctors.umiamihealth.org/provider/alejandra-perez/524894", "role": "Breast cancer oncologist in South Florida who enrolled patients in BOLERO-2, the trial that brought the mTOR inhibitor everolimus into breast cancer treatment", "studies": [ "BAS2012", "PIC2014" ], "url": "https://mtor-atlas.org/author/alejandra-perez/" }, { "id": "kathleen-pritchard", "name": "Kathleen Pritchard", "corpus_name": "Pritchard KI", "orcid": null, "lab": "Sunnybrook Odette Cancer Centre and Sunnybrook Research Institute, University of Toronto (Toronto, Ontario, Canada)", "lab_url": "https://sunnybrook.ca/media/item.asp?i=1704", "role": "Breast cancer medical oncologist at Sunnybrook in Toronto, professor emerita at the University of Toronto and long-time leader of breast cancer trials, co-author of the BOLERO-2 everolimus trial", "studies": [ "BAS2012", "PIC2014" ], "url": "https://mtor-atlas.org/author/kathleen-pritchard/" }, { "id": "hope-rugo", "name": "Hope Rugo", "corpus_name": "Rugo HS", "orcid": null, "lab": "Division of Breast Medical Oncology, City of Hope (Duarte, California, USA)", "lab_url": null, "role": "Breast cancer oncologist and clinical trialist, long at UCSF, who helped run BOLERO-2 and studied how to manage the side effects of mTOR inhibitors such as everolimus", "studies": [ "BAS2012", "PIC2014" ], "url": "https://mtor-atlas.org/author/hope-rugo/" }, { "id": "david-lebwohl", "name": "David Lebwohl", "corpus_name": "Lebwohl D", "orcid": null, "lab": "Intellia Therapeutics (Cambridge, Massachusetts, USA)", "lab_url": null, "role": "Medical oncologist and drug developer who led the clinical development of everolimus (Afinitor) at Novartis through approvals in several cancers and tuberous sclerosis, and later served as Chief Medical Officer of the gene-editing company Intellia Therapeutics", "studies": [ "MOT2008", "BIS2013", "BAS2012", "YAO2011", "FRA2013" ], "url": "https://mtor-atlas.org/author/david-lebwohl/" }, { "id": "tarek-sahmoud", "name": "Tarek Sahmoud", "corpus_name": "Sahmoud T", "orcid": null, "lab": "Novartis Oncology (Florham Park, New Jersey, USA)", "lab_url": null, "role": "Physician and epidemiologist who worked as a clinical program head in Novartis oncology drug development during the everolimus trials, and later as chief medical officer at several cancer drug companies", "studies": [ "BIS2013", "BAS2012", "FRA2013" ], "url": "https://mtor-atlas.org/author/tarek-sahmoud/" }, { "id": "julie-st-pierre", "name": "Julie St-Pierre", "corpus_name": "St-Pierre J", "orcid": null, "lab": "Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa (Ottawa, Ontario, Canada)", "lab_url": "https://uottawa.ca/about-us/leadership-governance/vice-presidents/julie-st-pierre", "role": "Biochemist and Vice-President, Research and Innovation at the University of Ottawa who studies how cancer cells adapt their metabolism, and a co-author on McGill work linking mTORC1 to mitochondria and to rapamycin-induced fatty liver", "studies": [ "BCH2026", "MOR2013" ], "url": "https://mtor-atlas.org/author/julie-st-pierre/" }, { "id": "fiona-menzies", "name": "Fiona Menzies", "corpus_name": "Menzies FM", "orcid": null, "lab": "Rubinsztein Lab, Cambridge Institute for Medical Research, University of Cambridge (Cambridge, England, United Kingdom)", "lab_url": null, "role": "Cell biologist who worked for many years in David Rubinsztein's Cambridge lab on autophagy and the clearance of disease proteins in neurodegeneration", "studies": [ "KOR2011", "BER2006" ], "url": "https://mtor-atlas.org/author/fiona-menzies/" }, { "id": "cahir-okane", "name": "Cahir O'Kane", "corpus_name": "O'Kane CJ", "orcid": null, "lab": "O'Kane Lab, Department of Genetics, University of Cambridge (Cambridge, England, United Kingdom)", "lab_url": "https://www.gen.cam.ac.uk/people/cahir-okane", "role": "Fruit-fly geneticist at Cambridge who studies how the endoplasmic reticulum is built inside nerve fibres and how its failure causes hereditary spastic paraplegia, and who helped bring Drosophila models into David Rubinsztein's autophagy work", "studies": [ "KOR2011", "BER2006", "RAV2004" ], "url": "https://mtor-atlas.org/author/cahir-okane/" }, { "id": "lisa-young", "name": "Lisa Young", "corpus_name": "Young LR", "orcid": null, "lab": "Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, and Perelman School of Medicine, University of Pennsylvania (Philadelphia, Pennsylvania, USA)", "lab_url": "https://www.chop.edu/doctors/young-lisa-r", "role": "Lung physician-scientist who helped run the first sirolimus trials in lymphangioleiomyomatosis (LAM) and now leads pulmonary medicine at the Children's Hospital of Philadelphia", "studies": [ "BIS2008", "MCC2011" ], "url": "https://mtor-atlas.org/author/lisa-young/" }, { "id": "elena-belousova", "name": "Elena Belousova", "corpus_name": "Belousova E", "orcid": null, "lab": "Department of Psychoneurology and Epileptology, Moscow Research Institute of Pediatrics and Pediatric Surgery (Moscow, Russia)", "lab_url": "https://rjdn.eco-vector.com/jour/pages/view/Belousova", "role": "Child neurologist and epilepsy specialist in Moscow who heads a department of psychoneurology and epileptology and has been a principal investigator in international drug trials for tuberous sclerosis complex", "studies": [ "BIS2013", "FRA2013" ], "url": "https://mtor-atlas.org/author/elena-belousova/" }, { "id": "vicky-h-whittemore", "name": "Vicky H Whittemore", "corpus_name": "Whittemore VH", "orcid": null, "lab": "Channels, Synapses and Circuits Cluster, Division of Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health (Bethesda, Maryland, USA)", "lab_url": "https://www.ninds.nih.gov/About-NINDS/Who-We-Are/staff/Vicky-Whittemore", "role": "Neuroscientist and NIH program director for epilepsy and ME/CFS research who spent over two decades working for patient organisations, including the Tuberous Sclerosis Alliance", "studies": [ "FRA2013" ], "url": "https://mtor-atlas.org/author/vicky-h-whittemore/" }, { "id": "trevor-n-stitt", "name": "Trevor N Stitt", "corpus_name": "Stitt TN", "orcid": null, "lab": "Regeneron Pharmaceuticals (Tarrytown, New York, USA)", "lab_url": null, "role": "Regeneron scientist who worked in David Glass and George Yancopoulos's muscle program on the 2001 papers showing that the Akt/mTOR pathway drives muscle growth and protects against muscle wasting", "studies": [ "BOD2001", "ROM2001" ], "url": "https://mtor-atlas.org/author/trevor-n-stitt/" }, { "id": "kristen-n-pollizzi", "name": "Kristen N. Pollizzi", "corpus_name": "Pollizzi KN", "orcid": null, "lab": "Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Johns Hopkins University School of Medicine (Baltimore, Maryland, USA)", "lab_url": null, "role": "Immunologist trained in Jonathan Powell's lab at Johns Hopkins who used gene deletions in mice to show how the two mTOR complexes push killer T cells toward effector or memory fates", "studies": [ "POL2015", "DEL2011" ], "url": "https://mtor-atlas.org/author/kristen-n-pollizzi/" }, { "id": "adam-t-waickman", "name": "Adam T. Waickman", "corpus_name": "Waickman AT", "orcid": null, "lab": "Department of Microbiology and Immunology, SUNY Upstate Medical University (Syracuse, New York, USA)", "lab_url": null, "role": "Immunologist who trained in Jonathan Powell's mTOR and T cell lab at Johns Hopkins and now studies human immune responses to dengue virus at SUNY Upstate Medical University", "studies": [ "POL2015", "DEL2011" ], "url": "https://mtor-atlas.org/author/adam-t-waickman/" }, { "id": "tsuneo-ikenoue", "name": "Tsuneo Ikenoue", "corpus_name": "Ikenoue T", "orcid": null, "lab": "Institute of Medical Science, University of Tokyo (Tokyo, Japan)", "lab_url": null, "role": "Gastroenterologist and cancer researcher at the University of Tokyo who trained in Kun-Liang Guan's mTOR lab and now builds mouse models of liver, bile duct and pancreatic cancer driven by the PI3K-Akt-mTOR pathway", "studies": [ "YAN2006" ], "url": "https://mtor-atlas.org/author/tsuneo-ikenoue/" }, { "id": "peter-m-finan", "name": "Peter M Finan", "corpus_name": "Finan PM", "orcid": null, "lab": "Epidarex Capital (Edinburgh, Scotland, United Kingdom)", "lab_url": "https://enterprisetherapeutics.com/board/dr-peter-finan/", "role": "Biochemist and drug-discovery leader who started the PI 3-kinase drug discovery program at Novartis and ran its Developmental and Molecular Pathways group in Cambridge, Massachusetts, before moving into life-science venture investing", "studies": [ "DIB2012", "DUV2010" ], "url": "https://mtor-atlas.org/author/peter-m-finan/" }, { "id": "leon-o-murphy", "name": "Leon O Murphy", "corpus_name": "Murphy LO", "orcid": null, "lab": "Casma Therapeutics (Boston, Massachusetts, USA)", "lab_url": null, "role": "Cell biologist who led autophagy and mTOR drug discovery at Novartis in Cambridge, Massachusetts, and is now Chief Scientific Officer of Casma Therapeutics, a company that develops drugs acting on the autophagy-lysosome system", "studies": [ "DIB2012", "DUV2010" ], "url": "https://mtor-atlas.org/author/leon-o-murphy/" }, { "id": "johannes-beckers", "name": "Johannes Beckers", "corpus_name": "Beckers J", "orcid": null, "lab": "Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Munich (Neuherberg, Germany)", "lab_url": null, "role": "Geneticist at Helmholtz Munich and the Technical University of Munich whose group at the Institute of Experimental Genetics runs gene-expression profiling for the German Mouse Clinic", "studies": [ "EIS2016", "NEF2013" ], "url": "https://mtor-atlas.org/author/johannes-beckers/" }, { "id": "helmut-fuchs", "name": "Helmut Fuchs", "corpus_name": "Fuchs H", "orcid": null, "lab": "German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Munich (Neuherberg, Germany)", "lab_url": "https://www.helmholtz-munich.de/en/ieg/helmut-fuchs", "role": "Scientific and technical head of the German Mouse Clinic at Helmholtz Munich, the standardised many-organ testing platform for mouse models that Fuchs helped build", "studies": [ "EIS2016", "NEF2013" ], "url": "https://mtor-atlas.org/author/helmut-fuchs/" }, { "id": "valerie-gailus-durner", "name": "Valérie Gailus-Durner", "corpus_name": "Gailus-Durner V", "orcid": null, "lab": "German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Munich (Neuherberg, Germany)", "lab_url": "https://www.helmholtz-munich.de/en/ieg/valerie-gailus-durner", "role": "Biochemist who co-founded the German Mouse Clinic at Helmholtz Munich and leads it as scientific head, running standardised testing of mouse models across many organ systems", "studies": [ "EIS2016", "NEF2013" ], "url": "https://mtor-atlas.org/author/valerie-gailus-durner/" }, { "id": "marion-horsch", "name": "Marion Horsch", "corpus_name": "Horsch M", "orcid": null, "lab": "German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Munich (Neuherberg, Germany)", "lab_url": null, "role": "Scientist at the Institute of Experimental Genetics, Helmholtz Munich, who has worked with Johannes Beckers on gene-expression studies of mouse models for the German Mouse Clinic", "studies": [ "EIS2016", "NEF2013" ], "url": "https://mtor-atlas.org/author/marion-horsch/" }, { "id": "kristin-moreth", "name": "Kristin Moreth", "corpus_name": "Moreth K", "orcid": null, "lab": "German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Munich (Neuherberg, Germany)", "lab_url": null, "role": "Scientist at the German Mouse Clinic of Helmholtz Munich who contributed to its phenotyping of mouse models, including heart measurements", "studies": [ "EIS2016", "NEF2013" ], "url": "https://mtor-atlas.org/author/kristin-moreth/" }, { "id": "birgit-rathkolb", "name": "Birgit Rathkolb", "corpus_name": "Rathkolb B", "orcid": null, "lab": "German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Munich (Neuherberg, Germany)", "lab_url": null, "role": "Scientist at the German Mouse Clinic of Helmholtz Munich and the Gene Center of LMU Munich who contributes to the clinic's phenotyping of mouse models", "studies": [ "EIS2016", "NEF2013" ], "url": "https://mtor-atlas.org/author/birgit-rathkolb/" }, { "id": "jan-rozman", "name": "Jan Rozman", "corpus_name": "Rozman J", "orcid": null, "lab": "German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Munich (Neuherberg, Germany)", "lab_url": null, "role": "Scientist who worked at the German Mouse Clinic of Helmholtz Munich on the standardised phenotyping of mouse models", "studies": [ "EIS2016", "NEF2013" ], "url": "https://mtor-atlas.org/author/jan-rozman/" }, { "id": "tuong-huynh", "name": "Tuong Huynh", "corpus_name": "Huynh T", "orcid": null, "lab": "Zoghbi Lab, Department of Molecular and Human Genetics, Baylor College of Medicine (Houston, Texas, USA)", "lab_url": "https://www.bcm.edu/people-search/tuong-huynh-23474", "role": "Research associate at Baylor College of Medicine in Houston and co-author on a long run of papers from Andrea Ballabio's group on TFEB, the master switch for lysosome and autophagy genes, including the work that tied TFEB to mTOR, starvation and fat metabolism", "studies": [ "FER2026", "SET2012", "SET2011", "SET2013" ], "url": "https://mtor-atlas.org/author/tuong-huynh/" }, { "id": "david-b-shackelford", "name": "David B. Shackelford", "corpus_name": "Shackelford DB", "orcid": null, "lab": "Shackelford Lab, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles (Los Angeles, California, USA)", "lab_url": "https://www.uclahealth.org/cancer/members/david-shackelford", "role": "Cancer biologist at UCLA who studies lung tumours that have lost the LKB1 tumour suppressor, the upstream activator of AMPK, and who trained in Reuben Shaw's lab at the Salk Institute", "studies": [ "GWI2008", "EGA2010" ], "url": "https://mtor-atlas.org/author/david-b-shackelford/" }, { "id": "wolfgang-oppliger", "name": "Wolfgang Oppliger", "corpus_name": "Oppliger W", "orcid": null, "lab": "Hall Lab, Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": null, "role": "Long-serving Biozentrum researcher who worked for more than two decades in Basel labs, first on how proteins enter mitochondria and then on TOR signalling with Michael Hall", "studies": [ "DUR2012" ], "url": "https://mtor-atlas.org/author/wolfgang-oppliger/" }, { "id": "clinton-astle", "name": "Clinton Astle", "corpus_name": "Astle CM", "orcid": null, "lab": "Harrison Laboratory, The Jackson Laboratory (Bar Harbor, Maine, USA)", "lab_url": null, "role": "Long-time research associate of David Harrison at The Jackson Laboratory, with work on mouse blood stem cells and aging since the 1970s, and a co-author of the Interventions Testing Program papers that showed rapamycin extends mouse lifespan", "studies": [ "STR2012", "HAR2014", "MIL2011", "MIL2014", "HAR2009" ], "url": "https://mtor-atlas.org/author/clinton-astle/" }, { "id": "kevin-flurkey", "name": "Kevin Flurkey", "corpus_name": "Flurkey K", "orcid": null, "lab": "The Jackson Laboratory (Bar Harbor, Maine, USA)", "lab_url": null, "role": "Biologist of aging at The Jackson Laboratory who has studied mouse lifespan and hormones since the early 1980s and co-authored the Interventions Testing Program papers on rapamycin", "studies": [ "HAR2014", "MIL2011", "MIL2014", "HAR2009" ], "url": "https://mtor-atlas.org/author/kevin-flurkey/" }, { "id": "nancy-l-nadon", "name": "Nancy L. Nadon", "corpus_name": "Nadon NL", "orcid": null, "lab": "Division of Aging Biology, National Institute on Aging, National Institutes of Health (Bethesda, Maryland, USA)", "lab_url": null, "role": "Scientist and programme official at the US National Institute on Aging who oversaw research resources for aging biology and helped run the Interventions Testing Program that found rapamycin extends mouse lifespan", "studies": [ "STR2012", "HAR2014", "MIL2011", "MIL2014", "HAR2009" ], "url": "https://mtor-atlas.org/author/nancy-l-nadon/" }, { "id": "zelton-dave-sharp", "name": "Zelton Dave Sharp", "corpus_name": "Sharp ZD", "orcid": null, "lab": "Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "Molecular biologist at UT Health San Antonio who works on rapamycin and aging in mice, from the Interventions Testing Program lifespan studies to cancer prevention in tumour-prone mice", "studies": [ "MIL2011", "MIL2014", "HAR2009" ], "url": "https://mtor-atlas.org/author/zelton-dave-sharp/" }, { "id": "kivanc-birsoy", "name": "Kivanç Birsoy", "corpus_name": "Birsoy K", "orcid": null, "lab": "Laboratory of Metabolic Regulation and Genetics, The Rockefeller University (New York, New York, USA)", "lab_url": null, "role": "Cancer metabolism researcher who trained with Jeffrey Friedman and David Sabatini and now heads the Laboratory of Metabolic Regulation and Genetics at The Rockefeller University, using genetic screens to find how cancer cells rewire their metabolism", "studies": [ "GRA2014", "YIL2012" ], "url": "https://mtor-atlas.org/author/kivanc-birsoy/" }, { "id": "marion-cornu", "name": "Marion Cornu", "corpus_name": "Cornu M", "orcid": null, "lab": "Hall Lab, Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": null, "role": "Physiologist from Michael Hall's Basel lab who showed in mice that mTORC1 in the liver controls body temperature, movement and fat metabolism through the hormone FGF21", "studies": [ "HAG2012", "ROB2013" ], "url": "https://mtor-atlas.org/author/marion-cornu/" }, { "id": "nadine-cybulski", "name": "Nadine Cybulski", "corpus_name": "Cybulski N", "orcid": null, "lab": "Hall Lab, Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": null, "role": "Cell biologist from Michael Hall's Basel lab who showed that mTORC2 in fat tissue helps control how big the whole body grows", "studies": [ "HAG2012", "POL2008" ], "url": "https://mtor-atlas.org/author/nadine-cybulski/" }, { "id": "sujuti-hidayat", "name": "Sujuti Hidayat", "corpus_name": "Hidayat S", "orcid": null, "lab": "Biosignal Research Center, Kobe University (Kobe, Japan)", "lab_url": null, "role": "Member of Kazuyoshi Yonezawa's Kobe team that co-discovered raptor and worked out how mTOR senses amino acids, and first author of a study showing that a leucine derivative can block amino acid-mTOR signalling", "studies": [ "HARA2002", "NOJ2003" ], "url": "https://mtor-atlas.org/author/sujuti-hidayat/" }, { "id": "chiharu-tokunaga", "name": "Chiharu Tokunaga", "corpus_name": "Tokunaga C", "orcid": null, "lab": "Biosignal Research Center, Kobe University (Kobe, Japan)", "lab_url": null, "role": "Member of Kazuyoshi Yonezawa's Kobe team that co-discovered raptor, and first author of a 2004 review on how mTOR combines amino acid and energy signals", "studies": [ "HARA2002", "NOJ2003" ], "url": "https://mtor-atlas.org/author/chiharu-tokunaga/" }, { "id": "joseph-a-baur", "name": "Joseph A. Baur", "corpus_name": "Baur JA", "orcid": null, "lab": "Baur Lab, Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania (Philadelphia, Pennsylvania, USA)", "lab_url": "https://www.med.upenn.edu/baurlab", "role": "Biologist of aging at the University of Pennsylvania whose lab showed that rapamycin's harm to glucose control comes from mTORC2 loss and studies how NAD levels shape health", "studies": [ "LAM2012" ], "url": "https://mtor-atlas.org/author/joseph-a-baur/" }, { "id": "jens-otto-l-jrgensen", "name": "Jens Otto L Jørgensen", "corpus_name": "Jørgensen JO", "orcid": "0000-0001-7408-1526", "lab": "Department of Clinical Medicine (Hormone and Bone Diseases), Aarhus University, and Department of Endocrinology and Internal Medicine, Aarhus University Hospital (Aarhus, Denmark)", "lab_url": "https://clin.au.dk/da/contact/staff/vis/person/303ebe86-6861-4b19-b4d7-6bda0526b27e", "role": "Clinical professor of endocrinology at Aarhus University who studies growth hormone, the pituitary and adrenal glands and metabolism in people, and senior author of a trial showing that high-dose resveratrol did not improve metabolism in obese men", "studies": [ "POU2013" ], "url": "https://mtor-atlas.org/author/jens-otto-l-jrgensen/" }, { "id": "anita-parmigiani", "name": "Anita Parmigiani", "corpus_name": "Parmigiani A", "orcid": null, "lab": "Budanov Lab, Department of Human and Molecular Genetics, Virginia Commonwealth University (Richmond, Virginia, USA)", "lab_url": null, "role": "Molecular biologist who worked in Andrei Budanov's lab at Virginia Commonwealth University on Sestrins, stress-induced proteins that hold back mTORC1", "studies": [ "PAR2014" ], "url": "https://mtor-atlas.org/author/anita-parmigiani/" }, { "id": "robert-a-lindquist", "name": "Robert A Lindquist", "corpus_name": "Lindquist RA", "orcid": null, "lab": "Sabatini Lab, Whitehead Institute for Biomedical Research (Cambridge, Massachusetts, USA)", "lab_url": null, "role": "Researcher in David Sabatini's group at the Whitehead Institute who ran large image-based RNAi screens for regulators of TORC1 signaling and helped build the CellProfiler image-analysis software", "studies": [ "SAN2008", "SAN2007" ], "url": "https://mtor-atlas.org/author/robert-a-lindquist/" }, { "id": "diego-l-medina", "name": "Diego L. Medina", "corpus_name": "Medina DL", "orcid": null, "lab": "Telethon Institute of Genetics and Medicine (TIGEM) and Department of Translational Medical Science, University of Naples Federico II (Pozzuoli, Campania, Italy)", "lab_url": null, "role": "Cell biologist at the Telethon Institute of Genetics and Medicine in Naples who showed how TFEB, the master switch for lysosome genes, is controlled by calcium released from lysosomes, and who works on lysosomal storage diseases", "studies": [ "SET2012" ], "url": "https://mtor-atlas.org/author/diego-l-medina/" }, { "id": "david-carling", "name": "David Carling", "corpus_name": "Carling D", "orcid": null, "lab": "Cellular Stress Group, MRC Laboratory of Medical Sciences, Imperial College London (London, England, United Kingdom)", "lab_url": "https://lms.mrc.ac.uk/research-group/cellular-stress/", "role": "Biochemist who heads the Cellular Stress group at the MRC Laboratory of Medical Sciences in London and has spent decades working out how the energy sensor AMPK is switched on and what it controls", "studies": [ "XIA2011" ], "url": "https://mtor-atlas.org/author/david-carling/" }, { "id": "steven-j-gamblin", "name": "Steven J. Gamblin", "corpus_name": "Gamblin SJ", "orcid": null, "lab": "Scientific Platforms, The Francis Crick Institute (London, England, United Kingdom)", "lab_url": "https://www.crick.ac.uk/research/find-a-researcher/steve-gamblin", "role": "Structural biologist and Fellow of the Royal Society who solved the crystal structure of active mammalian AMPK, the cell's energy sensor and the main counterweight to mTORC1, and who now directs the scientific platforms of the Francis Crick Institute", "studies": [ "XIA2011" ], "url": "https://mtor-atlas.org/author/steven-j-gamblin/" }, { "id": "zhenpeng-qiu", "name": "Zhenpeng Qiu", "corpus_name": "Qiu Z", "orcid": null, "lab": "School of Pharmacy, Hubei University of Chinese Medicine (Wuhan, Hubei, China)", "lab_url": "https://yxy.hbucm.edu.cn/info/1032/12002.htm", "role": "Pharmacologist and Professor at Hubei University of Chinese Medicine who studies how natural medicines act on liver and kidney disease, including fatty liver disease and drug-induced organ damage", "studies": [ "GAO2026" ], "url": "https://mtor-atlas.org/author/zhenpeng-qiu/" }, { "id": "brooke-gile", "name": "Brooke Gile", "corpus_name": "Gile B", "orcid": null, "lab": "Research and Development Lab, Simmaron Research (Milwaukee, Wisconsin, USA)", "lab_url": null, "role": "Researcher in Simmaron Research's laboratory in Milwaukee who works on low-dose rapamycin as a possible treatment for ME/CFS and led the 2026 analysis of its effects on purine metabolism", "studies": [ "GIL2026" ], "url": "https://mtor-atlas.org/author/brooke-gile/" }, { "id": "avik-roy", "name": "Avik Roy", "corpus_name": "Roy A", "orcid": null, "lab": "Simmaron Research (Milwaukee, Wisconsin, USA)", "lab_url": null, "role": "Neuroscientist who studies brain inflammation in Parkinson's disease and now leads research on ME/CFS as Chief Scientific Officer of the nonprofit Simmaron Research", "studies": [ "GIL2026" ], "url": "https://mtor-atlas.org/author/avik-roy/" }, { "id": "yang-zong", "name": "Yang Zong", "corpus_name": "Zong Y", "orcid": null, "lab": "Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health (Madison, Wisconsin, USA)", "lab_url": null, "role": "Pathologist at the University of Wisconsin-Madison who works on the diagnosis of kidney and genitourinary tumours, senior author of a 2026 study proposing GPR143 as a marker for kidney tumours driven by the FLCN/TSC/mTOR-TFE pathway", "studies": [ "LI2026" ], "url": "https://mtor-atlas.org/author/yang-zong/" }, { "id": "guoqing-ouyang", "name": "Guoqing Ouyang", "corpus_name": "Ouyang G", "orcid": null, "lab": "Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University (Nanning, China)", "lab_url": null, "role": "Liver surgery researcher at Guangxi Medical University and senior author of a 2026 study in which the plant compound notoginsenoside R1 eased paracetamol liver injury by boosting autophagy", "studies": [ "LIS2026" ], "url": "https://mtor-atlas.org/author/guoqing-ouyang/" }, { "id": "nianyin-lv", "name": "Nianyin Lv", "corpus_name": "Lv N", "orcid": null, "lab": "School of Medicine, Nanjing University of Chinese Medicine (Nanjing, China)", "lab_url": null, "role": "Researcher at Nanjing University of Chinese Medicine who led a mouse study showing that the age-related loss of Lamtor5, a part of the lysosomal platform that helps switch on mTORC1, drives immune ageing through inflammation", "studies": [ "LV2026" ], "url": "https://mtor-atlas.org/author/nianyin-lv/" }, { "id": "liyun-shi", "name": "Liyun Shi", "corpus_name": "Shi L", "orcid": null, "lab": "Institute of Translational Medicine, Zhejiang Shuren University (Hangzhou, Zhejiang, China)", "lab_url": null, "role": "Immunologist at Zhejiang Shuren University in Hangzhou whose group showed in mice that losing the lysosomal mTOR-activating protein Lamtor5 with age pushes macrophages into senescence and spreads inflammation", "studies": [ "LV2026" ], "url": "https://mtor-atlas.org/author/liyun-shi/" }, { "id": "diogo-martins-branco", "name": "Diogo Martins-Branco", "corpus_name": "Martins-Branco D", "orcid": null, "lab": "Scientific and Medical Division, European Society for Medical Oncology (Lugano, Switzerland)", "lab_url": null, "role": "Portuguese medical oncologist focused on breast cancer who moved from clinical research at the Institut Jules Bordet to the scientific division of the European Society for Medical Oncology", "studies": [ "MAR2026" ], "url": "https://mtor-atlas.org/author/diogo-martins-branco/" }, { "id": "evandro-de-azambuja", "name": "Evandro de Azambuja", "corpus_name": "de Azambuja E", "orcid": null, "lab": "Academic Trials Promoting Team, Institut Jules Bordet, Université libre de Bruxelles (Brussels, Belgium)", "lab_url": null, "role": "Brazilian-born medical oncologist at the Institut Jules Bordet in Brussels who designs and runs large academic breast cancer trials", "studies": [ "MAR2026" ], "url": "https://mtor-atlas.org/author/evandro-de-azambuja/" }, { "id": "su-bo", "name": "Su Bo", "corpus_name": "Bo S", "orcid": null, "lab": "Department of Cardiothoracic Surgery, Xiangyang No.1 People's Hospital, Hubei University of Medicine (Xiangyang, China)", "lab_url": null, "role": "Cardiothoracic surgery researcher in Xiangyang who tests natural compounds against lung cancer cells, including gambogic acid acting on the AKT and mTOR pathway", "studies": [ "BO2026" ], "url": "https://mtor-atlas.org/author/su-bo/" }, { "id": "agnieszka-dabkowska", "name": "Agnieszka Dąbkowska", "corpus_name": "Dąbkowska A", "orcid": null, "lab": "Laboratory of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences (Warsaw, Poland)", "lab_url": null, "role": "Leukemia researcher in Warsaw who works on new drug combinations for B-cell acute lymphoblastic leukemia, including mTORC1 inhibitors that make leukemia cells easier targets for anti-CD20 antibodies", "studies": [ "DAB2026" ], "url": "https://mtor-atlas.org/author/agnieszka-dabkowska/" }, { "id": "malgorzata-firczuk", "name": "Malgorzata Firczuk", "corpus_name": "Firczuk M", "orcid": null, "lab": "Laboratory of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences (Warsaw, Poland)", "lab_url": null, "role": "Immunologist in Warsaw who leads research on the weak points of B-cell leukemias and lymphomas, from the thioredoxin antioxidant system to combinations of mTORC1 inhibitors with antibody drugs", "studies": [ "DAB2026" ], "url": "https://mtor-atlas.org/author/malgorzata-firczuk/" }, { "id": "onur-deniz", "name": "Onur Deniz", "corpus_name": "Deniz O", "orcid": null, "lab": "Nutrient Sensing group (Hietakangas lab), Faculty of Biological and Environmental Sciences and Institute of Biotechnology, University of Helsinki (Helsinki, Finland)", "lab_url": "https://www.helsinki.fi/en/researchgroups/nutrient-sensing/people", "role": "Doctoral researcher in Ville Hietakangas's nutrient-sensing group in Helsinki, and first author of the fruit-fly study that found Spalt-related to be a stress-activated brake on mTORC1-driven growth", "studies": [ "DEN2026" ], "url": "https://mtor-atlas.org/author/onur-deniz/" }, { "id": "ville-hietakangas", "name": "Ville Hietakangas", "corpus_name": "Hietakangas V", "orcid": null, "lab": "Nutrient Sensing group, Faculty of Biological and Environmental Sciences and Institute of Biotechnology (HiLIFE), University of Helsinki (Helsinki, Finland)", "lab_url": "https://www.helsinki.fi/en/researchgroups/nutrient-sensing", "role": "Professor of gene regulation at the University of Helsinki who uses fruit flies to study how animals sense nutrients and how diet controls growth, metabolism and stem cells", "studies": [ "DEN2026" ], "url": "https://mtor-atlas.org/author/ville-hietakangas/" }, { "id": "denisa-pirscoveanu", "name": "Denisa Pirscoveanu", "corpus_name": "Pirscoveanu DF", "orcid": null, "lab": "Department of Neurology, University of Medicine and Pharmacy of Craiova (Craiova, Romania)", "lab_url": null, "role": "Neurology researcher in Craiova who works with Aurel Popa-Wagner on aging and stroke, and first author of a 2026 review on why mTOR-type lifespan gains shrink from worms to mammals", "studies": [ "PIR2026" ], "url": "https://mtor-atlas.org/author/denisa-pirscoveanu/" }, { "id": "aurel-popa-wagner", "name": "Aurel Popa-Wagner", "corpus_name": "Popa-Wagner A", "orcid": null, "lab": "Department of Neurology, University of Medicine and Pharmacy of Craiova (Craiova, Romania)", "lab_url": null, "role": "Neuroscientist of brain aging and stroke recovery working between Craiova and Essen, senior author of a 2026 review on the limits of extending lifespan through the mTOR pathway", "studies": [ "PIR2026" ], "url": "https://mtor-atlas.org/author/aurel-popa-wagner/" }, { "id": "hangyul-song", "name": "Hangyul Song", "corpus_name": "Song H", "orcid": null, "lab": "Oh Lab, Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (Gwangju, South Korea)", "lab_url": null, "role": "Researcher in Chang-Myung Oh's lab at GIST who tested urolithin A, a gut-microbe product, in mice with a stiff-heart form of heart failure", "studies": [ "SONH2026" ], "url": "https://mtor-atlas.org/author/hangyul-song/" }, { "id": "chang-myung-oh", "name": "Chang-Myung Oh", "corpus_name": "Oh CM", "orcid": null, "lab": "Oh Lab, Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (Gwangju, South Korea)", "lab_url": null, "role": "Metabolism researcher at GIST in South Korea whose lab studies heart and metabolic disease in mice, including how urolithin A protects the stiff heart in HFpEF", "studies": [ "SONH2026" ], "url": "https://mtor-atlas.org/author/chang-myung-oh/" }, { "id": "madhav-nilakhanth-mugale", "name": "Madhav Nilakhanth Mugale", "corpus_name": "Mugale MN", "orcid": null, "lab": "Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute (Lucknow, India)", "lab_url": null, "role": "Toxicologist at CSIR-CDRI in Lucknow whose group studies how organs such as the liver and lung are injured and scarred, and how hormones and drugs change that process", "studies": [ "VER2026" ], "url": "https://mtor-atlas.org/author/madhav-nilakhanth-mugale/" }, { "id": "lifu-zhu", "name": "Lifu Zhu", "corpus_name": "Zhu L", "orcid": null, "lab": "Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University (Hefei, China)", "lab_url": null, "role": "Environmental health researcher at Anhui Medical University and first author of a 2026 mouse study on how the solvent trichloroethylene damages the liver when the LKB1/AMPK energy sensor is missing", "studies": [ "ZHU2026" ], "url": "https://mtor-atlas.org/author/lifu-zhu/" }, { "id": "wafiya-jibrin", "name": "Wafiya Jibrin", "corpus_name": "Jibrin W", "orcid": null, "lab": "Diabetes, Endocrinology and Reproductive Biology, School of Medicine, University of Dundee (Dundee, Scotland, United Kingdom)", "lab_url": null, "role": "Researcher at the University of Dundee School of Medicine who led a 2026 cell-culture test of whether rapamycin can shield sperm-precursor cells from the cancer drug cisplatin", "studies": [ "JIB2026" ], "url": "https://mtor-atlas.org/author/wafiya-jibrin/" }, { "id": "federica-lopes", "name": "Federica Lopes", "corpus_name": "Lopes F", "orcid": null, "lab": "Diabetes, Endocrinology and Reproductive Biology, School of Medicine, University of Dundee (Dundee, Scotland, United Kingdom)", "lab_url": "https://dundee.ac.uk/people/federica-lopes", "role": "Reproductive biologist and Lecturer at the University of Dundee who studies how chemotherapy damages the immature testis and ovary, with the aim of protecting the future fertility of children treated for cancer", "studies": [ "JIB2026" ], "url": "https://mtor-atlas.org/author/federica-lopes/" }, { "id": "jonathan-j-halloran", "name": "Jonathan J. Halloran", "corpus_name": "Halloran J", "orcid": null, "lab": "Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "First author of a 2012 mouse study showing that lifelong rapamycin does not cost the brain anything and even protects learning and memory with age; long-time member of Veronica Galvan's aging and Alzheimer's research group in San Antonio", "studies": [ "HAL2012" ], "url": "https://mtor-atlas.org/author/jonathan-j-halloran/" }, { "id": "fatima-abrar", "name": "Fatima Abrar", "corpus_name": "Abrar F", "orcid": null, "lab": "NeurdyPhagy Lab, Department of Biology, University of Waterloo (Waterloo, Ontario, Canada)", "lab_url": null, "role": "First author of a 2026 review on how chemical tags on the autophagy receptor SQSTM1/p62 are linked to neurodegenerative disease", "studies": [ "ABR2026" ], "url": "https://mtor-atlas.org/author/fatima-abrar/" }, { "id": "daniele-stracka", "name": "Daniele Stracka", "corpus_name": "Stracka D", "orcid": null, "lab": "Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": null, "role": "Co-author of two studies from Michael Hall's laboratory in Basel that placed mTORC2, the second mTOR complex, at the ribosome and at contact sites between the endoplasmic reticulum and mitochondria", "studies": [ "BET2013", "ZIN2011" ], "url": "https://mtor-atlas.org/author/daniele-stracka/" }, { "id": "shuo-lin", "name": "Shuo Lin", "corpus_name": "Lin S", "orcid": null, "lab": "Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": null, "role": "Co-author of the 2008 mouse study showing that muscle needs raptor, the mTORC1 component, to stay healthy", "studies": [ "BEN2008" ], "url": "https://mtor-atlas.org/author/shuo-lin/" }, { "id": "walter-w-chen", "name": "Walter W. Chen", "corpus_name": "Chen WW", "orcid": null, "lab": "Department of Pediatrics, UT Southwestern Medical Center (Dallas, Texas, USA)", "lab_url": null, "role": "Co-author of the 2017 Cell paper showing that SLC38A9 releases essential amino acids from lysosomes to switch on mTORC1", "studies": [ "WYA2017" ], "url": "https://mtor-atlas.org/author/walter-w-chen/" }, { "id": "markus-a-ruegg", "name": "Markus A. Rüegg", "corpus_name": "Rüegg MA", "orcid": "0000-0002-4974-9384", "lab": "Rüegg Group, Biozentrum, University of Basel (Basel, Switzerland)", "lab_url": "https://www.biozentrum.unibas.ch/research/research-groups/research-groups-a-z/own-content/unit/research-group-markus-rueegg/rueegg-cv", "role": "Neurobiologist at the Biozentrum of the University of Basel who studies how muscles and the nerve connections that drive them develop, age and fail, including the role of mTOR signalling in muscle.", "studies": [ "HAG2012", "BEN2008", "POL2008", "JAC2004" ], "url": "https://mtor-atlas.org/author/markus-a-ruegg/" }, { "id": "laurent-guibaud", "name": "Laurent Guibaud", "corpus_name": "Guibaud L", "orcid": null, "lab": "Pediatric and Fetal Imaging, Reference Center for Superficial Vascular Anomalies, Hôpital Femme Mère Enfant, Université Claude Bernard Lyon 1 (Lyon, France)", "lab_url": null, "role": "First author of a 2026 case series on giving sirolimus (rapamycin) to pregnant women to treat large lymphatic malformations in their unborn babies", "studies": [ "GUIB2026" ], "url": "https://mtor-atlas.org/author/laurent-guibaud/" }, { "id": "arnab-mukhopadhyay", "name": "Arnab Mukhopadhyay", "corpus_name": "Mukhopadhyay A", "orcid": null, "lab": "Molecular Aging Laboratory, National Institute of Immunology (New Delhi, India)", "lab_url": "https://sites.google.com/a/nii.ac.in/arnab/", "role": "Studies how diet and gene activity interact to set lifespan in the roundworm C. elegans; his 2026 paper links loss of the mTORC2 component RICTOR to longevity on vitamin B12-rich diets through the methionine cycle and mitophagy.", "studies": [ "MOT2026" ], "url": "https://mtor-atlas.org/author/arnab-mukhopadhyay/" }, { "id": "zoya-n-demidenko", "name": "Zoya N Demidenko", "corpus_name": "Demidenko ZN", "orcid": null, "lab": "Department of Cell Stress Biology, Roswell Park Cancer Institute (Buffalo, New York, USA)", "lab_url": null, "role": "First author of the 2009 Cell Cycle study showing that rapamycin slows cellular senescence.", "studies": [ "DEM2009" ], "url": "https://mtor-atlas.org/author/zoya-n-demidenko/" }, { "id": "stephanie-baulac", "name": "Stéphanie Baulac", "corpus_name": "Baulac S", "orcid": null, "lab": "Paris Brain Institute (ICM), Sorbonne Université, Inserm, CNRS (Paris, France)", "lab_url": null, "role": "Last author of the 2019 Acta Neuropathologica cohort study showing that focal cortical dysplasia type 2 is a mosaic mTORopathy.", "studies": [ "BAL2019", "LEE2021" ], "url": "https://mtor-atlas.org/author/stephanie-baulac/" }, { "id": "sara-baldassari", "name": "Sara Baldassari", "corpus_name": "Baldassari S", "orcid": null, "lab": "Paris Brain Institute (ICM), Sorbonne Université, Inserm, CNRS (Paris, France)", "lab_url": null, "role": "First author of the 2019 Acta Neuropathologica cohort study on the genetic basis of focal cortical dysplasia.", "studies": [ "BAL2019", "LEE2021" ], "url": "https://mtor-atlas.org/author/sara-baldassari/" }, { "id": "homa-adle-biassette", "name": "Homa Adle-Biassette", "corpus_name": "Adle-Biassette H", "orcid": null, "lab": "INSERM UMR 1141, Hôpital Robert-Debré (Paris, France)", "lab_url": null, "role": "Neuropathology co-author on two studies of mTOR pathway variants in cortical dysplasia.", "studies": [ "BAL2019", "LEE2021" ], "url": "https://mtor-atlas.org/author/homa-adle-biassette/" }, { "id": "mathilde-chipaux", "name": "Mathilde Chipaux", "corpus_name": "Chipaux M", "orcid": null, "lab": "Department of Pediatric Neurosurgery, Rothschild Foundation Hospital (Paris, France)", "lab_url": null, "role": "Paediatric neurosurgery co-author on two studies of mTOR pathway variants in cortical dysplasia.", "studies": [ "BAL2019", "LEE2021" ], "url": "https://mtor-atlas.org/author/mathilde-chipaux/" }, { "id": "wei-shern-lee", "name": "Wei Shern Lee", "corpus_name": "Lee WS", "orcid": null, "lab": "Bruce Lefroy Centre, Murdoch Children's Research Institute (Parkville, Victoria, Australia)", "lab_url": null, "role": "First author of the 2021 report that brain mosaic RHEB variants cause a continuum of cortical dysplasia.", "studies": [ "LEE2021" ], "url": "https://mtor-atlas.org/author/wei-shern-lee/" }, { "id": "richard-j-leventer", "name": "Richard J Leventer", "corpus_name": "Leventer RJ", "orcid": null, "lab": "Murdoch Children's Research Institute, Royal Children's Hospital (Parkville, Victoria, Australia)", "lab_url": null, "role": "Last author of the 2021 report on brain mosaic RHEB variants in cortical dysplasia.", "studies": [ "LEE2021" ], "url": "https://mtor-atlas.org/author/richard-j-leventer/" }, { "id": "elizabeth-p-henske", "name": "Elizabeth P Henske", "corpus_name": "Henske EP", "orcid": null, "lab": "Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital (Boston, Massachusetts, USA)", "lab_url": null, "role": "Tuberous sclerosis researcher and co-author of the 2026 TSC2 minipig study and the 2017 Cancer Cell paper on mTORC1 and nucleotide synthesis.", "studies": [ "BOU2026", "VAL2017" ], "url": "https://mtor-atlas.org/author/elizabeth-p-henske/" }, { "id": "elias-bou-farhat", "name": "Elias Bou Farhat", "corpus_name": "Bou Farhat E", "orcid": null, "lab": "Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital (Boston, Massachusetts, USA)", "lab_url": null, "role": "First author of the 2026 JCI Insight paper on a TSC2-mutant minipig model of cardiac rhabdomyoma.", "studies": [ "BOU2026" ], "url": "https://mtor-atlas.org/author/elias-bou-farhat/" }, { "id": "simran-motwani", "name": "Simran Motwani", "corpus_name": "Motwani S", "orcid": null, "lab": "Molecular Aging Laboratory, National Institute of Immunology (Delhi, India)", "lab_url": null, "role": "First author of the 2026 Nature Communications study on RICTOR, vitamin B12 diets and longevity in C. elegans.", "studies": [ "MOT2026" ], "url": "https://mtor-atlas.org/author/simran-motwani/" }, { "id": "darren-e-stewart", "name": "Darren E Stewart", "corpus_name": "Stewart DE", "orcid": null, "lab": "Department of Surgery, NYU Langone Health (New York, New York, USA)", "lab_url": null, "role": "First author of the 2026 GeroScience registry study of rapamycin and survival in kidney transplant recipients.", "studies": [ "STE2026" ], "url": "https://mtor-atlas.org/author/darren-e-stewart/" }, { "id": "william-e-fitzsimmons", "name": "William E Fitzsimmons", "corpus_name": "Fitzsimmons WE", "orcid": null, "lab": "Colleges of Pharmacy and Medicine, University of Illinois Chicago (Chicago, Illinois, USA)", "lab_url": null, "role": "Last and corresponding author of the 2026 GeroScience registry study of rapamycin and survival in kidney transplant recipients.", "studies": [ "STE2026" ], "url": "https://mtor-atlas.org/author/william-e-fitzsimmons/" }, { "id": "boris-shor", "name": "Boris Shor", "corpus_name": "Shor B", "orcid": null, "lab": "Discovery Oncology, Wyeth Research (Pearl River, New York, USA)", "lab_url": null, "role": "First author of the 2010 Journal of Biological Chemistry study on mTOR, Maf1 and RNA polymerase III transcription.", "studies": [ "SHO2010" ], "url": "https://mtor-atlas.org/author/boris-shor/" }, { "id": "ker-yu", "name": "Ker Yu", "corpus_name": "Yu K", "orcid": null, "lab": "Discovery Oncology, Wyeth Research (Pearl River, New York, USA)", "lab_url": null, "role": "Last author of the 2010 Journal of Biological Chemistry study on mTOR, Maf1 and RNA polymerase III transcription.", "studies": [ "SHO2010" ], "url": "https://mtor-atlas.org/author/ker-yu/" }, { "id": "christine-mayer", "name": "Christine Mayer", "corpus_name": "Mayer C", "orcid": null, "lab": "Division of Molecular Biology of the Cell II, German Cancer Research Center (Heidelberg, Germany)", "lab_url": null, "role": "First author of the 2004 Genes & Development study showing that mTOR activates TIF-IA to link rRNA synthesis to nutrients.", "studies": [ "MAY2004" ], "url": "https://mtor-atlas.org/author/christine-mayer/" }, { "id": "ingrid-grummt", "name": "Ingrid Grummt", "corpus_name": "Grummt I", "orcid": null, "lab": "Division of Molecular Biology of the Cell II, German Cancer Research Center (Heidelberg, Germany)", "lab_url": null, "role": "Last author of the 2004 Genes & Development study showing that mTOR activates TIF-IA to link rRNA synthesis to nutrients.", "studies": [ "MAY2004" ], "url": "https://mtor-atlas.org/author/ingrid-grummt/" }, { "id": "hanna-kalenta", "name": "Hanna Kalenta", "corpus_name": "Kalenta H", "orcid": null, "lab": "Barshop Institute for Longevity and Aging Studies, University of Texas at San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "Co-author of two 2026 studies on constitutive mTORC1 activation in skeletal muscle from the Rasmussen laboratory.", "studies": [ "MARCHANT2026", "MAR2026B" ], "url": "https://mtor-atlas.org/author/hanna-kalenta/" }, { "id": "jacquelyn-may", "name": "Jacquelyn May", "corpus_name": "May J", "orcid": null, "lab": "Barshop Institute for Longevity and Aging Studies, University of Texas at San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "Co-author of two 2026 studies on constitutive mTORC1 activation in skeletal muscle from the Rasmussen laboratory.", "studies": [ "MARCHANT2026", "MAR2026B" ], "url": "https://mtor-atlas.org/author/jacquelyn-may/" }, { "id": "zhao-lai", "name": "Zhao Lai", "corpus_name": "Lai Z", "orcid": null, "lab": "Greehey Children's Cancer Research Institute, University of Texas at San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "Co-author of two 2026 studies on constitutive mTORC1 activation in skeletal muscle from the Rasmussen laboratory.", "studies": [ "MARCHANT2026", "MAR2026B" ], "url": "https://mtor-atlas.org/author/zhao-lai/" }, { "id": "jiaqiang-jiang", "name": "Jiaqiang Jiang", "corpus_name": "Jiang J", "orcid": null, "lab": "Department of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University (Guangzhou, China)", "lab_url": null, "role": "Member of the Nanfang Hospital gastric-cancer surgery team that traced how a tumor-enriched gut bacterium rewires CD8+ T cells through an mTOR-linked checkpoint to blunt anti-PD-1 therapy.", "studies": [ "REN2026" ], "url": "https://mtor-atlas.org/author/jiaqiang-jiang/" }, { "id": "shuai-yu", "name": "Shuai Yu", "corpus_name": "Yu S", "orcid": null, "lab": "Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital), Gusu School, Nanjing Medical University (Suzhou, Jiangsu, China)", "lab_url": null, "role": "Neurology researcher who contributed to a study showing that the lipid kinase PIP4K2A protects the brain after ischaemic stroke by relieving a block on autophagy and boosting AKT/mTOR signalling", "studies": [ "MA2026" ], "url": "https://mtor-atlas.org/author/shuai-yu/" }, { "id": "shiting-yu", "name": "Shiting Yu", "corpus_name": "Yu S", "orcid": "0000-0002-8784-7743", "lab": "Northeast Asia Research Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine (Changchun, China)", "lab_url": null, "role": "Natural-products researcher who contributed to a study showing that a Chinese yam (Dioscorea polystachya) extract counters male reproductive ageing through the mTOR–Beclin-1 autophagy axis", "studies": [ "ZHANG2026B" ], "url": "https://mtor-atlas.org/author/shiting-yu/" }, { "id": "yukun-zhang", "name": "Yukun Zhang", "corpus_name": "Zhang Y", "orcid": "0000-0003-4487-9988", "lab": "Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (Wuhan, Hubei, China)", "lab_url": null, "role": "Senior author of a study showing that failing chaperone-mediated autophagy lets midnolin accumulate and degrade TSC2, overactivating mTORC1 and accelerating intervertebral disc degeneration", "studies": [ "CHEN2026C" ], "url": "https://mtor-atlas.org/author/yukun-zhang/" }, { "id": "yiwen-zhang", "name": "Yiwen Zhang", "corpus_name": "Zhang Y", "orcid": null, "lab": "Northeast Asia Research Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine (Changchun, China)", "lab_url": null, "role": "Researcher at Changchun University of Chinese Medicine who contributed to a study showing that a Chinese yam extract counters male reproductive ageing through mTOR–Beclin-1 autophagy", "studies": [ "ZHANG2026B" ], "url": "https://mtor-atlas.org/author/yiwen-zhang/" }, { "id": "meijie-li", "name": "Meijie Li", "corpus_name": "Li M", "orcid": null, "lab": "Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College (Luikart / Hong labs) (Hanover, New Hampshire, USA)", "lab_url": "https://www.synapticplasticity.com/", "role": "Dartmouth researcher, working with the Luikart and Hong labs, studying how PTEN controls the neuronal microtubule cytoskeleton through mTORC2 rather than mTORC1", "studies": [ "EVA2026" ], "url": "https://mtor-atlas.org/author/meijie-li/" }, { "id": "mei-li", "name": "Mei Li", "corpus_name": "Li M", "orcid": null, "lab": "Pediatrics Research Institute, Children's Hospital of Soochow University (Suzhou, Jiangsu, China)", "lab_url": null, "role": "Scientist at the Pediatrics Research Institute of Children's Hospital of Soochow University studying brain injury, who contributed to a study of how PIP4K2A protects the brain after stroke", "studies": [ "MA2026" ], "url": "https://mtor-atlas.org/author/mei-li/" }, { "id": "lei-zhang", "name": "Lei Zhang", "corpus_name": "Zhang L", "orcid": null, "lab": "College of Life Sciences, Yantai University (Yantai, China)", "lab_url": null, "role": "Contributed to a 2026 mouse study showing that the plant compound pungenin relieves androgenic alopecia through the PI3K/AKT/mTOR pathway", "studies": [ "ZHAI2026" ], "url": "https://mtor-atlas.org/author/lei-zhang/" }, { "id": "ling-zhang", "name": "Ling Zhang", "corpus_name": "Zhang L", "orcid": null, "lab": "School of Public Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology (Wuhan, Hubei, China)", "lab_url": null, "role": "Contributed to a 2026 toxicology study linking early-life exposure to microplastics and the plasticiser DEHP to autism-relevant brain changes through impaired mTOR-regulated autophagy", "studies": [ "YANG2026" ], "url": "https://mtor-atlas.org/author/ling-zhang/" }, { "id": "qingsong-liu", "name": "Qingsong Liu", "corpus_name": "Liu Q", "orcid": null, "lab": "Qingsong Liu Lab, Hefei Institutes of Physical Science, Chinese Academy of Sciences (Hefei, China)", "lab_url": "http://qsliulab.hmfl.cas.cn/Liu/", "role": "Medicinal chemist in Nathanael Gray's lab who helped discover Torin1, an ATP-competitive mTOR inhibitor, and later built an independent kinase-inhibitor drug-discovery program in China", "studies": [ "THO2009" ], "url": "https://mtor-atlas.org/author/qingsong-liu/" }, { "id": "qianqian-liu", "name": "Qianqian Liu", "corpus_name": "Liu Q", "orcid": null, "lab": "Department of Population Health Sciences, UT Health San Antonio (San Antonio, Texas, USA)", "lab_url": null, "role": "Biostatistician on one of the first randomised pilot trials of rapamycin's safety in older adults", "studies": [ "KRA2018" ], "url": "https://mtor-atlas.org/author/qianqian-liu/" }, { "id": "jing-wang", "name": "Jing Wang", "corpus_name": "Wang J", "orcid": null, "lab": "Institute of Metabolism and Integrative Biology, Fudan University (Shanghai, China)", "lab_url": "https://imib.fudan.edu.cn/imiben/22747/list.htm", "role": "Showed as first author that the CORVET/HOPS trafficking machinery is needed for T cells to sense amino acids and activate mTORC1", "studies": [ "WANG2026" ], "url": "https://mtor-atlas.org/author/jing-wang/" }, { "id": "jie-wang", "name": "Jie Wang", "corpus_name": "Wang J", "orcid": "0000-0001-7602-5050", "lab": "Wang Jie Lab, Department of Chemistry, Southern University of Science and Technology (SUSTech) (Shenzhen, China)", "lab_url": "https://www.sustech.edu.cn/en/faculties/wangjie.html", "role": "Corresponding author of a 2026 JACS paper identifying PKM2 as a direct methionine-sensing protein that signals into mTORC1 via GATOR2.", "studies": [ "SANG2026" ], "url": "https://mtor-atlas.org/author/jie-wang/" }, { "id": "xiaoge-sun", "name": "Xiaoge Sun", "corpus_name": "Sun X", "orcid": null, "lab": "Department of Radiation Oncology, Affiliated Hospital of Inner Mongolia Medical University (Hohhot, China)", "lab_url": null, "role": "Senior author of a 2026 study showing that the recurrent PIK3CA-E545K mutation drives cervical cancer growth and invasion through AKT/mTOR signalling", "studies": [ "HUANG2026" ], "url": "https://mtor-atlas.org/author/xiaoge-sun/" }, { "id": "xiaojie-sun", "name": "Xiaojie Sun", "corpus_name": "Sun X", "orcid": "0009-0003-6151-5542", "lab": "School of Public Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology (Wuhan, Hubei, China)", "lab_url": null, "role": "Contributed to a 2026 toxicology study linking early-life exposure to microplastics and the plasticiser DEHP to autism-relevant brain changes through impaired mTOR-regulated autophagy", "studies": [ "YANG2026" ], "url": "https://mtor-atlas.org/author/xiaojie-sun/" }, { "id": "siming-wang", "name": "Siming Wang", "corpus_name": "Wang S", "orcid": null, "lab": "Northeast Asia Research Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine (Changchun, China)", "lab_url": null, "role": "Member of Daqing Zhao's natural-products group who contributed to a study showing that a Chinese yam extract restores mTOR–Beclin-1-regulated autophagy in ageing testis cells", "studies": [ "ZHANG2026B" ], "url": "https://mtor-atlas.org/author/siming-wang/" }, { "id": "xiang-yu", "name": "Xiang Yu", "corpus_name": "Yu X", "orcid": null, "lab": "Department of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University (Guangzhou, China)", "lab_url": null, "role": "Member of Yanfeng Hu's gastric-cancer lab who contributed to a study showing how a microbiota-linked metabolite, kynurenic acid, drives resistance to PD-1 blockade", "studies": [ "REN2026" ], "url": "https://mtor-atlas.org/author/xiang-yu/" }, { "id": "xiaotian-yu", "name": "Xiaotian Yu", "corpus_name": "Yu X", "orcid": null, "lab": "Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital, Gusu School) (Suzhou, Jiangsu, China)", "lab_url": null, "role": "Stroke neurology researcher who contributed to a study of how PIP4K2A limits brain injury after ischaemia and reperfusion through the TRIB3–p62 and AKT–mTOR pathways", "studies": [ "MA2026" ], "url": "https://mtor-atlas.org/author/xiaotian-yu/" }, { "id": "jing-zhou", "name": "Jing Zhou", "corpus_name": "Zhou J", "orcid": null, "lab": "Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research, UT Southwestern Medical Center (Luis F. Parada lab) (Dallas, Texas, USA)", "lab_url": null, "role": "Researcher in Luis Parada's lab whose work includes the 2009 study showing that rapamycin prevents and reverses brain abnormalities in neural Pten-knockout mice", "studies": [ "ZHO2009" ], "url": "https://mtor-atlas.org/author/jing-zhou/" }, { "id": "jiangyuan-zhou", "name": "Jiangyuan Zhou", "corpus_name": "Zhou J", "orcid": null, "lab": "Division of Oncology, Department of Pediatric Surgery, and Rare Diseases Center, West China Hospital, Sichuan University (Chengdu, Sichuan, China)", "lab_url": null, "role": "Member of Yi Ji's pediatric vascular-anomalies and surgical-oncology team; co-author on the sirolimus-for-Kaposiform-hemangioendothelioma study.", "studies": [ "XU2026" ], "url": "https://mtor-atlas.org/author/jiangyuan-zhou/" }, { "id": "wanying-chen", "name": "Wanying Chen", "corpus_name": "Chen W", "orcid": null, "lab": "Department of Plastic Surgery, The First Affiliated Hospital of Wenzhou Medical University (Wenzhou, China)", "lab_url": null, "role": "Member of a Wenzhou wound-healing and adipose-stem-cell research group who contributed to a study of FGF21-modified exosomes that promote wound healing through AMPK–mTOR", "studies": [ "CHEN2026" ], "url": "https://mtor-atlas.org/author/wanying-chen/" }, { "id": "wei-chen", "name": "Wei Chen", "corpus_name": "Chen W", "orcid": null, "lab": "Department of General Surgery, Hebei PetroChina Central Hospital (Langfang, China)", "lab_url": null, "role": "Showed that IGF2BP3-mediated m6A modification of OLR1 mRNA helps colorectal cancer evade CD8+ T cells through the PI3K/AKT/mTOR pathway", "studies": [ "CHEN2026B" ], "url": "https://mtor-atlas.org/author/wei-chen/" }, { "id": "jun-yang", "name": "Jun Yang", "corpus_name": "Yang J", "orcid": null, "lab": "College of Life Sciences, Yantai University (Yantai, China)", "lab_url": null, "role": "Contributed to a study showing that pungenin promotes hair growth in mouse models of androgenic alopecia through the PI3K/AKT/mTOR pathway", "studies": [ "ZHAI2026" ], "url": "https://mtor-atlas.org/author/jun-yang/" }, { "id": "juan-yang", "name": "Juan Yang", "corpus_name": "Yang J", "orcid": "0000-0003-3175-8124", "lab": "Department of Neurology, The General Hospital of Ningxia Medical University (Yinchuan, Ningxia, China)", "lab_url": null, "role": "Contributed to a study showing that the Brucella suis vaccine strain S2 drives macrophage polarisation and autophagy through PI3K/Akt/mTOR signalling to survive inside cells", "studies": [ "LI2026B" ], "url": "https://mtor-atlas.org/author/juan-yang/" }, { "id": "yulian-xiao", "name": "Yulian Xiao", "corpus_name": "Xiao Y", "orcid": null, "lab": "Department of Hematology, The Third Xiangya Hospital of Central South University (Changsha, China)", "lab_url": null, "role": "Contributed to a study identifying a tRNA fragment (tRF-17-8SPOL52) that drives bortezomib resistance in multiple myeloma by activating autophagy", "studies": [ "FU2026" ], "url": "https://mtor-atlas.org/author/yulian-xiao/" }, { "id": "sen-zhang", "name": "Sen Zhang", "corpus_name": "Zhang S", "orcid": null, "lab": "Research Centre of Environmental Ecology and Fish Nutrition (Ministry of Agriculture and Rural Affairs), College of Fisheries and Life Science, Shanghai Ocean University (Shanghai, China)", "lab_url": null, "role": "Contributed to a study showing that largemouth bass have a weak insulin/mTOR/SREBP1 fat-making pathway, so excess dietary carbohydrate is stored as liver glycogen rather than fat", "studies": [ "TAO2026" ], "url": "https://mtor-atlas.org/author/sen-zhang/" }, { "id": "susu-zhang", "name": "Susu Zhang", "corpus_name": "Zhang S", "orcid": null, "lab": "The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital (Lishui, China)", "lab_url": null, "role": "Contributed to a study showing that salvianolic acid B improves motor recovery after spinal cord injury in association with AKT/mTOR/HIF-1α activation and blood-vessel growth", "studies": [ "YAO2026" ], "url": "https://mtor-atlas.org/author/susu-zhang/" }, { "id": "sunghoon-kim", "name": "Sunghoon Kim", "corpus_name": "Kim S", "orcid": null, "lab": "Medicinal Bioconvergence Research Center, College of Pharmacy, Yonsei University (Incheon, South Korea)", "lab_url": "https://target.re.kr/about-us/", "role": "Senior author of the 2012 study proposing leucyl-tRNA synthetase as an intracellular leucine sensor for mTORC1, part of his broader work on the signalling roles of tRNA synthetases", "studies": [ "HAN2012" ], "url": "https://mtor-atlas.org/author/sunghoon-kim/" }, { "id": "seongbin-kim", "name": "Seongbin Kim", "corpus_name": "Kim S", "orcid": "0009-0000-1105-5558", "lab": "Department of Biological Sciences, KAIST & Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) (Daejeon, South Korea)", "lab_url": null, "role": "Contributed to a 2026 study showing that abnormal ERBB4 in excitatory neurons drives Alzheimer's pathology through mTOR signalling", "studies": [ "LEE2026" ], "url": "https://mtor-atlas.org/author/seongbin-kim/" }, { "id": "chunting-zhang", "name": "Chunting Zhang", "corpus_name": "Zhang C", "orcid": null, "lab": "Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University (Guangzhou, China)", "lab_url": null, "role": "Contributed to a study showing that the lncRNA LINP1 protects irradiated skin cells from senescence by disrupting the mTOR–p53 interaction", "studies": [ "LIANG2026" ], "url": "https://mtor-atlas.org/author/chunting-zhang/" }, { "id": "chen-zhang", "name": "Chen Zhang", "corpus_name": "Zhang C", "orcid": null, "lab": "Ding Lab, Dept. of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center (Kansas City, Kansas, USA)", "lab_url": "https://www.kumc.edu/school-of-medicine/academics/departments/pharmacology-toxicology-and-therapeutics/academics/graduate-students/chen-zhang.html", "role": "Ran the liver-specific Tsc1-knockout mouse study showing that non-canonical mTORC1–TFEB activation drives hepatocyte plasticity and aggressive liver cancer", "studies": [ "ZHANG2026" ], "url": "https://mtor-atlas.org/author/chen-zhang/" }, { "id": "long-he", "name": "Long He", "corpus_name": "He L", "orcid": "0000-0003-4721-9221", "lab": "Blenis Lab, Dept. of Pharmacology & Meyer Cancer Center, Weill Cornell Medicine (New York, New York, USA)", "lab_url": "https://vivo.weill.cornell.edu/display/cwid-loh2007", "role": "Research faculty member in John Blenis's lab at Weill Cornell who studies how mTORC1 controls cell metabolism, and first author of the lab's 2025 review of mTORC1 as a conductor of metabolism and growth", "studies": [ "HE2025" ], "url": "https://mtor-atlas.org/author/long-he/" }, { "id": "linling-he", "name": "Linling He", "corpus_name": "He L", "orcid": null, "lab": "Institute of Metabolism and Integrative Biology (IMIB), Fudan University (Shanghai, China)", "lab_url": null, "role": "Researcher in the Fudan team studying amino-acid sensing and stress resilience in T cells", "studies": [ "WANG2026" ], "url": "https://mtor-atlas.org/author/linling-he/" }, { "id": "jiayun-he", "name": "Jiayun He", "corpus_name": "He J", "orcid": null, "lab": "Lei Luo Lab, College of Pharmaceutical Sciences, Southwest University (Chongqing, China)", "lab_url": null, "role": "Contributing co-author in Lei Luo's team studying redox-driven mTOR-eIF4A translational control.", "studies": [ "JIN2026" ], "url": "https://mtor-atlas.org/author/jiayun-he/" }, { "id": "jiaxiong-he", "name": "Jiaxiong He", "corpus_name": "He J", "orcid": null, "lab": "Research Centre of Environmental Ecology and Fish Nutrition, College of Fisheries and Life Science, Shanghai Ocean University (Shanghai, China)", "lab_url": null, "role": "Contributing co-author in Songlin Li's aquaculture-nutrition team studying mTOR/SREBP1-driven lipogenesis in fish.", "studies": [ "TAO2026" ], "url": "https://mtor-atlas.org/author/jiaxiong-he/" }, { "id": "ruoning-wang", "name": "Ruoning Wang", "corpus_name": "Wang R", "orcid": null, "lab": "Center for Childhood Cancer, Abigail Wexner Research Institute, Nationwide Children's Hospital & Dept. of Pediatrics, Ohio State University College of Medicine (Columbus, Ohio, USA)", "lab_url": "https://www.nationwidechildrens.org/research/areas-of-research/center-for-childhood-cancer/wang-lab", "role": "Showed as first author, in Douglas Green's lab, that the transcription factor Myc drives the metabolic switch of activated T cells, and now leads an immunometabolism lab", "studies": [ "WAN2011" ], "url": "https://mtor-atlas.org/author/ruoning-wang/" }, { "id": "yanhui-xu", "name": "Yanhui Xu", "corpus_name": "Xu Y", "orcid": null, "lab": "Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences, Shanghai Medical College of Fudan University (Shanghai, China)", "lab_url": "https://ibs.fudan.edu.cn/ibsen/05/ca/c39095a460234/page.htm", "role": "Structural biologist whose Fudan lab solved a cryo-EM structure of human mTORC2 in 2018, showing how rictor and mSin1 block rapamycin's access to mTOR", "studies": [ "CHE2018" ], "url": "https://mtor-atlas.org/author/yanhui-xu/" }, { "id": "yulang-xu", "name": "Yulang Xu", "corpus_name": "Xu Y", "orcid": "0009-0006-3504-0354", "lab": "Division of Oncology, Department of Pediatric Surgery & Rare Diseases Center, West China Hospital, Sichuan University (Chengdu, Sichuan, China)", "lab_url": "https://www.wchscu.cn/details/51632.html", "role": "Paediatric surgeon-researcher who led a multicentre study showing that head-and-neck kaposiform hemangioendothelioma responds especially well to the mTOR inhibitor sirolimus", "studies": [ "XU2026" ], "url": "https://mtor-atlas.org/author/yulang-xu/" }, { "id": "eunjung-kim", "name": "Eunjung Kim", "corpus_name": "Kim E", "orcid": null, "lab": "Guan Laboratory, Department of Pharmacology & Moores Cancer Center, University of California San Diego (circa 2007–2010) (La Jolla, California, USA)", "lab_url": "http://guanlab.ucsd.edu/", "role": "Showed as first author, in Kun-Liang Guan's lab, that the Rag GTPases relay amino-acid availability to TORC1, in parallel with the Sabatini lab's discovery", "studies": [ "KIM2008" ], "url": "https://mtor-atlas.org/author/eunjung-kim/" }, { "id": "eunjoon-kim", "name": "Eunjoon Kim", "corpus_name": "Kim E", "orcid": "0000-0001-5518-6584", "lab": "Center for Synaptic Brain Dysfunctions, Institute for Basic Science & Department of Biological Sciences, KAIST (Daejeon, South Korea)", "lab_url": "https://molneuro.kaist.ac.kr/", "role": "Neuroscientist who directs the IBS Center for Synaptic Brain Dysfunctions and studies synaptic scaffold proteins linked to autism; he contributed to work linking neuronal ERBB4 and mTOR signalling to Alzheimer's pathology", "studies": [ "LEE2026" ], "url": "https://mtor-atlas.org/author/eunjoon-kim/" }, { "id": "shiwen-chen", "name": "Shiwen Chen", "corpus_name": "Chen S", "orcid": null, "lab": "Research Centre of Environmental Ecology & Fish Nutrition, College of Fisheries and Life Science, Shanghai Ocean University (Shanghai, China)", "lab_url": null, "role": "Aquaculture physiologist studying why the largemouth bass, a carnivorous fish, tolerates dietary carbohydrate so poorly", "studies": [ "TAO2026" ], "url": "https://mtor-atlas.org/author/shiwen-chen/" }, { "id": "sheng-chen", "name": "Sheng Chen", "corpus_name": "Chen S", "orcid": null, "lab": "Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (Wuhan, Hubei, China)", "lab_url": null, "role": "Orthopaedic researcher who contributed to a study showing that the plant compound corilagin protects joint cartilage by calming inflammation and restoring autophagy", "studies": [ "ZHOU2026B" ], "url": "https://mtor-atlas.org/author/sheng-chen/" }, { "id": "yunwei-wang", "name": "Yunwei Wang", "corpus_name": "Wang Y", "orcid": null, "lab": "Department of Burn Plastic and Wound Repair Surgery, The Second Hospital of Lanzhou University (Lanzhou, China)", "lab_url": null, "role": "Burn and wound-repair researcher who contributed to a study testing the plant flavonoid dihydromyricetin as an anti-scarring treatment", "studies": [ "CAO2026B" ], "url": "https://mtor-atlas.org/author/yunwei-wang/" }, { "id": "yifei-wang", "name": "Yifei Wang", "corpus_name": "Wang Y", "orcid": null, "lab": "Key Laboratory of Pesticide & Chemical Biology (Ministry of Education) & Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Normal University (Wuhan, Hubei, China)", "lab_url": null, "role": "Environmental toxicologist who contributed to a study of how early-life exposure to food-contact microplastics and a common plasticiser disrupts brain development through mTOR signalling", "studies": [ "YANG2026" ], "url": "https://mtor-atlas.org/author/yifei-wang/" }, { "id": "joy-zhao", "name": "Joy Zhao", "corpus_name": "Zhao J", "orcid": null, "lab": "Cregan Laboratory, Robarts Research Institute, University of Western Ontario (London, Ontario, Canada)", "lab_url": "https://www.robarts.ca/research/scientists/cregan_sean.html", "role": "Researcher in Sean Cregan's lab studying how chronic cell-stress signalling through ATF4 suppresses mTOR and kills dopamine neurons in Parkinson's disease models", "studies": [ "DEMMINGS2026" ], "url": "https://mtor-atlas.org/author/joy-zhao/" }, { "id": "jiaqi-zhao", "name": "Jiaqi Zhao", "corpus_name": "Zhao J", "orcid": null, "lab": "Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis & State Key Laboratory of Medical Proteomics, Southern University of Science and Technology (SUSTech) (Shenzhen, China)", "lab_url": null, "role": "Co-author; chemical biologist who helped build a chemical probe revealing a glycolytic enzyme's secret second job as a methionine sensor for mTORC1.", "studies": [ "SANG2026" ], "url": "https://mtor-atlas.org/author/jiaqi-zhao/" }, { "id": "jiyoung-pan", "name": "Jiyoung Pan", "corpus_name": "Pan J", "orcid": null, "lab": "Demetriades Lab, Max Planck Institute for Biology of Ageing (Cologne, North Rhine-Westphalia, Germany)", "lab_url": "https://www.age.mpg.de/demetriades", "role": "PhD student who co-authored the 2024 study showing that mTORC1 does different jobs at the lysosome and away from it, and first author of a 2026 review on why mTORC1 is better seen as a substrate-selective kinase than an on/off switch", "studies": [ "FER2024" ], "url": "https://mtor-atlas.org/author/jiyoung-pan/" } ] }